Review: Tramadol and Melatonin drug interactions
This review analyzes the interactions between Tramadol and Melatonin. It is created by eHealthMe based on 149 people who have drug interactions while taking the drugs. The review uses reports from FDA and social media, and is updated regularly.
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What are the drugs
Tramadol (latest outcomes from 41,165 users) has active ingredients of tramadol hydrochloride. It is often used in pain.
Melatonin (latest outcomes from 2,545 users) has active ingredients of melatonin. It is often used in insomnia.
On Mar, 2, 2014: 149 people who reported to have interactions when taking Tramadol, Melatonin are studied
Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Melatonin (melatonin)
Most common interactions experienced by people in the use of Tramadol, Melatonin:(click on each outcome to view in-depth analysis, incl. how people recovered)
|Interaction||Number of reports|
|Arthralgia (joint pain)||76|
|Gastrooesophageal Reflux Disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)||34|
|Nausea (feeling of having an urge to vomit)||32|
Most common interactions experienced by people in long term use of Tramadol, Melatonin:(click on each outcome to view in-depth analysis, incl. how people recovered)
|Interaction||Number of reports|
|Tremor (trembling or shaking movements in one or more parts of your body)||2|
|Palpitations (feelings or sensations that your heart is pounding or racing)||2|
|Heartburn - Chronic (a condition in which stomach contents leak backward from the stomach into the oesophagus)||2|
|Increased Tendency To Bruise (increased tendency to injure the underlying soft tissue or bone)||2|
|Headache (pain in head)||1|
|Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)||1|
How effective are the drugs:
|not at all||somewhat||moderate||high||very high|
Top conditions involved for these people * :
- Rheumatoid arthritis
Top co-used drugs for these people * :
* Approximation only. Some reports may have incomplete information.
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Complete drug side effects:
On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Tramadol is used in:
- Melatonin is used in:
Other drugs that are used to treat the same conditions:
- Tramadol alternatives:
- Melatonin alternatives:
Comments from related studies:
From this study (12 months ago):
From this study (2 years ago):
Covered in rash over half my body after starting Topiramate. Have also tested positive for Lupus.
Patient Dar on Feb, 18, 2013:
Complete list of symptoms that docs really don't want to hear at one time. Been going on for over 15 years. Headaches, low BP with high spikes that make me fall down, heart racing, hot flashes not related to menopause, cysts on top of each kidney, low white count and platelet count often, sores on head in nose and on face, so tired don't feel like doing anything, can't sleep without all the meds and then I only sleep a short time, positive anti-nuclear test. I feel like I am going crazy and now this rash is everywhere.
Ed on Mar, 5, 2013:
Have your doctor check for Pheochromocytoma. I had all those symptoms and more. Pheo had grown around blood supply to kidney so it had to come out too. Much better since the surgery but I still have IBS, bipolar 2, low T, neuromuscular pain, one doctor wants to call it fibromyalgia
rmaran on Mar, 14, 2013:
Have you had a sample taken of the sores to test them? One time I had a sore on my leg, they scraped a sample and performed a wide variety of tests on it. F 34 CA
have been on 100mcg synthroid for approximately 4 mos. am experiencing quite alot of confusion,great loss of appetite.
Can you answer these questions (what is this?):
- By Becky: Will tramadol cause rapid heart beat?
I have been taking Tramadol for 1 1/2 years and within the past 6 weeks have developed an unexplained rapid heart beat. The heart monitor I wore for 24 hours indicated a premature heart but after a month the EKG was normal. I was taken off of Toprol and instructed to take magnesium (400) milligrams ...
- By mda1270: Can tramadol and meloxicam be taken together?
What is causing my pain? The years of muscale atrophy or the joints
- By meisels: Can melatonin cause precocious puberty
can the use of Melatonin to help kids (girls) fall asleep cause Precocious puberty?
You may be interested at these reviews (what is this?):
- By greenjaybird: Bad side effect of melatonin/imitrex use together
I have taken melatonin for insomnia I've been experiencing recently (not a chronic condition). I haven't had any problems or interactions with my other regular medications while using the melatonin, other than drowsiness in the morning. Last night I had a migraine at bedtime, so took 50 mg. of imi ...
- By Lukeyi5: Horrific nightmares taking naproxen
I've Taking naproxen 500mg twice a day for 3 weeks on a course for 6 months, I've been having horrific dreams worse than horrer movies, the most recent is involving my ex & current partner where I had a psychotic stalker (my ex) switched around because in the dream I dump my partner for my ex, well ...
- By luvubug: Burning mouth syndrome
I went into a local emergency room for a sore throat with pustules and difficulty swallowing, i was given Tramadol for pain through my iv. About 2 days later i woke up with a very blistery tongue, which was mildly painful as the day progressed i felt like i had been eating habanero peppers all day.. ...
Recent related drug studies:
- A study of drug interactions between Celebrex, Tramadol Hydrochloride, Zolpidem Tartrate, Lyrica, Cymbalta, Acyclovir, Topiramate, Melatonin, Benadryl, Percocet, Multivitamin, Calcium, Ibuprofen, Vitamin E for a patient with Arthritis, Pain Management, Sleep Disorder Therapy, Rls, Depression, Herpes - Genital, Migraine, Allergic Sinusitis, Health, Osteoarthritis, Inflammation. The patient has Topiramate
- A study of drug interactions between Lotrel, Metformin Hydrochloride, Pravachol, Xanax, Ultram, Melatonin for a patient with Hypertension, Type 2 Diabetes Mellitus, High Density Lipoprotein, Anxiety Disorder, Muscle Spasms, Insomnia.
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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