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Review: Vicodin and Benadryl

This review analyzes the effectiveness and drug interactions between Vicodin and Benadryl. It is created by eHealthMe based on reports of 3,038 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: get help anytime and anywhere for people who take Vicodin and Benadryl >>>

What are the drugs

Vicodin (latest outcomes from 35,281 users) has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain.

Benadryl (latest outcomes from 29,318 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

On Jul, 16, 2014: 3,037 people who take Vicodin, Benadryl are studied

Vicodin, Benadryl outcomes

Drug combinations in study:
- Vicodin (acetaminophen; hydrocodone bitartrate)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Vicodin is effective44.00%
(11 of 25 people)
35.71%
(5 of 14 people)
28.57%
(2 of 7 people)
27.27%
(3 of 11 people)
42.86%
(6 of 14 people)
57.14%
(4 of 7 people)
25.00%
(1 of 4 people)
n/a
Benadryl is effective25.93%
(7 of 27 people)
27.27%
(3 of 11 people)
60.00%
(3 of 5 people)
20.00%
(2 of 10 people)
27.27%
(3 of 11 people)
33.33%
(3 of 9 people)
60.00%
(3 of 5 people)
0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PainSepsisIleusConvulsionDizzinessErection ProblemsDecreased InterestPain
AnxietyFebrile NeutropeniaConstipationHaemorrhageLoss Of ConsciousnessSkin StriaeDecreased AppetiteAnxiety
NauseaHypotensionPainCardiac ArrestBody OverheatingUrinary RetentionFood IntoleranceNausea
InjuryPulmonary EmbolismAbdominal PainGastrooesophageal Reflux DiseaseBlood Pressure IncreasedExcessive ThirstHypersomniaDyspnoea
VomitingGastrointestinal HaemorrhageNervousnessHepatic EncephalopathyCerebrovascular AccidentWeight Gain - UnintentionalDepression AggravatedBack Pain
PruritusConvulsionAbnormal DreamsPneumonia AspirationCytomegalovirus ColitisHigh Blood SugarDry MouthArthralgia
HypotensionMucosal InflammationFallParacentesisEar CongestionMorphoeaDry ThroatAnaemia
HeadacheAbdominal PainDysuriaBlood Pressure Systolic DecreasedPulmonary EmbolismSweating - ExcessiveThroat TightnessFatigue
Pain In ExtremityDehydrationHypophagiaComplications Of Transplanted LiverBarrett's OesophagusBlood Triglycerides IncreasedFatigue AggravatedFall
AnaemiaCondition AggravatedVomitingOsteopeniaPancreatic PseudocystExhaustion, Fatigue, Lethargy, Tiredness, WearinessMuscle Contractions InvoluntaryOsteonecrosis Of Jaw

Drug effectiveness by gender :

FemaleMale
Vicodin is effective38.71%
(24 of 62 people)
40.00%
(8 of 20 people)
Benadryl is effective30.51%
(18 of 59 people)
30.00%
(6 of 20 people)

Most common drug interactions by gender * :

FemaleMale
PainPain
AnxietyAnxiety
NauseaNausea
DyspnoeaBack Pain
AnaemiaDyspnoea
Back PainDepression
ArthralgiaFatigue
FallArthralgia
FatigueAsthenia
InjuryDehydration

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Vicodin is effectiven/an/an/a38.10%
(8 of 21 people)
24.14%
(7 of 29 people)
16.67%
(9 of 54 people)
40.00%
(4 of 10 people)
21.05%
(4 of 19 people)
Benadryl is effectiven/an/an/a35.00%
(7 of 20 people)
24.14%
(7 of 29 people)
7.55%
(4 of 53 people)
33.33%
(3 of 9 people)
15.79%
(3 of 19 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Unwanted PregnancyOverdosePainNauseaPainPainAnxietyAnaemia
Uterine HaemorrhageSomnolenceBlood Bilirubin IncreasedAbdominal Pain UpperAnaemiaAnxietyPainPain
Cleft PalateHypotensionPneumonitisBack PainDepressionBack PainNauseaDyspnoea
Antepartum HaemorrhageRespiratory DepressionHypotensionVomitingWeight IncreasedNauseaInjuryFall
Heart Rate IncreasedAcute Respiratory Distress SyndromeFatigueFatigueDyspnoeaOsteoarthritisAsthenia
ConstipationNephrogenic Systemic FibrosisPainArthralgiaArthralgiaFallAnxiety
ShockPulmonary EmbolismPain In ExtremityAbdominal PainFatigueOsteonecrosis Of JawConstipation
CoagulopathyCholelithiasisFlank PainVomitingDepressionBone DisorderBack Pain
TachycardiaCholecystitis ChronicPulmonary EmbolismGait DisturbanceInjuryPyrexiaNausea
SepsisNauseaChest PainPain In ExtremityFallAnaemiaFatigue

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Vicodin and Benadryl
- group for people who take Benadryl
- group for people who take Vicodin

Comments from related studies:

  • From this study (3 months ago):

  • 5/325 every 4 hours as needed. 0-4 per day. Would like to stop taking this drug as my eye pressure has increased. Only take it if the pain is 10+++. Looking for Orthopedic Surgeon to fix the bulging disks.

    Reply

  • From this study (4 months ago):

  • have been abstinent for 6 weeks; one testicle and penis became grossly swollen and painful, Dr. treated with Sulfamethox 2DSx twice daily-in six days had anaphylactic reaction hives,etc. so discontinued; after swelling subsided and resumption of sex,have had three bloody ejaculations.
    Have had quadruple heart bypass,AAA,permanent thrombosis in leg from vein harvest, double (saddlebag) pulmonary emboli.

    Reply

  • From this study (4 months ago):

  • have been abstinent for 6 weeks; one testicle and penis became grossly swollen and painful, Dr. treated with Sulfamethox 2DSx twice daily-in six days had anaphylactic reaction hives,etc. so discontinued; after swelling subsided and resumption of sex,have had three bloody ejaculations.

    Reply

Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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