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Review: taking Vicodin and Benadryl together

Summary: drug interactions are reported among people who take Vicodin and Benadryl together. This review analyzes the effectiveness and drug interactions between Vicodin and Benadryl. It is created by eHealthMe based on reports of 3,041 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. (latest outcomes from 35,345 Vicodin users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,405 Benadryl users)

On May, 3, 2015: 3,040 people who take Vicodin, Benadryl are studied

Vicodin, Benadryl outcomes

Drug combinations in study:
- Vicodin (acetaminophen; hydrocodone bitartrate)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Vicodin is effective44.00%
(11 of 25 people)
40.00%
(6 of 15 people)
28.57%
(2 of 7 people)
33.33%
(4 of 12 people)
42.86%
(6 of 14 people)
57.14%
(4 of 7 people)
25.00%
(1 of 4 people)
n/a
Benadryl is effective25.00%
(7 of 28 people)
27.27%
(3 of 11 people)
60.00%
(3 of 5 people)
20.00%
(2 of 10 people)
25.00%
(3 of 12 people)
33.33%
(3 of 9 people)
60.00%
(3 of 5 people)
0.00%
(0 of 1 people)

Drug effectiveness by gender :

FemaleMale
Vicodin is effective40.62%
(26 of 64 people)
40.00%
(8 of 20 people)
Benadryl is effective29.51%
(18 of 61 people)
30.00%
(6 of 20 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Vicodin is effectiven/an/an/a38.10%
(8 of 21 people)
25.71%
(9 of 35 people)
16.67%
(9 of 54 people)
40.00%
(4 of 10 people)
21.05%
(4 of 19 people)
Benadryl is effectiven/an/an/a35.00%
(7 of 20 people)
20.00%
(7 of 35 people)
7.55%
(4 of 53 people)
33.33%
(3 of 9 people)
15.79%
(3 of 19 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PainSepsisIleusConvulsionDizzinessErection ProblemsDecreased InterestPain
AnxietyFebrile NeutropeniaConstipationHeadacheLoss Of ConsciousnessSkin StriaeDecreased AppetiteAnxiety
NauseaHypotensionPainHaemorrhageBody OverheatingUrinary RetentionFood IntoleranceNausea
InjuryGastrointestinal HaemorrhageAbdominal PainCardiac ArrestCerebrovascular AccidentExcessive ThirstHypersomniaDyspnoea
VomitingPulmonary EmbolismNervousnessHepatic EncephalopathyCytomegalovirus ColitisWeight Gain - UnintentionalDepression AggravatedBack Pain
PruritusConvulsionAbnormal DreamsGastrooesophageal Reflux DiseasePancreatic PseudocystHigh Blood SugarDry MouthArthralgia
HypotensionMucosal InflammationFallComplications Of Transplanted LiverPain - BackMorphoeaDry ThroatAnaemia
Pain In ExtremityAbdominal PainDysuriaBlood Pressure Systolic DecreasedHeadacheSweating - ExcessiveThroat TightnessFatigue
HeadacheCondition AggravatedHypophagiaPneumonia AspirationChillsBlood Triglycerides IncreasedFatigue AggravatedFall
Confusional StateHaematemesisVomitingParacentesisBarrett's OesophagusExhaustion, Fatigue, Lethargy, Tiredness, WearinessMuscle Contractions InvoluntaryOsteonecrosis Of Jaw

Most common drug interactions by gender * :

FemaleMale
PainPain
AnxietyAnxiety
NauseaNausea
DyspnoeaBack Pain
AnaemiaDyspnoea
Back PainDepression
ArthralgiaFatigue
FallArthralgia
FatigueAsthenia
InjuryDehydration

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Unwanted PregnancyOverdosePainNauseaPainPainAnxietyAnaemia
Uterine HaemorrhageSomnolenceBlood Bilirubin IncreasedAbdominal Pain UpperAnaemiaAnxietyPainPain
Cleft PalateHypotensionPneumonitisBack PainDepressionBack PainNauseaFall
Antepartum HaemorrhageRespiratory DepressionHypotensionVomitingWeight IncreasedNauseaInjuryDyspnoea
Heart Rate IncreasedAcute Respiratory Distress SyndromeFatigueFatigueDyspnoeaOsteoarthritisAsthenia
ConstipationNephrogenic Systemic FibrosisPainArthralgiaArthralgiaFallAnxiety
ShockPulmonary EmbolismPain In ExtremityAbdominal PainFatigueOsteonecrosis Of JawConstipation
CoagulopathyCholelithiasisFlank PainVomitingDepressionBone DisorderBack Pain
TachycardiaCholecystitis ChronicPulmonary EmbolismGait DisturbanceInjuryPyrexiaNausea
SepsisNauseaChest PainPain In ExtremityFallAnaemiaFatigue

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Vicodin and Benadryl on

Do you take Vicodin and Benadryl?

 

You are not alone! Join a related support group:
- support group for people who take Benadryl
- support group for people who take Vicodin

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Benadryl, Vicodin

You may be interested at these reviews (Write a review):

More reviews for: Benadryl, Vicodin

Comments from related studies:

  • From this study (7 months ago):

  • I didn't take the Norco today, but the benadryl I take every night.

    Reply

  • From this study (8 months ago):

  • I have had these symptoms for many years but recently they have become worse. I don't know what to do or what to take.

    Reply

  • From this study (8 months ago):

  • I have an itchy rash of small bumps that have spread all over my body. Its terrible

    Reply

    Azy on Sep, 27, 2014:

    I am now exactly dealing with the same symptoms, how long does it take for you to get rid of those red itchy bumps

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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