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Review: Amitriptyline and Tramadol





Summary: drug interactions are reported among people who take Amitriptyline and Tramadol together.

This review analyzes the effectiveness and drug interactions between Amitriptyline and Tramadol. It is created by eHealthMe based on reports of 2,965 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Amitriptyline and Tramadol >>>

What are the drugs

Amitriptyline hydrochloride has active ingredients of amitriptyline hydrochloride. It is often used in depression. (latest outcomes from Amitriptyline hydrochloride 7,147 users)

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (view latest outcomes from 41,501 users)

On Dec, 13, 2014: 2,965 people who take Amitriptyline Hydrochloride, Tramadol are studied

Amitriptyline Hydrochloride, Tramadol outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective10.00%
(1 of 10 people)
12.50%
(4 of 32 people)
28.57%
(4 of 14 people)
38.89%
(7 of 18 people)
26.32%
(5 of 19 people)
46.67%
(7 of 15 people)
16.67%
(1 of 6 people)
0.00%
(0 of 3 people)
Tramadol is effective20.00%
(3 of 15 people)
25.00%
(4 of 16 people)
10.53%
(2 of 19 people)
18.52%
(5 of 27 people)
22.22%
(4 of 18 people)
23.08%
(3 of 13 people)
50.00%
(2 of 4 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RestlessnessDepressionNauseaHypotensionSuicidal IdeationDepressionInsomniaPain
DizzinessMental DisorderFallAtaxiaAnxietyAggressionHot Flushes NosAnxiety
AnxietyAggressionOedema PeripheralSinus TachycardiaDepressionAnxietyHeart RacingNausea
DyspnoeaScarConvulsionSudden DeathDrug Withdrawal SyndromeLoss Of ConsciousnessHeart PoundingHeadache
FatigueInjuryAbdominal PainDeathIncontinenceSinus TachycardiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepression
Pain In ExtremityDeep Vein ThrombosisAmnesiaBalance DisorderNightmareMuscle TwitchingDry MouthDyspnoea
ParaesthesiaHeadacheSuicide AttemptConfusional StateH1n1 InfluenzaHypotensionDizzinessFatigue
AgitationFatigueDeep Vein ThrombosisElectrocardiogram T Wave InversionSleep DisorderIntentional OverdoseArthralgia
DiarrhoeaAnxietyDepressionDiarrhoeaVomitingSuicide AttemptFall
PainAtaxiaApparent DeathHeadacheUrinary RetentionElectrocardiogram T Wave InversionAsthenia

Drug effectiveness by gender :

FemaleMale
Amitriptyline Hydrochloride is effective22.99%
(20 of 87 people)
27.59%
(8 of 29 people)
Tramadol is effective21.43%
(18 of 84 people)
16.67%
(5 of 30 people)

Most common drug interactions by gender * :

FemaleMale
PainAnxiety
AnxietyNausea
HeadachePain
NauseaDepression
FatigueDyspnoea
ArthralgiaHeadache
FallDrug Ineffective
DyspnoeaChest Pain
DepressionFatigue
AstheniaConfusional State

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Amitriptyline Hydrochloride is effectiven/an/a0.00%
(0 of 4 people)
14.29%
(3 of 21 people)
16.95%
(10 of 59 people)
6.94%
(5 of 72 people)
18.75%
(6 of 32 people)
35.71%
(5 of 14 people)
Tramadol is effectiven/an/a33.33%
(1 of 3 people)
9.09%
(2 of 22 people)
9.84%
(6 of 61 people)
7.04%
(5 of 71 people)
15.15%
(5 of 33 people)
33.33%
(4 of 12 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Convulsionn/aConfusional StateCompleted SuicideAnxietyNauseaPainPain
Respiratory ArrestHeadacheHyperhidrosisDepressionDepressionNauseaOsteoarthritis
Accidental Drug Intake By ChildTremorSerotonin SyndromeHeadacheHeadacheAnxietyFall
RashAnxietySuicidal IdeationPainFallDyspnoea
Hallucination, VisualConvulsionHypoaesthesiaChest PainDiarrhoeaAsthenia
Suicidal IdeationDrug ToxicityDrug Withdrawal SyndromeAnxietyFatigueAnxiety
FlushingPainDyspnoeaArthralgiaHeadacheNausea
Emotional DistressOvarian CystVomitingDrug IneffectivePyrexiaFatigue
Crohn's DiseaseNauseaAstheniaInsomniaAbdominal PainBack Pain
Weight DecreasedFeeling HotArthralgiaFatigueOedema PeripheralWeight Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Amitriptyline and Tramadol?

You are not alone! Join a related mobile support group:
- support group for people who take Amitriptyline and Tramadol
- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Tramadol

Can you answer these questions (Ask a question):

