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Review: Wellbutrin Xl and SAM-e





Summary: drug interactions are reported among people who take Wellbutrin Xl and SAM-e together.

This review analyzes the effectiveness and drug interactions between Wellbutrin Xl and SAM-e. It is created by eHealthMe based on reports of 11 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Wellbutrin Xl and SAM-e >>>

What are the drugs

Wellbutrin xl has active ingredients of bupropion hydrochloride. It is often used in depression. (latest outcomes from Wellbutrin xl 13,268 users)

Sam-e has active ingredients of same. It is often used in depression. (latest outcomes from Sam-e 68 users)

On Dec, 2, 2014: 11 people who take Wellbutrin Xl, SAM-e are studied

Wellbutrin Xl, SAM-e outcomes

Drug combinations in study:
- Wellbutrin Xl (bupropion hydrochloride)
- SAM-e (same)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Wellbutrin Xl is effective0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
n/a0.00%
(0 of 2 people)
n/a100.00%
(3 of 3 people)
n/an/a
SAM-e is effectiven/a100.00%
(1 of 1 people)
100.00%
(1 of 1 people)
n/a33.33%
(1 of 3 people)
n/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Nausean/an/aDizzinessTirednessSkin Hyperpigmentationn/aSkin Hyperpigmentation
SluggishnessNausea
TirednessSluggishness
ConfusionDizziness
HeadacheConfusion
Headache

Drug effectiveness by gender :

FemaleMale
Wellbutrin Xl is effective50.00%
(3 of 6 people)
0.00%
(0 of 1 people)
SAM-e is effective50.00%
(2 of 4 people)
100.00%
(1 of 1 people)

Most common drug interactions by gender * :

FemaleMale
Sluggishnessn/a
Dizziness
Tiredness
Nausea
Confusion
Headache
Skin Hyperpigmentation

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Wellbutrin Xl is effectiven/an/an/a10.00%
(1 of 10 people)
28.57%
(2 of 7 people)
n/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
SAM-e is effectiven/an/an/a0.00%
(0 of 9 people)
100.00%
(2 of 2 people)
n/a100.00%
(1 of 1 people)
0.00%
(0 of 1 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
n/an/an/aSluggishnessn/an/an/aNausea
Tiredness
Dizziness
Headache
Confusion
Skin Hyperpigmentation

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Wellbutrin Xl and SAM-e?

You are not alone! Join a related mobile support group:
- support group for people who take Wellbutrin Xl and SAM-e
- support group for people who take SAM-e
- support group for people who take Wellbutrin Xl

Can you answer these questions (Ask a question):

More questions for: SAM-e, Wellbutrin Xl

You may be interested at these reviews (Write a review):

