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Review: taking Zoloft and Cipro together

Summary: drug interactions are reported among people who take Zoloft and Cipro together.

This review analyzes the effectiveness and drug interactions between Zoloft and Cipro. It is created by eHealthMe based on reports of 259 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Zoloft and Cipro >>>

What are the drugs

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from 78,343 Zoloft users)

Cipro has active ingredients of ciprofloxacin hydrochloride. It is often used in urinary tract infection. (latest outcomes from 6,864 Cipro users)

On Jan, 27, 2015: 259 people who take Zoloft, Cipro are studied

Zoloft, Cipro outcomes

Drug combinations in study:
- Zoloft (sertraline hydrochloride)
- Cipro (ciprofloxacin hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effective0.00%
(0 of 3 people)
(1 of 5 people)
(1 of 4 people)
(0 of 2 people)
(2 of 3 people)
Cipro is effective25.00%
(3 of 12 people)
(1 of 1 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Abdominal PainSkin DiscolourationUrination - PainfulBleeding Time Abnormaln/aPulmonary EmbolismCholelithiasisPain
Urination - PainfulOedema PeripheralRaoultella Ornithinolytica InfectionPainAnxiety
Raoultella Ornithinolytica InfectionMuscular WeaknessFatigueInjury
HypophagiaSkin PlaqueGallbladder DisorderOsteonecrosis Of Jaw
NauseaMuscle FibrosisGastrointestinal DisorderHeadache
PyrexiaMyocardial FibrosisCardiac DisorderAbdominal Pain
Oral HerpesMuscle ContractureDyspepsiaPyrexia
Oedema MouthJoint Range Of Motion DecreasedNausea
Chronic Skin UlcerHypoaesthesiaBone Disorder
Extrasystoles NosHypokinesiaDepression

Drug effectiveness by gender :

Zoloft is effective30.77%
(4 of 13 people)
(0 of 4 people)
Cipro is effective50.00%
(5 of 10 people)
(0 of 4 people)

Most common drug interactions by gender * :

Abdominal PainPain
Osteonecrosis Of JawBack Pain
Bone DisorderOedema Peripheral
PyrexiaChest Pain
DepressionNeck Pain

Drug effectiveness by age :

Zoloft is effectiven/an/a0.00%
(0 of 1 people)
(0 of 2 people)
(2 of 5 people)
(1 of 1 people)
(1 of 6 people)
(0 of 4 people)
Cipro is effectiven/an/a0.00%
(0 of 1 people)
(1 of 4 people)
(2 of 2 people)
(0 of 5 people)
(2 of 4 people)

Most common drug interactions by age * :

Abdominal Pain UpperNauseaAbdominal PainAnxietyPainPain
ConstipationAbdominal PainChest PainPain In JawAnaemiaInjury
Gastrointestinal PainPyrexiaDiabetes MellitusDepressionOsteonecrosis Of JawBack Pain
Cholecystitis ChronicVomitingPainPain In ExtremityBone DisorderOedema Peripheral
Abdominal DistensionGallbladder PainHeadacheBone DisorderAbdominal PainOsteoarthritis
HeadachePainWeight IncreasedHeadacheNauseaOsteonecrosis Of Jaw
PallorAbdominal Pain UpperFatigueUrinary Tract InfectionImpaired HealingNeck Pain
RetchingCholecystitis ChronicInjuryDental CariesDyspnoeaMalaise

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Zoloft and Cipro?

