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Review: taking Xanax and Synthroid together

Summary: drug interactions are reported among people who take Xanax and Synthroid together.

This review analyzes the effectiveness and drug interactions between Xanax and Synthroid. It is created by eHealthMe based on reports of 8,730 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 3, 2015: 8,730 people who take Xanax, Synthroid are studied

Xanax, Synthroid outcomes

Drug combinations in study:
- Xanax (alprazolam)
- Synthroid (levothyroxine sodium)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Xanax is effective41.67%
(10 of 24 people)
(25 of 43 people)
(23 of 42 people)
(32 of 61 people)
(42 of 72 people)
(44 of 65 people)
(39 of 60 people)
(2 of 2 people)
Synthroid is effective20.00%
(2 of 10 people)
(9 of 28 people)
(11 of 22 people)
(14 of 32 people)
(33 of 62 people)
(52 of 90 people)
(85 of 119 people)
(2 of 2 people)

Drug effectiveness by gender :

Xanax is effective60.00%
(192 of 320 people)
(23 of 47 people)
Synthroid is effective56.01%
(177 of 316 people)
(31 of 48 people)

Drug effectiveness by age :

Xanax is effectiven/an/a0.00%
(0 of 1 people)
(10 of 26 people)
(41 of 121 people)
(53 of 203 people)
(62 of 244 people)
(50 of 149 people)
Synthroid is effectiven/an/a0.00%
(0 of 1 people)
(11 of 26 people)
(40 of 114 people)
(48 of 199 people)
(55 of 248 people)
(54 of 147 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
AnxietyAspartate Aminotransferase IncreasedNauseaDizzinessDepressionDepressionAnxietyNausea
DiarrhoeaAlanine Aminotransferase IncreasedDizzinessAnxietyAnxietyAnxietyDeep Vein ThrombosisFatigue
Intentional OverdoseAnxietyInsomniaAstheniaPainDizzinessPulmonary EmbolismAnxiety
Suicide AttemptNauseaAnxietyPalpitationsInsomniaNauseaPainPain
DizzinessDepressionShortness Of BreathNauseaSuicide AttemptInsomniaSwellingDyspnoea
Panic AttackVomitingSomnolenceWeight DecreasedRoad Traffic AccidentExhaustion, Fatigue, Lethargy, Tiredness, WearinessMobility DecreasedDepression
Heart Rate IncreasedFatigueFoetal Exposure During PregnancySomnolenceHallucinationOsteoarthritisDizzinessHeadache
NauseaChest PainThyroid DisorderMuscular WeaknessSuicidal IdeationSuicide AttemptPost Thrombotic SyndromeDizziness
Drug IneffectiveDeep Vein ThrombosisBlood Pressure IncreasedDyspnoeaHeadacheSleep Apnoea SyndromeImpaired Driving AbilityAsthenia
HeadacheHepatic Function AbnormalWeight GainMusculoskeletal StiffnessAngerOverdoseDepressionDrug Ineffective

Most common drug interactions by gender * :

DepressionChest Pain
Drug IneffectiveDrug Ineffective

Most common drug interactions by age * :

Foetal Exposure During PregnancyHyponatraemiaDrug IneffectiveCholecystitis ChronicDepressionNauseaNauseaFatigue
Thyroid DisorderHeadacheCholecystitis ChronicNauseaFatigueAnxietyAnxietyNausea
Benign Intracranial HypertensionMemory ImpairmentAnxietyPainHeadacheDepressionAsthenia
Drug Administration ErrorWeight IncreasedWeight IncreasedVomitingOedema PeripheralPain
Disturbance In AttentionConstipationHeadacheChest PainDyspnoeaDrug Ineffective
TremorDeep Vein ThrombosisPain In ExtremityWeight IncreasedChest PainAnxiety
Suicide AttemptDizzinessBlood Cholesterol IncreasedDrug IneffectiveWeight DecreasedHeadache

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Xanax and Synthroid?




You are not alone! Join a related support group:
- support group for people who take Synthroid
- support group for people who take Xanax

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Xanax (alprazolam) is often used to treat stress and anxiety. Synthroid (levothyroxine sodium) is often used to treat hypothyroidism. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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