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Review: Zyrtec and Advil

This review analyzes the effectiveness and drug interactions between Zyrtec and Advil. It is created by eHealthMe based on reports of 2,065 people who take the same drugs from FDA and social media, and is updated regularly.

Get connected: join a mobile support group for people who take Zyrtec and Advil >>>

What are the drugs

Zyrtec (latest outcomes from 29,926 users) has active ingredients of cetirizine hydrochloride. It is often used in allergies.

Advil (latest outcomes from 22,807 users) has active ingredients of ibuprofen. It is often used in headache.

On Sep, 13, 2014: 2,065 people who take Zyrtec, Advil are studied

Zyrtec, Advil outcomes

Drug combinations in study:
- Zyrtec (cetirizine hydrochloride)
- Advil (ibuprofen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zyrtec is effective11.11%
(2 of 18 people)
(7 of 14 people)
(3 of 10 people)
(8 of 19 people)
(15 of 25 people)
(6 of 11 people)
(3 of 5 people)
(1 of 1 people)
Advil is effective61.29%
(19 of 31 people)
(7 of 15 people)
(0 of 2 people)
(4 of 9 people)
(6 of 17 people)
(7 of 9 people)
(12 of 17 people)
(1 of 5 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaCongenital Cystic Kidney DiseaseAnxietyCerebrovascular AccidentColonic PolypAnxietyCholecystitis ChronicPain
VomitingClostridial InfectionPainHypertensionDizzinessDepressionPainNausea
PyrexiaVomitingMuscle SpasmsHeadacheWeight GainDeep Vein ThrombosisDeep Vein ThrombosisAnxiety
Swelling FaceSingle Functional KidneyLiver InjuryPyrexiaHeadacheCholecystitis ChronicInjuryPyrexia
Condition AggravatedAnxietyWeight IncreasedVomitingMemory ImpairmentPainAnxietyDyspnoea
HeadacheConjunctivitisBiliary DyskinesiaNauseaKidney SmallInjuryGallbladder DisorderVomiting
ErythemaDrug Exposure During PregnancyEmotional DistressHepatitisChest PainPulmonary EmbolismDepressionFatigue
Abdominal Pain UpperDepressionInjuryHepatic FailureHeart RacingInsomniaCholelithiasisHeadache
HypersensitivityBruxismCholecystitis ChronicHaemangiomaNauseaRenal FailureComaArthralgia
RashDisturbance In AttentionType 2 Diabetes MellitusFibrosisArthritisEmotional DistressAggressionDiarrhoea

Drug effectiveness by gender :

Zyrtec is effective40.54%
(30 of 74 people)
(15 of 29 people)
Advil is effective48.68%
(37 of 76 people)
(19 of 29 people)

Most common drug interactions by gender * :

Deep Vein ThrombosisFall
Pulmonary EmbolismCerebrovascular Accident

Drug effectiveness by age :

Zyrtec is effective0.00%
(0 of 1 people)
(1 of 4 people)
(4 of 10 people)
(9 of 21 people)
(12 of 35 people)
(11 of 51 people)
(5 of 27 people)
(3 of 10 people)
Advil is effective100.00%
(2 of 2 people)
(4 of 5 people)
(4 of 10 people)
(7 of 21 people)
(16 of 34 people)
(13 of 51 people)
(5 of 28 people)
(5 of 10 people)

Most common drug interactions by age * :

InsomniaVomitingVomitingPulmonary EmbolismAnxietyAnxietyArthralgiaNausea
ChillsErythema MultiformeHistiocytosis HaematophagicAnxietyPulmonary EmbolismInjuryNauseaChest Pain
Eating DisorderEye SwellingDyspnoeaFatigueDeep Vein ThrombosisNauseaCerebrovascular AccidentPneumonia
WheezingMalaisePyrexiaInjuryCholecystitis ChronicAnaemiaHypertensionAnxiety
MalaiseRashNauseaDeep Vein ThrombosisInjuryHeadacheDyspnoeaFatigue
DyspnoeaPneumoniaPulmonary EmbolismDizzinessNauseaArthralgiaHypoaesthesiaPleural Effusion
Adverse EventAbdominal Pain UpperAbdominal PainHodgkin's DiseaseGallbladder DisorderDeep Vein ThrombosisBack PainHypotension
PneumoniaLip SwellingClostridial InfectionNight SweatsDepressionOsteonecrosis Of JawHeadacheDyspnoea
Acute Myeloid LeukaemiaDyspnoeaPleural EffusionUpper Respiratory Tract InfectionFatiguePain In ExtremityDiarrhoeaAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Do you take Zyrtec and Advil?

Get connected! Join a mobile support group:
- group for people who take Zyrtec and Advil
- group for people who take Advil
- group for people who take Zyrtec

Comments from related studies:

  • From this study (4 months ago):

  • I've been taking Flonase and zyrtec together for about a month. Last night I developed a stiff neck. I haven't done any strenuous exercise or injured it. The pain is coming from the back of my head, bottom of my skull and behind the ears. I was wondering if this could be a drug related reaction.


  • From this study (2 years ago):

  • Jemini on Feb, 11, 2013:

    I'm a female, age 53. My doctor prescribed HCTZ 25/ Triamterene 37.5 MG for my High Blood Pressure. After taking it for about 3 days, on the 4th day I developed really bad muscle spasms in my mid back area. I did loose water weight really good but could not deal with the spasms. I informed my Dr and was taken off the medication. I explained to my Dr the pain & the Dr told me if it was spasms it was a rare side effect. I did read up on the medication once I started developing the pain in back and read that HCTZ could cause muscle spasms. After about 3 - 4 days after not taking HCTZ the pain went away. If it wasn't for the pain I would have continued it because I lost about 9 pds & my BP went down.


  • From this study (2 years ago):

  • The Bloody stools co incide with increased bowel movements 2-3 times a day. The condition tends to come and go but I have not correleated it to the Ibuprophen ( 600MG 4 times/day for a week ) /oxycondonelow dose with 325MG acetaminiphen @4times/day ) I've been taking. I've been taking this for at first lower left side back pain which has now moved more to the left side lower rib cage. The bloody stool issue seems to come and go with 1-2 months seperation of condition last for a week or two then subsides. I n also have a burning sensation and light red blood on wiping myself. First bowel movement is OK 2nd is OK 3rd tends to burn and if a fourth occurs it get pretty sore/senative. Stool is soft and formed


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Complete drug side effects:

On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Advil (ibuprofen) is often used to treat headache. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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