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Review: taking Tramadol and Codeine Sulfate together

Summary: drug interactions are reported among people who take Tramadol and Codeine Sulfate together. This review analyzes the effectiveness and drug interactions between Tramadol and Codeine Sulfate. It is created by eHealthMe based on reports of 188 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Tramadol hydrochloride has active ingredients of tramadol hydrochloride. It is often used in pain. (latest outcomes from 6,868 Tramadol hydrochloride users)

Codeine sulfate has active ingredients of codeine sulfate. It is often used in pain. (latest outcomes from 2,147 Codeine sulfate users)

On Apr, 30, 2015: 188 people who take Tramadol Hydrochloride, Codeine Sulfate are studied

Tramadol Hydrochloride, Codeine Sulfate outcomes

Drug combinations in study:
- Tramadol Hydrochloride (tramadol hydrochloride)
- Codeine Sulfate (codeine sulfate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol Hydrochloride is effective66.67%
(2 of 3 people)
(1 of 1 people)
(0 of 2 people)
(1 of 2 people)
(0 of 1 people)
(0 of 1 people)
Codeine Sulfate is effective33.33%
(1 of 3 people)
(1 of 2 people)
(0 of 2 people)
(1 of 3 people)
(0 of 1 people)

Drug effectiveness by gender :

Tramadol Hydrochloride is effective33.33%
(2 of 6 people)
(2 of 4 people)
Codeine Sulfate is effective33.33%
(2 of 6 people)
(1 of 5 people)

Drug effectiveness by age :

Tramadol Hydrochloride is effectiven/an/an/a50.00%
(1 of 2 people)
(3 of 11 people)
(0 of 2 people)
(0 of 1 people)
Codeine Sulfate is effectiven/an/an/a50.00%
(1 of 2 people)
(0 of 2 people)
(2 of 11 people)
(0 of 2 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Muscle RigidityGait DisturbanceFibromyalgiaJoint SwellingUrinary Retentionn/an/aDyspnoea
NeutropeniaBalance DisorderIrregular Sleep PhaseGait DisturbanceDeliriumVomiting
ConvulsionVomitingMusculoskeletal StiffnessH1n1 InfluenzaSerotonin Syndrome
DyskinesiaTremorBalance DisorderVisual ImpairmentArthralgia
SyncopeCogwheel RigidityOedema PeripheralArthralgiaAnxiety
HyperbilirubinaemiaDeliriumSkin TightnessConvulsionDepression
ThrombocytopeniaAnxietyTendon DisorderNightmarePruritus
PneumoniaSuicidal IdeationMuscle ContractureHeadacheDizziness
Liver Function Test AbnormalBlood Sodium DecreasedMuscle TightnessCogwheel RigidityMalaise
FibromyalgiaSerotonin SyndromeSkin HypertrophyDrug Withdrawal SyndromeAsthenia

Most common drug interactions by gender * :

Serotonin SyndromePneumonia
AnxietyDrug Toxicity
MalaiseBack Pain
DepressionParkinson's Disease

Most common drug interactions by age * :

n/an/an/aConvulsionSerotonin SyndromeSerotonin SyndromeBacterial SepsisBack Pain
MalaiseSuicidal IdeationSkin Burning SensationCompleted SuicideGait Disturbance
AnxietyNightmareBrain OedemaDrug Level IncreasedOsteoarthritis
PruritusVisual ImpairmentHypersensitivityEncephalitisFatigue
DyspnoeaBlood Sodium DecreasedMyalgiaMultiple Drug OverdoseOsteomyelitis
HeadacheSleep DisorderPruritusDisabilityPain In Extremity
ManiaMalaisePulmonary OedemaMalaiseVomiting
Sensory LossHeadacheDrug ToxicityBlood Fibrinogen IncreasedHyperplasia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Tramadol and Codeine Sulfate on

Do you take Tramadol and Codeine Sulfate?


You are not alone! Join a related support group:
- support group for people who take Codeine Sulfate
- support group for people who take Tramadol Hydrochloride

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Codeine Sulfate, Tramadol Hydrochloride

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More reviews for: Codeine Sulfate, Tramadol Hydrochloride

Comments from related studies:

  • From this study (8 months ago):

  • I have had chronic fatigue since 5 May 2012 - nearly 2 and a half years. Recently stopped Lexapro for depression which I was on for a year and slowly reduced before cessation. Old back problem bulging disk L5/S1 pain left thigh, hip, buttock worst at night. Recently went on tramadol and immediate sleep disturbance. The month before was the best in >2 years when I started Endep.


  • From this study (1 year ago):

  • Is it common to suffer with toothache/gum inflammation whilst taking the above pain killers? I have stopped taking the painkillers a week ago and now i am suffering with pain in my jaw/teeth.


  • From this study (2 years ago):

  • Have been reluctant to leave house,
    The symptoms started when I began to take the meds..Symptoms started December 2012, and are still with me now in Oct 2013
    I have had bowel investigations ..all clear


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Complete drug side effects:

On eHealthMe, Tramadol Hydrochloride (tramadol hydrochloride) is often used to treat pain. Codeine Sulfate (codeine sulfate) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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