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Review: Tramadol and St. John's Wort

This review analyzes the effectiveness and drug interactions between Tramadol and St. John's Wort. It is created by eHealthMe based on reports of 26 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Tramadol and St. John's Wort >>>

What are the drugs

Tramadol (latest outcomes from 41,403 users) has active ingredients of tramadol hydrochloride. It is used in pain.

St. john's wort (latest outcomes from 271 users) has active ingredients of st. john's wort. It is used in depression.

On Aug, 12, 2014: 26 people who take Tramadol, St. John's Wort are studied

Tramadol, St. John's Wort outcomes

Drug combinations in study:
- Tramadol (tramadol hydrochloride)
- St. John's Wort (st. john's wort)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol is effectiven/an/a100.00%
(1 of 1 people)
St. John's Wort is effectiven/an/an/an/an/a100.00%
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Rash Maculo-papularn/aEyelid Twitchn/an/aEyelid Twitchn/aSerotonin Syndrome
Rash PruriticHallucination, Visual
Skin Test PositiveTremor
Generalised OedemaConfusional State
Epidermal NecrosisPyrexia
CholestasisRoad Traffic Accident
Drug EruptionLower Limb Fracture
Cell DeathBlood Creatinine Increased

Drug effectiveness by gender :

Tramadol is effective100.00%
(1 of 1 people)
St. John's Wort is effective100.00%
(1 of 1 people)

Most common drug interactions by gender * :

Serotonin SyndromeBlood Creatinine Increased
Hallucination, VisualArthralgia
Confusional StateEmbolism
Lower Limb FractureOcular Hypertension
Road Traffic AccidentRenal Failure Chronic
MalaiseVision Blurred
InfluenzaTendon Injury
Increased Tendency To BruiseBack Pain

Drug effectiveness by age :

Tramadol is effectiven/an/an/an/an/an/an/a100.00%
(1 of 1 people)
St. John's Wort is effectiven/an/an/an/an/an/an/a100.00%
(1 of 1 people)

Most common drug interactions by age * :

n/an/an/an/aStaphylococcal Skin Infectionn/aMalaiseDecubitus Ulcer
Tongue BlisteringInfluenzaTendon Injury
Tongue DisorderIncreased Tendency To BruiseVision Blurred
PancreatitisVenous Insufficiency
Hepatic Enzyme IncreasedGeneral Physical Health Deterioration
Joint StiffnessAnxiety
NauseaFractured Sacrum
ArthralgiaBack Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Tramadol and St. John's Wort
- group for people who take St. John's Wort
- group for people who take Tramadol

Can you answer these questions (what is this?):

More questions for: St. John's Wort, Tramadol

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    I went into a local emergency room for a sore throat with pustules and difficulty swallowing, i was given Tramadol for pain through my iv. About 2 days later i woke up with a very blistery tongue, which was mildly painful as the day progressed i felt like i had been eating habanero peppers all day.. ...

More reviews for: St. John's Wort, Tramadol

Complete drug side effects:

On eHealthMe, Tramadol (tramadol hydrochloride) is often used to treat pain. St. John's Wort (st. john's wort) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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