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Review: Zofran and Zantac

This review analyzes the effectiveness and drug interactions between Zofran and Zantac. It is created by eHealthMe based on reports of 1,129 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Zofran and Zantac >>>

What are the drugs

Zofran (latest outcomes from 869 users) has active ingredients of ondansetron hydrochloride. It is often used in nausea.

Zantac (latest outcomes from 35,508 users) has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease.

On Oct, 13, 2014: 1,129 people who take Zofran, Zantac are studied

Zofran, Zantac outcomes

Drug combinations in study:
- Zofran (ondansetron hydrochloride)
- Zantac (ranitidine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zofran is effective25.00%
(1 of 4 people)
(2 of 6 people)
(0 of 1 people)
(1 of 1 people)
Zantac is effective0.00%
(0 of 6 people)
(0 of 1 people)
(0 of 1 people)
(1 of 2 people)
(1 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
NauseaFebrile NeutropeniaPeripheral Motor NeuropathyNauseaCardiac ArrestBurning EyesDiarrhoeaNausea
Febrile NeutropeniaDiarrhoeaAbdominal Pain UpperDyspnoeaNephrogenic Systemic FibrosisHypomagnesaemiaPyrexia
DiarrhoeaDyspnoeaCholecystitis ChronicSinus TachycardiaAstheniaVomiting
Renal Failure AcuteDehydrationGallbladder InjuryPain In ExtremityLower Respiratory Tract InfectionPain
FatigueMelaenaPco2 DecreasedDecreased AppetiteDyspnoea
VomitingNauseaMyocardial InfarctionOral CandidiasisAnaemia
PneumoniaVomitingMusculoskeletal PainNauseaNeutropenia
Clostridium Difficile ColitisClostridium Difficile ColitisLeukocytosisCoughDiarrhoea
Acute Respiratory Distress SyndromeRenal Failure AcuteProductive CoughDyspepsiaDehydration
DyspnoeaPneumoniaRenal FailureHypoalbuminaemiaAnxiety

Drug effectiveness by gender :

Zofran is effective30.00%
(3 of 10 people)
(1 of 2 people)
Zantac is effective20.00%
(2 of 10 people)
(1 of 2 people)

Most common drug interactions by gender * :


Drug effectiveness by age :

Zofran is effectiven/a0.00%
(0 of 1 people)
(2 of 4 people)
(0 of 1 people)
(1 of 1 people)
(0 of 2 people)
(1 of 3 people)
Zantac is effectiven/a0.00%
(0 of 1 people)
(0 of 4 people)
(1 of 1 people)
(1 of 1 people)
(0 of 2 people)
(1 of 3 people)

Most common drug interactions by age * :

Maternal Drugs Affecting FoetusVomitingVomitingAcute Respiratory Distress SyndromeFoetal Growth RestrictionPainNauseaNausea
Extrapyramidal DisorderHeadacheMuscular WeaknessCholecystitis ChronicAcute Respiratory Distress SyndromeAnxietyDiarrhoeaPyrexia
ThrombocytopeniaPyrexiaLiver Function Test AbnormalAnxietyPremature BabyOedema PeripheralDehydrationVomiting
PyrexiaNauseaSeptic ShockKidney MalformationNauseaExcoriationPyrexiaDiarrhoea
NeutropeniaAbdominal PainBone Marrow FailureBiliary DyskinesiaVomitingDeformityVomitingAnaemia
Abdominal DistensionCoughHypersensitivityEmotional DistressDecreased AppetiteAnhedoniaAnaemiaFatigue
Tardive DyskinesiaDyskinesiaPyrexiaPainDehydrationHypotensionFatiguePain
Hypertonia NeonatalDyspnoeaNeutropeniaGallbladder InjuryMaternal Exposure During PregnancyPruritusFebrile NeutropeniaDyspnoea
BlisterStevens Johnson SyndromeRenal Failure AcuteGeneral Physical Health DeteriorationLive BirthUrinary Tract InfectionNeutropeniaThrombocytopenia
Premature BabyMulti-organ FailurePainFoetal Exposure During PregnancyPainPneumoniaAstheniaAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Zofran and Zantac?

Get connected! Join a related mobile support group:
- support group for people who take Zofran and Zantac
- support group for people who take Zantac
- support group for people who take Zofran

Comments from related studies:

  • From this study (12 months ago):

  • Symptoms have been going on for three years. Doctor's have done MRI's, CT's, Ultrasounds, and several lab test. They have yet to find any cause for the nausea, vomiting and dizziness. Only thing they have not tried is discontinuing some of the medicine.


Can you answer these questions (what is this?):

More questions for: Zantac, Zofran

You may be interested at these reviews (what is this?):

  • Polyuria associated with zantac
    I was prescribed Zantac 150mg before breakfast and before dinner. After two days, I felt tired and had polyuria (by weight change 650 mL). I had kidney pain so drank water with a tiny bit of salt. Felt very nauseous, but more water helped. Continued to sip water til kidney pain eased. Have discontin ...

  • I got pneumonia while taking topamax, obvious correlation
    I do not take all the medicines above all the time but I am using an implanted pump giving me less than 2mg of dilaudid per day, 75 mg effexor daily and usually buspar. Dr prescribed topamax within 4 days I was hospitalized with Pneumonia, stayed a week came home a week had a clear chest x ray and ...

More reviews for: Zantac, Zofran

Complete drug side effects:

On eHealthMe, Zofran (ondansetron hydrochloride) is often used to treat nausea. Zantac (ranitidine hydrochloride) is often used to treat gastroesophageal reflux disease. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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