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Review: taking Zyrtec and Advil together

Summary: drug interactions are reported among people who take Zyrtec and Advil together.

This review analyzes the effectiveness and drug interactions between Zyrtec and Advil. It is created by eHealthMe based on reports of 2,069 people who take the same drugs from FDA and social media, and is updated regularly.





You are not alone: join a mobile support group for people who take Zyrtec and Advil >>>

What are the drugs

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. (latest outcomes from 29,963 Zyrtec users)

Advil has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from 22,823 Advil users)

On Feb, 26, 2015: 2,069 people who take Zyrtec, Advil are studied

Zyrtec, Advil outcomes

Drug combinations in study:
- Zyrtec (cetirizine hydrochloride)
- Advil (ibuprofen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zyrtec is effective11.11%
(2 of 18 people)
(7 of 14 people)
(3 of 10 people)
(8 of 19 people)
(16 of 27 people)
(7 of 12 people)
(4 of 6 people)
(1 of 1 people)
Advil is effective61.29%
(19 of 31 people)
(7 of 15 people)
(0 of 2 people)
(4 of 9 people)
(6 of 17 people)
(7 of 9 people)
(13 of 21 people)
(1 of 5 people)

Drug effectiveness by gender :

Zyrtec is effective41.56%
(32 of 77 people)
(16 of 30 people)
Advil is effective48.10%
(38 of 79 people)
(19 of 30 people)

Drug effectiveness by age :

Zyrtec is effective0.00%
(0 of 1 people)
(1 of 4 people)
(4 of 10 people)
(9 of 21 people)
(13 of 36 people)
(12 of 52 people)
(5 of 28 people)
(4 of 11 people)
Advil is effective100.00%
(2 of 2 people)
(4 of 5 people)
(4 of 10 people)
(7 of 21 people)
(16 of 35 people)
(13 of 52 people)
(5 of 29 people)
(6 of 11 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
DyspnoeaCongenital Cystic Kidney DiseaseAnxietyCerebrovascular AccidentColonic PolypAnxietyCholecystitis ChronicPain
VomitingClostridial InfectionPainHypertensionDizzinessDepressionPainNausea
PyrexiaVomitingMuscle SpasmsHeadacheWeight GainDeep Vein ThrombosisInjuryAnxiety
Swelling FaceSingle Functional KidneyLiver InjuryPyrexiaHeadacheCholecystitis ChronicDeep Vein ThrombosisPyrexia
Condition AggravatedAnxietyWeight IncreasedVomitingMemory ImpairmentPainGallbladder DisorderDyspnoea
HeadacheConjunctivitisBiliary DyskinesiaNauseaKidney SmallInjuryDepressionVomiting
ErythemaDrug Exposure During PregnancyEmotional DistressHepatitisChest PainPulmonary EmbolismCholelithiasisFatigue
Abdominal Pain UpperDepressionInjuryHepatic FailureHeart RacingInsomniaAnxietyHeadache
HypersensitivityBruxismCholecystitis ChronicHaemangiomaNauseaRenal FailureNauseaArthralgia
RashDisturbance In AttentionType 2 Diabetes MellitusFibrosisArthritisGeneral Physical Health DeteriorationAggressionDiarrhoea

Most common drug interactions by gender * :

Deep Vein ThrombosisFall
Pulmonary EmbolismCerebrovascular Accident

Most common drug interactions by age * :

InsomniaVomitingVomitingPulmonary EmbolismAnxietyAnxietyArthralgiaNausea
ChillsErythema MultiformeHistiocytosis HaematophagicAnxietyPulmonary EmbolismInjuryNauseaChest Pain
Eating DisorderEye SwellingDyspnoeaFatigueCholecystitis ChronicNauseaCerebrovascular AccidentAnxiety
WheezingMalaisePyrexiaInjuryDeep Vein ThrombosisAnaemiaHypertensionFatigue
MalaiseRashNauseaDeep Vein ThrombosisInjuryHeadacheDyspnoeaPneumonia
DyspnoeaPneumoniaPulmonary EmbolismDizzinessNauseaArthralgiaHypoaesthesiaHypotension
Adverse EventAbdominal Pain UpperAbdominal PainHodgkin's DiseaseDepressionDeep Vein ThrombosisBack PainPleural Effusion
PneumoniaLip SwellingClostridial InfectionNight SweatsGallbladder DisorderOsteonecrosis Of JawHeadacheDyspnoea
Acute Myeloid LeukaemiaDyspnoeaPleural EffusionUpper Respiratory Tract InfectionCholelithiasisBack PainDiarrhoeaAsthenia

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Zyrtec and Advil on

Do you take Zyrtec and Advil?

