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Review: Tramadol and Melatonin





Summary: drug interactions are reported among people who take Tramadol and Melatonin together.

This review analyzes the effectiveness and drug interactions between Tramadol and Melatonin. It is created by eHealthMe based on reports of 166 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Tramadol and Melatonin >>>

What are the drugs

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (view latest outcomes from 41,501 users)

Melatonin has active ingredients of melatonin. It is often used in insomnia. (view latest outcomes from 2,658 users)

On Nov, 29, 2014: 166 people who take Tramadol, Melatonin are studied

Tramadol, Melatonin outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective0.00%
(0 of 4 people)
0.00%
(0 of 2 people)
0.00%
(0 of 2 people)
25.00%
(1 of 4 people)
40.00%
(2 of 5 people)
50.00%
(1 of 2 people)
0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
Melatonin is effective0.00%
(0 of 3 people)
33.33%
(2 of 6 people)
50.00%
(3 of 6 people)
0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RestlessnessShort-term Memory LossExercise Tolerance DecreasedInsomniaWeight Gain - UnintentionalSkin HyperpigmentationPruritus AggravatedAnxiety
Panic AttacksLong-term Memory LossSkin HyperpigmentationRestlessnessHeadacheDecreased InterestNight SweatsDepression
Visual ImpairmentBlood Cortisol AbnormalDecreased InterestInability To CrawlHeartburn - ChronicBone PainDizziness AggravatedInsomnia
Visual BrightnessBlood Cortisol IncreasedHeat IntoleranceFear Of Public SpeakingPalpitationsExercise Tolerance DecreasedRestless Leg SyndromeBack Pain
Generalized Anxiety DisorderBlood Cortisol DecreasedIncreased Tendency To BruiseFatigueInsomniaHeat IntoleranceWeight Above NormalArthralgia
Major Depressive DisorderRestlessnessLung NoduleThrombocytopeniaRestlessnessFallImpaired Healing
TachycardiaThrombocytopeniaMuscle TwitchingMuscle TwitchingIncreased Tendency To BruiseGait Disturbance
HypomaniaFallMood SwingsItchingDecreased ActivityMuscular Weakness
Gender Identity DisorderBone PainDepressionMalaiseAppetite IncreasedCough
Breathing - Slowed Or StoppedDecreased ActivityPanic AttacksDrowsinessMigraine AggravatedNausea

Drug effectiveness by gender :

FemaleMale
Tramadol is effective21.05%
(4 of 19 people)
50.00%
(1 of 2 people)
Melatonin is effective35.29%
(6 of 17 people)
50.00%
(1 of 2 people)

Most common drug interactions by gender * :

FemaleMale
InsomniaAnxiety
DepressionSpinal Column Stenosis
AnxietyAsthenia
Back PainDyspnoea
Impaired HealingDysphemia
TremorOsteolysis
Gait DisturbanceMetastases To Bone
Muscular WeaknessThyroid Cancer
CoughChills
ArthralgiaGastrooesophageal Reflux Disease

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Tramadol is effectiven/an/a0.00%
(0 of 1 people)
2.99%
(2 of 67 people)
3.92%
(2 of 51 people)
0.00%
(0 of 7 people)
14.29%
(1 of 7 people)
0.00%
(0 of 3 people)
Melatonin is effectiven/an/a0.00%
(0 of 1 people)
2.94%
(1 of 34 people)
8.16%
(4 of 49 people)
0.00%
(0 of 7 people)
14.29%
(1 of 7 people)
33.33%
(1 of 3 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aEpistaxisMuscle SpasmsInsomniaPainGastrooesophageal Reflux DiseaseArthralgia
Anal HaemorrhageNauseaPainFatigueMetastases To BoneNausea
ScabPallorArthralgiaBalance DisorderMental Status ChangesAbdominal Pain Upper
Nasal CongestionChillsDepressionWeight IncreasedBack PainVomiting
Intentional Self-injuryDizzinessTremorOedema PeripheralCoughFatigue
Weight IncreasedSinusitisHeart Rate IncreasedNauseaGait DisturbanceFall
Rash PapularSepsisBlood Creatinine IncreasedHeadacheMuscular WeaknessDepression
Rash PruriticAstheniaAccident At WorkParaesthesiaToothacheAsthenia
CushingoidPollakiuriaCervicobrachial SyndromeDrug IneffectiveImpaired HealingMuscle Spasms
OverweightSomnolenceAngerNephrogenic Systemic FibrosisInjuryAnxiety

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tramadol and Melatonin?

You are not alone! Join a related mobile support group:
- support group for people who take Tramadol and Melatonin
- support group for people who take Melatonin
- support group for people who take Tramadol

Can you answer these questions (Ask a question):

