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Review: Tramadol and Metformin

This review analyzes the effectiveness and drug interactions between Tramadol and Metformin. It is created by eHealthMe based on 2,601 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 31, 2014: 2,601 people who reported to have interactions when taking Tramadol, Metformin are studied

Trend of Tramadol, Metformin's drug interactions, side effects and effectiveness reports (9068742)

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Metformin (metformin hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Tramadol, Metformin:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Pain1,025
Dyspnoea (difficult or laboured respiration)1,017
Fatigue (feeling of tiredness)1,000
Vomiting926
Asthenia (weakness)778
Nausea (feeling of having an urge to vomit)768
Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)714
Anaemia (lack of blood)711
Diarrhoea694
Haemorrhoids (a swollen vein or group of veins in the region of the anus)454

Most common interactions experienced by people in long term use of Tramadol, Metformin:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety36
Hyperkalaemia (damage to or disease of the kidney)36
Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)27
Vomiting25
Deep Vein Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)21
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)20
Depression20
Renal Failure Acute (rapid kidney dysfunction)20
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)20
Nausea (feeling of having an urge to vomit)14

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Tramadol0.00%8.33%41.67%50.00%0.00%
Metformin0.00%11.11%55.56%33.33%0.00%

Top conditions involved for these people * :

  1. Diabetes mellitus
  2. Pain
  3. Hypertension
  4. Type 2 diabetes mellitus
  5. Depression

Top co-used drugs for these people * :

  1. Seroquel
  2. Glucophage
  3. Aspirin
  4. Ultram
  5. Lisinopril

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Metformin, Tramadol

You can also:

Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Metformin (metformin hydrochloride) is often used to treat type 2 diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (2 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (3 months ago):

  • had sciatica and an epidural shot. After the shot tremors started on left leg and now I have been diagnosed with early Parkinsons. Can the tremors be caused by a drug interaction? The tremors stopped after taking a low dose on dopamine but it makes me dizzy.

    Reply

Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

More questions for: Metformin, Tramadol

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More reviews for: Metformin, Tramadol

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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