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Review: Amitriptyline and Tramadol

This review analyzes the effectiveness and drug interactions between Amitriptyline and Tramadol. It is created by eHealthMe based on reports of 2,963 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Amitriptyline and Tramadol >>>

What are the drugs

Amitriptyline hydrochloride (latest outcomes from 7,109 users) has active ingredients of amitriptyline hydrochloride. It is often used in migraine.

Tramadol (latest outcomes from 41,430 users) has active ingredients of tramadol hydrochloride. It is often used in pain.

On Oct, 13, 2014: 2,963 people who take Amitriptyline Hydrochloride, Tramadol are studied

Amitriptyline Hydrochloride, Tramadol outcomes

Drug combinations in study:
- Amitriptyline Hydrochloride (amitriptyline hydrochloride)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Amitriptyline Hydrochloride is effective10.00%
(1 of 10 people)
(4 of 31 people)
(4 of 14 people)
(7 of 18 people)
(5 of 18 people)
(7 of 15 people)
(1 of 6 people)
(0 of 3 people)
Tramadol is effective20.00%
(3 of 15 people)
(4 of 16 people)
(2 of 19 people)
(5 of 26 people)
(3 of 17 people)
(3 of 13 people)
(2 of 4 people)
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RestlessnessDepressionNauseaSudden DeathSuicidal IdeationDepressionInsomniaPain
DizzinessMental DisorderFallSinus TachycardiaAnxietyAggressionHot Flushes NosAnxiety
AnxietyAggressionOedema PeripheralHypotensionDepressionAnxietyHeart RacingNausea
DyspnoeaScarConvulsionAtaxiaDrug Withdrawal SyndromeLoss Of ConsciousnessHeart PoundingHeadache
FatigueInjuryAbdominal PainDeathNightmareSinus TachycardiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessDepression
Pain In ExtremityDeep Vein ThrombosisAmnesiaDiarrhoeaIncontinenceMuscle TwitchingDry MouthDyspnoea
ParaesthesiaAnxietySuicide AttemptElectrocardiogram T Wave InversionMalaiseHypotensionDizzinessFatigue
AgitationFatigueDeep Vein ThrombosisBalance DisorderH1n1 InfluenzaIntentional OverdoseArthralgia
DiarrhoeaHeadacheDepressionAcneRestlessnessSuicide AttemptFall
PainThrombosisApparent DeathDisorientationAgitationElectrocardiogram T Wave InversionAsthenia

Drug effectiveness by gender :

Amitriptyline Hydrochloride is effective23.53%
(20 of 85 people)
(8 of 29 people)
Tramadol is effective20.73%
(17 of 82 people)
(5 of 30 people)

Most common drug interactions by gender * :

FallDrug Ineffective
DyspnoeaChest Pain
AstheniaConfusional State

Drug effectiveness by age :

Amitriptyline Hydrochloride is effectiven/an/a0.00%
(0 of 4 people)
(3 of 21 people)
(10 of 59 people)
(5 of 51 people)
(6 of 32 people)
(5 of 14 people)
Tramadol is effectiven/an/a33.33%
(1 of 3 people)
(2 of 22 people)
(6 of 61 people)
(4 of 50 people)
(5 of 33 people)
(4 of 12 people)

Most common drug interactions by age * :

Convulsionn/aConfusional StateCompleted SuicideAnxietyNauseaPainPain
Respiratory ArrestHeadacheHyperhidrosisDepressionDepressionNauseaOsteoarthritis
Accidental Drug Intake By ChildTremorSerotonin SyndromeHeadacheHeadacheAnxietyFall
RashAnxietySuicidal IdeationPainFallDyspnoea
Hallucination, VisualConvulsionHypoaesthesiaChest PainDiarrhoeaAsthenia
Suicidal IdeationDrug ToxicityDrug Withdrawal SyndromeAnxietyFatigueAnxiety
Emotional DistressOvarian CystVomitingDrug IneffectivePyrexiaFatigue
Crohn's DiseaseNauseaAstheniaInsomniaAbdominal PainBack Pain
Weight DecreasedFeeling HotArthralgiaFatigueOedema PeripheralWeight Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Amitriptyline and Tramadol?

Get connected! Join a related mobile support group:
- support group for people who take Amitriptyline and Tramadol
- support group for people who take Amitriptyline Hydrochloride
- support group for people who take Tramadol

Comments from related studies:

  • From this study (5 days ago):

  • I have had chronic fatigue since 5 May 2012 - nearly 2 and a half years. Recently stopped Lexapro for depression which I was on for a year and slowly reduced before cessation. Old back problem bulging disk L5/S1 pain left thigh, hip, buttock worst at night. Recently went on tramadol and immediate sleep disturbance. The month before was the best in >2 years when I started Endep.


  • From this study (2 weeks ago):

  • I've not felt like my bladder is completely empty and starting a streem is sometimes difficult


  • From this study (5 months ago):

  • Recent blood test high WBC Esterase, WBC and ALT


Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

More questions for: Amitriptyline Hydrochloride, Tramadol

You may be interested at these reviews (what is this?):

  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.

  • Androgel for secondary hypogonadism
    Severe swelling in legs, ankles and feet after being on my feet for more than one hour. Pain in calves and ankles. Feels like they're being squeezed or compressed. Pain dissipates after laying down for a few hours. Swelling never completely dissipates. Always some swelling in ankles.

  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered A ...

More reviews for: Amitriptyline Hydrochloride, Tramadol

Complete drug side effects:

On eHealthMe, Amitriptyline Hydrochloride (amitriptyline hydrochloride) is often used to treat migraine. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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