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Review: taking Tramadol and Metformin together

Summary: drug interactions are reported among people who take Tramadol and Metformin together.

This review analyzes the effectiveness and drug interactions between Tramadol and Metformin. It is created by eHealthMe based on reports of 2,653 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Tramadol has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from 41,556 Tramadol users)

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from 101,000 Metformin users)

On Feb, 26, 2015: 2,653 people who take Tramadol, Metformin are studied

Tramadol, Metformin outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Metformin (metformin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective40.00%
(2 of 5 people)
(3 of 5 people)
(6 of 11 people)
(1 of 6 people)
(5 of 14 people)
(3 of 11 people)
(2 of 3 people)
Metformin is effective0.00%
(0 of 1 people)
(3 of 7 people)
(1 of 6 people)
(3 of 11 people)
(4 of 9 people)
(8 of 12 people)
(3 of 7 people)

Drug effectiveness by gender :

Tramadol is effective35.14%
(13 of 37 people)
(9 of 17 people)
Metformin is effective28.57%
(10 of 35 people)
(12 of 18 people)

Drug effectiveness by age :

Tramadol is effectiven/an/an/a100.00%
(1 of 1 people)
(2 of 11 people)
(4 of 35 people)
(9 of 25 people)
(6 of 25 people)
Metformin is effectiven/an/an/a0.00%
(0 of 1 people)
(1 of 10 people)
(5 of 34 people)
(9 of 25 people)
(7 of 24 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Pulmonary EmbolismObsessive-compulsive Personality DisorderVomitingRenal Failure AcuteAnxietyDiarrhoeaFatiguePain
SomnolencePathological GamblingMalaiseThrombosisRenal Failure AcuteBack PainElectrocardiogram Pr ProlongationFatigue
Thrombotic Thrombocytopenic PurpuraHypersexualityNauseaMyocardial InfarctionMental DisorderCerebrovascular AccidentHyperkalaemiaNausea
Confusional StateEmotional DistressPyrexiaIliac Artery StenosisCerebrovascular AccidentMetabolic AcidosisMetabolic AcidosisDyspnoea
Renal Failure AcuteSkin ExfoliationPancreatitis ChronicConfusional StateDepressionColitisUrinary Tract InfectionVomiting
FallSuicidal IdeationHepatic SteatosisMuscle TwitchingCardiac DisorderVomitingNauseaDiabetes Mellitus
Deep Vein ThrombosisPulmonary EmbolismConstipationAmnesiaCardiovascular DisorderPyrexiaRunny NoseChest Pain
NauseaRestlessnessColitisDehydrationBack InjuryTendonitisVomitingDiarrhoea
Drug IneffectiveHypoglycaemiaDyspepsiaPeripheral Vascular DisorderAbdominal Pain UpperSciaticaSleepiness - During The DayAsthenia

Most common drug interactions by gender * :

VomitingMyocardial Infarction
Diabetes MellitusDiarrhoea
Pleural EffusionDepression
Chest PainDiabetes Mellitus

Most common drug interactions by age * :

TremorInfluenza Like IllnessBiliary DyskinesiaDyspnoeaDiabetes MellitusDiabetes MellitusNauseaFatigue
Muscular WeaknessJoint SwellingCholecystitis ChronicNauseaType 2 Diabetes MellitusNauseaDepressionAnaemia
Type 2 Diabetes MellitusMyositisGallbladder DisorderDiabetes MellitusDeep Vein ThrombosisPainAnxietyPain
Neoplasm MalignantArthritis BacterialOropharyngeal PainCholelithiasisPainType 2 Diabetes MellitusPainHaemorrhoids
ObesityLethargyHypoglycaemiaCholecystitis ChronicPulmonary EmbolismVomitingDiarrhoeaColonic Polyp
LeiomyomaMultiple Drug Overdose AccidentalHypertensionChest PainDiabetic NeuropathyBack PainMyocardial InfarctionPleural Effusion
Cerebrovascular AccidentSomnolenceCoughPulmonary EmbolismHeadacheHeadacheVomitingGastritis Erosive
OsteoarthritisAccidental Drug Intake By ChildDiabetes MellitusVomitingKetosisChest PainDizzinessCystitis
Patellofemoral Pain SyndromeDyshidrosisBack PainNeuropathy PeripheralDiarrhoeaChest PainHepatic Enzyme Increased
HyperprolactinaemiaBack PainNeck PainDehydrationDyspnoeaArthralgiaNausea

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Tramadol and Metformin on

Do you take Tramadol and Metformin?

