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Review: Trazodone and Diphenhydramine

This review analyzes the effectiveness and drug interactions between Trazodone and Diphenhydramine. It is created by eHealthMe based on reports of 1,071 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Trazodone and Diphenhydramine >>>

What are the drugs

Trazodone hydrochloride (latest outcomes from 6,540 users) has active ingredients of trazodone hydrochloride. It is used in insomnia.

Diphenhydramine hydrochloride (latest outcomes from 2,983 users) has active ingredients of diphenhydramine hydrochloride. It is used in insomnia.

On Aug, 11, 2014: 1,071 people who take Trazodone Hydrochloride, Diphenhydramine Hydrochloride are studied

Trazodone Hydrochloride, Diphenhydramine Hydrochloride outcomes

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Diphenhydramine Hydrochloride (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Trazodone Hydrochloride is effective0.00%
(0 of 4 people)
37.50%
(3 of 8 people)
25.00%
(1 of 4 people)
60.00%
(3 of 5 people)
37.50%
(3 of 8 people)
50.00%
(1 of 2 people)
0.00%
(0 of 2 people)
n/a
Diphenhydramine Hydrochloride is effective14.29%
(1 of 7 people)
0.00%
(0 of 3 people)
40.00%
(2 of 5 people)
25.00%
(1 of 4 people)
75.00%
(3 of 4 people)
40.00%
(2 of 5 people)
0.00%
(0 of 3 people)
n/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyPulmonary EmbolismDrug Exposure During PregnancyType 2 Diabetes MellitusMood SwingsHypomaniaSleepyAnxiety
PainDeep Vein ThrombosisStillbirthPancreatitisNightmareAtaxiaDepression SuicidalPain
Renal FailureInsomniaChokingUrethral StenosisDepressionErectile DysfunctionAnxietyFall
Multi-organ FailureDrug Effect DecreasedFlank PainWeight IncreasedInsomniaMalaiseHeadache
Anaphylactic ReactionPalpitationsConstipationRenal FailureAnxietyManiaNausea
NauseaErectile DysfunctionAnxiety AggravatedObstruction GastricPost-traumatic Stress DisorderMental Status ChangesDyspnoea
Renal InjuryAnxietyDiarrheaPainSuicide AttemptMeniere's DiseaseFatigue
InjuryAmnesiaNauseaHyperlipidaemiaAngerSleep Disorder Due To General Medical Condition, Insomnia TypeBack Pain
DeathMemory ImpairmentDiabetes MellitusIntentional OverdoseGlucose Tolerance ImpairedChest Pain
AnhedoniaOpportunistic InfectionDementia Alzheimer's TypeAggressionDiabetic NephropathyDepression

Drug effectiveness by gender :

FemaleMale
Trazodone Hydrochloride is effective29.63%
(8 of 27 people)
50.00%
(3 of 6 people)
Diphenhydramine Hydrochloride is effective34.62%
(9 of 26 people)
0.00%
(0 of 5 people)

Most common drug interactions by gender * :

FemaleMale
AnxietyPain
FallDiabetes Mellitus
HeadacheType 2 Diabetes Mellitus
PainAnxiety
NauseaFall
FatigueDrug Toxicity
DyspnoeaNausea
OsteoarthritisDepression
Osteonecrosis Of JawBack Pain
Back PainDiarrhoea

