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Review: taking Vistaril and Benadryl together

Summary: drug interactions are reported among people who take Vistaril and Benadryl together.

This review analyzes the effectiveness and drug interactions between Vistaril and Benadryl. It is created by eHealthMe based on reports of 912 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 20, 2015: 912 people who take Vistaril, Benadryl are studied

Vistaril, Benadryl outcomes

Drug combinations in study:
- Vistaril (hydroxyzine hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Vistaril is effective11.11%
(1 of 9 people)
(1 of 9 people)
(1 of 1 people)
(0 of 2 people)
(2 of 3 people)
(0 of 1 people)
(0 of 1 people)
Benadryl is effective0.00%
(0 of 7 people)
(1 of 5 people)
(2 of 2 people)
(2 of 5 people)
(1 of 1 people)
(1 of 4 people)

Drug effectiveness by gender :

Vistaril is effective19.05%
(4 of 21 people)
(1 of 5 people)
Benadryl is effective30.00%
(6 of 20 people)
(1 of 4 people)

Drug effectiveness by age :

Vistaril is effectiven/a50.00%
(1 of 2 people)
(1 of 14 people)
(0 of 13 people)
(1 of 12 people)
(1 of 4 people)
(1 of 3 people)
Benadryl is effectiven/a0.00%
(0 of 1 people)
(2 of 14 people)
(1 of 13 people)
(1 of 11 people)
(2 of 4 people)
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Renal Failure AcuteOsteonecrosisConvulsionConvulsionIrregular Heart Beatn/aAbdominal Pain LowerDyspnoea
Abortion InducedHaemorrhageHaemorrhageHaemorrhageHysterectomyBreathing Difficulty - Lying DownArthralgia
Engraftment SyndromeOedema PeripheralCardiac ArrestCardiac ArrestJoint PainChronic PainBack Pain
Blood Bilirubin IncreasedToothacheSwelling Of The FaceCardiomegalyTremorBreathing SoundsPain
Blood Pressure IncreasedStomatitisCardiac Failure CongestiveCardiac Failure CongestiveItchingFatigue
PyrexiaSwelling FaceCondition AggravatedCongenital Cardiovascular AnomalyFall
Acute Myeloid LeukaemiaStevens-johnson SyndromeSwelling Of The Ankles - Feet - LegsPleural EffusionNausea
Trisomy 21Jaundice CholestaticMenstrual Periods - Heavy, Prolonged, Or IrregularVentricular Septal DefectAnxiety
Oedema PeripheralStevens Johnson SyndromeHypoglycaemic SeizureAtrial Septal DefectHeadache
Bone PainRashErythemaDrug Exposure During PregnancyDepression

Most common drug interactions by gender * :

Back PainPyrexia
HeadacheWeight Decreased
Pain In ExtremityRenal Failure Acute

Most common drug interactions by age * :

Cushing's SyndromeDiarrhoeaVomitingBlood Pressure IncreasedPruritusDyspnoeaHeadacheDyspnoea
Weight DecreasedSwelling FaceRash ErythematousDyspnoeaBronchitisDepressionAnxietyHypotension
UrticariaIrritabilityPyrexiaTachycardiaObesityPyrexiaPainBack Pain
Blood Glucose IncreasedUrticariaHistiocytosis HaematophagicPainFatigueNauseaFallFall
HypertensionInfusion Related ReactionBlood Pressure DecreasedAbdominal PainContusionFatigueBack PainAnaemia
Growth RetardationPyrexiaRashChest DiscomfortAbdominal PainPruritusDizzinessWeight Decreased
Adrenal SuppressionPruritusArthritisPalpitationsFallPainDyspnoeaFatigue
Dermatitis AtopicPain In ExtremityArthralgiaLacrimation IncreasedBlood Triglycerides IncreasedBlood Glucose IncreasedInjuryArthralgia
SynostosisRashAlanine Aminotransferase IncreasedImpetigoDepressionArthralgiaConvulsionChest Pain
NauseaAtelectasisHodgkin's DiseaseBlood Cholesterol IncreasedInsomniaNauseaGastrointestinal Haemorrhage

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Benadryl
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Vistaril (hydroxyzine hydrochloride) is often used to treat stress and anxiety. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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