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Review: taking Zofran and Zantac together

Summary: drug interactions are reported among people who take Zofran and Zantac together.

This review analyzes the effectiveness and drug interactions between Zofran and Zantac. It is created by eHealthMe based on reports of 1,130 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. (latest outcomes from 895 Zofran users)

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. (latest outcomes from 35,538 Zantac users)

On Feb, 12, 2015: 1,130 people who take Zofran, Zantac are studied

Zofran, Zantac outcomes

Drug combinations in study:
- Zofran (ondansetron hydrochloride)
- Zantac (ranitidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zofran is effective25.00%
(1 of 4 people)
(2 of 6 people)
(0 of 1 people)
(1 of 1 people)
(1 of 1 people)
Zantac is effective0.00%
(0 of 6 people)
(0 of 1 people)
(0 of 1 people)
(2 of 3 people)
(1 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaFebrile NeutropeniaPeripheral Motor NeuropathyNauseaNephrogenic Systemic FibrosisBurning EyesDiarrhoeaNausea
Febrile NeutropeniaDiarrhoeaAbdominal Pain UpperDyspnoeaCardiac ArrestHypomagnesaemiaPyrexia
DiarrhoeaDyspnoeaCholecystitis ChronicSinus TachycardiaConstipationAstheniaVomiting
Renal Failure AcuteDehydrationGallbladder InjuryPain In ExtremityDiarrheaLower Respiratory Tract InfectionPain
FatigueMelaenaPco2 DecreasedSkin Burning SensationDecreased AppetiteDyspnoea
VomitingNauseaMyocardial InfarctionPancreatitis AggravatedOral CandidiasisAnaemia
PneumoniaVomitingMusculoskeletal PainHeadacheNauseaNeutropenia
Clostridium Difficile ColitisClostridium Difficile ColitisLeukocytosisChronic SinusitisCoughDiarrhoea
Acute Respiratory Distress SyndromeRenal Failure AcuteProductive CoughNauseaDyspepsiaDehydration
DyspnoeaPneumoniaRenal FailureNausea AggravatedHypoalbuminaemiaAnxiety

Drug effectiveness by gender :

Zofran is effective36.36%
(4 of 11 people)
(1 of 2 people)
Zantac is effective27.27%
(3 of 11 people)
(1 of 2 people)

Most common drug interactions by gender * :

Febrile NeutropeniaDyspnoea

Drug effectiveness by age :

Zofran is effectiven/a0.00%
(0 of 1 people)
(2 of 4 people)
(0 of 1 people)
(1 of 1 people)
(1 of 26 people)
(1 of 3 people)
Zantac is effectiven/a0.00%
(0 of 1 people)
(0 of 4 people)
(1 of 1 people)
(1 of 1 people)
(1 of 26 people)
(1 of 3 people)

Most common drug interactions by age * :

Maternal Drugs Affecting FoetusVomitingVomitingAcute Respiratory Distress SyndromeFoetal Growth RestrictionPainNauseaNausea
Extrapyramidal DisorderHeadacheMuscular WeaknessCholecystitis ChronicAcute Respiratory Distress SyndromeAnxietyDiarrhoeaPyrexia
ThrombocytopeniaPyrexiaLiver Function Test AbnormalAnxietyPremature BabyOedema PeripheralDehydrationVomiting
PyrexiaNauseaSeptic ShockKidney MalformationNauseaExcoriationPyrexiaDiarrhoea
NeutropeniaAbdominal PainBone Marrow FailureBiliary DyskinesiaVomitingDeformityVomitingAnaemia
Abdominal DistensionCoughHypersensitivityEmotional DistressDecreased AppetiteAnhedoniaAnaemiaFatigue
Tardive DyskinesiaDyskinesiaPyrexiaPainDehydrationHypotensionFatiguePain
Hypertonia NeonatalDyspnoeaNeutropeniaGallbladder InjuryMaternal Exposure During PregnancyPruritusNeutropeniaDyspnoea
BlisterStevens Johnson SyndromeRenal Failure AcuteGeneral Physical Health DeteriorationLive BirthUrinary Tract InfectionFebrile NeutropeniaThrombocytopenia
Premature BabyMulti-organ FailurePainFoetal Exposure During PregnancyPainPneumoniaAstheniaAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Zofran and Zantac on

Do you take Zofran and Zantac?

You are not alone! Join a related mobile support group:
- support group for people who take Zofran and Zantac
- support group for people who take Zantac
- support group for people who take Zofran

Can you answer these questions (Ask a question):

More questions for: Zantac, Zofran

You may be interested at these reviews (Write a review):

  • Nightmares from miralax
    Used for an endoscopy prep, great for what it does but gave me horrid and vivid nightmares
  • Ranitidine is bad juju
    Used 3-5 times per week for about 1 1/2 years. Noticed:
    shortness of breath
    contstricted throat
    chest pain/pressure
    heart palpatations
    dryness - more so than usual

    I quit taking it and felt much better within 2-3 days.
  • Polyuria associated with zantac
    I was prescribed Zantac 150mg before breakfast and before dinner. After two days, I felt tired and had polyuria (by weight change 650 mL). I had kidney pain so drank water with a tiny bit of salt. Felt very nauseous, but more water helped. Continued to sip water til kidney pain eased. Have discontinued Zantac. Kidneys stopped hurting after about 4 hours. Seem to be ok, now.
  • I got pneumonia while taking topamax, obvious correlation
    I do not take all the medicines above all the time but I am using an implanted pump giving me less than 2mg of dilaudid per day, 75 mg effexor daily and usually buspar. Dr prescribed topamax within 4 days I was hospitalized with Pneumonia, stayed a week came home a week had a clear chest x ray and the next week I got it again and was hospitalized 9 days that time. I knew I had been on the med but could not remember the side effect that made me come off previously until i started it again 2 days ago and woke today with Pneumonia again. Last time my pulmonologist said that the med in combination with the antidepressant which is all I take right now relaxes me too much and it paralyzes my choking reflex causing aspiration of saliva and ultimately waking up sick as the bacteria laced fluid goes crazy in the moist conditions of the lungs.

More reviews for: Zantac, Zofran

Comments from related studies:

  • From this study (1 year ago):

  • Symptoms have been going on for three years. Doctor's have done MRI's, CT's, Ultrasounds, and several lab test. They have yet to find any cause for the nausea, vomiting and dizziness. Only thing they have not tried is discontinuing some of the medicine.


Complete drug side effects:

On eHealthMe, Zofran (ondansetron hydrochloride) is often used to treat nausea. Zantac (ranitidine hydrochloride) is often used to treat gastroesophageal reflux disease. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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