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Review: Trazodone and Seroquel

Summary: drug interactions are reported among people who take Trazodone and Seroquel together.

This review analyzes the effectiveness and drug interactions between Trazodone and Seroquel. It is created by eHealthMe based on reports of 4,783 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Trazodone and Seroquel >>>

What are the drugs

Trazodone hydrochloride has active ingredients of trazodone hydrochloride. It is often used in insomnia. (latest outcomes from Trazodone hydrochloride 6,611 users)

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. (latest outcomes from Seroquel 79,098 users)

On Nov, 27, 2014: 4,783 people who take Trazodone Hydrochloride, Seroquel are studied

Trazodone Hydrochloride, Seroquel outcomes

Drug combinations in study:
- Trazodone Hydrochloride (trazodone hydrochloride)
- Seroquel (quetiapine fumarate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Trazodone Hydrochloride is effective11.11%
(2 of 18 people)
(5 of 26 people)
(2 of 7 people)
(6 of 18 people)
(9 of 18 people)
(2 of 8 people)
(1 of 7 people)
(0 of 1 people)
Seroquel is effective17.65%
(3 of 17 people)
(1 of 28 people)
(5 of 15 people)
(3 of 10 people)
(5 of 19 people)
(6 of 12 people)
(2 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Type 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
Diabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetes MellitusDiabetic RetinopathyType 2 Diabetes Mellitus
InsomniaDiabetes Mellitus Inadequate ControlNeuropathy PeripheralObesityBlood Cholesterol IncreasedBlood Cholesterol IncreasedPancreatitisWeight Increased
Loss Of ConsciousnessPancreatitisWeight IncreasedHyperlipidaemiaObesityObesityDiabetes Mellitus Inadequate ControlBlood Cholesterol Increased
PainNeuropathy PeripheralDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate ControlPancreatitisHyperlipidaemiaBlood Cholesterol IncreasedDepression
PneumoniaObesityBlood Cholesterol IncreasedWeight IncreasedWeight IncreasedDiabetes Mellitus Inadequate ControlHeadachePancreatitis
AnaemiaHyperglycaemiaObesityBlood Cholesterol IncreasedHyperlipidaemiaPancreatitisUrinary Tract InfectionInsomnia
IleusInsomniaHyperglycaemiaBlood Triglycerides IncreasedDiabetes Mellitus Inadequate ControlNeuropathy PeripheralHyperlipidaemiaDiabetes Mellitus Inadequate Control
Mental Status ChangesBlood Cholesterol IncreasedBack PainNeuropathy PeripheralSuicidal IdeationDiabetic KetoacidosisWeight IncreasedNeuropathy Peripheral
FallDepressionVision BlurredPancreatitisBlood Triglycerides IncreasedWeight IncreasedDyspnoeaAnxiety

Drug effectiveness by gender :

Trazodone Hydrochloride is effective30.56%
(22 of 72 people)
(5 of 31 people)
Seroquel is effective26.03%
(19 of 73 people)
(6 of 30 people)

Most common drug interactions by gender * :

Type 2 Diabetes MellitusDiabetes Mellitus
Diabetes MellitusType 2 Diabetes Mellitus
Weight IncreasedInsomnia
Blood Cholesterol IncreasedWeight Increased
ObesityBlood Cholesterol Increased
NauseaSuicidal Ideation
Diabetes Mellitus Inadequate ControlDepression
PancreatitisNeuropathy Peripheral

Drug effectiveness by age :

Trazodone Hydrochloride is effectiven/an/a20.00%
(1 of 5 people)
(8 of 49 people)
(2 of 27 people)
(8 of 56 people)
(7 of 45 people)
(1 of 9 people)
Seroquel is effectiven/an/a40.00%
(2 of 5 people)
(5 of 43 people)
(3 of 29 people)
(5 of 54 people)
(5 of 52 people)
(5 of 11 people)

Most common drug interactions by age * :

Diabetes MellitusObesityElectrocardiogram Qt ProlongedType 2 Diabetes MellitusDiabetes MellitusType 2 Diabetes MellitusType 2 Diabetes MellitusDiabetes Mellitus
PancreatitisHyperglycaemiaDeliriumDiabetes MellitusType 2 Diabetes MellitusDiabetes MellitusDiabetes MellitusFall
Blood Cholesterol IncreasedDrug Withdrawal SyndromeHypotensionSuicidal IdeationWeight IncreasedWeight IncreasedBlood Cholesterol IncreasedAnxiety
Type 2 Diabetes MellitusType 2 Diabetes MellitusTachycardiaWeight IncreasedObesityBlood Cholesterol IncreasedInsomniaType 2 Diabetes Mellitus
HypertensionDiabetes MellitusOverdoseInsomniaDiabetes Mellitus Inadequate ControlDiabetes Mellitus Inadequate ControlNeuropathy PeripheralMalaise
Weight IncreasedPanic AttackSomnolenceHeadacheBlood Cholesterol IncreasedNeuropathy PeripheralWeight IncreasedDepression
TremorGlucose Tolerance ImpairedType 2 Diabetes MellitusAbdominal PainPancreatitisDiabetic NeuropathyDepressionInsomnia
HyperlipidaemiaType 1 Diabetes MellitusLethargyDizzinessDepressionPancreatitisDiabetic NeuropathyPain
Muscular WeaknessDyspnoeaWeight IncreasedObesityNauseaHyperglycaemiaAnxietyFatigue
AggressionArrhythmiaAggressionBlood Cholesterol IncreasedInsomniaObesityObesityChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Trazodone and Seroquel?

