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Review: taking Zoloft and Benadryl together

Summary: drug interactions are reported among people who take Zoloft and Benadryl together.

This review analyzes the effectiveness and drug interactions between Zoloft and Benadryl. It is created by eHealthMe based on reports of 1,591 people who take the same drugs from FDA and social media, and is updated regularly.

 

 

 

 

You are not alone: join a mobile support group for people who take Zoloft and Benadryl >>>

What are the drugs

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from 78,365 Zoloft users)

Benadryl has active ingredients of diphenhydramine hydrochloride. It is often used in allergies. (latest outcomes from 29,393 Benadryl users)

On Feb, 11, 2015: 1,591 people who take Zoloft, Benadryl are studied

Zoloft, Benadryl outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Benadryl (diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective12.50%
(1 of 8 people)
14.29%
(3 of 21 people)
18.18%
(2 of 11 people)
25.00%
(3 of 12 people)
80.00%
(8 of 10 people)
69.23%
(9 of 13 people)
66.67%
(4 of 6 people)
100.00%
(1 of 1 people)
Benadryl is effective36.00%
(9 of 25 people)
63.64%
(7 of 11 people)
33.33%
(2 of 6 people)
50.00%
(4 of 8 people)
80.00%
(12 of 15 people)
57.14%
(4 of 7 people)
75.00%
(3 of 4 people)
0.00%
(0 of 2 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaThrombocytopeniaMaternal Exposure During PregnancyDepressionBack PainPanic AttacksRashNausea
PneumoniaMuscle Contractions InvoluntaryHeart Disease CongenitalRestless Leg SyndromeDrug Toxicity NosBlood Creatinine IncreasedHeart Rate AbnormalPain
VomitingExhaustion, Fatigue, Lethargy, Tiredness, WearinessFallot's TetralogyInsomniaComaSuicide AttemptCrying - Excessive (0-6 Months)Headache
Motor DysfunctionMelaenaStatus EpilepticusNeck PainRespiratory ArrestHepatic FailureParanoid Personality DisorderAnxiety
Urinary RetentionHaemorrhage IntracranialSyncopeNeck SwellingOedema PeripheralConfusional StateWeight GainFatigue
Haemoglobin DecreasedNumbness And TinglingUterine Disorder NosGastrointestinal HaemorrhagePhysical DisabilityOliguriaInsomniaDyspnoea
Urinary Bladder HaemorrhageDrug ToxicitySleep Apnoea SyndromeNauseaDeep Vein ThrombosisAbdomen - SwollenAdjustment Disorder With Mixed Anxiety And Depressed MoodVomiting
AbasiaDepressed Level Of ConsciousnessRash NosMuscle TwitchingThrombosisConstipationNervousnessPyrexia
Abnormal BehaviourSomnolenceSkin Lesion NosHair LossPain In ExtremityPitting OedemaWeight Loss DietChest Pain
DysuriaDrug Specific Antibody PresentVisual Disturbance NosRinging In The EarsPainDepressionDepressionAsthenia

Drug effectiveness by gender :

FemaleMale
Zoloft is effective38.81%
(26 of 67 people)
35.71%
(5 of 14 people)
Benadryl is effective58.73%
(37 of 63 people)
21.43%
(3 of 14 people)

Most common drug interactions by gender * :

FemaleMale
PainHeadache
NauseaNausea
HeadachePain
AnxietyAnxiety
Chest PainBack Pain
FatigueDepression
PyrexiaDyspnoea
DyspnoeaVomiting
AnaemiaPneumonia
VomitingFatigue

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Zoloft is effectiven/an/a12.50%
(1 of 8 people)
13.04%
(6 of 46 people)
22.73%
(10 of 44 people)
42.31%
(11 of 26 people)
17.65%
(3 of 17 people)
0.00%
(0 of 3 people)
Benadryl is effectiven/an/a50.00%
(4 of 8 people)
23.91%
(11 of 46 people)
23.26%
(10 of 43 people)
24.00%
(6 of 25 people)
44.44%
(8 of 18 people)
50.00%
(1 of 2 people)

Most common drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
NervousnessPosture AbnormalPainPainCompleted SuicideHeadacheChest PainNausea
Drug Withdrawal Syndrome NeonatalObsessive-compulsive DisorderParaesthesiaHeadacheDepressionPainDyspnoeaDehydration
Apgar Score LowMuscle SpasmsDizzinessAnxietyHeadacheBack PainPainPneumonia
Eyelid PtosisHeadachePyrexiaDiabetes MellitusAnxietyNauseaAsthenia
HyperhidrosisLymphadenitisDizzinessNauseaArthralgiaAnxietyFatigue
SomnolenceVomitingNauseaPyrexiaNauseaPyrexiaPain
Speech DisorderPhotophobiaPalpitationsAnxietyAstheniaFatigueBack Pain
Weight IncreasedDrug HypersensitivityFatigueInsomniaFallHeadacheHaemoglobin Decreased
Withdrawal SyndromeHypotensionDepressionPainPain In ExtremityPneumoniaDiarrhoea
VomitingWeight IncreasedHypoaesthesiaChest PainAnaemiaVomitingAnaemia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Zoloft and Benadryl on

Do you take Zoloft and Benadryl?

