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Review: taking Tramadol and Metformin together

Summary: drug interactions are reported among people who take Tramadol and Metformin together.

This review analyzes the effectiveness and drug interactions between Tramadol and Metformin. It is created by eHealthMe based on reports of 2,654 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 29, 2015: 2,654 people who take Tramadol, Metformin are studied

Tramadol, Metformin outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective40.00%
(2 of 5 people)
(3 of 5 people)
(6 of 11 people)
(1 of 6 people)
(5 of 14 people)
(3 of 11 people)
(2 of 3 people)
Metformin is effective0.00%
(0 of 1 people)
(3 of 7 people)
(1 of 6 people)
(3 of 11 people)
(4 of 9 people)
(8 of 12 people)
(3 of 7 people)

Drug effectiveness by gender :

Tramadol is effective35.14%
(13 of 37 people)
(9 of 17 people)
Metformin is effective28.57%
(10 of 35 people)
(12 of 18 people)

Drug effectiveness by age :

Tramadol is effectiven/an/an/a100.00%
(1 of 1 people)
(2 of 11 people)
(4 of 35 people)
(9 of 25 people)
(6 of 25 people)
Metformin is effectiven/an/an/a0.00%
(0 of 1 people)
(1 of 10 people)
(5 of 34 people)
(9 of 25 people)
(7 of 24 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pulmonary EmbolismObsessive-compulsive Personality DisorderVomitingRenal Failure AcuteAnxietyDiarrhoeaFatiguePain
SomnolencePathological GamblingMalaiseThrombosisRenal Failure AcuteBack PainElectrocardiogram Pr ProlongationFatigue
Thrombotic Thrombocytopenic PurpuraHypersexualityNauseaMyocardial InfarctionMental DisorderCerebrovascular AccidentHyperkalaemiaNausea
Confusional StateEmotional DistressPyrexiaIliac Artery StenosisCerebrovascular AccidentMetabolic AcidosisMetabolic AcidosisDyspnoea
Renal Failure AcuteSkin ExfoliationPancreatitis ChronicConfusional StateDepressionColitisUrinary Tract InfectionVomiting
FallSuicidal IdeationHepatic SteatosisMuscle TwitchingCardiac DisorderVomitingNauseaDiabetes Mellitus
Deep Vein ThrombosisPulmonary EmbolismConstipationAmnesiaCardiovascular DisorderPyrexiaRunny NoseChest Pain
NauseaRestlessnessColitisDehydrationBack InjuryTendonitisVomitingDiarrhoea
Drug IneffectiveHypoglycaemiaDyspepsiaPeripheral Vascular DisorderAbdominal Pain UpperSciaticaSleepiness - During The DayAsthenia

Most common drug interactions by gender * :

VomitingMyocardial Infarction
Diabetes MellitusDiarrhoea
Chest PainDepression
Pleural EffusionDiabetes Mellitus

Most common drug interactions by age * :

TremorInfluenza Like IllnessBiliary DyskinesiaDyspnoeaDiabetes MellitusDiabetes MellitusNauseaFatigue
Muscular WeaknessJoint SwellingCholecystitis ChronicNauseaType 2 Diabetes MellitusNauseaDepressionAnaemia
Type 2 Diabetes MellitusMyositisGallbladder DisorderDiabetes MellitusDeep Vein ThrombosisPainAnxietyPain
Neoplasm MalignantArthritis BacterialOropharyngeal PainCholelithiasisPainType 2 Diabetes MellitusPainHaemorrhoids
ObesityLethargyHypoglycaemiaCholecystitis ChronicPulmonary EmbolismVomitingDiarrhoeaColonic Polyp
LeiomyomaMultiple Drug Overdose AccidentalHypertensionChest PainDiabetic NeuropathyBack PainMyocardial InfarctionPleural Effusion
Cerebrovascular AccidentSomnolenceCoughPulmonary EmbolismHeadacheHeadacheVomitingGastritis Erosive
OsteoarthritisAccidental Drug Intake By ChildDiabetes MellitusVomitingDehydrationChest PainDizzinessCystitis
Patellofemoral Pain SyndromeDyshidrosisBack PainKetosisDiarrhoeaChest PainHepatic Enzyme Increased
HyperprolactinaemiaBack PainNeck PainNeuropathy PeripheralDyspnoeaArthralgiaNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Metformin
- support group for people who take Tramadol

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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