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Review: Unisom and Prozac

This review analyzes the effectiveness and drug interactions between Unisom and Prozac. It is created by eHealthMe based on reports of 92 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Unisom and Prozac >>>

What are the drugs

Unisom (latest outcomes from 1,151 users) has active ingredients of doxylamine succinate. It is often used in insomnia.

Prozac (latest outcomes from 42,137 users) has active ingredients of fluoxetine hydrochloride. It is often used in depression.

On Jul, 14, 2014: 92 people who take Unisom, Prozac are studied

Unisom, Prozac outcomes

Drug combinations in study:
- Unisom (doxylamine succinate)
- Prozac (fluoxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Unisom is effective50.00%
(1 of 2 people)
(0 of 3 people)
(1 of 1 people)
Prozac is effective0.00%
(0 of 1 people)
(3 of 4 people)
(0 of 3 people)
(1 of 1 people)
(1 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Blood Pressure DecreasedMuscle Painn/aSuicide AttemptSuicide Attemptn/an/aAnaemia
Suicide AttemptSleep Disorder Due To General Medical Condition, Insomnia TypeAkathisiaMultiple Drug OverdosePain In Extremity
Completed SuicideFrequent Or Urgent UrinationMultiple Drug OverdoseHepatocellular DamageCompleted Suicide
DepressionRestless Legs SyndromeHepatocellular DamageDrug IneffectiveArthropathy
Overdose NosDrug IneffectiveNauseaMuscle Spasms
Intentional OverdoseNauseaPneumonia
Sleep Disorder Due To General Medical Condition, Insomnia TypeAsthenia
Restless Legs SyndromeHeadache
Frequent Or Urgent UrinationDizziness
Muscle PainMusculoskeletal Pain

Drug effectiveness by gender :

Unisom is effective25.00%
(1 of 4 people)
(1 of 2 people)
Prozac is effective44.44%
(4 of 9 people)
(2 of 2 people)

Most common drug interactions by gender * :

Completed SuicideAsthenia
Cardiac ArrestOverdose
Respiratory ArrestPain
Pain In ExtremityPulmonary Hypertension
Suicide AttemptConnective Tissue Disorder
FallOsteonecrosis Of Jaw
Cardio-respiratory ArrestOsteomyelitis
Lower Gastrointestinal HaemorrhageSpinal Compression Fracture

Drug effectiveness by age :

Unisom is effectiven/an/an/a100.00%
(1 of 1 people)
(0 of 1 people)
(1 of 3 people)
(0 of 5 people)
Prozac is effectiven/an/a100.00%
(1 of 1 people)
(1 of 1 people)
(0 of 3 people)
(2 of 4 people)
(1 of 1 people)
(1 of 5 people)

Most common drug interactions by age * :

n/an/aWoundDeliriumCompleted SuicideHaematocheziaCompleted SuicideAnaemia
Skin MacerationHypertensionPneumoniaMuscular WeaknessRespiratory ArrestPain In Extremity
AllodyniaTachycardiaErythemaPain In ExtremityCardiac ArrestMuscle Spasms
Cardiac ArrestIll-defined DisorderSensation Of HeavinessCardio-respiratory ArrestArthropathy
Body Temperature IncreasedLaryngeal OedemaAnaemiaSuicide AttemptOsteoarthritis
Drug Screen PositiveOedemaColitisComa NecMusculoskeletal Pain
Blood Pressure DecreasedAstheniaDizzinessNon-accidental OverdoseUrinary Tract Infection
Multiple Drug OverdoseHeadacheBalance DisorderPneumoniaPyrexia
Completed SuicideBursitisAccidental OverdoseFatigueOverdose
Overdose NosMyalgiaRoad Traffic AccidentFeeling AbnormalMultiple Myeloma

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Unisom and Prozac
- group for people who take Prozac
- group for people who take Unisom

Comments from related studies:

  • From this study (7 months ago):

  • Diagnosed with clinical depression for the last 3 years, finally see positive results but having side effects. Not taking antidepressant for 2 years the fibromyalgia pain and symptoms gone. Symptoms have returned in the last two weeks from pain, sleepless night. Two to four hours of sleep. Constant pain on the level of 7. Scale of 1 to 10 Fatigue constantly.


  • From this study (4 years ago):

  • Kelly on Apr, 25, 2010:

    recently lamictal dose has been increased to 400mg, prozac 60mg also adderall 10mg and clonazapam and have been feeling nausous and spotting with period.

    Can all meds taken together cause the 2 above side effects?


Can you answer these questions (what is this?):

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More reviews for: Prozac, Unisom

Complete drug side effects:

On eHealthMe, Unisom (doxylamine succinate) is often used to treat insomnia. Prozac (fluoxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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