  • Intrsoccular pressure increase associated with wellbutrin
    I was given a prescription for Wellbutrin in approximately 1998. I had has my ocular pressure checked a year prior to this and it was okay. At the time, I only needed to wear reading glasses, common in people over 45. I took the drug at the full prescribed dosage for two weeks. Immediately prior to the narrow angle glaucoma episode, my vision had actually seemed to improve. For one day, prior, I could read without reading glasses. The following night, I was watching tv, and things suddenly became foggy. It was actually as if a fog had enveloped the room. I could not see anything except to discern between light and dark areas. I had to have emergency laser surgery the next morning. I mentioned to the doctor that Iwas taking Wellbutrin to stop smoking, and asked if it could have caused the ocular pressure increase. he consulted the PDR, and said there was no mention of it causing increases in ocular pressure. One year later my primary care doctor again insisted that I stop smoking, and again I mentioned that I thought it might increase ocular pressure. She told me to take a half dose, I did, and I took it one week, at which time I again experienced another episode of narrow angle glaucoma. When I go to the doctor's office my pressure in my left eye was 72, and 68 in my right eye. I was then referred on a triage basis to another doctor. I spent the rest of the day in his office having drops administered every fifteen minutes(extremely painful). I had extensive laser surgery the next morning.It required over fifty shots from the laser machine into each eye, (also extremely painful). I had lost considerable peripheral AND CENTRAL VISION in my left eye, and a good deal in my right. As a result of having to have such extensive laser surgery I also had cataracts that began at 50% maturity. I was advised by the surgeon that I should wait to have the cataracts removed "until my vision and quality of life was so poor that I was ready to commit suicide" because having the cataracts removed would cause the pressure in my eyes to become very difficult to control, and that more than likely I would end up being black blind. I would never use Wellbutrin under any circumstances, and I always check to make sure that any new meds I may be put on don't have anything to do with an increase in ocular pressure. If they do, I refuse to take them. The surgeon said he was surprised that I didn't lose more vision than I did, and I am grateful that I didn't, and that he was a good surgen. He wrote an article concerning this case for a medical journal since he said he had been seeing a recent increase of narrow angle glaucoma.
  • Librium 25mg and wellbutrin 300mg for >1 month
    I've been taking librium twice daily, morning and night, for about 3 months now along with wellbutrin XL in the morning. I've basically had the mood of "I don't care" and a great boost in confidence.
  • Bedwetting with paxil and wellbutrin
    I have been using both of these drugs and now have bedwetting issues 5 times a week on average. I would rate the bedwetting as moderate about a6/10 but my wife and I can live with this as she had made the comment " you are back to the man I married ". I started taking these due to depression about work and anxiety about work. We both think we can live with the bedwetting as no one needs to know about it
  • Wellbutrin caused my trigeminal neurlagia
    So I'm writing this to hopefully shed light to other users in the same position I was in. I had taken Wellbutrin for about 4 years. The pain experienced in my face was excruciatingly painful. It was just on one side of my face between my temple and upper lip. All the symptoms reflected Trigeminal Neuralgia. But even with an MRI nothing could be found. I suffered for 3 of those years with pain coming and going, not understanding what was going on. Finally one day I decided hell with Wellbutrin and just stopped taking it. It's been 6 months now and I have yet to have a single shred of pain. Coincidence? I doubt it.
  • Lorazepam nearly killed me during cancer treatment
    Day 31 of cold turkey and I want to die. It is a roller coaster from body tics and sweats to rage and crying in one day. I felt so good the 4h day of c/t. It was like before my cancer diagnosis. My bowels are better off Lorazepam. I threw up during bowel movements from the pain. Off Lorazepam first normal bowel movement in over 2 years. Stomach so damaged by Lorazepam that I have absolutely no appetite. I force myself to eat. Neuropathy in hands nearly gone. Feet are better but slower. Lymphedema that appeared after one year on Lorazepam is now gone. I have full range of motion.

More reviews for: SAM-e, Wellbutrin Xl

Comments from related studies:

  • From this study (11 months ago):

  • Do not take all drugs listed at same time. Am on "pulse therapy" with antimacrobials. Do not take coq10 when on Mepron/malarone. Take Florastor probiotic 2x's a day to fight c.diff & other probiotics. Also take FiberSmart, DigestSmart, & slippery elm, marshmallow root for GI regularity. Drink at least 4 cups green tea daily. CDC confirmed lyme positive in 2010 (September), was bit in May of same year. Had psychiatric & cognitive dysfunction immediately following rash. Further testing show active infection in brain - neuro-lyme dx'd.

    Reply

  • From this study (2 years ago):

  • All checked side effects started the day after taking Trazodone and have continued for last few days. Severity of all side effects are new and do not think they are related to conditions of fibromyalgia, PTSD, anxiety and depression. I've never been in such a confused mental state and been so sluggish until starting Trazodone.

    Reply

  • From this study (2 years ago):

  • Dark discoloration around mouth.

    Reply

Complete drug side effects:

On eHealthMe, Wellbutrin Xl (bupropion hydrochloride) is often used to treat depression. Sam-e (same) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

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