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Review: taking Trazodone and Seroquel together

Summary: drug interactions are reported among people who take Trazodone and Seroquel together. This review analyzes the effectiveness and drug interactions between Trazodone and Seroquel. It is created by eHealthMe based on reports of 4,786 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from 6,694 Trazodone hydrochloride users)

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. (latest outcomes from 79,174 Seroquel users)

On Apr, 29, 2015: 4,786 people who take Trazodone Hydrochloride, Seroquel are studied

Trazodone Hydrochloride, Seroquel outcomes

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Seroquel (quetiapine fumarate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Trazodone Hydrochloride is effective11.11%
(2 of 18 people)
(5 of 26 people)
(2 of 8 people)
(6 of 19 people)
(9 of 19 people)
(2 of 8 people)
(1 of 7 people)
(0 of 1 people)
Seroquel is effective17.65%
(3 of 17 people)
(1 of 30 people)
(5 of 15 people)
(3 of 11 people)
(5 of 19 people)
(6 of 12 people)
(2 of 3 people)

Drug effectiveness by gender :

Trazodone Hydrochloride is effective29.33%
(22 of 75 people)
(5 of 31 people)
Seroquel is effective25.00%
(19 of 76 people)
(6 of 30 people)

Drug effectiveness by age :

Trazodone Hydrochloride is effectiven/an/a20.00%
(1 of 5 people)
(8 of 50 people)
(2 of 27 people)
(8 of 56 people)
(7 of 46 people)
(1 of 10 people)
Seroquel is effectiven/an/a40.00%
(2 of 5 people)
(5 of 44 people)
(3 of 29 people)
(5 of 54 people)
(5 of 53 people)
(5 of 12 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Type 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetic RetinopathyType 2 Diabetes Mellitus
InsomniaDiabetes Mellitus Inadequate ControlNeuropathy PeripheralObesityBlood Cholesterol IncreasedBlood Cholesterol IncreasedPancreatitisWeight Increased
Loss Of ConsciousnessPancreatitisWeight IncreasedHyperlipidaemiaObesityObesityDiabetes Mellitus Inadequate ControlBlood Cholesterol Increased
PainNeuropathy PeripheralDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate ControlPancreatitisHyperlipidaemiaBlood Cholesterol IncreasedDepression
PneumoniaInsomniaBlood Cholesterol IncreasedWeight IncreasedWeight IncreasedDiabetes Mellitus Inadequate ControlHeadachePancreatitis
AnaemiaHyperglycaemiaObesityBlood Cholesterol IncreasedHyperlipidaemiaPancreatitisUrinary Tract InfectionInsomnia
IleusObesityHyperglycaemiaBlood Triglycerides IncreasedDiabetes Mellitus Inadequate ControlNeuropathy PeripheralHyperlipidaemiaDiabetes Mellitus Inadequate Control
Mental Status ChangesBlood Cholesterol IncreasedBack PainNeuropathy PeripheralSuicidal IdeationDiabetic KetoacidosisWeight IncreasedNeuropathy Peripheral
FallDepressionVision BlurredPancreatitisBlood Triglycerides IncreasedWeight IncreasedDyspnoeaAnxiety

Most common drug interactions by gender * :

Type 2 Diabetes MellitusDiabetes Mellitus
Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedInsomnia
Blood Cholesterol IncreasedWeight Increased
ObesityBlood Cholesterol Increased
NauseaSuicidal Ideation
Diabetes Mellitus Inadequate ControlDepression
PancreatitisNeuropathy Peripheral

Most common drug interactions by age * :

Diabetes MellitusObesityElectrocardiogram Qt ProlongedType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
PancreatitisHyperglycaemiaDeliriumDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes MellitusFall
Blood Cholesterol IncreasedDrug Withdrawal SyndromeHypotensionSuicidal IdeationWeight IncreasedWeight IncreasedBlood Cholesterol IncreasedAnxiety
Type 2 Diabetes MellitusType 2 Diabetes MellitusTachycardiaWeight IncreasedObesityBlood Cholesterol IncreasedInsomniaType 2 Diabetes Mellitus
HypertensionDiabetes MellitusOverdoseInsomniaDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate ControlNeuropathy PeripheralMalaise
Weight IncreasedPanic AttackSomnolenceHeadacheBlood Cholesterol IncreasedNeuropathy PeripheralWeight IncreasedDepression
TremorGlucose Tolerance ImpairedType 2 Diabetes MellitusAbdominal PainPancreatitisDiabetic NeuropathyDepressionInsomnia
HyperlipidaemiaType 1 Diabetes MellitusLethargyDizzinessDepressionPancreatitisDiabetic NeuropathyPain
Muscular WeaknessDyspnoeaWeight IncreasedObesityNauseaHyperglycaemiaAnxietyFatigue
AggressionArrhythmiaAggressionPancreatitisInsomniaObesityObesityWeight Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Trazodone and Seroquel on

Do you take Trazodone and Seroquel?


You are not alone! Join a related support group:
- support group for people who take Seroquel
- support group for people who take Trazodone Hydrochloride

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

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    is there employer who would accept employee with only 3 hours of work per day because he is ill (tremor, insomnia, schizophrenia)?
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    patient diagnosed with alzheimers since 2004.she recently developed the awake bruxism. I just began giving her 10 mg of buspirone. it appears to be somewhat effective but not quite as I expected. from reading I've seen that galatamine helps.
  • I tested positive for methadone, i have never taken this drug (1 answer)
    I tested positive for methadone, I have never taken this drug. My Dr said I had to have taken it because it was there and that a false positive is out of the question. Could my meds cause methadone to show up on a urine drug test

More questions for: Seroquel, Trazodone Hydrochloride

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    It will kill you.

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More reviews for: Seroquel, Trazodone Hydrochloride

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Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Seroquel (quetiapine fumarate) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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