You are not alone! Join a related mobile support group:
- support group for people who take Tramadol and Metformin
- support group for people who take Metformin
- support group for people who take Tramadol

Can you answer these questions (Ask a question):

More questions for: Metformin, Tramadol

You may be interested at these reviews (Write a review):

  • Roaring in the ears from tramadol (taken with dexamethasone)
    It seems the roaring in my right ear happens more around taking the tramadol (2-3/day). Of course, I have a (5) day regiment of dexamethasone at (2/day) so maybe there's a connection. This was prescribed by my GP ( highly regarded) for severe lower back bulging disc pain and down left leg. Also prescribed tizanidine for muscle spasms and gabapentin for, maybe nerve swelling? Both at 2/day but I take less of these two.

    Back pain much better but have the roaring in right ear and can't sleep much. Also doing the Dr recommended exercises daily. Will follow up with chiropractic if this doesn't get me there.

    This is a chronic condition, maybe 20 years, no specific injury, just an accumulation of doing dumb things in my youth.
  • Tramadol and severe rls and restless arms
    After back surgery I was prescribed Tramadol for pain. After about a month I developed severe RLS and also restless arms that seemed to make it hard to breath. Like a weight on my chest. I noticed that after taking the Tramadol, only at night for sleep, the restless symptoms got worse for about an hour and then settled down some. Before long there was no settling down. My pain after several months being better in my back I, not liking to take medicine period, decided to stop the Tramadol. To my surprise my RLS came to almost a complete halt. After about a week it was gone completely.
  • Blood sugar level while taking veltrex
    I been taking Veltrex for a viral infection in my eye for 3 days and today my blood sugar was 448.My normal blood sugar runs around 146.
  • Mom died of stomach blockage while on tramadol
    my mom was taking tramadol for hip pain. she went in the hospital for a hip replacement and died 3 days after the surgery in the hospital from an intestinal blockage
  • Using tramadol with anti-depressants
    Using Tramadol with Anti-depressants

    I was taking Tramadol for pain instead of Endone to cut out the opiates as well as my usual anti-depressant. After about 6 months of feeling dizzy spells and nausea I stumbled across information that these two medications should not be mixed. After all of the extensive tests they did to find out why I had these symptoms, I informed my Doctor of what I had discovered. Much the their embarrassment, they realised I was correct and immediately took me off the tramadol. I just thought I would share this information in case any one else is going through what I did.

More reviews for: Metformin, Tramadol

Comments from related studies:

  • From this study (4 weeks ago):

  • I am waiting for my 2nd revision (3rd attempt) to a supposed routine hip replacement on a 40 year old woman. We found out after the second attempt that as they put it "my bones were just too soft to hold the screws in place, even though I was keeping correct alignment, my bones were just soft." I said like osteoporosis???! They said no, no! Just. soft, like wet wood, from severe arthritis. You think someone would check this before surgery? Right? I don't know.


  • From this study (2 months ago):

  • GI symptoms began as constipation when first starting Chantix, then flatulence became progressively more prononuced and diarrhea began approximately 3 weeks after starting Chantix which progressed to totally liquid, frequent stools with abdominal cramping. Medical testing for pathogens associated with diarrhea was negative one week ago. I stopped Chantix appromixately 2 weeks ago, and symptoms are less urgent and distressing, but flatulance continues and stools remain liquid.


  • From this study (13 months ago):

  • Have been on Gabapentin for years now. For the past 3-4 yrs, I have had a chronically elevated WBC without evidence of illness. WBCs run 10.5 to 13.0 consistently. Even when on antibiotics, has not dropped below 10.5. Am now wondering if this could be related to Gabapentin. The elevated WBCs have resulted in delay of care for back pain issues. At one time, I tried to get off of gabapentin - was titrating the dose(c my provider's permission). I noticed that the Restless Leg Syndrome that I had been experiencing had disappeared with the lower dose of Gabapentin. Unfortunately, the Meralgia Paresthetica synotoms increased & had to increase the Gabapentin back up. RLS came back with increased dose.


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Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Metformin (metformin hydrochloride) is often used to treat diabetes. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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