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Review: taking Zofran and Dramamine together

Summary: drug interactions are reported among people who take Zofran and Dramamine together. This review analyzes the effectiveness and drug interactions between Zofran and Dramamine. It is created by eHealthMe based on reports of 129 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. (latest outcomes from 905 Zofran users)

Dramamine has active ingredients of dimenhydrinate. It is often used in motion sickness. (latest outcomes from 406 Dramamine users)

On May, 13, 2015: 129 people who take Zofran, Dramamine are studied

Zofran, Dramamine outcomes

Drug combinations in study:
- Zofran (ondansetron hydrochloride)
- Dramamine (dimenhydrinate)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zofran is effectiven/an/an/an/a0.00%
(0 of 1 people)
Dramamine is effective0.00%
(0 of 1 people)

Drug effectiveness by gender :

Zofran is effective0.00%
(0 of 1 people)
Dramamine is effective0.00%
(0 of 1 people)

Drug effectiveness by age :

Zofran is effectiven/an/an/an/a0.00%
(0 of 1 people)
Dramamine is effectiven/an/an/an/a0.00%
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Oedema PeripheralCerebral Infarctionn/an/an/an/an/aVentricular Tachycardia
Palmar-plantar Erythrodysaesthesia SyndromePseudomembranous ColitisDiarrhoea
Depressed Level Of ConsciousnessEpistaxisNausea
Febrile NeutropeniaUrinary Tract InfectionThrombocytopenia
Renal Failure AcuteLeukopeniaVentricular Extrasystoles
Clostridium Difficile ColitisOedema PeripheralLeukopenia
DeathSeptic ShockPalmar-plantar Erythrodysaesthesia Syndrome
Nephritic SyndromeFatigueElectrocardiogram Qt Prolonged
Genital HerpesPalmar-plantar Erythrodysaesthesia SyndromeConvulsion

Most common drug interactions by gender * :

Ventricular TachycardiaLeukopenia
Ventricular ExtrasystolesPalmar-plantar Erythrodysaesthesia Syndrome
NauseaDepressed Level Of Consciousness
Electrocardiogram Qt ProlongedDeath
ConvulsionRenal Failure Acute
Bronchopleural FistulaOedema Peripheral
Respiratory AcidosisPhotophobia
Drug Clearance DecreasedBrain Oedema

Most common drug interactions by age * :

n/aDiarrhoeaVentricular Tachycardian/aBronchopleural FistulaNephritic SyndromeDiarrhoeaClostridium Difficile Colitis
Palmar-plantar Erythrodysaesthesia SyndromeThrombocytopeniaPneumoniaFatigueRespiratory Distress
Radiation InjuryLeukopeniaMalignant Neoplasm ProgressionDepressed Level Of ConsciousnessFebrile Neutropenia
DyskinesiaVentricular ExtrasystolesMetastases To BonePalmar-plantar Erythrodysaesthesia SyndromeNausea
Cerebral InfarctionElectrocardiogram Qt ProlongedTumour NecrosisOedema PeripheralRenal Failure Acute
DysphoniaNauseaPneumonia BacterialPyrexiaVomiting
VomitingProcedural NauseaFebrile NeutropeniaPneumonitisDeath
Movement DisorderVomitingHypotensionThrombosisUrinary Tract Infection
Abdominal PainProcedural VomitingRashIntracranial HypotensionPseudomembranous Colitis
HypoaesthesiaRespiratory AcidosisPleural EffusionLung InfectionHyponatraemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Zofran and Dramamine on

Do you take Zofran and Dramamine?


You are not alone! Join a related support group:
- support group for people who take Dramamine
- support group for people who take Zofran

Recent conversations of related support groups:

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More questions for: Dramamine, Zofran

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More reviews for: Dramamine, Zofran

Complete drug side effects:

On eHealthMe, Zofran (ondansetron hydrochloride) is often used to treat nausea. Dramamine (dimenhydrinate) is often used to treat motion sickness. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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