  • Does amitriptyline increase eye pressure when you have acute angle closure glaucoma
    Does taking Amitriptyline increase eye pressure in a case of someone who has had acute angle closure glaucoma for 12 years?
  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
  • Does anyone experience heart palpitations causedby their acid reflux ?
    I have had acid reflux/Gerd for 4 years + Was not believed that symptoms were real for a while as had no heartburn and a diagnosis of Fibromyalgia which even now some medics think is imaginary...it's NOT!!! Following a demeester score of 45 ( very high confirmation of acid reflux) and discovery of a large hiatal hernia, ( a classic physical cause of acid reflux) I had hernia repair operation and LINX anti reflux surgery. Throughout the four years a major symptom of my acid reflux were heart palpatations. They started at the same time I started with reflux and cleared up after the surgery. I have been reflux free palpitation free and antacid free for four months. then I was put on Gabapentin for back spasm and the reflux returned along with the palpitations. Medics keep insisting this is just anxiety yet eat a food that gives me reflux also starts the palps which is the indicator of the reflux as I do not have heartburn. Comes on when relaxing and eating watching tv ( no anxiety present) and when I am sleeping peacefully ( no anxiety present) my heart wakes me up and fires off into tachycardia. Recently a doctor has said it is now known that acid reflux irritates the nerves in the solar plexus area and that triggers the palps. Anyone else experienced this? Are there any studies on it at all? Thanks all.
  • I have been having a horrible reaction to tramadol now from the er doctor. what do i do now for pain . i've tried the shots made things even worse. so many trials it's hurts 2 try to gr better ? (3 answers)
    Tramadol so been making me so sick from the ER doctor 2 c my doctor if I can hold on. It's a shame ! So many things they keep trying . It's pain not the knew in thing of treating fibromyalgia. Disk problems nerve sciatic. Anxiety u wouldn't believe. I've talked to the FDA
    I don't feel safe at all anymore and want to get better . My family gets so upset and we all have lives to live but mine has been on hold 4-5yrs. Just to do the simple things then I have to rest. It's sad . I've always been active . And watch out for Savella !! My god all I would like is to fel better. I can't believe all the things I've read about tramadol it makes me mad that an ER doctor gave it to me first and I told doctors and pain management It wsnt helping. Can't sleep anger horrible thoughts.please I can't do those shots they made things even worse and they don't help me.
  • Can you loose weight while taking hydroxyzine?
    Hydroxyzine has been my life saver but I have noticed a gradual increase in weight. My blood pressure has also gone up. I don't have the increased hunger but what scares me is I am not eating more than I normally do. I do not eat breakfast. I have a Glucerna at lunch and then dinner, protein potatoes/rice and veggies, sometimes pasta nothing huge and a snack at night. Maybe a small bowl of ice cream but not every night. I do not drink soda, lots of water and with dinner a large glass of apple juice. I have noticed every year I put on a little bit more weight. I was tested for my thyroid and it is normal. I haven't started an avid work out program. Doing high intense impact will not work due to my IC. I would like to try power walking. Anyone else experience any of these issues?

More questions for: Amitriptyline Hydrochloride, Tramadol

You may be interested at these reviews (Write a review):

  • Amitriptyline involuntary eye movements
    I've began having sparatic involuntary eye movements a few days after I started taking amitriptyline. It's not faint either, it's like my eye is having a seizure, emabrassing. Just wanted to share.
  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.
  • Androgel for secondary hypogonadism
    Severe swelling in legs, ankles and feet after being on my feet for more than one hour. Pain in calves and ankles. Feels like they're being squeezed or compressed. Pain dissipates after laying down for a few hours. Swelling never completely dissipates. Always some swelling in ankles.
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • Inflammation in leg and around pelvis
    I gave birth two years ago, in my birthing plan it only stated that i wished for gas & air ONlY.
    I was very confused what with all the gas & air.. So all i heared was midewife saying that she will order pethidine. Next minute i know midwife injects me with pethidine in right buttuck.
    Later that day i feel extreamly bruised where i was injected but thought nothing of it. The bruised feeling continued for two weeks getting stronger and more painful when i just couldnt move. I literally couldnt move my leg, the pain had got so bad that i was screaming and had to call 999.
    Doctors had to check if i was paralyed as i couldnt move my leg. Turns out i was not paralysed.
    I was sent home in crazy pain, screaming. It got so bad that i had to urinate myself in bed as i couldnt move to get out. Again i called 999. Hospital kept me in for a week, they though it was sciatica nerve. MRI scan showed inflammation in leg ad around the pelvis area. In hopital i learnt to walk all over again using zimmer frame. (This all happened in july and i finally was off crutches that october.) a couple of weeks after being out of hospital my left collar bone was swallon badly and i couldnt lift my left arm all the way up and my two fingers in left had were slightly numb. Again i had a MRI scan which showed again inflammation.
    A doctor who had been treating me had told me that he has never seen this before and his does not know what has causes all this.. I suggest the pethidine.. And he quickly snaps and says that he does not know the cause but is certain its not the pethidine. I truely believe it was the pethidine. I made a full recovery, but the past year i have been experiencing discomfort in my buttuck and sometimes hip and shooting pains down my leg and in my foot (all the same side where i was injected)
    I had an MRI scan on my spine lumber & sacral and pelvis but strangly results say its normal.
    What is this pain? And been physio but this did not help it made pain worse. It is all a mystery, i want answers, i know it has something to do with the pethidine.

More reviews for: Amitriptyline Hydrochloride, Tramadol

Comments from related studies:

  • From this study (2 months ago):

  • I have had chronic fatigue since 5 May 2012 - nearly 2 and a half years. Recently stopped Lexapro for depression which I was on for a year and slowly reduced before cessation. Old back problem bulging disk L5/S1 pain left thigh, hip, buttock worst at night. Recently went on tramadol and immediate sleep disturbance. The month before was the best in >2 years when I started Endep.

    Reply

  • From this study (3 months ago):

  • I've not felt like my bladder is completely empty and starting a streem is sometimes difficult

    Reply

  • From this study (7 months ago):

  • Recent blood test high WBC Esterase, WBC and ALT

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat depression. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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