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Review: taking Verapamil and Benadryl together

Summary: drug interactions are reported among people who take Verapamil and Benadryl together. This review analyzes the effectiveness and drug interactions between Verapamil and Benadryl. It is created by eHealthMe based on reports of 397 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Verapamil hydrochloride has active ingredients of verapamil hydrochloride. It is often used in high blood pressure. (latest outcomes from 3,196 Verapamil hydrochloride users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,405 Benadryl users)

On Apr, 27, 2015: 397 people who take Verapamil Hydrochloride, Benadryl are studied

Verapamil Hydrochloride, Benadryl outcomes

Drug combinations in study:
- Verapamil Hydrochloride (verapamil hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Verapamil Hydrochloride is effectiven/a100.00%
(1 of 1 people)
(1 of 1 people)
(1 of 2 people)
(1 of 1 people)
(0 of 1 people)
Benadryl is effective100.00%
(1 of 1 people)
(2 of 3 people)
(1 of 1 people)

Drug effectiveness by gender :

Verapamil Hydrochloride is effective100.00%
(1 of 1 people)
(3 of 5 people)
Benadryl is effective0.00%
(0 of 1 people)
(3 of 4 people)

Drug effectiveness by age :

Verapamil Hydrochloride is effectiven/an/an/a7.69%
(1 of 13 people)
(1 of 2 people)
(2 of 2 people)
(0 of 5 people)
Benadryl is effectiven/an/an/a7.69%
(1 of 13 people)
(1 of 2 people)
(1 of 2 people)
(1 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Hepatitis CholestaticDrowsinessn/aSyncopeHypokalaemian/aIleusNausea
Migraine NosErythemaHypotension NosSmall Intestinal ObstructionDyspnoea
Diarrhoea NosDyspnoeaUrinary Tract Infection ViralAsthenia
Weight DecreasedDeathLupus-like SyndromePain
CholelithiasisComaLupus EnteritisVomiting
Cholecystitis Chronic NosFlushingCardiac Failure CongestiveDepression
HallucinationHaematocrit DecreasedDyspnoeaArthralgia
Drug HypersensitivityRespiratory ArrestRenal InsufficiencyAnxiety
HeadacheRed Blood Cell Count DecreasedPneumoniaWeight Decreased
PainPlatelet Count DecreasedFeeling AbnormalMyalgia

Most common drug interactions by gender * :

Chest PainArthralgia
HypotensionMuscle Spasms
Status AsthmaticusWeight Decreased
Pain In ExtremityDyspnoea

Most common drug interactions by age * :

n/an/aAbdominal DistensionCholecystitis ChronicCardiac ArrestAstheniaCompleted SuicideNausea
Blood Bilirubin IncreasedGallbladder CholesterolosisStatus AsthmaticusMyalgiaWeight DecreasedDyspnoea Nos
Vaginal HaemorrhageSubclavian Vein ThrombosisRespiratory ArrestHypothyroidismEmotional DistressVomiting
Pathogen ResistanceMajor Depressive Disorder NosArthralgiaPainCholelithiasisDyspnoea
Enterococcal BacteraemiaPruritusChest PainPain In ExtremityDyspnoeaCondition Aggravated
Blood Creatinine IncreasedNauseaDrug ToxicityFatigueMyocardial InfarctionHeadache
AscitesAbdominal Pain UpperFatigueDepressionChest PainChest Pain
Blood Lactate Dehydrogenase IncreasedInfusion Related ReactionDyspnoeaOedema PeripheralPalpitationsCardiac Arrest
OsteoarthritisGait DisturbanceLiver Function Test AbnormalPain In ExtremityOedema Lower Limb
Muscle SpasmsNeck PainDyspnoeaMemory ImpairmentDizziness

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Verapamil and Benadryl on

Do you take Verapamil and Benadryl?


You are not alone! Join a related support group:
- support group for people who take Benadryl
- support group for people who take Verapamil Hydrochloride

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Benadryl, Verapamil Hydrochloride

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Complete drug side effects:

On eHealthMe, Verapamil Hydrochloride (verapamil hydrochloride) is often used to treat high blood pressure. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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