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Review: Tramadol and Clonazepam





Summary: drug interactions are reported among people who take Tramadol and Clonazepam together.

This review analyzes the effectiveness and drug interactions between Tramadol and Clonazepam. It is created by eHealthMe based on reports of 2,599 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Tramadol and Clonazepam >>>

What are the drugs

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 41,511 users)

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Clonazepam 41,274 users)

On Dec, 14, 2014: 2,599 people who take Tramadol, Clonazepam are studied

Tramadol, Clonazepam outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Clonazepam (clonazepam)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective43.48%
(10 of 23 people)
11.43%
(4 of 35 people)
20.00%
(4 of 20 people)
38.10%
(8 of 21 people)
40.00%
(12 of 30 people)
47.06%
(8 of 17 people)
42.86%
(3 of 7 people)
0.00%
(0 of 1 people)
Clonazepam is effective31.25%
(5 of 16 people)
44.00%
(11 of 25 people)
40.00%
(6 of 15 people)
68.75%
(11 of 16 people)
58.97%
(23 of 39 people)
62.50%
(15 of 24 people)
50.00%
(7 of 14 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Weight DecreasedAnxietyDizzinessEmotional DistressFatigueDepressionCholelithiasisPain
Mucosal InflammationCyanosisDisorientationAnxietyAnxietyAnxietyDyspnoeaDepression
Febrile Bone Marrow AplasiaDizzinessFatiguePainDepressionPainGallbladder DisorderAnxiety
Febrile NeutropeniaRestlessnessMental Status ChangesDepressionHeadacheSuicidal IdeationCholecystitisNausea
Confusional StateAgitationLoss Of ConsciousnessPeripheral IschaemiaSleep DisorderDiabetes MellitusChest PainHeadache
AstheniaDepressionHypotensionCyanosisSuicidal IdeationEuphoric MoodChronic Fatigue SyndromeFatigue
Balance DisorderSerotonin SyndromePneumoniaObsessive-compulsive Personality DisorderArthralgiaDeep Vein ThrombosisAffective DisorderArthralgia
VomitingConvulsionPost-thoracotomy Pain SyndromeHypersexualityDizzinessEmotional DistressHyperglycaemiaDyspnoea
Pain In ExtremityHeadacheAgitationSuicidal IdeationVomitingThrombosisHypertensionDizziness
Toxic Skin EruptionCogwheel RigidityFungal InfectionPathological GamblingConvulsionCholecystitisMusculoskeletal Chest PainFall

Drug effectiveness by gender :

FemaleMale
Tramadol is effective29.91%
(32 of 107 people)
34.04%
(16 of 47 people)
Clonazepam is effective52.78%
(57 of 108 people)
48.84%
(21 of 43 people)

Most common drug interactions by gender * :

FemaleMale
PainDepression
AnxietyPain
DepressionHeadache
NauseaFall
ArthralgiaAnxiety
HeadacheDizziness
FatigueDrug Ineffective
DyspnoeaFatigue
VomitingNausea
DizzinessDyspnoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Tramadol is effectiven/an/a0.00%
(0 of 3 people)
11.76%
(6 of 51 people)
13.95%
(12 of 86 people)
17.57%
(13 of 74 people)
16.00%
(12 of 75 people)
21.43%
(6 of 28 people)
Clonazepam is effectiven/an/a0.00%
(0 of 3 people)
19.23%
(10 of 52 people)
21.69%
(18 of 83 people)
36.11%
(26 of 72 people)
21.92%
(16 of 73 people)
32.00%
(8 of 25 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Diabetes MellitusPanic DisorderFebrile NeutropeniaHeadacheHeadacheNauseaNauseaFall
HyperammonaemiaHallucination, VisualMucosal InflammationOverdoseDepressionPainFatiguePain
EncephalopathyDeathWeight DecreasedDepressionAnxietyHeadacheInsomniaDyspnoea
Blood Chromogranin A IncreasedFebrile Bone Marrow AplasiaVomitingDizzinessAnxietyDepressionAnxiety
VomitingAnxietyDyspnoeaDepressionArthralgiaPain In Extremity
Cholecystitis ChronicDyspnoeaArthralgiaFatigueDiarrhoeaAsthenia
NauseaConvulsionVomitingDizzinessPainConfusional State
PainAbdominal PainHyperhidrosisArthralgiaAnxietyBack Pain
Gallbladder DisorderDizzinessAstheniaInsomniaCompleted SuicideChest Pain
Sphincter Of Oddi DysfunctionDiarrhoeaAgitationVomitingFallNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tramadol and Clonazepam?

