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Review: taking Vicodin and Cymbalta together

Summary: drug interactions are reported among people who take Vicodin and Cymbalta together.

This review analyzes the effectiveness and drug interactions between Vicodin and Cymbalta. It is created by eHealthMe based on reports of 3,807 people who take the same drugs from FDA and social media, and is updated regularly.


You are not alone: join a support group for people who take Vicodin and Cymbalta >>>

On Mar, 28, 2015: 3,807 people who take Vicodin, Cymbalta are studied

Vicodin, Cymbalta outcomes

Drug combinations in study:
- Vicodin (acetaminophen; hydrocodone bitartrate)
- Cymbalta (duloxetine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Vicodin is effective26.47%
(9 of 34 people)
(19 of 51 people)
(17 of 32 people)
(20 of 55 people)
(33 of 75 people)
(16 of 40 people)
(6 of 18 people)
(0 of 3 people)
Cymbalta is effective11.43%
(4 of 35 people)
(21 of 67 people)
(10 of 37 people)
(12 of 49 people)
(26 of 70 people)
(7 of 27 people)
(4 of 9 people)
(0 of 2 people)

Drug effectiveness by gender :

Vicodin is effective39.00%
(94 of 241 people)
(26 of 67 people)
Cymbalta is effective29.61%
(69 of 233 people)
(15 of 62 people)

Drug effectiveness by age :

Vicodin is effectiven/an/a100.00%
(1 of 1 people)
(10 of 34 people)
(20 of 130 people)
(40 of 181 people)
(36 of 145 people)
(13 of 59 people)
Cymbalta is effectiven/an/a100.00%
(1 of 1 people)
(9 of 33 people)
(14 of 114 people)
(28 of 186 people)
(27 of 147 people)
(5 of 60 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyDizzinessAnxietyDrug IneffectiveDepressionDepressionFatiguePain
FallPainFeeling AbnormalInsomniaAnxietyAnxietyNauseaAnxiety
Suicidal IdeationHeadacheDepressed MoodDepressionPainDrug IneffectiveConstipationNausea
DyspnoeaAlanine Aminotransferase IncreasedMalaiseArthralgiaConstipationFatigueDeep Vein ThrombosisFall
Drug IneffectiveAspartate Aminotransferase IncreasedSuicidal IdeationAnxietyRoad Traffic AccidentDrug Withdrawal SyndromePulmonary EmbolismDepression
IrritabilityNauseaPain In ExtremityMental Status ChangesInsomniaNauseaAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionBack Pain
NauseaLoss Of ConsciousnessDrug Withdrawal SyndromeSinusitisSuicide AttemptPainDrug DependenceHeadache
FatigueDrug IneffectiveAngerFatiguePancreatitisSuicide AttemptMouth Ulceration AggravatedInsomnia
AstheniaFatigueBack PainConfusional StateHeadacheAbdominal PainCryingArthralgia
MalaiseAnxietySelf Injurious BehaviourAstheniaConvulsionJoint PainDepressionFatigue

Most common drug interactions by gender * :

DepressionBack Pain
Back PainHeadache
FatigueWeight Decreased

Most common drug interactions by age * :

Meningomyelocelen/aCholecystitis ChronicPainDepressionPainPainFall
Neural Tube DefectPainNauseaPainHeadacheAnxietyPain
Spina BifidaGallbladder DisorderPneumoniaNauseaFatigueNauseaAnxiety
TalipesAbdominal Pain UpperAbdominal Pain UpperAnxietyAnxietyFallNausea
Maternal Drugs Affecting FoetusSphincter Of Oddi DysfunctionInsomniaWeight IncreasedNauseaInsomniaBack Pain
Congenital HydrocephalusHeadacheCholecystitis ChronicArthralgiaFallArthralgiaHypertension
ObesityPancreatitisVomitingDrug IneffectiveDepressionPyrexiaDepression
Type 2 Diabetes MellitusBone InfarctionMigraineAbdominal Pain UpperBack PainDiarrhoeaFatigue
Abortion InducedArthropathyHeadacheSuicidal IdeationVomitingInjuryDyspnoea
Congenital Central Nervous System AnomalyBone PainAnxietyWeight DecreasedHypoaesthesiaDepressionAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Cymbalta
- support group for people who take Vicodin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Vicodin (acetaminophen; hydrocodone bitartrate) is often used to treat pain. Cymbalta (duloxetine hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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