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Review: Zoloft and Benadryl





Summary: drug interactions are reported among people who take Zoloft and Benadryl together.

This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on reports of 1,590 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Zoloft and Benadryl >>>

What are the drugs

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 78,283 users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from Benadryl 29,367 users)

On Dec, 12, 2014: 1,590 people who take Zoloft, Benadryl are studied

Zoloft, Benadryl outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective12.50%
(1 of 8 people)
15.00%
(3 of 20 people)
18.18%
(2 of 11 people)
25.00%
(3 of 12 people)
80.00%
(8 of 10 people)
69.23%
(9 of 13 people)
66.67%
(4 of 6 people)
100.00%
(1 of 1 people)
Benadryl is effective33.33%
(8 of 24 people)
63.64%
(7 of 11 people)
33.33%
(2 of 6 people)
50.00%
(4 of 8 people)
80.00%
(12 of 15 people)
57.14%
(4 of 7 people)
75.00%
(3 of 4 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PneumoniaThrombocytopeniaMaternal Exposure During PregnancyDepressionBack PainPanic AttacksRashNausea
DyspnoeaMuscle Contractions InvoluntaryHeart Disease CongenitalRestless Leg SyndromeDrug Toxicity NosBlood Creatinine IncreasedHeart Rate AbnormalPain
VomitingRespiratory ArrestFallot's TetralogyInsomniaComaSuicide AttemptCrying - Excessive (0-6 Months)Headache
AbasiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessStatus EpilepticusNeck PainRespiratory ArrestHepatic FailureParanoid Personality DisorderAnxiety
DysuriaHaemorrhage IntracranialSyncopeNeck SwellingOedema PeripheralConfusional StateWeight GainFatigue
Urinary Bladder HaemorrhageDrug Specific Antibody PresentUterine Disorder NosGastrointestinal HaemorrhagePhysical DisabilityOliguriaInsomniaDyspnoea
Motor DysfunctionNumbness And TinglingSleep Apnoea SyndromeNauseaDeep Vein ThrombosisAbdomen - SwollenAdjustment Disorder With Mixed Anxiety And Depressed MoodVomiting
Haemoglobin DecreasedDrug ToxicityRash NosMuscle TwitchingThrombosisConstipationNervousnessPyrexia
Urinary RetentionDepressed Level Of ConsciousnessSkin Lesion NosHair LossPain In ExtremityPitting OedemaWeight Loss DietChest Pain
Abnormal BehaviourSomnolenceVisual Disturbance NosRinging In The EarsPainDepressionDepressionAsthenia

Drug effectiveness by gender :

FemaleMale
Zoloft is effective39.39%
(26 of 66 people)
35.71%
(5 of 14 people)
Benadryl is effective58.06%
(36 of 62 people)
21.43%
(3 of 14 people)

Most common drug interactions by gender * :

FemaleMale
PainHeadache
NauseaNausea
HeadachePain
AnxietyAnxiety
Chest PainBack Pain
FatigueDepression
PyrexiaDyspnoea
DyspnoeaVomiting
AnaemiaPneumonia
VomitingFatigue

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Zoloft is effectiven/an/a12.50%
(1 of 8 people)
13.64%
(6 of 44 people)
22.73%
(10 of 44 people)
42.31%
(11 of 26 people)
17.65%
(3 of 17 people)
0.00%
(0 of 3 people)
Benadryl is effectiven/an/a50.00%
(4 of 8 people)
22.73%
(10 of 44 people)
23.26%
(10 of 43 people)
24.00%
(6 of 25 people)
44.44%
(8 of 18 people)
50.00%
(1 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NervousnessPosture AbnormalPainPainCompleted SuicideHeadacheChest PainNausea
Drug Withdrawal Syndrome NeonatalObsessive-compulsive DisorderParaesthesiaHeadacheDepressionPainDyspnoeaDehydration
Apgar Score LowMuscle SpasmsDizzinessAnxietyHeadacheBack PainPainPneumonia
Eyelid PtosisHeadachePyrexiaDiabetes MellitusAnxietyNauseaAsthenia
HyperhidrosisLymphadenitisDizzinessNauseaArthralgiaAnxietyFatigue
SomnolenceVomitingFatiguePyrexiaNauseaPyrexiaPain
Speech DisorderPhotophobiaDepressionAnxietyAstheniaFatigueBack Pain
Weight IncreasedDrug HypersensitivityPalpitationsInsomniaFallHeadacheHaemoglobin Decreased
Withdrawal SyndromeHypotensionNauseaPainPain In ExtremityPneumoniaDiarrhoea
VomitingWeight IncreasedHypoaesthesiaChest PainAnaemiaVomitingAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Zoloft and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Zoloft and Benadryl
- support group for people who take Benadryl
- support group for people who take Zoloft

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Benadryl, Zoloft

You may be interested at these reviews (Write a review):

  • Loss of menstruation
    Hi
    I stopped using setralin 50 µg in August 2014. (I have been taken it in 1 year for my PMS). After stopping taking the pills my period become very short in september and then desappeard. I got a funcional cyste (about 30 mm) and after 10-days treatment with progesterone I got my period in the end of oktober. Two weeks afterwards I got a spare bleeding and my gyn thought that it my be an ovulation bleeding. Anyhow I have not got my period yet. The samples taken in oktober showed low FSH and heigt E2. The doctor explained that it is posible that stopping setralin could cause this hormonal imbalance. I must say that my periods were not so regular for very long time like during that year with setralin but I had other side effects like problem with concentartion, nussea etc.
    For many years ago I was on Zoloft but I had not experienced the same problem. When I started the treatment this time they did not want to give me zoloft (because of the price). I had no choice but i experienced many symptoms from different generica of Setralin. I will meet my doctor om Monday again.
  • Dyphenhydramine and headaches horrible going one almost 24 hours a day for 4 weeks and cant get them to stop, now looking for cause . think its the dyphenhydramine im taking to help me sleep .
    have been taking 3 dyphenhydramine for some time to help me sleep , just in last few weeks began having severe headache almost all the time.. cant get it to go away. just found out it can cause headache and am going to lower my intake to one per night and see if my headaches get better. am taking migrane meds and that hasnt helped a bit so think its not migranes im having. some other reason.
  • Soar throat after taking sertaline
    half a pill first timw. severe soar throat 2 hrs after taking 25mg
  • Nightmare on benadryl
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I think I'm going to pass on this meds, and pass out next time :) thank you,God bless
  • Miscarriage 6 weeks while on sertraline
    On sertraline 150 mg a day, alcohol (1+ drink a day) and high caffeine. Sertraline lowered to 100mg when 4.5 weeks pregnant, no alcohol no caffeine. Miscarried at 6 weeks.

More reviews for: Benadryl, Zoloft

Comments from related studies:

  • From this study (2 months ago):

  • My ears were bothering me last week and were clogged and had ringing in the ears. I got them cleaned and the ringing was still there. I noticed it even more when I raised my Zoloft intake.

    Reply

  • From this study (2 months ago):

  • Had clogged ears with ear wax this week. Got them cleaned and noticed the ringing. Also noticed the ringing after raising my Zoloft.

    Reply

  • From this study (1 year ago):

  • Have developed muscle pain about the chest and upper back. Am wondering whether this has been caused by one or both drugs, or something else.

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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