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Review: Trazodone and Diphenhydramine





Summary: drug interactions are reported among people who take Trazodone and Diphenhydramine together.

This review analyzes the effectiveness and drug interactions between Trazodone and Diphenhydramine. It is created by eHealthMe based on reports of 1,072 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Trazodone and Diphenhydramine >>>

What are the drugs

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from Trazodone hydrochloride 6,611 users)

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. (view latest outcomes from 2,998 users)

On Dec, 13, 2014: 1,072 people who take Trazodone Hydrochloride, Diphenhydramine Hydrochloride are studied

Trazodone Hydrochloride, Diphenhydramine Hydrochloride outcomes

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Diphenhydramine Hydrochloride (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Trazodone Hydrochloride is effective0.00%
(0 of 4 people)
37.50%
(3 of 8 people)
25.00%
(1 of 4 people)
60.00%
(3 of 5 people)
37.50%
(3 of 8 people)
50.00%
(1 of 2 people)
0.00%
(0 of 2 people)
n/a
Diphenhydramine Hydrochloride is effective14.29%
(1 of 7 people)
0.00%
(0 of 3 people)
40.00%
(2 of 5 people)
25.00%
(1 of 4 people)
75.00%
(3 of 4 people)
40.00%
(2 of 5 people)
0.00%
(0 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyPulmonary EmbolismDrug Exposure During PregnancyType 2 Diabetes MellitusMood SwingsHypomaniaSleepyAnxiety
PainDeep Vein ThrombosisStillbirthPancreatitisNightmareAtaxiaDepression SuicidalPain
Renal FailureInsomniaChokingUrethral StenosisDepressionErectile DysfunctionAnxietyFall
Multi-organ FailureDrug Effect DecreasedFlank PainWeight IncreasedInsomniaMalaiseHeadache
Anaphylactic ReactionPalpitationsConstipationRenal FailureAnxietyManiaNausea
NauseaErectile DysfunctionAnxiety AggravatedObstruction GastricPost-traumatic Stress DisorderMental Status ChangesDyspnoea
Renal InjuryAnxietyDiarrheaPainSuicide AttemptMeniere's DiseaseFatigue
InjuryAmnesiaNauseaHyperlipidaemiaAngerSleep Disorder Due To General Medical Condition, Insomnia TypeBack Pain
DeathMemory ImpairmentDiabetes MellitusIntentional OverdoseGlucose Tolerance ImpairedChest Pain
AnhedoniaOpportunistic InfectionDementia Alzheimer's TypeAggressionDiabetic NephropathyDepression

Drug effectiveness by gender :

FemaleMale
Trazodone Hydrochloride is effective29.63%
(8 of 27 people)
50.00%
(3 of 6 people)
Diphenhydramine Hydrochloride is effective34.62%
(9 of 26 people)
0.00%
(0 of 5 people)

Most common drug interactions by gender * :

FemaleMale
AnxietyPain
FallDiabetes Mellitus
HeadacheType 2 Diabetes Mellitus
PainAnxiety
NauseaFall
FatigueDrug Toxicity
DyspnoeaNausea
OsteoarthritisDepression
Osteonecrosis Of JawBack Pain
Back PainDiarrhoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Trazodone Hydrochloride is effectiven/an/a50.00%
(1 of 2 people)
30.00%
(3 of 10 people)
17.39%
(4 of 23 people)
25.00%
(2 of 8 people)
0.00%
(0 of 2 people)
11.11%
(1 of 9 people)
Diphenhydramine Hydrochloride is effectiven/an/a0.00%
(0 of 2 people)
25.00%
(3 of 12 people)
19.05%
(4 of 21 people)
28.57%
(2 of 7 people)
0.00%
(0 of 2 people)
0.00%
(0 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
AggressionNauseaDrug Administration ErrorAnxietyDiabetes MellitusDiabetes MellitusAnxietyFall
ConvulsionOedema MouthCompartment SyndromePancreatitisDrug ToxicityType 2 Diabetes MellitusPainChest Pain
AgitationIrritabilityExtremity NecrosisPainCompleted SuicidePainFallAnaemia
Tardive DyskinesiaHyperaesthesiaRhabdomyolysisDepressionType 2 Diabetes MellitusHeadacheNauseaArthralgia
Weight IncreasedGlossodyniaNeuroleptic Malignant SyndromeType 2 Diabetes MellitusAstheniaAnxietyCardiomegalyBack Pain
Foaming At MouthOedema PeripheralAgitationPulmonary EmbolismNauseaHypoaesthesiaAtelectasisFatigue
Type 2 Diabetes MellitusPain In ExtremityAggressionDrug ToxicityVomitingNauseaDiarrhoeaPain
NephrolithiasisTongue GeographicConvulsionSinusitisAnxietyArthralgiaCoughOsteoporosis
Obstruction GastricSwelling FaceHypokalaemiaInsomniaDepressionBack PainOsteonecrosis Of JawOsteomyelitis
PancreatitisSkin ExfoliationFoaming At MouthNauseaFatigueOedema PeripheralOsteoarthritisChronic Obstructive Pulmonary Disease

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Trazodone and Diphenhydramine?