  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!
  • Does anyone experience heart palpitations causedby their acid reflux ?
    I have had acid reflux/Gerd for 4 years + Was not believed that symptoms were real for a while as had no heartburn and a diagnosis of Fibromyalgia which even now some medics think is imaginary...it's NOT!!! Following a demeester score of 45 ( very high confirmation of acid reflux) and discovery of a large hiatal hernia, ( a classic physical cause of acid reflux) I had hernia repair operation and LINX anti reflux surgery. Throughout the four years a major symptom of my acid reflux were heart palpatations. They started at the same time I started with reflux and cleared up after the surgery. I have been reflux free palpitation free and antacid free for four months. then I was put on Gabapentin for back spasm and the reflux returned along with the palpitations. Medics keep insisting this is just anxiety yet eat a food that gives me reflux also starts the palps which is the indicator of the reflux as I do not have heartburn. Comes on when relaxing and eating watching tv ( no anxiety present) and when I am sleeping peacefully ( no anxiety present) my heart wakes me up and fires off into tachycardia. Recently a doctor has said it is now known that acid reflux irritates the nerves in the solar plexus area and that triggers the palps. Anyone else experienced this? Are there any studies on it at all? Thanks all.
  • I have been having a horrible reaction to tramadol now from the er doctor. what do i do now for pain . i've tried the shots made things even worse. so many trials it's hurts 2 try to gr better ? (2 answers)
    Tramadol so been making me so sick from the ER doctor 2 c my doctor if I can hold on. It's a shame ! So many things they keep trying . It's pain not the knew in thing of treating fibromyalgia. Disk problems nerve sciatic. Anxiety u wouldn't believe. I've talked to the FDA
    I don't feel safe at all anymore and want to get better . My family gets so upset and we all have lives to live but mine has been on hold 4-5yrs. Just to do the simple things then I have to rest. It's sad . I've always been active . And watch out for Savella !! My god all I would like is to fel better. I can't believe all the things I've read about tramadol it makes me mad that an ER doctor gave it to me first and I told doctors and pain management It wsnt helping. Can't sleep anger horrible thoughts.please I can't do those shots they made things even worse and they don't help me.
  • Can you loose weight while taking hydroxyzine?
    Hydroxyzine has been my life saver but I have noticed a gradual increase in weight. My blood pressure has also gone up. I don't have the increased hunger but what scares me is I am not eating more than I normally do. I do not eat breakfast. I have a Glucerna at lunch and then dinner, protein potatoes/rice and veggies, sometimes pasta nothing huge and a snack at night. Maybe a small bowl of ice cream but not every night. I do not drink soda, lots of water and with dinner a large glass of apple juice. I have noticed every year I put on a little bit more weight. I was tested for my thyroid and it is normal. I haven't started an avid work out program. Doing high intense impact will not work due to my IC. I would like to try power walking. Anyone else experience any of these issues?
  • Can i take melatonin if i take prograf?
    I take Prograf to prevent organ rejection in a liver transplant.

More questions for: Melatonin, Tramadol

You may be interested at these reviews (Write a review):

  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.
  • I need advise, badly ckd!! (1 response)
    The orthostatic BP started in mid April, I was only dizzy upon wakening then it would subside. I have never been a big breakfast eater so I started doing that. We were in Disney later in April and I was extremely fatigued, to the point of not wanting to walk, Disney would be the first time I passed out when getting dizzy. I of course said I had gotten too warm and was exhausted from work the previous week. The dizziness continued in the mornings & I passed out several more times. On May 1st, I passed out while putting my make-up on and hit my eye on the faucet and head on the tile floor, despite that I went to work thinking it would subside, it didn't. I went to the ER directly after work. They ran a B-met on me and my GFR was 11 and creatinine 3.95. They admitted me to a larger hospital for evaluation. While in there, they pumped me with fluids continuously, saying I had severe dehydration. My kidney function improved, my creatinine levels went back down to 1.34. After 5 days I was discharged and told to see a cardiologist and endo. The endo doc cancelled my appointment on the basis it was not his area. I had had a cortisol and ACTH testing which I guess was normal. I saw the cardiologist, who said it wasn't cardio. I had had an echocardiogram in the hospital and EKG monitoring. Cardio sent me to neurology, the PNRN did a basic neurological exam and drew blood for disease markers such as Lupus, sjorgens, hepatitis, ect. All disease markers came back negative, but my GFR was at 11 again and creatinine was 4.25, BUN 50 along with an elevated ACE level. They called me and said I sarcoidosis. I really don't have any of the primary S/S of this autoimmune disease. I don't know where to go from here, they are referring me to another neurologist at a bigger hospital. I can't live my normal life, can't walk on my feet due extreme pain and I pass out at least 2x a week, which is not good for my old body. My BP upon laying and sitting runs like 117/72, upon standing it drops to like 70/50-50/30. I am on 0.1 mg of florinef, I tried increasing it but then my legs swelled up for a gain of 23#. I talked to Mayo Clinic today and all there specialists are booked out thru December. I have to be able to work, I can't stay home any longer than September 8th! Please advise me!
  • Melatonin reduces essential tremor of the hand
    After taking Melatonin 1mg as a sleep aid for several nights, I noticed that my essential tremor of the hand was showing improvement. Within a week the tremor was almost unnoticeable, and I could print and write neatly, even when slightly stressed at work. I haven't seen this response reported anywhere else; have other people noticed this effect?
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.
  • Melatonin and diarrhea
    I have had difficulty sleeping most of my life. Difficulty going to sleep and waking up multiple times during the night were a usual pattern for me. Testing for sleep apnea did not show a positive result. A friend said to try Melatonin that for him it worked fine. I tried it and the diarrhea started almost immediately. Within days it was full blown water diarrhea. For fear of dehydration I stopped using Melatonin before two weeks time. And the hoped for results of helping my sleep problems were not solved with the Melatonin.

More reviews for: Melatonin, Tramadol

Comments from related studies:

  • From this study (7 months ago):

  • Severity level**

    Reply

  • From this study (9 months ago):

  • suspicious lung nodule seen in x-ray, going in for a cat scan

    Reply

  • From this study (2 years ago):

  • Covered in rash over half my body after starting Topiramate. Have also tested positive for Lupus.

    Reply

    rmaran on Mar, 14, 2013:

    Have you had a sample taken of the sores to test them? One time I had a sore on my leg, they scraped a sample and performed a wide variety of tests on it. F 34 CA

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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