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Review: Tramadol and Metformin





Summary: drug interactions are reported among people who take Tramadol and Metformin together.

This review analyzes the effectiveness and drug interactions between Tramadol and Metformin. It is created by eHealthMe based on reports of 2,650 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Tramadol and Metformin >>>

What are the drugs

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from Tramadol 41,511 users)

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin 100,917 users)

On Nov, 25, 2014: 2,650 people who take Tramadol, Metformin are studied

Tramadol, Metformin outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective40.00%
(2 of 5 people)
60.00%
(3 of 5 people)
50.00%
(5 of 10 people)
0.00%
(0 of 5 people)
38.46%
(5 of 13 people)
30.00%
(3 of 10 people)
66.67%
(2 of 3 people)
n/a
Metformin is effective0.00%
(0 of 1 people)
42.86%
(3 of 7 people)
16.67%
(1 of 6 people)
30.00%
(3 of 10 people)
44.44%
(4 of 9 people)
63.64%
(7 of 11 people)
42.86%
(3 of 7 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pulmonary EmbolismObsessive-compulsive Personality DisorderMalaiseRenal Failure AcuteAnxietyDiarrhoeaFatiguePain
SomnolencePathological GamblingVomitingThrombosisRenal Failure AcuteBack PainElectrocardiogram Pr ProlongationFatigue
Thrombotic Thrombocytopenic PurpuraHypersexualityNauseaMyocardial InfarctionDepressionCerebrovascular AccidentHyperkalaemiaNausea
Confusional StateEmotional DistressPyrexiaIliac Artery StenosisMental DisorderHepatic SteatosisMetabolic AcidosisDyspnoea
Renal Failure AcuteSkin ExfoliationPancreatitis ChronicConfusional StateCerebrovascular AccidentHyperkalaemiaUrinary Tract InfectionVomiting
KetosisDepressionTendonitisMydriasisAggressionDyspepsiaHyponatraemiaAnaemia
FallSuicidal IdeationBack PainMuscle TwitchingSpinal Fusion SurgeryConstipationNauseaDiabetes Mellitus
Deep Vein ThrombosisPulmonary EmbolismDyspepsiaAmnesiaHyperkalaemiaWeight DecreasedRunny NoseChest Pain
NauseaRestlessnessWeight DecreasedDehydrationBack InjuryMalaiseVomitingDiarrhoea
Drug IneffectiveHypoglycaemiaNight SweatsPeripheral Vascular DisorderRespiratory Tract InfectionMetabolic AcidosisSleepiness - During The DayAsthenia

Drug effectiveness by gender :

FemaleMale
Tramadol is effective34.29%
(12 of 35 people)
50.00%
(8 of 16 people)
Metformin is effective29.41%
(10 of 34 people)
64.71%
(11 of 17 people)

Most common drug interactions by gender * :

FemaleMale
PainNausea
FatigueFatigue
NauseaAsthenia
AnaemiaVomiting
DyspnoeaDyspnoea
VomitingMyocardial Infarction
Diabetes MellitusDiarrhoea
Pleural EffusionDepression
Chest PainDiabetes Mellitus
HaemorrhoidsPain

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Tramadol is effectiven/an/an/a100.00%
(1 of 1 people)
18.18%
(2 of 11 people)
12.90%
(4 of 31 people)
33.33%
(8 of 24 people)
20.83%
(5 of 24 people)
Metformin is effectiven/an/an/a0.00%
(0 of 1 people)
10.00%
(1 of 10 people)
15.62%
(5 of 32 people)
36.00%
(9 of 25 people)
26.09%
(6 of 23 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
TremorInfluenza Like IllnessBiliary DyskinesiaDyspnoeaDiabetes MellitusDiabetes MellitusNauseaFatigue
Muscular WeaknessJoint SwellingCholecystitis ChronicNauseaType 2 Diabetes MellitusNauseaDepressionAnaemia
Type 2 Diabetes MellitusMyositisGallbladder DisorderDiabetes MellitusDeep Vein ThrombosisPainPainPain
Neoplasm MalignantArthritis BacterialOropharyngeal PainCholelithiasisPainType 2 Diabetes MellitusAnxietyHaemorrhoids
ObesityLethargyHypoglycaemiaCholecystitis ChronicPulmonary EmbolismVomitingMyocardial InfarctionColonic Polyp
LeiomyomaMultiple Drug Overdose AccidentalHypertensionChest PainDiabetic NeuropathyBack PainDiarrhoeaPleural Effusion
Cerebrovascular AccidentSomnolenceCoughPulmonary EmbolismHeadacheHeadacheVomitingGastritis Erosive
OsteoarthritisAccidental Drug Intake By ChildDiabetes MellitusVomitingKetosisChest PainChest PainCystitis
Patellofemoral Pain SyndromeDyshidrosisBack PainNeuropathy PeripheralDiarrhoeaDizzinessHepatic Enzyme Increased
HyperprolactinaemiaBack PainNeck PainDehydrationDyspnoeaArthralgiaNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Tramadol and Metformin?