You are not alone! Join a related mobile support group:
- support group for people who take Zoloft and Cipro
- support group for people who take Cipro
- support group for people who take Zoloft

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Cipro, Zoloft

You may be interested at these reviews (Write a review):

  • The zoloft/vyvanse concoction ruined my life.
    I started taking these drugs about two months ago. I am diagnosed ADHD by a psychiatrist. I received these medications from a doctor whom I know and is married to a friend my wife. She, the doctor, gave them to me from her personal medications in a plastic baggy. I was given loose instructions for taking these on a piece of paper. I was never given the paperwork with warning signs. 10 days after starting these medications, I attacked my wife and am now separated. I am barred from seeing her and my daughter by means of a Victims Protective Order. I am a normally nonviolent person. Most who know me call me a peacemaker...a pacifist. I am still horrified by the events of that night. 15 seconds changed my life forever. I hope and pray my story helps others. Don't be naïve, as I was, when given medications. Ask questions.
  • Loss of menstruation
    I stopped using setralin 50 µg in August 2014. (I have been taken it in 1 year for my PMS). After stopping taking the pills my period become very short in september and then desappeard. I got a funcional cyste (about 30 mm) and after 10-days treatment with progesterone I got my period in the end of oktober. Two weeks afterwards I got a spare bleeding and my gyn thought that it my be an ovulation bleeding. Anyhow I have not got my period yet. The samples taken in oktober showed low FSH and heigt E2. The doctor explained that it is posible that stopping setralin could cause this hormonal imbalance. I must say that my periods were not so regular for very long time like during that year with setralin but I had other side effects like problem with concentartion, nussea etc.
    For many years ago I was on Zoloft but I had not experienced the same problem. When I started the treatment this time they did not want to give me zoloft (because of the price). I had no choice but i experienced many symptoms from different generica of Setralin. I will meet my doctor om Monday again.
  • Soar throat after taking sertaline
    half a pill first timw. severe soar throat 2 hrs after taking 25mg
  • Miscarriage 6 weeks while on sertraline
    On sertraline 150 mg a day, alcohol (1+ drink a day) and high caffeine. Sertraline lowered to 100mg when 4.5 weeks pregnant, no alcohol no caffeine. Miscarried at 6 weeks.
  • Laryngitis and fluconazole
    Occasionally when I have a severe yeast infection, I get laryngitis. I am so thankful your article addresses this, as the doctors I have seen were less than receptive when I suggested a link. I do not have any of the other health concerns listed in the study, but am taking fluconazole.

More reviews for: Cipro, Zoloft

Comments from related studies:

  • From this study (2 months ago):

  • Developed severe pelvic pain, frequent and urgent urination with blood n urine. Treated with 500 mgs Cipro twice day for 10 days. Still have bacterial infection and blood n itinerary.


  • From this study (2 years ago):

  • i was given this in July 2012 and still have dizziness problem


  • From this study (2 years ago):

  • I was diagnosed with Prurigo nodularis in Jan '12 after biopsy was done and previously had two months of itching, sores, bumps on legs, head, shoulders, arms. Out of work due to skin condition, which has worsened - ulcers on legs, neck, shoulders, arms, infected, sore, stabbing pain, sensitive to clothing, touch, red, swollen. I have been treated by two different dermatologists thus far, but the ulcers are still on my legs despite antibiotics, oral and creams. I have appt with rheumatologist for further evaluation and testing. I am also getting another opinion from new dermatologist in December. Blood tests (twice this month) reveal kidney function diminished, WBC lower; no celiac disease or other issues except High Cholesterol. It appears my immune system is weak, and not responding to various antibiotics. I was severely affected and sick with bacterial infection in July 2012 from bad drinking water (broken pipes in our town); I was prescribed antibiotics (CIPRO) for this but once prescription was completed, I was still sick (giardia?) and went to ER on 8/7/12 as I still had abdominal pain, green stools, chills, nausea, and diarrhea. C/T scan, blood tests and stool cultures taken but I was released from ER before results;


    tami lucas on Nov, 21, 2012:

    Fluoroquinolone Antibiotic Toxicity (Cipro, Levaquin, Avelox, Floxin) on facebook or google Cipro join us


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Complete drug side effects:

On eHealthMe, Zoloft (sertraline hydrochloride) is often used to treat depression. Cipro (ciprofloxacin hydrochloride) is often used to treat urinary tract infection. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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