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Review: Wellbutrin and Trazodone

This review analyzes the effectiveness and drug interactions between Wellbutrin and Trazodone. It is created by eHealthMe based on reports of 3,740 people who take the same drugs from FDA and social media, and is updated regularly.

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What are the drugs

Wellbutrin (what 54,854 Wellbutrin users reported?) has active ingredients of bupropion hydrochloride. It is used in depression.

Trazodone hydrochloride (what 6,569 Trazodone Hydrochloride users reported?) has active ingredients of trazodone hydrochloride. It is used in insomnia.

On Sep, 19, 2014: 3,740 people who take Wellbutrin, Trazodone Hydrochloride are studied

Wellbutrin, Trazodone Hydrochloride outcomes

Drug combinations in study:
- Wellbutrin (bupropion hydrochloride)
- Trazodone Hydrochloride (trazodone hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin is effective16.13%
(5 of 31 people)
33.33%
(19 of 57 people)
20.00%
(6 of 30 people)
40.91%
(18 of 44 people)
44.07%
(26 of 59 people)
59.57%
(28 of 47 people)
65.62%
(21 of 32 people)
16.67%
(1 of 6 people)
Trazodone Hydrochloride is effective38.71%
(12 of 31 people)
50.00%
(29 of 58 people)
35.48%
(11 of 31 people)
59.52%
(25 of 42 people)
53.03%
(35 of 66 people)
75.56%
(34 of 45 people)
64.29%
(18 of 28 people)
40.00%
(2 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyDepressionType 2 Diabetes MellitusType 2 Diabetes MellitusDepressionType 2 Diabetes MellitusProteinuriaDepression
DepressionInsomniaDiabetes MellitusPainSuicidal IdeationDiabetes MellitusDiabetic RetinopathyPain
TremorType 2 Diabetes MellitusHysterectomyWeight IncreasedPainDepressionDiabetes Mellitus Inadequate ControlAnxiety
NauseaPainBack PainConvulsionAnxietyAnxietyWeight IncreasedDiabetes Mellitus
Drug IneffectiveHeadacheInflammationHypertensionWeight DecreasedBlood Triglycerides IncreasedBlood Glucose IncreasedNausea
Suicide AttemptAnxietyGastric UlcerAnxietySuicide AttemptSuicidal IdeationRenal DisorderType 2 Diabetes Mellitus
InsomniaBlood Cholesterol IncreasedHeadacheNauseaPancreatitisObesityDiabetic NeuropathyFatigue
DizzinessDiabetes MellitusNauseaPulmonary EmbolismHallucinationInsomniaDiabetic Eye DiseaseWeight Increased
HyperglycaemiaCompleted SuicideFungal InfectionDiabetes MellitusTardive DyskinesiaDry MouthInsomniaVomiting
FatigueFatigueBacterial InfectionFatigueConvulsionMental DisorderOsteoporosis Post-menopausalInsomnia

Drug effectiveness by gender :

FemaleMale
Wellbutrin is effective42.36%
(97 of 229 people)
35.62%
(26 of 73 people)
Trazodone Hydrochloride is effective57.94%
(135 of 233 people)
42.47%
(31 of 73 people)

Most common drug interactions by gender * :

FemaleMale
DepressionDepression
NauseaDiabetes Mellitus
AnxietyAnxiety
PainPain
Diabetes MellitusType 2 Diabetes Mellitus
Type 2 Diabetes MellitusInsomnia
FatigueFatigue
Weight IncreasedBack Pain
DiarrhoeaConstipation
HeadacheWeight Decreased

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Wellbutrin is effectiven/an/a16.67%
(2 of 12 people)
20.00%
(14 of 70 people)
21.28%
(20 of 94 people)
24.55%
(41 of 167 people)
22.31%
(27 of 121 people)
23.75%
(19 of 80 people)
Trazodone Hydrochloride is effectiven/an/a58.33%
(7 of 12 people)
31.67%
(19 of 60 people)
35.05%
(34 of 97 people)
28.67%
(43 of 150 people)
29.51%
(36 of 122 people)
32.93%
(27 of 82 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Type 2 Diabetes MellitusLethargyWeight IncreasedCompleted SuicideDiabetes MellitusDiabetes MellitusDepressionMyocardial Infarction
PancreatitisGruntingAnxietyCardiac ArrestType 2 Diabetes MellitusType 2 Diabetes MellitusPainDepression
Pancreatitis AcuteDysarthriaSuicidal IdeationType 2 Diabetes MellitusNauseaDepressionNauseaTremor
Pelvic Fluid CollectionRespiratory Rate IncreasedAggressionAnxietyWeight IncreasedNauseaAnxietyPain
Neuroleptic Malignant SyndromeDrug IneffectiveNauseaDiabetes MellitusDiabetes Mellitus Inadequate ControlAnxietyFatigueDrug Ineffective
IschaemiaManiaInsomniaTorsade De PointesDepressionFatigueDiarrhoeaDiarrhoea
NauseaAnxiety NecSuicide AttemptDepressionSuicidal IdeationPainType 2 Diabetes MellitusSuicidal Ideation
Peritoneal EffusionAbnormal Behaviour NosEmotional DistressBlood Cholesterol IncreasedCompleted SuicideBack PainFallAnxiety
Metabolic AcidosisConfusional StateDepressionRespiratory ArrestBack PainWeight IncreasedVomitingCardio-respiratory Arrest
PneumoniaCommunication DisorderHeadacheConstipationPainBlood Cholesterol IncreasedHeadacheBlood Glucose Increased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Wellbutrin and Trazodone?

Comments from related studies:

  • From this study (2 days ago):

  • Hand tremors, voi e tremors, noint pain to hips and shoulders, worse on dominate side, severe, unable to feed with fork, have to eat finger foods and drink from a straw. I was taken off wellbutrin had withdraws after 4 days, started back and now have all symptoMs of Parkinson's. Any information is helpful. I am a mother of 3. Age 42, have ringing in my ears, they have me on fmla until they can get an answer.

    Reply

  • From this study (3 weeks ago):

  • just took at 150MG tablet of Wellbutrin and going to try taking the Trazodone 50mg for sleep tonight.. wish me luck

    Reply

  • From this study (1 month ago):

  • I have a cough that strangles me. Had this once before as a side effect to a drug. I just started a higher dose of bupropion. Could this be the problem or any of the other drugs I take?

    Reply

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Complete drug side effects:

On eHealthMe, Wellbutrin (bupropion hydrochloride) is often used to treat depression. Trazodone Hydrochloride (trazodone hydrochloride) is often used to treat insomnia. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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