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Review: taking Tramadol and Ibuprofen together

Summary: drug interactions are reported among people who take Tramadol and Ibuprofen together.

This review analyzes the effectiveness and drug interactions between Tramadol and Ibuprofen. It is created by eHealthMe based on reports of 3,198 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 7, 2015: 3,198 people who take Tramadol Hydrochloride, Ibuprofen are studied

Tramadol Hydrochloride, Ibuprofen outcomes

Drug combinations in study:
- Tramadol Hydrochloride (tramadol hydrochloride)
- Ibuprofen (ibuprofen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tramadol Hydrochloride is effective41.67%
(10 of 24 people)
(3 of 17 people)
(6 of 21 people)
(6 of 23 people)
(6 of 16 people)
(6 of 13 people)
(0 of 3 people)
(2 of 3 people)
Ibuprofen is effective44.44%
(8 of 18 people)
(4 of 16 people)
(2 of 11 people)
(2 of 10 people)
(2 of 20 people)
(8 of 19 people)
(8 of 20 people)
(1 of 3 people)

Drug effectiveness by gender :

Tramadol Hydrochloride is effective32.18%
(28 of 87 people)
(10 of 32 people)
Ibuprofen is effective32.56%
(28 of 86 people)
(7 of 31 people)

Drug effectiveness by age :

Tramadol Hydrochloride is effectiven/an/an/a4.08%
(4 of 98 people)
(9 of 61 people)
(17 of 67 people)
(5 of 84 people)
(3 of 10 people)
Ibuprofen is effectiven/an/an/a7.81%
(5 of 64 people)
(6 of 63 people)
(14 of 67 people)
(7 of 83 people)
(3 of 10 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
VomitingHaemorrhoidsConstipationPainPainDepressionLiver DisorderPain
PainAbdominal DistensionPainHaemorrhageDepressionAnxietyNauseaNausea
NauseaGastrooesophageal Reflux DiseaseNauseaDeep Vein ThrombosisAnxietyConstipationTired EyesAnxiety
DiarrhoeaRectal HaemorrhageDepressionInternational Normalised Ratio IncreasedDeep Vein ThrombosisGastrooesophageal Reflux DiseaseMuscle TwitchingFatigue
HypotensionConstipationDyspepsiaRetroperitoneal HaematomaHypertensionLiver DisorderFatigueDepression
Drug IneffectiveDyspepsiaDiarrhoeaPulmonary EmbolismPulmonary EmbolismAbdominal DistensionMigraine Without AuraBack Pain
InsomniaFaeces HardColitisGeneral Physical Health DeteriorationOedema PeripheralDyspepsiaDepressionDyspnoea
DyspnoeaOedemaTherapeutic Response DecreasedFatiguePain In ExtremityFaeces HardSuicidal IdeationVomiting
Abdominal PainDepressionArthralgiaHeadacheGallbladder Non-functioningSuicidal IdeationTremorFall
MelaenaSuicidal IdeationBack PainOedema PeripheralCholecystitis ChronicNauseaTearfulnessDizziness

Most common drug interactions by gender * :

Pain In ExtremityInsomnia
Back PainDyspnoea
InjuryBack Pain

Most common drug interactions by age * :

Diabetes Mellitusn/aPainPainPainPainNauseaFatigue
Cholecystitis ChronicNauseaDepressionAnxietyAnxietyNausea
Abdominal PainAnxietyAnxietyNauseaDepressionPain
Gallbladder DisorderDeep Vein ThrombosisNauseaHeadachePainDyspnoea
AnxietyCholelithiasisHeadacheBack PainInsomniaAnxiety
InjuryPulmonary EmbolismChest PainDepressionDiarrhoeaFall
Pulmonary EmbolismCholecystitis ChronicPain In ExtremityDyspnoeaBack PainAsthenia
DepressionGallbladder DisorderDeep Vein ThrombosisAnaemiaVomitingChest Pain
CholelithiasisDepressionDrug IneffectiveAbdominal PainHypoaesthesiaDizziness
VomitingInjuryInjuryInsomniaOedema PeripheralVomiting

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Ibuprofen
- support group for people who take Tramadol Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Tramadol Hydrochloride (tramadol hydrochloride) is often used to treat pain. Ibuprofen (ibuprofen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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