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Review: taking Venlafaxine and Cyclobenzaprine together

Summary: drug interactions are reported among people who take Venlafaxine and Cyclobenzaprine together.

This review analyzes the effectiveness and drug interactions between Venlafaxine and Cyclobenzaprine. It is created by eHealthMe based on reports of 1,532 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 6, 2015: 1,532 people who take Venlafaxine Hydrochloride, Cyclobenzaprine Hydrochloride are studied

Venlafaxine Hydrochloride, Cyclobenzaprine Hydrochloride outcomes

Drug combinations in study:
- Venlafaxine Hydrochloride (venlafaxine hydrochloride)
- Cyclobenzaprine Hydrochloride (cyclobenzaprine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Venlafaxine Hydrochloride is effective0.00%
(0 of 1 people)
(4 of 11 people)
(1 of 6 people)
(2 of 10 people)
(6 of 17 people)
(8 of 19 people)
(6 of 6 people)
(1 of 1 people)
Cyclobenzaprine Hydrochloride is effective7.69%
(1 of 13 people)
(4 of 12 people)
(0 of 6 people)
(4 of 10 people)
(4 of 14 people)
(2 of 4 people)
(3 of 5 people)

Drug effectiveness by gender :

Venlafaxine Hydrochloride is effective41.67%
(25 of 60 people)
(3 of 10 people)
Cyclobenzaprine Hydrochloride is effective29.09%
(16 of 55 people)
(2 of 9 people)

Drug effectiveness by age :

Venlafaxine Hydrochloride is effectiven/an/an/a0.00%
(0 of 7 people)
(8 of 24 people)
(16 of 61 people)
(3 of 41 people)
(1 of 8 people)
Cyclobenzaprine Hydrochloride is effectiven/an/an/a22.22%
(2 of 9 people)
(4 of 19 people)
(6 of 51 people)
(4 of 39 people)
(2 of 8 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
InsomniaPainAnxietyDepressionAnxietyAnxietyAbnormal BehaviourPain
Confusional StateNauseaOsteonecrosisAnxietyDepressionNauseaSuicide AttemptAnxiety
Completed SuicideGastrooesophageal Reflux DiseaseVertigoCerebral CystSuicidal IdeationConstipationAnxietyBack Pain
NauseaType 2 Diabetes MellitusWoundArthropathyInsomniaInsomniaIntentional OverdoseDepression
Acute Myocardial InfarctionSleep Apnoea SyndromeOral HerpesOral HerpesHot FlushDehydrationDepressionDyspnoea
Abnormal BehaviourVomitingTemporomandibular Joint SyndromeOsteonecrosisDrug Withdrawal SyndromeDrug HypersensitivityFrequent HeadachesFall
DeliriumHyperglycaemiaCerebral CystWoundMemory ImpairmentAnxiety NecAngerNausea
Unresponsive To StimuliDiabetic NeuropathyDepressionVertigoPanic AttackSweating IncreasedAgitationHeadache
Suicide AttemptObesityArthropathyTemporomandibular Joint SyndromeAggressionMigraine NosMemory ImpairmentArthralgia
Respiratory FailureHeadacheAphthous StomatitisAphthous StomatitisNauseaGastroenteritis NosParanoiaFatigue

Most common drug interactions by gender * :

AnxietyBack Pain
HeadacheOedema Peripheral
Back PainPyrexia

Most common drug interactions by age * :

Pancreatitisn/aDepressionCholelithiasisDiabetes MellitusPainPainFall
Diabetes MellitusNauseaSuicidal IdeationOedema PeripheralDepressionDyspnoeaFatigue
PyrexiaDepressionPain In ExtremityChest PainHypertensionBack Pain
PainDrug Withdrawal SyndromeBack PainNauseaNeuropathy PeripheralDyspnoea
Drug Withdrawal SyndromeAnxietyPulmonary EmbolismHeadacheHeadachePain
Drug IneffectivePyrexiaHypoaesthesiaDyspnoeaFatigueArthralgia
Drug DependenceDehydrationDepressionBack PainBack PainHeadache
CoughWeight DecreasedType 2 Diabetes MellitusFatigueDiarrhoeaOsteonecrosis Of Jaw
PapilloedemaVomitingDeep Vein ThrombosisInsomniaDepressionChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Venlafaxine and Cyclobenzaprine on

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You are not alone! Join a related support group:
- support group for people who take Cyclobenzaprine Hydrochloride
- support group for people who take Venlafaxine Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Venlafaxine Hydrochloride (venlafaxine hydrochloride) is often used to treat depression. Cyclobenzaprine Hydrochloride (cyclobenzaprine hydrochloride) is often used to treat muscle spasms. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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