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Review: Amitriptyline and Tramadol

This review analyzes the effectiveness and drug interactions between Amitriptyline and Tramadol. It is created by eHealthMe based on reports of 2,959 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Amitriptyline and Tramadol >>>

What are the drugs

Amitriptyline hydrochloride (what 7,098 Amitriptyline Hydrochloride users reported?) has active ingredients of amitriptyline hydrochloride. It is used in migraine.

Tramadol (what 41,420 Tramadol users reported?) has active ingredients of tramadol hydrochloride. It is used in pain.

On Sep, 11, 2014: 2,959 people who take Amitriptyline Hydrochloride, Tramadol are studied

Amitriptyline Hydrochloride, Tramadol outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective10.00%
(1 of 10 people)
(4 of 29 people)
(4 of 14 people)
(6 of 17 people)
(4 of 17 people)
(7 of 15 people)
(1 of 6 people)
(0 of 3 people)
Tramadol is effective15.38%
(2 of 13 people)
(4 of 16 people)
(2 of 19 people)
(5 of 24 people)
(3 of 17 people)
(3 of 13 people)
(2 of 4 people)
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RestlessnessDepressionNauseaDeathSuicidal IdeationDepressionInsomniaPain
DizzinessInjuryFallSudden DeathAnxietyAggressionHot Flushes NosAnxiety
AnxietyDeep Vein ThrombosisOedema PeripheralSinus TachycardiaDepressionAnxietyHeart RacingNausea
DyspnoeaAggressionConvulsionHypotensionNightmareLoss Of ConsciousnessHeart PoundingHeadache
FatigueScarAbdominal PainAtaxiaDrug Withdrawal SyndromeSinus TachycardiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepression
Pain In ExtremityMental DisorderAmnesiaDisorientationConvulsionMuscle TwitchingDry MouthDyspnoea
AgitationAnxietySuicide AttemptOverdoseHeadacheHypotensionDizzinessFatigue
DiarrhoeaFatigueDeep Vein ThrombosisConfusional StateArthralgiaIntentional OverdoseArthralgia
PainHeadacheDepressionCirculatory CollapseAgitationSuicide AttemptFall
ParaesthesiaThrombosisApparent DeathBalance DisorderH1n1 InfluenzaElectrocardiogram T Wave InversionAsthenia

Drug effectiveness by gender :

Amitriptyline Hydrochloride is effective23.81%
(20 of 84 people)
(6 of 26 people)
Tramadol is effective20.99%
(17 of 81 people)
(4 of 27 people)

Most common drug interactions by gender * :

ArthralgiaDrug Ineffective
DepressionChest Pain

Drug effectiveness by age :

Amitriptyline Hydrochloride is effectiven/an/a0.00%
(0 of 2 people)
(3 of 21 people)
(8 of 53 people)
(5 of 49 people)
(6 of 32 people)
(5 of 14 people)
Tramadol is effectiven/an/a100.00%
(1 of 1 people)
(2 of 22 people)
(6 of 55 people)
(3 of 48 people)
(5 of 33 people)
(4 of 12 people)

Most common drug interactions by age * :

Convulsionn/aConfusional StateCompleted SuicideAnxietyNauseaPainPain
Respiratory ArrestHeadacheHyperhidrosisDepressionDepressionNauseaOsteoarthritis
Accidental Drug Intake By ChildSuicidal IdeationSerotonin SyndromeHeadacheHeadacheAnxietyFall
FlushingAnxietySuicidal IdeationChest PainFallDyspnoea
TremorDrug ToxicityDrug Withdrawal SyndromeAnxietyFatigueAnxiety
Hallucination, VisualPainDyspnoeaDrug IneffectiveHeadacheNausea
Emotional DistressOvarian CystVomitingArthralgiaPyrexiaFatigue
Crohn's DiseaseNauseaAstheniaInsomniaAbdominal PainBack Pain
Weight DecreasedFeeling HotParaesthesiaFatigueOedema PeripheralWeight Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Amitriptyline and Tramadol
- group for people who take Amitriptyline Hydrochloride
- group for people who take Tramadol

Comments from related studies:

  • From this study (4 months ago):

  • Recent blood test high WBC Esterase, WBC and ALT


  • From this study (4 months ago):

  • I see a pain doctor once a month. They do a drug screen to see if you take you're meds, and if there's any meds you should not be taking. I did produce very little urine, approx. 1tsp-1tbl, but the nurse said she had a reading. it showed positive for Nuycnta in my system. I did not take anything than my prescribed drugs. I didn't even know what type of drug it was, so I am very curios to know why I tested positive for it.


  • From this study (4 months ago):

  • I am still undergoing procedures to find a diagnosis, Doctors are unsure if I actually have fibromyalgia and suspect a nerve disorder.


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Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat migraine. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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