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Review: taking Venlafaxine and Tramadol together

Summary: drug interactions are reported among people who take Venlafaxine and Tramadol together.

This review analyzes the effectiveness and drug interactions between Venlafaxine and Tramadol. It is created by eHealthMe based on reports of 1,995 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 17, 2015: 1,995 people who take Venlafaxine Hydrochloride, Tramadol are studied

Venlafaxine Hydrochloride, Tramadol outcomes

Drug combinations in study:
- Venlafaxine Hydrochloride (venlafaxine hydrochloride)
- Tramadol (tramadol hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Venlafaxine Hydrochloride is effective0.00%
(0 of 3 people)
(6 of 17 people)
(4 of 10 people)
(5 of 11 people)
(7 of 19 people)
(7 of 15 people)
(6 of 11 people)
(1 of 2 people)
Tramadol is effective38.46%
(5 of 13 people)
(3 of 13 people)
(2 of 13 people)
(7 of 15 people)
(7 of 14 people)
(2 of 6 people)
(2 of 6 people)
(2 of 4 people)

Drug effectiveness by gender :

Venlafaxine Hydrochloride is effective39.13%
(27 of 69 people)
(9 of 19 people)
Tramadol is effective36.92%
(24 of 65 people)
(6 of 19 people)

Drug effectiveness by age :

Venlafaxine Hydrochloride is effectiven/an/an/a1.77%
(2 of 113 people)
(11 of 76 people)
(7 of 41 people)
(10 of 49 people)
(6 of 15 people)
Tramadol is effectiven/an/an/a3.75%
(3 of 80 people)
(5 of 74 people)
(11 of 37 people)
(7 of 49 people)
(4 of 15 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Serotonin SyndromeAbdominal DistensionFatigueDepressionSuicidal IdeationBlood Cholesterol AbnormalAnxietyPain
Confusional StateDepressionConstipationIncreased Tendency To BruiseConstipationBipolar DisorderHeadacheAnxiety
Drug Withdrawal SyndromeConstipationFallEmotional DistressDyspepsiaAnxietyDrug Withdrawal SyndromeNausea
MalnutritionHaemorrhoidsDepressionDry MouthAbdominal DistensionDepressionDizzinessFall
AnxietyDyspepsiaDrug DependenceInjuryGastrooesophageal Reflux DiseaseHypoaesthesiaInsomniaDyspnoea
TremorRectal HaemorrhageHallucination, AuditoryAnxietyFaeces HardParaesthesiaDepressionHeadache
Suicidal IdeationFaeces HardCognitive DisorderFood IntoleranceDepressionMalaiseAffect LabilityFatigue
Completed SuicideGastrooesophageal Reflux DiseaseSerotonin SyndromeKeratoconjunctivitis SiccaInsomniaAgitationDepression AggravatedDepression
NauseaOedemaOverdoseEar PruritusHaemorrhoidsPanic AttackConfusional StateArthralgia
FallSuicidal IdeationAnxietyInsomniaRectal HaemorrhageNeuropathy PeripheralDrug IneffectiveInsomnia

Most common drug interactions by gender * :

FatigueConfusional State
Chest PainBack Pain

Most common drug interactions by age * :

Urinary Tract InfectionCardio-respiratory ArrestGastrooesophageal Reflux DiseaseInsomniaConvulsionPainAnxietyFall
Drug Exposure During PregnancyConstipationDepressionInsomniaCompleted SuicideNauseaDyspnoea
TalipesDyspepsiaDrug AbuseNauseaDepressionPainFatigue
Type 2 Diabetes MellitusOedemaHeadacheTremorAnxietyDiarrhoeaPain
SepsisFaeces HardPainVomitingDiabetes MellitusDepressionBack Pain
NephrolithiasisAbdominal DistensionDyspepsiaHeadacheDyspnoeaInsomniaAnxiety
Pericardial EffusionSuicidal IdeationSuicidal IdeationBack PainNauseaBone DisorderHeadache
Pulmonary HypertensionRectal HaemorrhageAbdominal DistensionDiarrhoeaFatigueFallArthralgia
Chest PainHaemorrhoidsOverdoseDrug ToxicityDrug IneffectiveAnaemiaConstipation
DepressionNauseaPain In ExtremityPain In ExtremityHeadacheWeight Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Venlafaxine and Tramadol?




You are not alone! Join a related support group:
- support group for people who take Tramadol
- support group for people who take Venlafaxine Hydrochloride

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Venlafaxine Hydrochloride (venlafaxine hydrochloride) is often used to treat depression. Tramadol (tramadol hydrochloride) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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