You are not alone! Join a related mobile support group:
- support group for people who take Tramadol and Clonazepam
- support group for people who take Clonazepam
- support group for people who take Tramadol

Can you answer these questions (Ask a question):

  • I had bladder cancer and my doctor put me on metformin should i get off this
    I do not want to take this metformin if it may cause my bladder cancer to come badk
  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
  • Does anyone experience heart palpitations causedby their acid reflux ?
    I have had acid reflux/Gerd for 4 years + Was not believed that symptoms were real for a while as had no heartburn and a diagnosis of Fibromyalgia which even now some medics think is imaginary...it's NOT!!! Following a demeester score of 45 ( very high confirmation of acid reflux) and discovery of a large hiatal hernia, ( a classic physical cause of acid reflux) I had hernia repair operation and LINX anti reflux surgery. Throughout the four years a major symptom of my acid reflux were heart palpatations. They started at the same time I started with reflux and cleared up after the surgery. I have been reflux free palpitation free and antacid free for four months. then I was put on Gabapentin for back spasm and the reflux returned along with the palpitations. Medics keep insisting this is just anxiety yet eat a food that gives me reflux also starts the palps which is the indicator of the reflux as I do not have heartburn. Comes on when relaxing and eating watching tv ( no anxiety present) and when I am sleeping peacefully ( no anxiety present) my heart wakes me up and fires off into tachycardia. Recently a doctor has said it is now known that acid reflux irritates the nerves in the solar plexus area and that triggers the palps. Anyone else experienced this? Are there any studies on it at all? Thanks all.
  • I have been having a horrible reaction to tramadol now from the er doctor. what do i do now for pain . i've tried the shots made things even worse. so many trials it's hurts 2 try to gr better ? (3 answers)
    Tramadol so been making me so sick from the ER doctor 2 c my doctor if I can hold on. It's a shame ! So many things they keep trying . It's pain not the knew in thing of treating fibromyalgia. Disk problems nerve sciatic. Anxiety u wouldn't believe. I've talked to the FDA
    I don't feel safe at all anymore and want to get better . My family gets so upset and we all have lives to live but mine has been on hold 4-5yrs. Just to do the simple things then I have to rest. It's sad . I've always been active . And watch out for Savella !! My god all I would like is to fel better. I can't believe all the things I've read about tramadol it makes me mad that an ER doctor gave it to me first and I told doctors and pain management It wsnt helping. Can't sleep anger horrible thoughts.please I can't do those shots they made things even worse and they don't help me.
  • Can you loose weight while taking hydroxyzine?
    Hydroxyzine has been my life saver but I have noticed a gradual increase in weight. My blood pressure has also gone up. I don't have the increased hunger but what scares me is I am not eating more than I normally do. I do not eat breakfast. I have a Glucerna at lunch and then dinner, protein potatoes/rice and veggies, sometimes pasta nothing huge and a snack at night. Maybe a small bowl of ice cream but not every night. I do not drink soda, lots of water and with dinner a large glass of apple juice. I have noticed every year I put on a little bit more weight. I was tested for my thyroid and it is normal. I haven't started an avid work out program. Doing high intense impact will not work due to my IC. I would like to try power walking. Anyone else experience any of these issues?

More questions for: Clonazepam, Tramadol

You may be interested at these reviews (Write a review):

