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Related topic: Suboxone, Tramadol Hydrochloride

Review: Tramadol and Suboxone

This review analyzes the effectiveness and drug interactions between Tramadol and Suboxone. It is created by eHealthMe based on 41 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 2, 2014: 41 people who reported to have interactions when taking Tramadol Hydrochloride, Suboxone are studied

Trend of Tramadol Hydrochloride, Suboxone's drug interactions, side effects and effectiveness reports (4375568)

Drug combinations in study:
- Tramadol Hydrochloride (tramadol hydrochloride)
- Suboxone (buprenorphine hydrochloride; naloxone hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Tramadol Hydrochloride, Suboxone:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Syncope (loss of consciousness with an inability to maintain postural tone)41
Arteriosclerosis (thickening and hardening of arteries)41
Anaemia (lack of blood)38
Spinal Osteoarthritis (joint cartilage loss in spine)36
Weight Decreased36
Gastritis (inflammation of stomach)36
Confusional State36
Loose Tooth32
Failure To Thrive (inadequate weight gain and physical growth in children)32

Most common interactions experienced by people in long term use of Tramadol Hydrochloride, Suboxone:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Seizures (abnormal excessive or synchronous neuronal activity in the brain)1

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Tramadol Hydrochloride0.

Top conditions involved for these people * :

  1. Pain
  2. Drug dependence
  3. Depression
  4. Antipsychotic drug level
  5. Insomnia

Top co-used drugs for these people * :

  1. Ultram
  2. Tramadol hcl
  3. Zyrtec
  4. Cymbalta
  5. Neurontin

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Complete drug side effects:

On eHealthMe, Tramadol Hydrochloride (tramadol hydrochloride) is often used to treat acupuncture and pain. Suboxone (buprenorphine hydrochloride; naloxone hydrochloride) is often used to treat opiate withdrawal. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (13 months ago):

  • Just started suboxone yesterday for pain management. About an hour after I took it yesterday I did experience some sweating and nausea. Today however, it caused me to vomit lunch. I went and ate dinner an hour or two later and took a naproxen for a developing migrane. About an hour after taking the naproxen I began vomiting again, once the bulk of dinner was done coming up, I began throwing up blood. Is this because of the suboxone?


    MJ on Apr, 12, 2013:

    It very well could be from the Suboxone. I have been on it for the last 6 years. The first 3 were hell. I would vomit several times evry day along with severe abdominal pain. I was taking 32mg a day..high dose..went down to just 12mg a day and problem went away. Best advise is to taper off slowly and try to get off it completly.


    shannon on Apr, 13, 2013:

    About is a tagonist/antagonist drug, therefore, can cause some rather abrupt withdrawl type effects and the issues you describe can be one of many symptoms you would have if you were NOT taking the suboxone. It works to give narcotic management yet deter overuse by having the drug Naloxone, the same med we carry on the ambulance to reverse narcotics, in it. Too much or even very little of the narcan part of the drug will cause immediate withdrawl type symptoms that can include severe nausea and vomiting, sweats, chills, diarrhea, headaches and many other symptoms. Talk to your prescriber and see what they say is my advice.


    Snoods on May, 1, 2013:

    I am a 54 year old pysch nurse that uses suboxone in my practice. I think there is confusion regarding the naloxone(Narcan) included in this drug. The Narcan has little to no effect unless you try to inject suboxone. The Narcan is not the main opiate blocker, as it is metabolized by the liver almost immediately. Suboxone is a "mu" agonist (stimulator) and a kappa antagonist (blocker). That is why you get pain relief without much intoxication. Paramedics tend to focus on the 20 or so drugs they carry on an ambulance and do not have the broad knowledge of a complex drug like suboxone.


    Snood on May, 1, 2013:

    Sweating, nausea, vomiting, and headache are all signs of opiate use. Suboxone is a powerful opiate, although it may not feel like one. You will slowly adapt to these symptoms, and faster if you decrease you dose


    MJ on May, 2, 2013:

    "Sweating, nausea, vomiting, and headache are all signs of opiate use" Suboxone is a very confusing drug..My old Dr thought I wasn't getting enough and was going thru withdrawal, so he raised my dose to 32mg.big mistake, but even at only 8mg I feel like I have the flu, now that's withdrawal. I hate this drug because most dr's don't kno jack about it and are destroying peoples lives from it. I haven't been the same since it, and not from abuse. I just can't find the happy medium dose I need to just feel normal again. Any help will help.


    MJ on May, 2, 2013:

    Yes it is.I had the same problem. How much are you taking? How long has it been since you had an opiate? You can't mix the two..EVER. You need about a two day (min.) window between the two. It sounds like your body is having a hard time with such a strong drug. Suboxone is VERY strong and lasts VERY long so it is very hard to know if you had too much until it is to late. Try not taking any more until your symptoms go away..then take a little bit and wait for at least an hour and repeat until better. NOTE..I do not know your dosage so please do not take more than your dose..EVER...but try to lower it if able.


Can you answer these questions (what is this?):

More questions for: Suboxone, Tramadol Hydrochloride

You may be interested at these reviews (what is this?):

  • Insomnia from suboxone
    Does Suboxone cause insomnia? Hell yes, I haven't slept properly for years and I wish I had never gone on it. My night is my day and daybreak is when i'm heading off to sleep,I try to wake up about 11 am but that is still half the day gone. I am so so over it, all I can do is reduce my dose and th ...

  • Horrific nightmares taking naproxen
    I've Taking naproxen 500mg twice a day for 3 weeks on a course for 6 months, I've been having horrific dreams worse than horrer movies, the most recent is involving my ex & current partner where I had a psychotic stalker (my ex) switched around because in the dream I dump my partner for my ex, well ...

  • Burning mouth syndrome
    I went into a local emergency room for a sore throat with pustules and difficulty swallowing, i was given Tramadol for pain through my iv. About 2 days later i woke up with a very blistery tongue, which was mildly painful as the day progressed i felt like i had been eating habanero peppers all day.. ...

More reviews for: Suboxone, Tramadol Hydrochloride

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related studies

- Suboxone side effects
- Tramadol Hydrochloride side effects



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