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Review: taking Tramadol and Omeprazole together

Summary: drug interactions are reported among people who take Tramadol and Omeprazole together.

This review analyzes the effectiveness and drug interactions between Tramadol and Omeprazole. It is created by eHealthMe based on reports of 5,892 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 17, 2015: 5,892 people who take Tramadol, Omeprazole are studied

Tramadol, Omeprazole outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- Omeprazole (omeprazole)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effective23.08%
(3 of 13 people)
(11 of 27 people)
(5 of 27 people)
(12 of 32 people)
(7 of 22 people)
(3 of 17 people)
(2 of 8 people)
(0 of 1 people)
Omeprazole is effective25.00%
(1 of 4 people)
(7 of 21 people)
(7 of 15 people)
(17 of 25 people)
(24 of 38 people)
(21 of 26 people)
(14 of 19 people)
(0 of 1 people)

Drug effectiveness by gender :

Tramadol is effective33.33%
(34 of 102 people)
(9 of 45 people)
Omeprazole is effective61.54%
(64 of 104 people)
(27 of 45 people)

Drug effectiveness by age :

Tramadol is effectiven/an/a42.86%
(3 of 7 people)
(3 of 11 people)
(9 of 82 people)
(8 of 74 people)
(10 of 97 people)
(10 of 68 people)
Omeprazole is effectiven/an/a14.29%
(1 of 7 people)
(4 of 11 people)
(11 of 82 people)
(21 of 73 people)
(25 of 103 people)
(29 of 68 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Confusional StateAbdominal PainConstipationErectile DysfunctionDepressionAnxietyDepressionPain
PyrexiaMuscle SpasmsDeep Vein ThrombosisDepressionAstheniaDelusionSuicidal IdeationArthralgia
NeutropeniaBurning SensationDiarrhoeaMuscle SpasmsSuicidal IdeationParanoiaSleepyFatigue
DyspnoeaParaesthesiaBack PainChest PainDizzinessCerebral HaemorrhageRestless Leg SyndromeDyspnoea
AnaemiaHypoaesthesiaPulmonary EmbolismMuscle TwitchingIncontinenceAggressionShort-term Memory LossVomiting
ThrombocytopeniaPyrexiaPainNauseaFatigueShort-term Memory LossCramps - LegAnxiety
PneumoniaPneumoniaNight SweatsGastrooesophageal Reflux DiseaseNightmarePancytopeniaFear Of FallingDiarrhoea
Pain In ExtremityAnaemiaVomitingDry MouthHeadacheSuicidal IdeationRheumatoid FactorAsthenia
Pleural EffusionHyperkalaemiaDepressionBurning SensationSleep DisorderDisseminated TuberculosisAgoraphobiaFall

Most common drug interactions by gender * :

FallConfusional State
Back PainMyocardial Infarction

Most common drug interactions by age * :

Skin SwellingSepsisTremorCholecystitis ChronicHeadachePainNauseaFall
Skin WrinklingArthralgiaRashDyspnoeaArthralgiaChest PainPainPain
Diabetes MellitusBone PainHeadacheNauseaDepressionNauseaDepressionDyspnoea
Pain Of SkinTumour Lysis SyndromeFlushingDiarrhoeaAnxietyDepressionDiarrhoeaNausea
PainRespiratory FailureHallucination, VisualGallbladder DisorderPyrexiaBack PainFatigueFatigue
ProteinuriaPneumoniaSuicidal IdeationPainSuicidal IdeationAnxietyAnxietyDiarrhoea
Renal Failure AcuteRenal FailureConfusional StateVomitingMalaiseArthralgiaArthralgiaAsthenia
Muscular WeaknessAbdominal PainEmotional DistressCholelithiasisVomitingAbdominal PainVomitingArthralgia
Leukocytoclastic VasculitisSomnolenceBiliary DyskinesiaPyrexiaParaesthesiaPain In ExtremityPyrexiaVomiting
Depressed Level Of ConsciousnessCholecystitis ChronicAnxietyDyspnoeaOedema PeripheralAnaemiaConfusional State

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Omeprazole
- support group for people who take Tramadol

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. Omeprazole (omeprazole) is often used to treat gastroesophageal reflux disease. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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