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Trazodone Hydrochloride is effectiven/an/a50.00%
(1 of 2 people)
30.00%
(3 of 10 people)
17.39%
(4 of 23 people)
25.00%
(2 of 8 people)
0.00%
(0 of 2 people)
11.11%
(1 of 9 people)
Diphenhydramine Hydrochloride is effectiven/an/a0.00%
(0 of 2 people)
25.00%
(3 of 12 people)
19.05%
(4 of 21 people)
28.57%
(2 of 7 people)
0.00%
(0 of 2 people)
0.00%
(0 of 8 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
AggressionNauseaDrug Administration ErrorAnxietyDiabetes MellitusDiabetes MellitusAnxietyFall
ConvulsionOedema MouthCompartment SyndromePancreatitisDrug ToxicityType 2 Diabetes MellitusPainChest Pain
AgitationIrritabilityExtremity NecrosisPainCompleted SuicidePainFallAnaemia
Tardive DyskinesiaHyperaesthesiaRhabdomyolysisDepressionType 2 Diabetes MellitusHeadacheNauseaArthralgia
Weight IncreasedGlossodyniaNeuroleptic Malignant SyndromeType 2 Diabetes MellitusAstheniaAnxietyCardiomegalyBack Pain
Foaming At MouthOedema PeripheralAgitationPulmonary EmbolismNauseaHypoaesthesiaAtelectasisFatigue
Type 2 Diabetes MellitusPain In ExtremityAggressionDrug ToxicityVomitingNauseaDiarrhoeaPain
NephrolithiasisTongue GeographicConvulsionSinusitisAnxietyArthralgiaCoughOsteoporosis
Obstruction GastricSwelling FaceHypokalaemiaInsomniaDepressionBack PainOsteonecrosis Of JawOsteomyelitis
PancreatitisSkin ExfoliationFoaming At MouthNauseaFatigueOedema PeripheralOsteoarthritisChronic Obstructive Pulmonary Disease

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group to help out with your experience or learn from others anytime and anywhere:
- group for people who take Trazodone and Diphenhydramine
- group for people who take Diphenhydramine Hydrochloride
- group for people who take Trazodone Hydrochloride

Comments from related studies:

  • From this study (2 years ago):

  • Overall: Diabetes stays under 120, testosterone levels remain low for age (48, but testosterone levels of 90 year old man). Atypically small penis, testes often recede so that the scrotum is flat and tight. Bi-sexual with periodic gender issues (desire to be feminine). Married, two children and no family issues to include sexual oddities, wife is supportive.

    I am reluctant to bring up sexual and gender issues to Doctor, but have the feeling that gender drift (feelings), small penis and receding testicles and attraction to both sexes (including transgendered males with feminine qualities and penis). I know that all of this makes me rather unusual in terms of societal norms, but this is an honest assessment to the best of my ability. I started becoming sexually active at 13 years old with males first and later (15) with females. I desire only a relationship with a female or shemale (preferable but not realistic so I don't dwell on it).

    Despite gender struggles from 14 to present I joined the US Army and went Airborne and Special Forces, spending a majority of my adult life (even unitl present) as an operator in Special Forces (albeit my age is making that more and more difficult).

    I'm looking for a medical opinion that takes in current health conditions and issues, sexual history and other factors that are tell tale signs of a condition that I am unaware of.

    Reply

    Me on Jan, 4, 2013:

    Forgot to mention that I have one son who has only one testicle but is not infertile. He was operated on at 3 to determine is it was an undescended testicle, however no trace of a second testicle was found. In his 20s he fathered a female child and still no trace of second testicle.

    Reply

  • From this study (2 years ago):

  • I seem to have more RLS when combining promethazine, methocarbomal, and/or diphenhydramine. Is this a problem for blood clots? About to start Seasonale and all birth control pills are warning about blood clots.

    Reply

    deerfisherman on Dec, 23, 2012:

    Benadryl is a trigger for Restless Leg s. do not take it or your legs will jump.

    Reply

  • From this study (4 years ago):

  • Kindra Mathis on May, 14, 2010:

    I would like to know the side effects of taking Depakote,Trazodone and Benadryl for almost two years while in jail because I don't remember the trail and was very sleeping during the trail my dad was there and I can"t re call him being there.

    Reply

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More reviews for: Diphenhydramine Hydrochloride, Trazodone Hydrochloride

Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Diphenhydramine Hydrochloride (diphenhydramine hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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