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Review: taking Wellbutrin and Trazodone together

Summary: drug interactions are reported among people who take Wellbutrin and Trazodone together.

This review analyzes the effectiveness and drug interactions between Wellbutrin and Trazodone. It is created by eHealthMe based on reports of 3,753 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 6, 2015: 3,753 people who take Wellbutrin, Trazodone Hydrochloride are studied

Wellbutrin, Trazodone Hydrochloride outcomes

Drug combinations in study:
- Wellbutrin (bupropion hydrochloride)
- Trazodone Hydrochloride (trazodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin is effective16.13%
(5 of 31 people)
(22 of 61 people)
(6 of 31 people)
(18 of 46 people)
(26 of 60 people)
(29 of 49 people)
(23 of 35 people)
(1 of 6 people)
Trazodone Hydrochloride is effective38.24%
(13 of 34 people)
(30 of 61 people)
(11 of 32 people)
(25 of 42 people)
(36 of 67 people)
(36 of 48 people)
(18 of 29 people)
(2 of 5 people)

Drug effectiveness by gender :

Wellbutrin is effective42.50%
(102 of 240 people)
(27 of 75 people)
Trazodone Hydrochloride is effective57.61%
(140 of 243 people)
(31 of 75 people)

Drug effectiveness by age :

Wellbutrin is effectiven/an/a16.67%
(2 of 12 people)
(14 of 70 people)
(22 of 111 people)
(43 of 170 people)
(29 of 138 people)
(19 of 83 people)
Trazodone Hydrochloride is effectiven/an/a58.33%
(7 of 12 people)
(19 of 60 people)
(35 of 114 people)
(45 of 153 people)
(37 of 139 people)
(28 of 84 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyDepressionType 2 Diabetes MellitusType 2 Diabetes MellitusDepressionType 2 Diabetes MellitusDiabetic RetinopathyDepression
DepressionInsomniaDiabetes MellitusPainSuicidal IdeationDiabetes MellitusWeight IncreasedPain
TremorType 2 Diabetes MellitusHysterectomyConvulsionPainDepressionDiabetes Mellitus Inadequate ControlAnxiety
NauseaPainBack PainWeight IncreasedAnxietyAnxietyProteinuriaDiabetes Mellitus
Suicide AttemptHeadacheInflammationHypertensionWeight DecreasedBlood Triglycerides IncreasedBlood Glucose IncreasedNausea
Drug IneffectiveFatigueHeadachePulmonary EmbolismSuicide AttemptObesityDiabetic NeuropathyType 2 Diabetes Mellitus
DizzinessAnxietyGastric UlcerAnxietyPancreatitisInsomniaRenal DisorderFatigue
FatigueBlood Cholesterol IncreasedBladder DisorderNauseaHallucinationSuicidal IdeationDiabetic Eye DiseaseWeight Increased
InsomniaCompleted SuicideFungal InfectionObesityTardive DyskinesiaMental DisorderTremorVomiting
DiarrhoeaDiabetes MellitusNauseaDiabetes MellitusConvulsionNeoplasmInsomniaInsomnia

Most common drug interactions by gender * :

NauseaDiabetes Mellitus
Diabetes MellitusType 2 Diabetes Mellitus
Type 2 Diabetes MellitusInsomnia
Weight IncreasedConstipation
DiarrhoeaBack Pain
HeadacheWeight Decreased

Most common drug interactions by age * :

Type 2 Diabetes MellitusLethargyWeight IncreasedCompleted SuicideDiabetes MellitusDiabetes MellitusDepressionMyocardial Infarction
PancreatitisGruntingAnxietyCardiac ArrestType 2 Diabetes MellitusType 2 Diabetes MellitusPainDepression
Pancreatitis AcuteDysarthriaSuicidal IdeationType 2 Diabetes MellitusNauseaDepressionNauseaTremor
Pelvic Fluid CollectionRespiratory Rate IncreasedAggressionAnxietyWeight IncreasedNauseaAnxietyDrug Ineffective
Neuroleptic Malignant SyndromeDrug IneffectiveNauseaDiabetes MellitusDiabetes Mellitus Inadequate ControlAnxietyFatiguePain
IschaemiaManiaInsomniaTorsade De PointesDepressionFatigueDiarrhoeaDiarrhoea
NauseaAnxiety NecSuicide AttemptDepressionSuicidal IdeationPainType 2 Diabetes MellitusSuicidal Ideation
Peritoneal EffusionAbnormal Behaviour NosEmotional DistressBlood Cholesterol IncreasedCompleted SuicideBack PainVomitingCardio-respiratory Arrest
Metabolic AcidosisConfusional StateDepressionRespiratory ArrestBack PainWeight IncreasedFallAnxiety
PneumoniaCommunication DisorderHeadacheConstipationPainBlood Cholesterol IncreasedHeadacheBlood Glucose Increased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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You are not alone! Join a related support group:
- support group for people who take Trazodone Hydrochloride
- support group for people who take Wellbutrin

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used to treat depression. Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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