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Review: taking Zyrtec and Acetaminophen together

Summary: drug interactions are reported among people who take Zyrtec and Acetaminophen together.

This review analyzes the effectiveness and drug interactions between Zyrtec and Acetaminophen. It is created by eHealthMe based on reports of 2,404 people who take the same drugs from FDA and social media, and is updated regularly.





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What are the drugs

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. (latest outcomes from 29,963 Zyrtec users)

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. (latest outcomes from 70,716 Acetaminophen users)

On Feb, 14, 2015: 2,403 people who take Zyrtec, Acetaminophen are studied

Zyrtec, Acetaminophen outcomes

Drug combinations in study:
- Zyrtec (cetirizine hydrochloride)
- Acetaminophen (acetaminophen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zyrtec is effective18.18%
(2 of 11 people)
(4 of 11 people)
(0 of 2 people)
(0 of 4 people)
(3 of 10 people)
(2 of 8 people)
(1 of 1 people)
(0 of 1 people)
Acetaminophen is effective36.36%
(4 of 11 people)
(1 of 2 people)
(0 of 1 people)
(2 of 7 people)
(1 of 4 people)
(4 of 8 people)
(5 of 10 people)
(0 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
RashThinking AbnormalRespiratory Tract InfectionNight SweatsOesophagitisInsomniaDrowsinessNausea
Liver InjuryCardiac ArrestAbdominal DiscomfortHepatitis CBarrett's OesophagusPneumoniaPalpitationsPyrexia
Drug Rash With Eosinophilia And Systemic SymptomsChest PainGastroenteritis ViralBack PainContusionDrowsinessMuscle TwitchingFatigue
RestlessnessViolence-related SymptomVomitingLoss Of Sensation, Numbness And Tingling, Paresthesias, Sensory Loss, Tingling And NumbnessHepatic FailureTremorItchingVomiting
Febrile NeutropeniaAbdominal DiscomfortHeadacheUrinary FrequencyHepatic CirrhosisFatigueTinnitusHeadache
UrticariaEnterocolitisThrombocytopeniaHigh Blood PressurePulmonary EmbolismRestlessnessMental ImpairmentDyspnoea
DyspnoeaBack PainBlood Pressure IncreasedSweating - ExcessivePain In ExtremityBlood Pressure IncreasedHypothyroidismDizziness
NeutropeniaClostridial InfectionFlatulenceHeadachesDyspnoeaDepressionMalaiseAnxiety
VomitingHepatic SteatosisHaemorrhageBlood Alkaline Phosphatase Liver IncreasedHair Loss In WomenAbnormal DreamsRestlessnessArthralgia

Drug effectiveness by gender :

Zyrtec is effective17.86%
(5 of 28 people)
(7 of 20 people)
Acetaminophen is effective29.63%
(8 of 27 people)
(9 of 17 people)

Most common drug interactions by gender * :


Drug effectiveness by age :

Zyrtec is effective0.00%
(0 of 1 people)
(1 of 5 people)
(1 of 6 people)
(4 of 5 people)
(4 of 48 people)
(0 of 11 people)
(2 of 25 people)
(0 of 13 people)
Acetaminophen is effective100.00%
(1 of 1 people)
(1 of 4 people)
(2 of 6 people)
(2 of 5 people)
(5 of 49 people)
(4 of 6 people)
(1 of 25 people)
(1 of 12 people)

Most common drug interactions by age * :

PyrexiaWheezingPyrexiaFatigueBlood Pressure IncreasedNauseaPyrexiaNausea
InsomniaPneumoniaVomitingUpper Respiratory Tract InfectionAbdominal PainHeadachePainDiarrhoea
Eating DisorderLymphadenopathySuicide AttemptDizzinessAnaemiaAnxietyNauseaPain
WheezingLethargyAbdominal PainPyrexiaPain In ExtremityVomitingFallDyspnoea
DyspnoeaVomitingClostridial InfectionHodgkin's DiseaseDepressionPainDepressionFatigue
Adverse EventAbdominal Pain UpperInfusion Related ReactionNight SweatsPruritusInjuryDizzinessHeadache
VomitingDiarrhoeaAbdominal Pain UpperAstheniaSinusitisWeight DecreasedFatigueChest Pain

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Do you take Zyrtec and Acetaminophen?

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- support group for people who take Zyrtec and Acetaminophen
- support group for people who take Acetaminophen
- support group for people who take Zyrtec

Can you answer these questions (Ask a question):

More questions for: Acetaminophen, Zyrtec

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More reviews for: Acetaminophen, Zyrtec

Comments from related studies:

  • From this study (12 months ago):

  • I was prescribed Fluticasone Propionate for really bad Allergic Sinusitis however it gave me a real bad headache and it also effected my sugar level dropping it to 71 and I became very thirsty and disoriented and I had a small glass of orange juice to bring the sugar back up I'm a healthy 30 year old male with no history of hypoglycemia (low blood sugar) in fact I just had a yearly psychical and the lab work came back perfect so it's most likely caused by the drug "Fluticasone Propionate" aka Flonase.


  • From this study (1 year ago):

  • Past distal injuries returning with increased pressure symptoms. Eye pain with movement. Increased pressure and pain with neck movement. Connective tissue disease - Ehlers Danlos Syndrome.


  • From this study (1 year ago):

  • I take Benicar, Toprol and aspirin for high blood pressure. I take Lasix for swelling hand and blood pressure. Lipitor for high cholesterol. I take prednisone and indomethacin for swelling hand pain. Synthroid for low thyroid due to amiodarone. Zyrtec for sneezing. I take Tylenol for hand swelling pain. I have been told that I have had pneunmonia for 6 days. I was given an antibiotic (Cednifir) but has not helped. My red blood cells are low. I have bruing on both arms. I have lost a lot of muscle. last year I had 6 inches of my intestine removed after been hospitalized for what I felt as stomach pain


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Complete drug side effects:

On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Acetaminophen (acetaminophen) is often used to treat pain. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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