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Review: Vicodin and Benadryl

This review analyzes the effectiveness and drug interactions between Vicodin and Benadryl. It is created by eHealthMe based on 2,949 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Mar, 31, 2014: 2,949 people who reported to have interactions when taking Vicodin, Benadryl are studied

Trend of Vicodin, Benadryl's drug interactions, side effects and effectiveness reports (9169043)

Drug combinations in study:
- Vicodin (acetaminophen; hydrocodone bitartrate)
- Benadryl (diphenhydramine hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Vicodin, Benadryl:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety2,491
Dyspnoea (difficult or laboured respiration)1,995
Pain1,895
Arthralgia (joint pain)1,770
Nausea (feeling of having an urge to vomit)1,302
Anaemia (lack of blood)1,208
Back Pain1,202
Fatigue (feeling of tiredness)1,129
Osteonecrosis Of Jaw (death of bone of jaw)1,110
Fall1,084

Most common interactions experienced by people in long term use of Vicodin, Benadryl:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)12
Dizziness8
Cardiac Arrest8
Haemorrhage (bleeding)8
Erection Problems4
Portal Shunt4
Pulse Absent4
Osteopenia (a condition where bone mineral density is lower than normal)4
Transplant Failure (transplantation failed to meet outcome)4
Peritonitis Bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)4

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Vicodin0.00%31.58%36.84%15.79%15.79%
Benadryl18.18%18.18%36.36%27.27%0.00%

Top conditions involved for these people * :

  1. Pain
  2. Premedication
  3. Depression
  4. Hypertension
  5. Nausea

Top co-used drugs for these people * :

  1. Lortab
  2. Seroquel
  3. Heparin sodium injection
  4. Aspirin
  5. Zofran

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Vicodin

You can also:

Complete drug side effects:

On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (1 week ago):

  • 5/325 every 4 hours as needed. 0-4 per day. Would like to stop taking this drug as my eye pressure has increased. Only take it if the pain is 10+++. Looking for Orthopedic Surgeon to fix the bulging disks.

    Reply

  • From this study (3 weeks ago):

  • have been abstinent for 6 weeks; one testicle and penis became grossly swollen and painful, Dr. treated with Sulfamethox 2DSx twice daily-in six days had anaphylactic reaction hives,etc. so discontinued; after swelling subsided and resumption of sex,have had three bloody ejaculations.
    Have had quadruple heart bypass,AAA,permanent thrombosis in leg from vein harvest, double (saddlebag) pulmonary emboli.

    Reply

  • From this study (3 weeks ago):

  • have been abstinent for 6 weeks; one testicle and penis became grossly swollen and painful, Dr. treated with Sulfamethox 2DSx twice daily-in six days had anaphylactic reaction hives,etc. so discontinued; after swelling subsided and resumption of sex,have had three bloody ejaculations.

    Reply

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More questions for: Benadryl, Vicodin

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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