Review: Tramadol and Metformin drug interactions
This review analyzes the interactions between Tramadol and Metformin. It is created by eHealthMe based on 2,604 people who have drug interactions while taking the drugs. The review uses reports from FDA and social media, and is updated regularly.
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What are the drugs
Tramadol (latest outcomes from 41,165 users) has active ingredients of tramadol hydrochloride. It is often used in pain.
Metformin (latest outcomes from 100,457 users) has active ingredients of metformin hydrochloride. It is often used in diabetes.
On Mar, 1, 2014: 2,604 people who reported to have interactions when taking Tramadol, Metformin are studied
Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Metformin (metformin hydrochloride)
Most common interactions experienced by people in the use of Tramadol, Metformin:(click on each outcome to view in-depth analysis, incl. how people recovered)
|Interaction||Number of reports|
|Dyspnoea (difficult or laboured respiration)||471|
|Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)||385|
|Fatigue (feeling of tiredness)||324|
|Nausea (feeling of having an urge to vomit)||289|
|Anaemia (lack of blood)||215|
Most common interactions experienced by people in long term use of Tramadol, Metformin:(click on each outcome to view in-depth analysis, incl. how people recovered)
|Interaction||Number of reports|
|Hyperkalaemia (damage to or disease of the kidney)||24|
|Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)||18|
|Myocardial Infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)||12|
|Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)||10|
|Fatigue (feeling of tiredness)||8|
|Electrocardiogram Pr Prolongation||6|
|Renal Failure Acute (rapid kidney dysfunction)||6|
How effective are the drugs:
|not at all||somewhat||moderate||high||very high|
Top conditions involved for these people * :
- Diabetes mellitus
- Type 2 diabetes mellitus
Top co-used drugs for these people * :
* Approximation only. Some reports may have incomplete information.
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Complete drug side effects:
On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.
What is the drug used for and how effective is it:
- Tramadol is used in:
- Metformin is used in:
Other drugs that are used to treat the same conditions:
- Tramadol alternatives:
- Metformin alternatives:
Comments from related studies:
From this study (3 days ago):
From this study (3 days ago):
From this study (4 weeks ago):
Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.
Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.
had sciatica and an epidural shot. After the shot tremors started on left leg and now I have been diagnosed with early Parkinsons. Can the tremors be caused by a drug interaction? The tremors stopped after taking a low dose on dopamine but it makes me dizzy.
Can you answer these questions (what is this?):
- By Becky: Will tramadol cause rapid heart beat?
I have been taking Tramadol for 1 1/2 years and within the past 6 weeks have developed an unexplained rapid heart beat. The heart monitor I wore for 24 hours indicated a premature heart but after a month the EKG was normal. I was taken off of Toprol and instructed to take magnesium (400) milligrams ...
- By mda1270: Can tramadol and meloxicam be taken together?
What is causing my pain? The years of muscale atrophy or the joints
- By Helen: Can metformin cause face pain ?
I have had face and jaw pain since starting to take Metformin. Also muscle pain and headaches. I am taking this drug for metabolic syndrome and wonder if it has lowered my blood sugar too much. I feel weird on it. This my 3rd week on it. I took half a pill with breakfast for 2 weeks and now am takin ...
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- By ctcrzy7: Spiriva caused me to swell up like a hippo.
My Doctor prescribed spiriva to help me breathe due to asthma/cold. I never smoked but my parents and friends were heavy smokers. I used the spiriva 3 times. Once a day for 3 days then I started swelling in my ankles and the swelling continued until my face, hands arms... basically I was so swollen ...
- By Lukeyi5: Horrific nightmares taking naproxen
I've Taking naproxen 500mg twice a day for 3 weeks on a course for 6 months, I've been having horrific dreams worse than horrer movies, the most recent is involving my ex & current partner where I had a psychotic stalker (my ex) switched around because in the dream I dump my partner for my ex, well ...
- By luvubug: Burning mouth syndrome
I went into a local emergency room for a sore throat with pustules and difficulty swallowing, i was given Tramadol for pain through my iv. About 2 days later i woke up with a very blistery tongue, which was mildly painful as the day progressed i felt like i had been eating habanero peppers all day.. ...
Recent related drug studies:
- A study of drug interactions between Vitamin D, Tramadol, Multivitamin, Ropinirole Hydrochloride, Omeprazole, Nitroglycerin, Methocarbamol, Metformin Hydrochloride, Lisinopril, Gabapentin, Cymbalta, Dicyclomine Hydrochloride, Calcium Carbonate, Atorvastatin Calcium, Aspirin, Amlodipine for a patient with Vitamin D Deficiency, Drugs For Pain, Daily Vitamin Tablet, Restless Leg Syndrome, Gerd, Chest Pain, Back Muscke Spasm, Diabetes Mellitus Non Insulin-dependent, High Balm, Meralgia Paraesthetica, Ibs, Ankle Replacement, High Blood Cholesterol, Prophylaxis. The patient has Restless Leg Syndrome, Chrinically Elevated Wbcs - 10.5 - 13.0
- A study of drug interactions between Multivitamin, Magnesium Sulfate, Calcium, Vitamin B12, Vitamin D, Ativan, Tramadol, Dopamine Hydrochloride, Coenzyme Q - 10, Zolpidem, Lisinopril, Hctz, Lovastatin, Carvedilol, Metformin for a patient with General Physical Condition, Bone Density Decreased, Anxiety, Back Pain, Parkinsonism, Heart Disease, Sleep Disorder, High Blood Pressure, High Blood Cholesterol, Diabetes Mellitus Non-insulin-dependent. The patient has Tremor
- A study of drug interactions between Tramadol, Iron EDTA, Calcium, Protonix, Prozac, Metformin Hydrochloride, Atenolol for a patient with Migraine, Vitamin B12 Deficiency, Vitamin Supplementation, Stomachache, Headache, Diabetes, Blood Pressure Management. The patient has Headache, Tiredness (Fatigue), Sleepiness (Drowsiness)
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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