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Review: taking Zoloft and Benadryl together

Summary: drug interactions are reported among people who take Zoloft and Benadryl together.

This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on reports of 1,591 people who take the same drugs from FDA and social media, and is updated regularly.

 

You are not alone: join a support group for people who take Zoloft and Benadryl >>>

On Apr, 12, 2015: 1,591 people who take Zoloft, Benadryl are studied

Zoloft, Benadryl outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective12.50%
(1 of 8 people)
14.29%
(3 of 21 people)
18.18%
(2 of 11 people)
25.00%
(3 of 12 people)
80.00%
(8 of 10 people)
69.23%
(9 of 13 people)
66.67%
(4 of 6 people)
100.00%
(1 of 1 people)
Benadryl is effective36.00%
(9 of 25 people)
63.64%
(7 of 11 people)
33.33%
(2 of 6 people)
50.00%
(4 of 8 people)
80.00%
(12 of 15 people)
57.14%
(4 of 7 people)
75.00%
(3 of 4 people)
0.00%
(0 of 2 people)

Drug effectiveness by gender :

FemaleMale
Zoloft is effective38.81%
(26 of 67 people)
35.71%
(5 of 14 people)
Benadryl is effective58.73%
(37 of 63 people)
21.43%
(3 of 14 people)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Zoloft is effectiven/an/a12.50%
(1 of 8 people)
13.04%
(6 of 46 people)
22.73%
(10 of 44 people)
42.31%
(11 of 26 people)
17.65%
(3 of 17 people)
0.00%
(0 of 3 people)
Benadryl is effectiven/an/a50.00%
(4 of 8 people)
23.91%
(11 of 46 people)
23.26%
(10 of 43 people)
24.00%
(6 of 25 people)
44.44%
(8 of 18 people)
50.00%
(1 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaThrombocytopeniaMaternal Exposure During PregnancyDepressionBack PainPanic AttacksRashNausea
PneumoniaMuscle Contractions InvoluntaryHeart Disease CongenitalRestless Leg SyndromeDrug Toxicity NosBlood Creatinine IncreasedHeart Rate AbnormalPain
VomitingExhaustion, Fatigue, Lethargy, Tiredness, WearinessFallot's TetralogyInsomniaComaSuicide AttemptCrying - Excessive (0-6 Months)Headache
Motor DysfunctionMelaenaStatus EpilepticusNeck PainRespiratory ArrestHepatic FailureParanoid Personality DisorderAnxiety
Urinary RetentionHaemorrhage IntracranialSyncopeNeck SwellingOedema PeripheralConfusional StateWeight GainFatigue
Haemoglobin DecreasedNumbness And TinglingUterine Disorder NosGastrointestinal HaemorrhagePhysical DisabilityOliguriaInsomniaDyspnoea
Urinary Bladder HaemorrhageDrug ToxicitySleep Apnoea SyndromeNauseaDeep Vein ThrombosisAbdomen - SwollenAdjustment Disorder With Mixed Anxiety And Depressed MoodVomiting
AbasiaDepressed Level Of ConsciousnessRash NosMuscle TwitchingThrombosisConstipationNervousnessPyrexia
Abnormal BehaviourSomnolenceSkin Lesion NosHair LossPain In ExtremityPitting OedemaWeight Loss DietChest Pain
DysuriaDrug Specific Antibody PresentVisual Disturbance NosRinging In The EarsPainDepressionDepressionAsthenia

Most common drug interactions by gender * :

FemaleMale
PainHeadache
NauseaNausea
HeadachePain
AnxietyAnxiety
Chest PainBack Pain
FatigueDepression
PyrexiaDyspnoea
DyspnoeaVomiting
AnaemiaPneumonia
VomitingFatigue

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NervousnessPosture AbnormalPainPainCompleted SuicideHeadacheChest PainNausea
Drug Withdrawal Syndrome NeonatalObsessive-compulsive DisorderParaesthesiaHeadacheDepressionPainDyspnoeaDehydration
Apgar Score LowMuscle SpasmsDizzinessAnxietyHeadacheBack PainPainPneumonia
Eyelid PtosisHeadachePyrexiaDiabetes MellitusAnxietyNauseaAsthenia
HyperhidrosisLymphadenitisDizzinessNauseaArthralgiaAnxietyFatigue
SomnolenceVomitingNauseaPyrexiaNauseaPyrexiaPain
Speech DisorderPhotophobiaPalpitationsAnxietyAstheniaFatigueBack Pain
Weight IncreasedDrug HypersensitivityFatigueInsomniaFallHeadacheHaemoglobin Decreased
Withdrawal SyndromeHypotensionDepressionPainPain In ExtremityPneumoniaDiarrhoea
VomitingWeight IncreasedHypoaesthesiaChest PainAnaemiaVomitingAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Zoloft and Benadryl on

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You are not alone! Join a related support group:
- support group for people who take Benadryl
- support group for people who take Zoloft

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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