You are not alone! Join a related mobile support group:
- support group for people who take Trazodone and Seroquel
- support group for people who take Seroquel
- support group for people who take Trazodone Hydrochloride

Can you answer these questions (Ask a question):

More questions for: Seroquel, Trazodone Hydrochloride

You may be interested at these reviews (Write a review):

  • Bipolar patient extremely violent on seraquel
    I have been diagnosed bipolar for over 10 years. 3 years ago I was taken off of topamax and my seraquel was upped to 300 mg from 100 because I was pregnant. I was very violent! Punching, breaking stuff, in jail, in the psych ward. Yes pregnancy and bipolar are not a perfect combination. I too thought it was the hormones. My husband and split several times over me punching him. We moved to a state cross country so there was no more family drama. Nothing worked! Over the last 3 years my life has been hell! I happen to run out of my seroquel (tg) it took 2 weeks to arrive. In that time my body went thru horrible withdrawals. I vowed I wouldn't take it any longer. I've been seraquel free for 2 months. I'm now on gabapentin and proud to say I have no anger issues! Not 1 punch has
    been thrown. I feel like a totally different person.
  • Seroquel and iron deficiency?
    I've been taking Seroquel for about four year, I have been having symptoms similar to hypothyroidism, and just found out I have an iron deficiency. The doctor said my platelets are smaller than average, and it is possible that my grandmother is anemic. But in trying to study Seroquel I kept finding things that made me wonder if Seroquel could be linked to iron deficiency.
  • Transition from mirtazapine to cymbalta (bipolar ii) 6 week duration taken in conjunction with seroquel, propranalol and implanon
    In early September I approached my Psychiatrist to report that I was having sleep paralysis episodes as well as insatiable appetite. I had put on about 20lb in the space of 6 months since the sleep paralysis started.

    My Psychiatrist opted to wean me off the Mirtazapine and onto Cymbalta. I have now been on 60mg of Cymbalta for about 4 weeks and completely titrated off the Mirtazapine.

    I have noted that since switching to Cymbalta that I no longer have the insatiable appetite, nor have I had any further sleep paralysis episodes (though I have had a brain MRI to rule out any physiological issues - yet to receive results).

    I have noticed that I have had mild to moderate rolling nausea with the Cymbalta and that I now have food aversions. Food does not interest me as much anymore and I find that certain foods (mostly processed snacks) are no longer palatable. I also find that I become full after much smaller meal portions.

    I have found that I can no longer drink wine or spirits because they now taste awful however I can still tolerate certain brands of beer. I also no longer enjoy drinking cola.

    I am also on the Implanon Implant. I have had this implant inserted for about 12 months and my cycles have been rather regular. Since starting the Cymbalta I have had some breakthrough bleeding yet my periods have not been as painful, though they have been heavier and longer.

    My Psychiatrist will commence titrating me off the Seroquel in about two weeks and onto Topamax as it is his belief it will be less sedating than the Seroquel and that it will hopefully help as a mood stabiliser, treat my migraines and allow me to come off the Propranolol. he also hopes that I am able to loose some of the weight gained since the sleep paralysis episodes started.

    As a side note regarding the Propranolol, I have naturally low blood pressure and I find while Propranalol is generally an effective migraine prophylactic, (I do get some breakthrough migraines) it does make my blood pressure even lower which leads to dizziness and faintness when I stand up too quickly from a recumbent position.
  • Hit and miss sleep with dextroamphetamine
    Started drug 2 months ago and have seen an improvement in my focus. Ziprosidone for my depression causes me to get dead tired by 7 pm. Once I started taking Dextroamphetamine I started having insomnia 2 times a week. I think I would rather sleep early than stay up all night and then try and stay awake at work. So many drugs and even more side effects. Also Trazadone is no help for getting me to sleep. The only good side affect I have seen is I am down 26 pounds.
  • Eczema and birth control-microgestin
    I started getting eczema over the last year and recently decided it may be from the birth control as well, which I started taking @ 2 months before I got the eczema and skin started breaking out...weight gain, etc. I am on singulair, westcort cream, moisture/kenalog, exederm cream, cerevue wash, cetaphil moisturizer, and started using the black soap which is apparently helping. I started a vegetarian diet and eat mainly the same foods daily to monitor anything for allergies. I stopped taking the pill 3 days ago and I am optimistic. I am hoping others have had positive experiences.

More reviews for: Seroquel, Trazodone Hydrochloride

Comments from related studies:

  • From this study (1 month ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!


    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor


    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Seroquel (quetiapine fumarate) is often used to treat bipolar disorder. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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