  • A life of depression and fatigue
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.
  • Sepsis hallucinations misdiagnosed
    I was admitted to the hospital at 10 p.m., with a total bowel blockage caused by scar-tissue adhesions. I had first gone to the ER at 3 a.m. that morning, but the ER doc misdiagnosed my condition as constipation. I was in extreme pain and also too weak to tell my husband when he first came home that I needed to return to the ER. By the time I returned, I became violently nauseated, and vomited repeatedly. Then a gastro-nasal tube was forced down my nose and into my stomach. I began hallucinating at approximately 5 p.m. the following day. I did not realize I was hallucinating, and thought my experiences were real. Some were quite coherent, such as believing there was a book sitting on table at home with a photo on the front showing a sculpture in white marble of a woman's hands holding the Bible, with barbed wire wrapped around her hands. I thought the sculpture had won the Nobel prize, and the book was the biography of the sculptor, whose mother had gone to extraordinary lengths to keep him safe from the Nazis. Some may actually have occurred during dreams, and were wildly improbable, but I don't recall ever going to sleep. At one point, I thought I was at a rest stop on the NJ turnpike, and saw the Nobel-winning sculptor there, working on a wood sculpture. The sculptor turned out to be the maintenance man on the hospital floor. I pulled out the naso-gastral tube three times, but was unaware that I had done so, although I do remember believing that I was buried beneath peat moss and feeling suffocated as I clawed my way out. I also thought I was at a party being given by a law firm which had sold its building to a school for gifted children, but I (also a lawyer) had been deposited there by my nurse and her boyfriend, who were supposed to have taken me to the OR. Some scenes from a book I had been reading made their way into my delusions, which were so real to me that I actually called some of the people involved later on and asked if the events had really happened. The hallucinations began before surgery and continued afterward. When I awoke from anesthesia, I thought the hospital staff was painting the doors to my upstairs bathroom, a project I'd been involved with before the blockage struck. I asked them how they knew what colors to use. They thought I was joking, and confirmed that they had gotten the colors right. Finally a neurologist was summoned, and I told her I was on the passenger ramp at La Guardia airport (instead of in a hospital in NC), and that I'd been born in Havana, Cuba (instead of Baltimore, MD.) I believed myself to be a member of the ruling party in Cuba (pre-Castro) and during an outdoor ceremony, an earthquake had struck, causing ancient monuments to come tumbling down. Later, I was bobbing in harbor waters near a huge ocean liner, with plastic bottles and other detritus floating by. The foregoing are only a small sample of the multitude of hallucinations. Occasionally, I was only an observer of astonishing events, but usually I was a participant. I recognized my husband and friends, but told them about many of these events, believing they had happened. The neurologist diagnosed clonazepam withdrawal. My other doctors later said this was unlikely, as I took clonazepam in small amounts on an erratic schedule, and was not dependent on the drug, although my prescription called for 3 mg. daily. Physician friends said my symptoms were more likely the result of sepsis. I did contract a urinary-tract infection from the catheter, and was being given antibiotics. Additionally, the nature of my underlying condition, and the delay in diagnosis and treatment, may have contributed to the sepsis. Hallucinations occur in only a very small percentage of sepsis sufferers, and in only a small percentage of those withdrawing suddenly from clonazepam. However, I do fit the profile of those who do experience hallucinations with sepsis, being female and aged 62 at the time of this description. After the three-day period, I returned to normal, although believing that my hallucinations had been real persisted for some days afterward. I recovered quickly from the surgery, although the pain persisted for a while, and I was walking easily (dragging my IV with me) through the hospital halls. This was the ONLY symptom I had. Not all the hallucinations were unpleasant -- in fact, they were highly interesting -- but they were incredibly complex. I still remember all the details, better than I remember what actually happened yesterday. Except for the urinary-tract infection, I had no other adverse effects from hospitalization -- no fever, chills, nausea, sweating, headaches, trembling or anything of that kind. The bowel blockage and the surgery were of course not fun, but in a way the hallucinations were fascinating. My own feeling, and that of the doctors who know me and my medical issues, is that my experiences were caused by sepsis, not clonazepam withdrawal, and the antibiotics I was given are probably what saved me.
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.

More reviews for: Clonazepam, Tramadol

Comments from related studies:

  • From this study (3 months ago):

  • I've had 4 hip surgeries since 2012 for AVN & I've been left with chronic pain in lower back, pelvis, left hip/groin/thigh/knee & pain in right groin/thigh/knee

    Reply

  • From this study (5 months ago):

  • I am now unable to walk with my crutches, my primary doctor put in for a wheelchair. This CRPS is getting worse and worse every day and spreading to both feet both knees both legs.

    Reply

  • From this study (5 months ago):

  • Iam now unable to walk with my crutches, my primary doctor put in for a wheelchair. This CRPS is getting worse and worse everyday spreading to both feet both knees both legs.

    Reply

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Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Clonazepam (clonazepam) is often used to treat stress and anxiety. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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