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Review: Tramadol and Melatonin

This review analyzes the effectiveness and drug interactions between Tramadol and Melatonin. It is created by eHealthMe based on 150 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 4, 2014: 150 people who reported to have interactions when taking Tramadol, Melatonin are studied

Trend of Tramadol, Melatonin's drug interactions, side effects and effectiveness reports (6042705)

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Melatonin (melatonin)

eHealthMe real world results:

Most common interactions experienced by people in the use of Tramadol, Melatonin:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety129
Arthralgia (joint pain)114
Depression82
Back Pain78
Insomnia (sleeplessness)74
Impaired Healing72
Gastrooesophageal Reflux Disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)68
Gait Disturbance66
Cough64
Nausea (feeling of having an urge to vomit)64

Most common interactions experienced by people in long term use of Tramadol, Melatonin:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Tremor (trembling or shaking movements in one or more parts of your body)4
Increased Tendency To Bruise (increased tendency to injure the underlying soft tissue or bone)4
Heartburn - Chronic (a condition in which stomach contents leak backward from the stomach into the oesophagus)3
Palpitations (feelings or sensations that your heart is pounding or racing)3
Weight Gain - Unintentional3
Restlessness (not able to rest)3
Drowsiness2
Insomnia (sleeplessness)2
Headache (pain in head)2
Neck Pain2

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Tramadol0.00%25.00%50.00%25.00%0.00%
Melatonin0.00%0.00%66.67%0.00%33.33%

Top conditions involved for these people * :

  1. Pain
  2. Fibromyalgia
  3. Anxiety
  4. Rheumatoid arthritis
  5. Depression

Top co-used drugs for these people * :

  1. Forteo
  2. Aspirin
  3. Ultram
  4. Neurontin
  5. Xanax

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Melatonin, Tramadol

You can also:

Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (3 days ago):

  • suspicious lung nodule seen in x-ray, going in for a cat scan

    Reply

  • From this study (1 year ago):

  • Covered in rash over half my body after starting Topiramate. Have also tested positive for Lupus.

    Reply

    Patient Dar on Feb, 18, 2013:

    Complete list of symptoms that docs really don't want to hear at one time. Been going on for over 15 years. Headaches, low BP with high spikes that make me fall down, heart racing, hot flashes not related to menopause, cysts on top of each kidney, low white count and platelet count often, sores on head in nose and on face, so tired don't feel like doing anything, can't sleep without all the meds and then I only sleep a short time, positive anti-nuclear test. I feel like I am going crazy and now this rash is everywhere.

    Reply

    Ed on Mar, 5, 2013:

    Have your doctor check for Pheochromocytoma. I had all those symptoms and more. Pheo had grown around blood supply to kidney so it had to come out too. Much better since the surgery but I still have IBS, bipolar 2, low T, neuromuscular pain, one doctor wants to call it fibromyalgia

    Reply

    rmaran on Mar, 14, 2013:

    Have you had a sample taken of the sores to test them? One time I had a sore on my leg, they scraped a sample and performed a wide variety of tests on it. F 34 CA

    Reply

  • From this study (2 years ago):

  • have been on 100mcg synthroid for approximately 4 mos. am experiencing quite alot of confusion,great loss of appetite.

    Reply

Can you answer these questions (what is this?):

More questions for: Melatonin, Tramadol

You may be interested at these reviews (what is this?):

  • Melatonin and skin dryness
    I've been having hard time to sleep, so I started taking Melatonin. It is OTC sleep aid with melatonin and herbal treatment (lemon balm and camomile). about three days after started taking the drug, my back of hands started showing red rashes, then neck and around lips. a week after taking medica ...

  • Bad side effect of melatonin/imitrex use together
    I have taken melatonin for insomnia I've been experiencing recently (not a chronic condition). I haven't had any problems or interactions with my other regular medications while using the melatonin, other than drowsiness in the morning. Last night I had a migraine at bedtime, so took 50 mg. of imi ...

  • Horrific nightmares taking naproxen
    I've Taking naproxen 500mg twice a day for 3 weeks on a course for 6 months, I've been having horrific dreams worse than horrer movies, the most recent is involving my ex & current partner where I had a psychotic stalker (my ex) switched around because in the dream I dump my partner for my ex, well ...

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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