You are not alone! Join a related mobile support group:
- support group for people who take Trazodone and Diphenhydramine
- support group for people who take Diphenhydramine Hydrochloride
- support group for people who take Trazodone Hydrochloride

Can you answer these questions (Ask a question):

More questions for: Diphenhydramine Hydrochloride, Trazodone Hydrochloride

You may be interested at these reviews (Write a review):

  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Benadryl completed suicide 50 year old
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.
  • Had nms in 2005, will trileptal increase chance of recurrence?
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrollable shivering) continued & got higher. By 5/05 my temps were reaching 105 deg F. Husband said I became combative, refused to go to hospital. Early June/05 he came home to find me wrapped in blankets, with a temp over 105 F. He tried to place me in a tub of cold water, said I was rigid & screamed when he tried to move me. I was in the tub, speaking "in tongues" (his description, I have no memory of this). He called 911, took me to hospital. I woke, no idea where I was or why. After a lumbar puncture & 2 days in ICU I went home. The fevers continued...2 weeks later he came home to find me wrapped in sheets, towels, blankets, with the heat on full (it was in the 90's outside) he called ambulance again. I awoke to find myself under an ice blanket with nurses pushing large vials of dantrolene into both arms, several liters. Another LP, a stint in ICU...this time they told me it was NMS. The dr who dxd me said he was surprised I was alive, & not a vegetable, as my temp had peaked at 109 deg F. I suffered brain damage; short-term memory loss, brain can't control my body temp, my blood pressure went up. An arteriogram showed completely healthy heart & arteries, no plaque at all. I lost all body fat as well as some muscle mass. The fevers continued even after stopping the Seroquel. I visited my PCP for a checkup in 9/05, temp was normal. I started shuddering, my temp went up a full degree every 5 minutes. PCP admitted me to ER, my heart rate was over 272 B/M; they stopped my heart 3 times to "reset" it, which didn't work. I spent 3 days in hospital. Several months later my P doc tried me on Lamictal alone; I got Stevens-Johnson syndrome. I stopped the drug as soon as the signs appeared. I've been untreated, except for Neurontin & Primidone, until my manic episodes became unlivable. 3 weeks ago I went 8 days with no sleep, became psychotic. My P doc gave me Trileptal, which has evened my moods, but I've been getting low-grade fevers (highest was 103.6). Would having had NMS in the past make me more prone to falling to it again with the Trileptal? It's the only new med I've taken in over a year.
  • Hit and miss sleep with dextroamphetamine
    Started drug 2 months ago and have seen an improvement in my focus. Ziprosidone for my depression causes me to get dead tired by 7 pm. Once I started taking Dextroamphetamine I started having insomnia 2 times a week. I think I would rather sleep early than stay up all night and then try and stay awake at work. So many drugs and even more side effects. Also Trazadone is no help for getting me to sleep. The only good side affect I have seen is I am down 26 pounds.

More reviews for: Diphenhydramine Hydrochloride, Trazodone Hydrochloride

Comments from related studies:

  • From this study (2 years ago):

  • Overall: Diabetes stays under 120, testosterone levels remain low for age (48, but testosterone levels of 90 year old man). Atypically small penis, testes often recede so that the scrotum is flat and tight. Bi-sexual with periodic gender issues (desire to be feminine). Married, two children and no family issues to include sexual oddities, wife is supportive.

    I am reluctant to bring up sexual and gender issues to Doctor, but have the feeling that gender drift (feelings), small penis and receding testicles and attraction to both sexes (including transgendered males with feminine qualities and penis). I know that all of this makes me rather unusual in terms of societal norms, but this is an honest assessment to the best of my ability. I started becoming sexually active at 13 years old with males first and later (15) with females. I desire only a relationship with a female or shemale (preferable but not realistic so I don't dwell on it).

    Despite gender struggles from 14 to present I joined the US Army and went Airborne and Special Forces, spending a majority of my adult life (even unitl present) as an operator in Special Forces (albeit my age is making that more and more difficult).

    I'm looking for a medical opinion that takes in current health conditions and issues, sexual history and other factors that are tell tale signs of a condition that I am unaware of.

    Reply

    Me on Jan, 4, 2013:

    Forgot to mention that I have one son who has only one testicle but is not infertile. He was operated on at 3 to determine is it was an undescended testicle, however no trace of a second testicle was found. In his 20s he fathered a female child and still no trace of second testicle.

    Reply

  • From this study (2 years ago):

  • I seem to have more RLS when combining promethazine, methocarbomal, and/or diphenhydramine. Is this a problem for blood clots? About to start Seasonale and all birth control pills are warning about blood clots.

    Reply

    deerfisherman on Dec, 23, 2012:

    Benadryl is a trigger for Restless Leg s. do not take it or your legs will jump.

    Reply

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Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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