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Review: Trazodone and Diphenhydramine

This review analyzes the effectiveness and drug interactions between Trazodone and Diphenhydramine. It is created by eHealthMe based on 1,030 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 30, 2014: 1,030 people who reported to have interactions when taking Trazodone Hydrochloride, Diphenhydramine Hydrochloride are studied

Trend of Trazodone Hydrochloride, Diphenhydramine Hydrochloride's drug interactions, side effects and effectiveness reports (4044640)

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Diphenhydramine Hydrochloride (diphenhydramine hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Trazodone Hydrochloride, Diphenhydramine Hydrochloride:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety599
Dyspnoea (difficult or laboured respiration)451
Diarrhoea373
Pain370
Fall346
Headache (pain in head)338
Nausea (feeling of having an urge to vomit)288
Chest Pain280
Fatigue (feeling of tiredness)261
Back Pain252

Most common interactions experienced by people in long term use of Trazodone Hydrochloride, Diphenhydramine Hydrochloride:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety23
Type 2 Diabetes Mellitus18
Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)15
Suicide Attempt10
Pain10
Insomnia (sleeplessness)10
Weight Increased10
Pancreatitis (inflammation of pancreas)10
Urethral Stenosis (narrowing of the urethra, may cause decreased urine output)8
Intentional Overdose8

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Trazodone Hydrochloride14.29%0.00%42.86%28.57%14.29%
Diphenhydramine Hydrochloride0.00%100.00%0.00%0.00%0.00%

Top conditions involved for these people * :

  1. Depression
  2. Pain
  3. Insomnia
  4. Anxiety
  5. Bipolar disorder

Top co-used drugs for these people * :

  1. Seroquel
  2. Trazodone hcl
  3. Benadryl
  4. Diphenhydramine hcl
  5. Aspirin

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

If the study doesn't answer your question, you can:

Related topic: Diphenhydramine Hydrochloride, Trazodone Hydrochloride

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Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (1 year ago):

  • Overall: Diabetes stays under 120, testosterone levels remain low for age (48, but testosterone levels of 90 year old man). Atypically small penis, testes often recede so that the scrotum is flat and tight. Bi-sexual with periodic gender issues (desire to be feminine). Married, two children and no family issues to include sexual oddities, wife is supportive.

    I am reluctant to bring up sexual and gender issues to Doctor, but have the feeling that gender drift (feelings), small penis and receding testicles and attraction to both sexes (including transgendered males with feminine qualities and penis). I know that all of this makes me rather unusual in terms of societal norms, but this is an honest assessment to the best of my ability. I started becoming sexually active at 13 years old with males first and later (15) with females. I desire only a relationship with a female or shemale (preferable but not realistic so I don't dwell on it).

    Despite gender struggles from 14 to present I joined the US Army and went Airborne and Special Forces, spending a majority of my adult life (even unitl present) as an operator in Special Forces (albeit my age is making that more and more difficult).

    I'm looking for a medical opinion that takes in current health conditions and issues, sexual history and other factors that are tell tale signs of a condition that I am unaware of.

    Reply

    Me on Jan, 4, 2013:

    Forgot to mention that I have one son who has only one testicle but is not infertile. He was operated on at 3 to determine is it was an undescended testicle, however no trace of a second testicle was found. In his 20s he fathered a female child and still no trace of second testicle.

    Reply

  • From this study (1 year ago):

  • I seem to have more RLS when combining promethazine, methocarbomal, and/or diphenhydramine. Is this a problem for blood clots? About to start Seasonale and all birth control pills are warning about blood clots.

    Reply

    deerfisherman on Dec, 23, 2012:

    Benadryl is a trigger for Restless Leg s. do not take it or your legs will jump.

    Reply

  • From this study (4 years ago):

  • Kindra Mathis on May, 14, 2010:

    I would like to know the side effects of taking Depakote,Trazodone and Benadryl for almost two years while in jail because I don't remember the trail and was very sleeping during the trail my dad was there and I can"t re call him being there.

    Reply

Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

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  • Toxicology level for gabapentin were 55 mcg/ ml can that cause respiratory arrest?
    Had just started Gralise 600mg tablets 2 days prior to respiratory arrest. Hydrocodone he had been on for a month (both were used for complex regional pain syndrome which he had just gotten due to a fall). All other medicines he had been on for 2 years. Toxicology report was 55 mcg/ mL for Gralise ...

More questions for: Diphenhydramine Hydrochloride, Trazodone Hydrochloride

You may be interested at these reviews (what is this?):

  • Trazodone effect memory
    After being on Trazodone 100 mg( to help me sleep because 50mg didn't help)for two weeks, my family begin to notice that I was very forgetful! I researched the Net to see if this was a side effect. I found this site and made up my mind to not continue to take it!!!!!!!!!

  • Ventricular tachycardia due to trazodone.
    I took trazodone for several years in my 40s for insomnia and depression. I began having symptoms similar to POTS (postural orthostatic tachycardia syndrome): that is, if i bent over to check an auto's tire pressure and stood up again, my heart would go into overdrive...rates of 180bpm or higher. Th ...

  • Leg pain and occasional arm and hand pain
    I started having leg pains at night, lower leg felt like the muscle and bone were being pulled causing sharp pain. It was relieved by getting up and walking but would last most of the night. I finally realized after suffering this over and over for months, that it only happened when I had taken be ...

More reviews for: Diphenhydramine Hydrochloride, Trazodone Hydrochloride

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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