You are not alone! Join a related mobile support group:
- support group for people who take Zoloft and Benadryl
- support group for people who take Benadryl
- support group for people who take Zoloft

Can you answer these questions (Ask a question):

  • What interaction could happen to a 7 1/2 yr. old inhaling symbicort and taking zoloft?
    Just starting Zoloft and has been on symbicort for some time. What could happen if taken together?
  • Ok to take losartan and zoloft together before bed? (2 answers)
    I've been on Losartan for a year without any problem. Six weeks ago I started on 25mg of Zoloft for general anxiety. All of a sudden during cardio exercise I feel lightheadedness and a feeling like I could pass out! I stop for a moment and then I feel ok. Is this normal? I thought I'd be getting more used to it after 6 weeks, but this is something new so I figured that it is now in my body and fatigue is normal. Or perhaps taking bp meds and Zoloft might be the cause.
  • Does the thymus affect dysthymia
    joy of living is imparted to the child by the bonding process. the thymus helps in developing antibodies and setting up the immune system and its function lessens through puberty until it effectively atrophies at maturity. my thesis is that a lack of bonding interferes with the action of the thymus leading to dysthymia (Greek for bad state of mind), elsewhere described as 'chronic discontent
  • I injected suboxone and now i feel weird this is not the first time i done it but the first time my arm is numb all over dizziness purple pinkish splotches all over my arm wat is wrong
    I shot an eighth of suboxone today and now my arm is purplish and red blotches there was no pain during or after injection only numbness dizziness and I can't get my nail nd to go to white it stays red this has never happened before.
  • What should i expect taking zoloft and hydroxyzine? (1 answer)
    I take 25mg Zoloft for one more day and bump up to 50 mg. I also take 25mg Hydroxyzine Pamoate 3 times per day as needed. I've been on these for a week and feel worse than when I wasn't. My depressive state seems to be getting worse and the anxiety is through the roof. My home is where I felt OK but now I hate it. My skin is crawling and I feel like I want to tear it off and crawl out. Is this a normal side effect of these drugs? I am also diabetic and take several meds for that, don't know if that makes a difference.

More questions for: Benadryl, Zoloft

You may be interested at these reviews (Write a review):

  • Sids/benedryl infant stopped breathing
    We are devastated. Our grand daughter was being breastfed and mother only took 1 tablet of Benedryl 25 mg and healthy baby girl died of SIDS following morning. Any information is appreciated.
  • Diphenhydramine and mental acuity
    For at least 10 years, I have taken diphenhydramine 50 mg. at bedtime for insomnia and allergies. The results have been that I sleep well with no hangover or any cognitive impairment. If I experience vertigo from allergies, I may take an additional 50 mg. but never exceeding 100 mg in a 24 hour period.

    After reading the report regarding an Alzheimer's study finding that after taking as little as 4mg diphenhydramine daily for more than 3 years, dementia rates were high.

    I stopped the diphenhydramine one night. I experienced symptoms of deep brain pulsating pain and severe insomnia. After 4 hours, I took 50 mg diphenhydramine and slept very well. The next night I took 37.5 mg. diphenhydramine, slept very well. However, some of my tasks require layers of mental challenges in which I became slower.

    My question is how did the study recipients obtain 4 mg doses of diphenhydramine when the standard over-the-counter (OTC) availability in tablets is 25 mg? How reliable is the information submitted from the study subjects? What manufacturer's diphendramine was used, or were there several?

    I felt sharper mentally when on 50 mg daily than so far on 37.5 mg.
  • Took buspirone once and got a blister
    Took Buspirone 5mg once and a few minutes later felt a bubble on my lip. The next morning I check and sure enough it's a blister on my top lip. Called a nurse and she said I had an allergic reaction.
  • Fluoxetine with hypnagogic hallucinations
    Was taking fluoxetine until recently for a depressive episode (suffered from depression pretty much my whole life). Strange hypnagogic hallucinations and bizarre thoughts, sometimes coupled with feeling faint. Also strong feelings of numbness for the first two weeks or so, headaches and dry mouth. Strangely only on 20mg...This is my second time on fluoxetine and the experience has been totally different (last time it seemed to make me act callously and superficially towards people, and to be generally irresponsible, going out, avoiding work etc.).

    Doctor had now changed me over to sertraline, been on it for 3 days and ok so far apart from minor headaches.
  • The zoloft/vyvanse concoction ruined my life.
    I started taking these drugs about two months ago. I am diagnosed ADHD by a psychiatrist. I received these medications from a doctor whom I know and is married to a friend my wife. She, the doctor, gave them to me from her personal medications in a plastic baggy. I was given loose instructions for taking these on a piece of paper. I was never given the paperwork with warning signs. 10 days after starting these medications, I attacked my wife and am now separated. I am barred from seeing her and my daughter by means of a Victims Protective Order. I am a normally nonviolent person. Most who know me call me a peacemaker...a pacifist. I am still horrified by the events of that night. 15 seconds changed my life forever. I hope and pray my story helps others. Don't be naïve, as I was, when given medications. Ask questions.

More reviews for: Benadryl, Zoloft

Comments from related studies:

  • From this study (4 months ago):

  • My ears were bothering me last week and were clogged and had ringing in the ears. I got them cleaned and the ringing was still there. I noticed it even more when I raised my Zoloft intake.

    Reply

  • From this study (4 months ago):

  • Had clogged ears with ear wax this week. Got them cleaned and noticed the ringing. Also noticed the ringing after raising my Zoloft.

    Reply

  • From this study (1 year ago):

  • Have developed muscle pain about the chest and upper back. Am wondering whether this has been caused by one or both drugs, or something else.

    Reply

Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Benadryl (diphenhydramine hydrochloride) is often used to treat allergies. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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