You are not alone! Join a related mobile support group:
- support group for people who take Zyrtec and Advil
- support group for people who take Advil
- support group for people who take Zyrtec

Can you answer these questions (Ask a question):

  • Does toviaz interact negatively with ibuproffen
    Male, 62 years old. Had a prostatectomy months ago (cancerous, 7 rating). One month after surgery, I started taking one 4 mg pill of Toviaz. Worked like magic with no side effects.
    Three weeks ago, I lost control again. The leakage was so bad in frequency that I had to go back to using pads. This lasted for 5 days before things gradually went back to "almost normal".
    The only difference in medication, food and drinks that I had in those 5 days is I used to take 2 ibuprofen pills (200 mg each) in the morning & 2 at night to deal with headache.
    Once I stopped taking the ibuprofen, things improved.
    Could what happened with me be the result of of interaction between Toviaz & Ibuproffen? I called Pfizer and the lady siad she does not have any information on this
  • 8 year old boy has erratic heartbeat. started tamiflu last week. do i need to quit tamiflu? he had a 104.1 temp when we started treatments.
    Shortly after being dosed with Tamiflu this morning, he had a very erratic heartbeat. He is positive for influenza last Thursday and has been on Tamiflu since and Ibuprofen to manage fever (was up to 104.1 last week). Local clinic wants to see him. I don't feel like taking him there will solve anything. Its returned to normal within an hour of dosing with Tamiflu.
  • My daughter has congenital php and diabetes(hyperglycemia) not diagnosed until 18.with 23...blood sugars are uncontrolled nothing so far is helping
    All the patients I have chatted with have LOW blood sugar but mine is high. Nothing is helping it just keeps climbing. What gives?
  • I tested positive for methadone, i have never taken this drug (1 answer)
    I tested positive for methadone, I have never taken this drug. My Dr said I had to have taken it because it was there and that a false positive is out of the question. Could my meds cause methadone to show up on a urine drug test
  • Is it safe to take demerol while taking tramadol hydrochloride and hydroxychloroquine (2 answers)
    I am experiencing acute, debilitating pain due to the Chikungunya virus, which has reintroduced all of the previous painful symptoms I have,ongoing and in the past, from Fibromyalgia, Arthritis, tendonitis and severe headaches. It's in its 38th day and I am basically crippled from neck to feet. Have to sleep propped up as arms throb with pain when horizontal. The only thing that has subdued the pain slightly are Oxycocet and Ibuprofen, but the pain never goes away. My hands and feet are so inflammed it's difficult to perform even the smallest tasks of personal hygiene and housekeeping. I have difficulty controlling my bladder and often don't make it to the washroom in time. Just started on Demerol today so will no longer take the Oxycocet, but am concerned of the interactions with Demerol, Hydroxychloroquine and Tramadol Hydrochloride extended release tablets that I take daily for the Fibromyalgia and Arthritis. I have dealt with a great deal of pain through the years, but I now have the pain of every serious illness I have had in my lifetime, all at the same time. I honestly didn't think a person could deal with this much pain at once. I have tried and am still taking several vitamins and herbal supplements as well as drinking tons of water and eating really well. Lots of berries, dark vegetables, apples, yogurt and minimal meat. Taking turmeric, papaya leaf, ginger, cinnamon and boswellia for the inflammation. Taking minimal wheat products, sugar and no alcohol. Also, drinking green, fennel and nettle tea daily. I know this is a lot of information, but I really need help and wonder if anyone has any suggestions! Thanking you in advance!!!

More questions for: Advil, Zyrtec

You may be interested at these reviews (Write a review):

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    Wheezing noted by primary physician in this non-smoker. Stopped Topamax per doctor's instruction. 48 hours later was examined by physician and noted that wheezing stopped.
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  • Migraine with dyazide
    Took Dyazide for blood pressure escalating due to Cyclosporine. Have history of bad migraines but have not had them routinely for many years. Within 24 hours of starting treatment with Dyazide, severe headache began that lasted throughout the day and eventually led to ER treatment. Was told to no longer take Dyazide, headache did not return. Was 49 at time of ER treatment and was on Dyazide for 1 week.
  • Tiredness on citalopram and cetirizine
    Extreme tiredness......sleep more sleep and slight confusion when I a zombie mode switched on inside my head ...all I can do is yawn and sleep not good when your a busy mum

More reviews for: Advil, Zyrtec

Comments from related studies:

  • From this study (3 months ago):

  • I have many side effects from the aforementioned drugs. I would like to officially confirm the side effects. I would also like to know if these drugs are okay to mix together.


  • From this study (9 months ago):

  • I've been taking Flonase and zyrtec together for about a month. Last night I developed a stiff neck. I haven't done any strenuous exercise or injured it. The pain is coming from the back of my head, bottom of my skull and behind the ears. I was wondering if this could be a drug related reaction.


  • From this study (2 years ago):

  • Jemini on Feb, 11, 2013:

    I'm a female, age 53. My doctor prescribed HCTZ 25/ Triamterene 37.5 MG for my High Blood Pressure. After taking it for about 3 days, on the 4th day I developed really bad muscle spasms in my mid back area. I did loose water weight really good but could not deal with the spasms. I informed my Dr and was taken off the medication. I explained to my Dr the pain & the Dr told me if it was spasms it was a rare side effect. I did read up on the medication once I started developing the pain in back and read that HCTZ could cause muscle spasms. After about 3 - 4 days after not taking HCTZ the pain went away. If it wasn't for the pain I would have continued it because I lost about 9 pds & my BP went down.


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Complete drug side effects:

On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Advil (ibuprofen) is often used to treat headache. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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