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Review: taking Trazodone and Diphenhydramine together

Summary: drug interactions are reported among people who take Trazodone and Diphenhydramine together.

This review analyzes the effectiveness and drug interactions between Trazodone and Diphenhydramine. It is created by eHealthMe based on reports of 1,072 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Trazodone and Diphenhydramine >>>

What are the drugs

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from 6,638 Trazodone hydrochloride users)

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. (latest outcomes from 3,003 Diphenhydramine hydrochloride users)

On Jan, 14, 2015: 1,072 people who take Trazodone Hydrochloride, Diphenhydramine Hydrochloride are studied

Trazodone Hydrochloride, Diphenhydramine Hydrochloride outcomes

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Diphenhydramine Hydrochloride (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Trazodone Hydrochloride is effective0.00%
(0 of 4 people)
37.50%
(3 of 8 people)
25.00%
(1 of 4 people)
60.00%
(3 of 5 people)
37.50%
(3 of 8 people)
50.00%
(1 of 2 people)
0.00%
(0 of 2 people)
n/a
Diphenhydramine Hydrochloride is effective14.29%
(1 of 7 people)
0.00%
(0 of 3 people)
40.00%
(2 of 5 people)
25.00%
(1 of 4 people)
75.00%
(3 of 4 people)
40.00%
(2 of 5 people)
0.00%
(0 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyPulmonary EmbolismDrug Exposure During PregnancyType 2 Diabetes MellitusMood SwingsHypomaniaSleepyAnxiety
PainDeep Vein ThrombosisStillbirthPancreatitisNightmareAtaxiaDepression SuicidalPain
Renal FailureInsomniaChokingUrethral StenosisDepressionErectile DysfunctionAnxietyFall
Multi-organ FailureDrug Effect DecreasedFlank PainWeight IncreasedInsomniaMalaiseHeadache
Anaphylactic ReactionPalpitationsConstipationRenal FailureAnxietyManiaNausea
NauseaErectile DysfunctionAnxiety AggravatedObstruction GastricPost-traumatic Stress DisorderMental Status ChangesDyspnoea
Renal InjuryAnxietyDiarrheaPainSuicide AttemptMeniere's DiseaseFatigue
InjuryAmnesiaNauseaHyperlipidaemiaAngerSleep Disorder Due To General Medical Condition, Insomnia TypeBack Pain
DeathMemory ImpairmentDiabetes MellitusIntentional OverdoseGlucose Tolerance ImpairedChest Pain
AnhedoniaOpportunistic InfectionDementia Alzheimer's TypeAggressionDiabetic NephropathyDepression

Drug effectiveness by gender :

FemaleMale
Trazodone Hydrochloride is effective29.63%
(8 of 27 people)
50.00%
(3 of 6 people)
Diphenhydramine Hydrochloride is effective34.62%
(9 of 26 people)
0.00%
(0 of 5 people)

Most common drug interactions by gender * :

FemaleMale
AnxietyPain
FallDiabetes Mellitus
HeadacheType 2 Diabetes Mellitus
PainAnxiety
NauseaFall
FatigueDrug Toxicity
DyspnoeaNausea
OsteoarthritisDepression
Osteonecrosis Of JawBack Pain
Back PainDiarrhoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Trazodone Hydrochloride is effectiven/an/a50.00%
(1 of 2 people)
30.00%
(3 of 10 people)
17.39%
(4 of 23 people)
25.00%
(2 of 8 people)
0.00%
(0 of 2 people)
11.11%
(1 of 9 people)
Diphenhydramine Hydrochloride is effectiven/an/a0.00%
(0 of 2 people)
25.00%
(3 of 12 people)
19.05%
(4 of 21 people)
28.57%
(2 of 7 people)
0.00%
(0 of 2 people)
0.00%
(0 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
AggressionNauseaDrug Administration ErrorAnxietyDiabetes MellitusDiabetes MellitusAnxietyFall
ConvulsionOedema MouthCompartment SyndromePancreatitisDrug ToxicityType 2 Diabetes MellitusPainChest Pain
AgitationIrritabilityExtremity NecrosisPainCompleted SuicidePainFallAnaemia
Tardive DyskinesiaHyperaesthesiaRhabdomyolysisDepressionType 2 Diabetes MellitusHeadacheNauseaArthralgia
Weight IncreasedGlossodyniaNeuroleptic Malignant SyndromeType 2 Diabetes MellitusAstheniaAnxietyCardiomegalyBack Pain
Foaming At MouthOedema PeripheralAgitationPulmonary EmbolismNauseaHypoaesthesiaAtelectasisFatigue
Type 2 Diabetes MellitusPain In ExtremityAggressionDrug ToxicityVomitingNauseaDiarrhoeaPain
NephrolithiasisTongue GeographicConvulsionSinusitisAnxietyArthralgiaCoughOsteoporosis
Obstruction GastricSwelling FaceHypokalaemiaInsomniaDepressionBack PainOsteonecrosis Of JawOsteomyelitis
PancreatitisSkin ExfoliationFoaming At MouthNauseaFatigueOedema PeripheralOsteoarthritisChronic Obstructive Pulmonary Disease

