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Review: taking Vyvanse and Wellbutrin together

Summary: drug interactions are reported among people who take Vyvanse and Wellbutrin together.

This review analyzes the effectiveness and drug interactions between Vyvanse and Wellbutrin. It is created by eHealthMe based on reports of 381 people who take the same drugs from FDA and social media, and is updated regularly.


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On Mar, 30, 2015: 381 people who take Vyvanse, Wellbutrin are studied

Vyvanse, Wellbutrin outcomes

Drug combinations in study:
- Vyvanse (lisdexamfetamine dimesylate)
- Wellbutrin (bupropion hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Vyvanse is effective36.84%
(7 of 19 people)
(12 of 39 people)
(12 of 31 people)
(24 of 42 people)
(17 of 32 people)
(2 of 4 people)
(1 of 2 people)
(1 of 3 people)
Wellbutrin is effective9.09%
(1 of 11 people)
(9 of 36 people)
(6 of 20 people)
(10 of 30 people)
(15 of 45 people)
(8 of 18 people)
(5 of 9 people)
(0 of 2 people)

Drug effectiveness by gender :

Vyvanse is effective40.50%
(49 of 121 people)
(27 of 51 people)
Wellbutrin is effective32.50%
(39 of 120 people)
(14 of 49 people)

Drug effectiveness by age :

Vyvanse is effectiven/an/a13.64%
(3 of 22 people)
(27 of 98 people)
(23 of 82 people)
(15 of 58 people)
(6 of 41 people)
(2 of 4 people)
Wellbutrin is effectiven/an/a13.64%
(3 of 22 people)
(17 of 93 people)
(12 of 81 people)
(13 of 64 people)
(7 of 43 people)
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DepressionNauseaDepressionAnxietyExhaustion, Fatigue, Lethargy, Tiredness, WearinessDizzinessSpottingDrug Ineffective
AngerExhaustion, Fatigue, Lethargy, Tiredness, WearinessNauseaErectile DysfunctionPain - JointsPndSexual DysfunctionDepression
Blood Pressure IncreasedIrritabilityHeadacheDrug IneffectiveErectile DysfunctionAngerAnorgasmiaNausea
Suicidal IdeationAngerDrug AbuseTremorFatigueMultiple Chemical SensitivityHeadache - TensionFatigue
HeadacheAttention Deficit/hyperactivity DisorderDrug Effect DecreasedDry MouthConstipationNauseaOverdose
Depressed MoodFatigueAngerAppetite DecreasedMuscle TightnessCryingSuicidal Ideation
Drug IneffectiveDrug IneffectiveIbsShort-term Memory LossInsomniaDepressionAnger
AnxietyMood SwingsAnxiety, Apprehension, Feeling Uptight, Jitters, Stress, Stress And Anxiety, TensionDepressed MoodFeeling JitteryOverdoseDisturbance In Attention
Decreased AppetiteDepressionGastroparesisSpondylolisthesis AcquiredIncreased Tendency To BruiseTheftAnxiety
AstheniaTachycardiaConversion DisorderFaintingParanoia AggravatedInsomniaDry Mouth

Most common drug interactions by gender * :

DepressionDrug Ineffective
FatigueErectile Dysfunction
Drug IneffectiveSuicidal Ideation
OverdoseBlood Pressure Increased
Suicidal IdeationDisturbance In Attention
Mood SwingsRectal Haemorrhage
TremorTherapeutic Response Unexpected

Most common drug interactions by age * :

n/aNegativismInsomniaVisual Field DefectNauseaDrug IneffectiveDrug IneffectiveMusculoskeletal Disorder
AngerAngerAutoimmune DisorderDizzinessDepressionOverdoseAccident
Abnormal BehaviourDepressionVisual ImpairmentFatigueSuicidal IdeationAmnesiaLower Limb Fracture
AgitationConvulsionRetinal DisorderHeadacheAstheniaRashUpper Limb Fracture
Weight DecreasedTardive DyskinesiaOverdoseAbdominal PainDepressed MoodFatigueFeeling Abnormal
Drug Administration ErrorSuicidal IdeationPyrexiaAbdominal Pain UpperFatigueDiabetes MellitusWrist Fracture
Drug IneffectiveDisturbance In AttentionVasculitisGastritisAnxietyAnxietyMultiple Fractures
Mood SwingsMiddle InsomniaUrticariaDehydrationRectal HaemorrhageNauseaLimb Crushing Injury
AggressionDrug Screen PositiveExhaustion, Fatigue, Lethargy, Tiredness, WearinessMenorrhagiaTherapeutic Response UnexpectedParaesthesiaSpinal Fracture
CryingErythemaSomnolenceAngerMental ImpairmentPelvic Fracture

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Vyvanse
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Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Vyvanse (lisdexamfetamine dimesylate) is often used to treat attention deficit hyperactivity disorder. Wellbutrin (bupropion hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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