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Review: Zoloft and Benadryl

This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on reports of 1,587 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: get help anytime and anywhere for people who take Zoloft and Benadryl >>>

What are the drugs

Zoloft (latest outcomes from 78,096 users) has active ingredients of sertraline hydrochloride. It is often used in depression.

Benadryl (latest outcomes from 29,318 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

On Jul, 11, 2014: 1,587 people who take Zoloft, Benadryl are studied

Zoloft, Benadryl outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective12.50%
(1 of 8 people)
15.79%
(3 of 19 people)
18.18%
(2 of 11 people)
25.00%
(3 of 12 people)
80.00%
(8 of 10 people)
75.00%
(9 of 12 people)
80.00%
(4 of 5 people)
100.00%
(1 of 1 people)
Benadryl is effective33.33%
(8 of 24 people)
63.64%
(7 of 11 people)
33.33%
(2 of 6 people)
50.00%
(3 of 6 people)
80.00%
(12 of 15 people)
57.14%
(4 of 7 people)
66.67%
(2 of 3 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PneumoniaThrombocytopeniaMaternal Exposure During PregnancyDepressionBack PainPanic AttacksAdjustment Disorder With Mixed Anxiety And Depressed MoodNausea
DyspnoeaMelaenaHeart Disease CongenitalRestless Leg SyndromeDrug Toxicity NosBlood Creatinine IncreasedInsomniaPain
VomitingRespiratory ArrestFallot's TetralogyInsomniaComaSuicide AttemptHeart Rate AbnormalHeadache
AbasiaHaemorrhage IntracranialStatus EpilepticusNeck SwellingRespiratory ArrestHepatic FailureRashAnxiety
DysuriaExhaustion, Fatigue, Lethargy, Tiredness, WearinessSyncopeNeck PainOedema PeripheralConfusional StateDepressionFatigue
Urinary Bladder HaemorrhageDrug Specific Antibody PresentUterine Disorder NosSuicidal IdeationPhysical DisabilityOliguriaWeight Loss DietDyspnoea
Motor DysfunctionNumbness And TinglingSleep Apnoea SyndromeGastrointestinal HaemorrhageDeep Vein ThrombosisAbdomen - SwollenNervousnessVomiting
Haemoglobin DecreasedDrug ToxicityRash NosNauseaThrombosisConstipationNumbness In Hands Or FeetPyrexia
Urinary RetentionDepressed Level Of ConsciousnessSkin Lesion NosAgitationPain In ExtremityPitting OedemaNumbness And TinglingChest Pain
Abnormal BehaviourSomnolenceVisual Disturbance NosMuscle TwitchingPainDepressionImplant Site BruisingAsthenia

Drug effectiveness by gender :

FemaleMale
Zoloft is effective40.62%
(26 of 64 people)
38.46%
(5 of 13 people)
Benadryl is effective58.33%
(35 of 60 people)
15.38%
(2 of 13 people)

Most common drug interactions by gender * :

FemaleMale
PainHeadache
NauseaNausea
HeadachePain
AnxietyAnxiety
Chest PainBack Pain
FatigueDepression
PyrexiaDyspnoea
DyspnoeaVomiting
AnaemiaFatigue
VomitingPneumonia

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Zoloft is effectiven/an/a12.50%
(1 of 8 people)
13.95%
(6 of 43 people)
26.32%
(10 of 38 people)
42.31%
(11 of 26 people)
17.65%
(3 of 17 people)
0.00%
(0 of 2 people)
Benadryl is effectiven/an/a50.00%
(4 of 8 people)
20.93%
(9 of 43 people)
24.32%
(9 of 37 people)
24.00%
(6 of 25 people)
44.44%
(8 of 18 people)
100.00%
(1 of 1 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NervousnessPosture AbnormalPainPainCompleted SuicideHeadacheChest PainNausea
Drug Withdrawal Syndrome NeonatalObsessive-compulsive DisorderParaesthesiaHeadacheDepressionPainDyspnoeaDehydration
Apgar Score LowMuscle SpasmsDizzinessAnxietyHeadacheBack PainPainPneumonia
Eyelid PtosisHeadacheDizzinessNauseaAnxietyNauseaAsthenia
HyperhidrosisLymphadenitisPyrexiaDiabetes MellitusArthralgiaAnxietyFatigue
SomnolenceVomitingNauseaPyrexiaNauseaPyrexiaPain
Speech DisorderPhotophobiaDepressionAnxietyAstheniaFatigueBack Pain
Weight IncreasedDrug HypersensitivityPalpitationsInsomniaFallHeadacheHaemoglobin Decreased
Withdrawal SyndromeHypotensionFatiguePainPain In ExtremityPneumoniaDiarrhoea
VomitingWeight IncreasedHypoaesthesiaHaemoglobin DecreasedAnaemiaVomitingWeight Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Zoloft and Benadryl
- group for people who take Benadryl
- group for people who take Zoloft

Comments from related studies:

  • From this study (10 months ago):

  • Have developed muscle pain about the chest and upper back. Am wondering whether this has been caused by one or both drugs, or something else.

    Reply

  • From this study (10 months ago):

  • I took all the medicines like I am supposed to at night and I used th mouthwash and about 30 minutes later I started to hallucinate. is the mixture of the medicine that caused me to hallucinate

    Reply

  • From this study (10 months ago):

  • I had several violent panic attacks just after 2 dosis of Benadryl, which I took to heal the skin itching. I suppose this itching is produced by Amoxiciline, correct?

    Reply

Post a new comment    OR    Read more comments

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Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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