You are not alone! Join a related mobile support group:
- support group for people who take Tramadol and Metformin
- support group for people who take Metformin
- support group for people who take Tramadol

Can you answer these questions (Ask a question):

  • In having a-fib, can one use xarelto along with temador for brain tumor treatment
    Both drugs lower platelets, is using Xarelto unwise
  • Can i take diclofenac sodium mispoprostol with tramadol hcl?
    I have bad arthritis in my hips - very painful and affecting my quality of life. My doctor like to prescribe pills. He has given me Diclofenac Sodium Mispoprostal and Tramadol HCL. I have experienced minimal side effects i.e.: drowsiness but thats about it. I just want to be sure that I can take these drugs together.
  • I had bladder cancer and my doctor put me on metformin should i get off this
    I do not want to take this metformin if it may cause my bladder cancer to come badk
  • I have been told by my gastroenterologist that i have gastroparesis, what are my treatment options, if any?
    I've had a CT scan and a Gastric Emptying study completed. My stomach is only 35% emptied after 4 hours, it should be at least 90% empty at that point. I have a colonoscopy and esophagealendoscopy scheduled for the first week of the year. What are my treatment options at this point?
  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!

More questions for: Metformin, Tramadol

You may be interested at these reviews (Write a review):

  • Hair loss with metformin hydrochloride usage
    I have been taking the drug Metformin Hydrochloride for about 5 months and definitely find that I am losing hair which is a problem I have never experienced. Always had the healthiest hair, no problems. Well, I am finding that I am losing lair significantly and feel that the manufacturer of this drug should post that this is a side effect as so many have been complaining of the same side effect. I also began having problems with my teeth and always prided myself of having great teeth with no problems. I also understand that if there is a deficiency of Vitamin B12 that this together with taking this drug can cause these issues of hair loss and mouth/teeth problems. Again; I feel this should be totally and more readily informed to anyone taking this drug. I don't feel that anyone should have to give up things important to them to maintain a healthy way of living...I am going to see my physician and discuss what other options that may exist as I am not feeling very comfortable with this drug and the side effects I am experiencing.
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  • No noticeable effects
    No noticeable effects when used together. Tramadol dose 50-100 mg's four times a day.
  • I wish i had never taken ambien
    Ambien was prescribed after my sleep study showed severe sleep latency and awakening. In the five hours I slept I woke 85 times and had only 5 minutes of deep sleep. However, the doctors couldn't make a recommendation because they could detect no cause for the poor sleep pattern. My doctor offered Ambien and since I had obviously needed the help sleeping I took it. For the next 10 years I suffered incredible depression. For example I remember laying in bed staring at the ceiling with tears rolling into my ears but I was too tired to wipe them away and realizing that I wanted to die so badly but there was no way I could have done anything about it. The worst effects were the loss of consciousness and the verbal abuse that I heaped on my husband and son. An example of each : I actually had sex with my husband that I could not remember amd hundreds of other actions and discussions. My husband started asking every morning what I remembered of the night before. He could usually tell when I was Ambien-awake (his name for it) he said my eyes would get glassy and my voice cadence would be off. Unfortunately my oldest son was going from infant to 8 years old at this time and any ifraction or even without provocation I would scream horrible things in his face. I don't remember much of it but what I do remember causes me enormous regret. He went from a happy and active toddler to a terrified amd anxious pre-teen. We are still working through the effects of this behavior. Finally, after a surprise pregnancy (see example above) My baby was placed in NICU and I stayed at the Ronald McDonald House and my son and husband visited when they could. Somehow my Ambien prescription was stopped and so I began going through withdrawal but I had no idea what was going on. My vision became so blurred thqt I couldn't identify items unless they were very large and then only by colors. When I visited my son those several days in the NICU I couldn't walk straight and would try to aim myself toward my goal until I hit a wall and I would correct course. These things didn't bother me at all but the nurses in the NICU were with me nearly the entire day because they were afraid I would have a stroke or who knew. Finally, after discussing these symptoms we decided to gradually stop the medication. Thankfully, i didn't have any withdrawal symptoms then. I did feel like an incredibly heavy and black blanket had been lifted away. Ever since I have had very little trouble with depression despite the continuation of sleep disturbance and pain. On a scale from one to 10 for depression with 10 being committing suicide I think my 10 years on the medicine was probably an 8.5 (I desperately wanted to die) and since stopping the medication I don't think it has gone above a 4 and is usually a 2 or 3. I will spend the rest of my life trying to repair the damage my verbal abuse caused my oldest son and my husband. For 10 years they lived in fear of my rages if I had a bad episode with Ambien.

More reviews for: Metformin, Tramadol

Comments from related studies:

  • From this study (3 days ago):

  • GI symptoms began as constipation when first starting Chantix, then flatulence became progressively more prononuced and diarrhea began approximately 3 weeks after starting Chantix which progressed to totally liquid, frequent stools with abdominal cramping. Medical testing for pathogens associated with diarrhea was negative one week ago. I stopped Chantix appromixately 2 weeks ago, and symptoms are less urgent and distressing, but flatulance continues and stools remain liquid.

    Reply

  • From this study (11 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

  • From this study (11 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness.WBCs run 10.5 tp 13.0 consistanly. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increase & had to increase the Gabapentin back up. RLS came back with increased dose.

    Reply

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Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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