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Review: taking Tizanidine and Xanax together

Summary: drug interactions are reported among people who take Tizanidine and Xanax together.

This review analyzes the effectiveness and drug interactions between Tizanidine and Xanax. It is created by eHealthMe based on reports of 1,220 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 31, 2015: 1,220 people who take Tizanidine Hydrochloride, Xanax are studied

Tizanidine Hydrochloride, Xanax outcomes

Drug combinations in study:
- Tizanidine Hydrochloride (tizanidine hydrochloride)
- Xanax (alprazolam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tizanidine Hydrochloride is effective50.00%
(2 of 4 people)
(5 of 13 people)
(3 of 11 people)
(5 of 12 people)
(8 of 13 people)
(2 of 3 people)
(2 of 4 people)
Xanax is effective0.00%
(0 of 1 people)
(7 of 9 people)
(3 of 5 people)
(5 of 12 people)
(13 of 22 people)
(4 of 5 people)
(7 of 9 people)

Drug effectiveness by gender :

Tizanidine Hydrochloride is effective37.50%
(18 of 48 people)
(9 of 12 people)
Xanax is effective58.82%
(30 of 51 people)
(9 of 12 people)

Drug effectiveness by age :

Tizanidine Hydrochloride is effectiven/an/an/a28.57%
(4 of 14 people)
(1 of 15 people)
(9 of 40 people)
(7 of 29 people)
(6 of 14 people)
Xanax is effectiven/an/an/a34.78%
(8 of 23 people)
(5 of 17 people)
(13 of 41 people)
(8 of 29 people)
(5 of 14 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Suicide AttemptDuodenal Ulcer PerforationTremorSudden Memory LossHeadacheBleeding Time ProlongedHot FlushesFatigue
HypotensionMassEmotional DistressDizzinessDizzinessNight SweatsStiffness In A JointAnxiety
DepressionObstructive Airways DisorderDrug Withdrawal SyndromeConstipationBlood Pressure IncreasedFatigue - ChronicDiaphoresisDepression
Emotional DistressLung HyperinflationCushingoidPersonality ChangeFatigueSeromaSweating - ExcessivePain
HypoxiaIntermittent ClaudicationArthralgiaNauseaSensation Of HeavinessFibromyalgiaPain - MusclesNausea
DysphagiaGraft InfectionAnxietyInsomniaInfluenzaNeuromaFall
Burns Third DegreeParaesthesiaPalpitationsLoss Of ConsciousnessPainDyspnoea
AggressionGlaucomaDehydrationLoss Of LibidoDepressed MoodHeadache
Suicidal IdeationTooth InfectionSkin DiscolourationHyperhidrosisSensory DisturbanceChest Pain
InjuryHaemoglobin DecreasedDyspnoeaGeneral Physical Health DeteriorationHypoaesthesiaDizziness

Most common drug interactions by gender * :

VomitingBack Pain
FallDrug Dependence
DepressionPain In Extremity
Chest PainFall

Most common drug interactions by age * :

Orthopnoean/aHeadacheDrug IneffectiveArthralgiaDepressionFallFall
Nervous System DisorderSomnolenceVomitingNauseaAnxietyFatigueFatigue
Pancreatitis AcuteDrug Screen PositiveDrug DependenceAnxietyHeadacheProgressive Multifocal LeukoencephalopathyUrinary Tract Infection
PneumoniaNauseaPainDyspnoeaMultiple Sclerosis RelapseDyspnoea
TremorFatigueHypoaesthesiaChest PainChest PainNausea
Renal ImpairmentDrug Withdrawal SyndromeDyspnoeaHypoaesthesiaPainPain
HypotensionInsomniaDrug Withdrawal SyndromeFatigueHeadacheTremor
HyponatraemiaDrug AbuserPain In ExtremityFallDrug IneffectiveAnxiety
BradycardiaBack PainHeadacheConstipationPneumoniaDizziness
Cholecystitis ChronicPainDepressionPainVomitingDepression

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Tizanidine Hydrochloride
- support group for people who take Xanax

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Tizanidine Hydrochloride (tizanidine hydrochloride) is often used to treat muscle spasms. Xanax (alprazolam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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