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Review: taking Tramadol and Melatonin together

Summary: drug interactions are reported among people who take Tramadol and Melatonin together.

This review analyzes the effectiveness and drug interactions between Tramadol and Melatonin. It is created by eHealthMe based on reports of 166 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Tramadol and Melatonin >>>

What are the drugs

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from 41,556 Tramadol users)

Melatonin has active ingredients of melatonin. It is often used in insomnia. (latest outcomes from 2,685 Melatonin users)

On Mar, 1, 2015: 166 people who take Tramadol, Melatonin are studied

Tramadol, Melatonin outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Melatonin (melatonin)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective0.00%
(0 of 4 people)
0.00%
(0 of 2 people)
0.00%
(0 of 2 people)
25.00%
(1 of 4 people)
40.00%
(2 of 5 people)
50.00%
(1 of 2 people)
0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
Melatonin is effective0.00%
(0 of 3 people)
33.33%
(2 of 6 people)
50.00%
(3 of 6 people)
0.00%
(0 of 1 people)
100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
0.00%
(0 of 1 people)
n/a

Drug effectiveness by gender :

FemaleMale
Tramadol is effective21.05%
(4 of 19 people)
50.00%
(1 of 2 people)
Melatonin is effective35.29%
(6 of 17 people)
50.00%
(1 of 2 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Tramadol is effectiven/an/a0.00%
(0 of 1 people)
2.99%
(2 of 67 people)
3.92%
(2 of 51 people)
0.00%
(0 of 7 people)
14.29%
(1 of 7 people)
0.00%
(0 of 3 people)
Melatonin is effectiven/an/a0.00%
(0 of 1 people)
2.94%
(1 of 34 people)
8.16%
(4 of 49 people)
0.00%
(0 of 7 people)
14.29%
(1 of 7 people)
33.33%
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RestlessnessShort-term Memory LossExercise Tolerance DecreasedInsomniaWeight Gain - UnintentionalSkin HyperpigmentationPruritus AggravatedAnxiety
Panic AttacksLong-term Memory LossSkin HyperpigmentationRestlessnessHeadacheDecreased InterestNight SweatsDepression
Visual ImpairmentBlood Cortisol AbnormalDecreased InterestInability To CrawlHeartburn - ChronicBone PainDizziness AggravatedInsomnia
Visual BrightnessBlood Cortisol IncreasedHeat IntoleranceFear Of Public SpeakingPalpitationsExercise Tolerance DecreasedRestless Leg SyndromeBack Pain
Generalized Anxiety DisorderBlood Cortisol DecreasedIncreased Tendency To BruiseFatigueInsomniaHeat IntoleranceWeight Above NormalArthralgia
Major Depressive DisorderRestlessnessLung NoduleThrombocytopeniaRestlessnessFallImpaired Healing
TachycardiaThrombocytopeniaMuscle TwitchingMuscle TwitchingIncreased Tendency To BruiseGait Disturbance
HypomaniaFallMood SwingsItchingDecreased ActivityMuscular Weakness
Gender Identity DisorderBone PainDepressionMalaiseAppetite IncreasedCough
Breathing - Slowed Or StoppedDecreased ActivityPanic AttacksDrowsinessMigraine AggravatedNausea

Most common drug interactions by gender * :

FemaleMale
InsomniaAnxiety
DepressionSpinal Column Stenosis
AnxietyAsthenia
Back PainDyspnoea
Impaired HealingDysphemia
TremorOsteolysis
Gait DisturbanceMetastases To Bone
Muscular WeaknessThyroid Cancer
CoughChills
ArthralgiaGastrooesophageal Reflux Disease

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/aEpistaxisMuscle SpasmsInsomniaPainGastrooesophageal Reflux DiseaseArthralgia
Anal HaemorrhageNauseaPainFatigueMetastases To BoneNausea
ScabPallorArthralgiaBalance DisorderMental Status ChangesAbdominal Pain Upper
Nasal CongestionChillsDepressionWeight IncreasedBack PainVomiting
Intentional Self-injuryDizzinessTremorOedema PeripheralCoughFatigue
Weight IncreasedSinusitisHeart Rate IncreasedNauseaGait DisturbanceFall
Rash PapularSepsisBlood Creatinine IncreasedHeadacheMuscular WeaknessDepression
Rash PruriticAstheniaAccident At WorkParaesthesiaToothacheAsthenia
CushingoidPollakiuriaCervicobrachial SyndromeDrug IneffectiveImpaired HealingMuscle Spasms
OverweightSomnolenceAngerNephrogenic Systemic FibrosisInjuryAnxiety

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tramadol and Melatonin?

