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Home > Zoloft > Benadryl > Zoloft and Benadryl

Review: Zoloft and Benadryl

Summary: drug interactions are reported among people who take Zoloft and Benadryl together.

This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on reports of 1,590 people who take the same drugs from FDA and social media, and is updated regularly.

You are not alone: join a mobile support group for people who take Zoloft and Benadryl >>>

What are the drugs

Zoloft (latest outcomes from 78,254 users) has active ingredients of sertraline hydrochloride. It is often used in depression.

Trend of zoloft reports

Benadryl (latest outcomes from 29,359 users) has active ingredients of diphenhydramine hydrochloride. It is often used in allergies.

Trend of benadryl reports

On Nov, 12, 2014: 1,590 people who take Zoloft, Benadryl are studied

Zoloft, Benadryl outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective12.50%
(1 of 8 people)
15.00%
(3 of 20 people)
18.18%
(2 of 11 people)
25.00%
(3 of 12 people)
80.00%
(8 of 10 people)
69.23%
(9 of 13 people)
66.67%
(4 of 6 people)
100.00%
(1 of 1 people)
Benadryl is effective33.33%
(8 of 24 people)
63.64%
(7 of 11 people)
33.33%
(2 of 6 people)
50.00%
(4 of 8 people)
80.00%
(12 of 15 people)
57.14%
(4 of 7 people)
75.00%
(3 of 4 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
PneumoniaThrombocytopeniaMaternal Exposure During PregnancyDepressionBack PainPanic AttacksRashNausea
DyspnoeaMuscle Contractions InvoluntaryHeart Disease CongenitalRestless Leg SyndromeDrug Toxicity NosBlood Creatinine IncreasedHeart Rate AbnormalPain
VomitingRespiratory ArrestFallot's TetralogyInsomniaComaSuicide AttemptCrying - Excessive (0-6 Months)Headache
AbasiaExhaustion, Fatigue, Lethargy, Tiredness, WearinessStatus EpilepticusNeck PainRespiratory ArrestHepatic FailureParanoid Personality DisorderAnxiety
DysuriaHaemorrhage IntracranialSyncopeNeck SwellingOedema PeripheralConfusional StateWeight GainFatigue
Urinary Bladder HaemorrhageDrug Specific Antibody PresentUterine Disorder NosGastrointestinal HaemorrhagePhysical DisabilityOliguriaInsomniaDyspnoea
Motor DysfunctionNumbness And TinglingSleep Apnoea SyndromeNauseaDeep Vein ThrombosisAbdomen - SwollenAdjustment Disorder With Mixed Anxiety And Depressed MoodVomiting
Haemoglobin DecreasedDrug ToxicityRash NosMuscle TwitchingThrombosisConstipationNervousnessPyrexia
Urinary RetentionDepressed Level Of ConsciousnessSkin Lesion NosHair LossPain In ExtremityPitting OedemaWeight Loss DietChest Pain
Abnormal BehaviourSomnolenceVisual Disturbance NosRinging In The EarsPainDepressionDepressionAsthenia

Drug effectiveness by gender :

FemaleMale
Zoloft is effective39.39%
(26 of 66 people)
35.71%
(5 of 14 people)
Benadryl is effective58.06%
(36 of 62 people)
21.43%
(3 of 14 people)

Most common drug interactions by gender * :

FemaleMale
PainHeadache
NauseaNausea
HeadachePain
AnxietyAnxiety
Chest PainBack Pain
FatigueDepression
PyrexiaDyspnoea
DyspnoeaVomiting
AnaemiaPneumonia
VomitingFatigue

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Zoloft is effectiven/an/a12.50%
(1 of 8 people)
13.64%
(6 of 44 people)
22.73%
(10 of 44 people)
42.31%
(11 of 26 people)
17.65%
(3 of 17 people)
0.00%
(0 of 3 people)
Benadryl is effectiven/an/a50.00%
(4 of 8 people)
22.73%
(10 of 44 people)
23.26%
(10 of 43 people)
24.00%
(6 of 25 people)
44.44%
(8 of 18 people)
50.00%
(1 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NervousnessPosture AbnormalPainPainCompleted SuicideHeadacheChest PainNausea
Drug Withdrawal Syndrome NeonatalObsessive-compulsive DisorderParaesthesiaHeadacheDepressionPainDyspnoeaDehydration
Apgar Score LowMuscle SpasmsDizzinessAnxietyHeadacheBack PainPainPneumonia
Eyelid PtosisHeadachePyrexiaDiabetes MellitusAnxietyNauseaAsthenia
HyperhidrosisLymphadenitisDizzinessNauseaArthralgiaAnxietyFatigue
SomnolenceVomitingFatiguePyrexiaNauseaPyrexiaPain
Speech DisorderPhotophobiaDepressionAnxietyAstheniaFatigueBack Pain
Weight IncreasedDrug HypersensitivityPalpitationsInsomniaFallHeadacheHaemoglobin Decreased
Withdrawal SyndromeHypotensionNauseaPainPain In ExtremityPneumoniaDiarrhoea
VomitingWeight IncreasedHypoaesthesiaChest PainAnaemiaVomitingAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Zoloft and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Zoloft and Benadryl
- support group for people who take Benadryl
- support group for people who take Zoloft

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Benadryl, Zoloft

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    half a pill first timw. severe soar throat 2 hrs after taking 25mg

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    (Posted by a 54 year old man who has Nightmare, Hard Time Sleeping, and takes Benadryl)
    After 5 nights without sleep and not having past bad dreams, the last 2 night's taking walfrin sub, for benadryl has terrified THE WORST OF WORST dream in my 55 years. Peaceful start of a dream then seeing myself or family,friends get slottard.crazy thing is I don't watch scary movies or the news. I ...

  • Miscarriage 6 weeks while on sertraline
    (Posted by a 37 year old woman who has Miscarriage, and takes Caffeine, Alcohol, Sertraline)
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  • Benadryl completed suicide 50 year old
    (Posted by a 50 year old woman who has Completed Suicide, and takes Alcohol, Methenamine Hippurate, Xanax, Benadryl)
    My mother comitted suicide by taking a bottle of Benadryl. She also had been drinking, she had taken xanax and drank beer, she also took 300 Benadryl pills and started having seizures and went to the hospital was brain dead and her heart stopped the next morning.

  • Had nms in 2005, will trileptal increase chance of recurrence?
    (Posted by a 62 year old woman who has Narcolepsy, Prinzmetal's Angina , Antiphospholipid Syndrome, High Blood Pressure, Obsessive-compulsive Personality Disorder, Cyclic Vomiting Syndrome, Migraine With Aura, Herniated Intervertebral Disk, Osteoarthritis, Fibromyalgia, Rheumatoid Arthritis, Diabetes Mellitus Insulin-dependent, Bipolar I Disorder, and takes Benadryl, Baclofen, Plaquenil, Nitro-bid, Maxalt-mlt, Imitrex, Zofran Odt, Ms Contin, Clonidine, Amlodipine Besylate, Novolog Flexpen, Levemir Flexpen, Halcion, Valium, Primidone, Neurontin, Trileptal)
    In 2005 I had NMS, which was not detected by my drs for 4 months. I'd been on Lexapro & Seroquel for 2 yrs, but was weaned from Lexapro & placed on Lamictal 3/05. Began getting low-grade fevers, which I was told were not caused by the Lamictal. I quit taking it anyway, fevers (along with uncontrolla ...

More reviews for: Benadryl, Zoloft

Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Recent related drug studies (Check your drugs):

More related studies for: Benadryl, Zoloft

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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