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Review: Zoloft and Benadryl

This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on 1,502 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

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On Apr, 4, 2014: 1,502 people who reported to have interactions when taking Zoloft, Benadryl are studied

Trend of Zoloft, Benadryl's drug interactions, side effects and effectiveness reports (8518686)

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

eHealthMe real world results:

Most common interactions experienced by people in the use of Zoloft, Benadryl:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Anxiety630
Dyspnoea (difficult or laboured respiration)505
Asthenia (weakness)468
Pain467
Vomiting447
Nausea (feeling of having an urge to vomit)428
Headache (pain in head)384
Chest Pain340
Fatigue (feeling of tiredness)321
Depression305

Most common interactions experienced by people in long term use of Zoloft, Benadryl:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
Coma (state of unconsciousness lasting more than six hours)15
Anxiety14
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)10
Back Pain10
Respiratory Arrest (cessation of normal respiration due to failure of the lungs to function effectively)9
Insomnia (sleeplessness)8
Depression8
Drug Ineffective6
Drug Interaction Nos6
Drug Toxicity Nos6

How effective are the drugs:

not at allsomewhatmoderatehighvery high
Zoloft9.52%28.57%33.33%28.57%0.00%
Benadryl0.00%9.09%27.27%54.55%9.09%

Top conditions involved for these people * :

  1. Depression
  2. Pain
  3. Ill-defined disorder
  4. Premedication
  5. Anxiety

Top co-used drugs for these people * :

  1. Seroquel
  2. Diphenhydramine hcl
  3. Heparin sodium injection
  4. Aspirin
  5. Sertraline hcl

* Approximation only. Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Benadryl, Zoloft

You can also:

Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergen. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

Comments from related studies:

  • From this study (7 months ago):

  • Have developed muscle pain about the chest and upper back. Am wondering whether this has been caused by one or both drugs, or something else.

    Reply

  • From this study (7 months ago):

  • I took all the medicines like I am supposed to at night and I used th mouthwash and about 30 minutes later I started to hallucinate. is the mixture of the medicine that caused me to hallucinate

    Reply

  • From this study (7 months ago):

  • I had several violent panic attacks just after 2 dosis of Benadryl, which I took to heal the skin itching. I suppose this itching is produced by Amoxiciline, correct?

    Reply

Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

More questions for: Benadryl, Zoloft

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More reviews for: Benadryl, Zoloft

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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