You are not alone! Join a related mobile support group:
- support group for people who take Tramadol and Melatonin
- support group for people who take Melatonin
- support group for people who take Tramadol

Can you answer these questions (Ask a question):

  • Is testicular from taking tramadol permanent?
    Since taking tramadol, which my doctor prescribed, I have had bad testicular pain, developed a lump in my right testicle, difficulty urinating, and a heaviness in my groin.
  • What are healthy steps should i take against cronary artery disease
    I feel sharp pains just below my left breast . At first i thought it was a breast cancer but ii ran a test that cancelled that out. Now, i strongly suspect a coronary artery disease. I also feel similar pains at my feets, restlessness at night and a bit of hallicinations at night. I also have high blood pressure.
  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Can tramadol usage cause a low white blood cell count?
    Low WBC of 2.7 on 10/21/15 and then 3.8 on 12/08/15
    Can these things be connected?
  • I take klonopin and diltiazem (calcium channel blocker blood pressure medicine) and am concerned about side effects. my accupuncturist recommends the ashwagandha. anyone have any issues with this?
    I take these prescription medications but have been going to an accupuncturist since 2012. I have trouble sleeping at night without my clonazepam and take naps during the day and am having trouble losing weight. She thinks that my adrenal glands may be fatigued and told me to try something called Adrenal Response which contains Sensoril Ashwagandha. When I looked up Ashwaganda it said that it could interact with the Clonazepam or Klonopin and also with High blood pressure medication. I am a little concerned. I mentioned this to her and she said they both are metabolized by the liver and it should be ok to take it, just to take it an hour or more after I take the Clonazepam. Has anyone had any issues with interactions with their prescribed meds while taking Ashwagandha? I don't want to have to monitor my blood pressure because my blood pressure medication works good for me. Any help would be appreciated because I want to try it but I am a little scared too. Thanks, Crystal

More questions for: Melatonin, Tramadol

You may be interested at these reviews (Write a review):

  • Melatonin and diarrhrea
    A lifetime of wakefulness during the night, almost never more than 7 hrs sleep and awake 2-4 times a night. Return to sleep easily. Doctors gave sleep aids. Usually somewhat ineffective and sometimes groggy mornings. So I decided to go the more natural route ... melatonin. Worse. It did not work for me. It gave me some if the wateriest and longest lasting diarrhea of my life. The uncontrolled continuous diarrhea was worse than not sleeping at night. Not listed as one of the side affects of Melatonin. More people should be made aware of the dangers of this dehydration.
  • Roaring in the ears from tramadol (taken with dexamethasone)
    It seems the roaring in my right ear happens more around taking the tramadol (2-3/day). Of course, I have a (5) day regiment of dexamethasone at (2/day) so maybe there's a connection. This was prescribed by my GP ( highly regarded) for severe lower back bulging disc pain and down left leg. Also prescribed tizanidine for muscle spasms and gabapentin for, maybe nerve swelling? Both at 2/day but I take less of these two.

    Back pain much better but have the roaring in right ear and can't sleep much. Also doing the Dr recommended exercises daily. Will follow up with chiropractic if this doesn't get me there.

    This is a chronic condition, maybe 20 years, no specific injury, just an accumulation of doing dumb things in my youth.
  • Tramadol and severe rls and restless arms
    After back surgery I was prescribed Tramadol for pain. After about a month I developed severe RLS and also restless arms that seemed to make it hard to breath. Like a weight on my chest. I noticed that after taking the Tramadol, only at night for sleep, the restless symptoms got worse for about an hour and then settled down some. Before long there was no settling down. My pain after several months being better in my back I, not liking to take medicine period, decided to stop the Tramadol. To my surprise my RLS came to almost a complete halt. After about a week it was gone completely.
  • Mom died of stomach blockage while on tramadol
    my mom was taking tramadol for hip pain. she went in the hospital for a hip replacement and died 3 days after the surgery in the hospital from an intestinal blockage
  • Using tramadol with anti-depressants
    Using Tramadol with Anti-depressants

    I was taking Tramadol for pain instead of Endone to cut out the opiates as well as my usual anti-depressant. After about 6 months of feeling dizzy spells and nausea I stumbled across information that these two medications should not be mixed. After all of the extensive tests they did to find out why I had these symptoms, I informed my Doctor of what I had discovered. Much the their embarrassment, they realised I was correct and immediately took me off the tramadol. I just thought I would share this information in case any one else is going through what I did.

More reviews for: Melatonin, Tramadol

Comments from related studies:

  • From this study (10 months ago):

  • Severity level**

    Reply

  • From this study (12 months ago):

  • suspicious lung nodule seen in x-ray, going in for a cat scan

    Reply

  • From this study (2 years ago):

  • Covered in rash over half my body after starting Topiramate. Have also tested positive for Lupus.

    Reply

    rmaran on Mar, 14, 2013:

    Have you had a sample taken of the sores to test them? One time I had a sore on my leg, they scraped a sample and performed a wide variety of tests on it. F 34 CA

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Melatonin (melatonin) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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