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Trazodone and Diphenhydramine?

You are not alone! Join a related mobile support group:
- support group for people who take Trazodone and Diphenhydramine
- support group for people who take Diphenhydramine Hydrochloride
- support group for people who take Trazodone Hydrochloride

Can you answer these questions (Ask a question):

More questions for: Diphenhydramine Hydrochloride, Trazodone Hydrochloride

You may be interested at these reviews (Write a review):

  • Pain meds that cause insomnia
    I currently take 7.5 mg of Vicoprofen for pain for my Anklyosing Spondylitis. I have tried Vicodin and Norco previously, but nothing worked as well as the Vicoprofen. I have never had to up my dosage and I am still getting the same level of relief as I was when I first started it over a year and a half ago. I swear by the Vicoprofen and would recommend it to anyone who has any type of related pain, but, there is one downfall. Every time I take my pain meds I get a huge burst of energy. My pain is usually worst at night, so I have no choice but to take it before bed. More times than not it causes me to suffer extreme insomnia, which is no fun. Up until recently I just suffered through it. I went and saw my primary today and told her about the issues and she suggested I try Trazodone to help ease my mind so I can fall asleep easier and faster. I'm really hoping it works because I don't want to have to switch pain meds because they work so well, but I can't go much longer only getting 2-3 hours of sleep during the week.
    I will wrote another review in a week or so regarding my experience taking the Trazodone with the Vicoprofen.
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    I have been taking Paxil daily since 1997. For 14 years, I have had severe itching, a constant low grade fever with chills and night sweats. The itching is constant and so extreme that I scratch until the top layer of skin is gone, leaving a large area of scabs. The lymphoma tumors just appeared 6 weeks ago. I was also recently diagnosed with myeloma. I feel that Paxil may be to blame. I do not have a family history of cancer. I have been taking Trazodone at bedtime for 14 years also, which might also be a cause.
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  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless

More reviews for: Diphenhydramine Hydrochloride, Trazodone Hydrochloride

Comments from related studies:

  • From this study (2 years ago):

  • Overall: Diabetes stays under 120, testosterone levels remain low for age (48, but testosterone levels of 90 year old man). Atypically small penis, testes often recede so that the scrotum is flat and tight. Bi-sexual with periodic gender issues (desire to be feminine). Married, two children and no family issues to include sexual oddities, wife is supportive.

    I am reluctant to bring up sexual and gender issues to Doctor, but have the feeling that gender drift (feelings), small penis and receding testicles and attraction to both sexes (including transgendered males with feminine qualities and penis). I know that all of this makes me rather unusual in terms of societal norms, but this is an honest assessment to the best of my ability. I started becoming sexually active at 13 years old with males first and later (15) with females. I desire only a relationship with a female or shemale (preferable but not realistic so I don't dwell on it).

    Despite gender struggles from 14 to present I joined the US Army and went Airborne and Special Forces, spending a majority of my adult life (even unitl present) as an operator in Special Forces (albeit my age is making that more and more difficult).

    I'm looking for a medical opinion that takes in current health conditions and issues, sexual history and other factors that are tell tale signs of a condition that I am unaware of.

    Reply

    Me on Jan, 4, 2013:

    Forgot to mention that I have one son who has only one testicle but is not infertile. He was operated on at 3 to determine is it was an undescended testicle, however no trace of a second testicle was found. In his 20s he fathered a female child and still no trace of second testicle.

    Reply

  • From this study (2 years ago):

  • I seem to have more RLS when combining promethazine, methocarbomal, and/or diphenhydramine. Is this a problem for blood clots? About to start Seasonale and all birth control pills are warning about blood clots.

    Reply

    deerfisherman on Dec, 23, 2012:

    Benadryl is a trigger for Restless Leg s. do not take it or your legs will jump.

    Reply

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Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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