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Review: Zyrtec and Phenergan

This review analyzes the effectiveness and drug interactions between Zyrtec and Phenergan. It is created by eHealthMe based on reports of 536 people who take the same drugs from FDA and social media, and is updated regularly.

Stay connected: join a mobile support group for people who take Zyrtec and Phenergan >>>

What are the drugs

Zyrtec (what 29,909 Zyrtec users reported?) has active ingredients of cetirizine hydrochloride. It is used in allergen.

Phenergan (what 13,013 Phenergan users reported?) has active ingredients of promethazine hydrochloride. It is used in nausea.

On Aug, 14, 2014: 536 people who take Zyrtec, Phenergan are studied

Zyrtec, Phenergan outcomes

Drug combinations in study:
- Zyrtec (cetirizine hydrochloride)
- Phenergan (promethazine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zyrtec is effective0.00%
(0 of 1 people)
(0 of 4 people)
(0 of 1 people)
(0 of 2 people)
(1 of 3 people)
(4 of 5 people)
(1 of 1 people)
Phenergan is effective66.67%
(4 of 6 people)
(1 of 1 people)
(1 of 1 people)
(1 of 3 people)
(2 of 3 people)
(1 of 3 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
GastritisChest PainChronic Fatigue SyndromeNauseaSjogren's SyndromePanic Attackn/aPain
Toxic Epidermal NecrolysisDyspnoea ExertionalHerpes SimplexDyspepsiaMigraineAnxietyNausea
VomitingPain In ExtremitySinusitisBiliary DyskinesiaChronic Fatigue SyndromeManiaBack Pain
PruritusHypoaesthesiaNephrolithiasisPainHepatic FailureVertigoDyspnoea
NauseaTendernessMigraineAbdominal PainJoint InstabilityVision BlurredVomiting
DiarrhoeaPulmonary EmbolismSjogren's SyndromeGallbladder DisorderLumbar PainDisorientationAnxiety
Blood Potassium IncreasedOedema PeripheralRestless Legs SyndromeImpaired Gastric EmptyingCervical Root PainMigraineAbdominal Pain
HypophagiaPainTinnitus AggravatedVomitingRestless Legs SyndromeHeadacheArthralgia
RashSubclavian Vein ThrombosisLumbar PainMigraineTinnitus AggravatedPsychomotor Skills ImpairedHeadache
Confusional StateGastrooesophageal Reflux DiseaseJoint InstabilityConstipationDepressionDiarrhoea

Drug effectiveness by gender :

Zyrtec is effective31.25%
(5 of 16 people)
(1 of 1 people)
Phenergan is effective56.25%
(9 of 16 people)
(1 of 1 people)

Most common drug interactions by gender * :

Back PainPyrexia
Abdominal PainConstipation
ArthralgiaChest Pain
Oedema PeripheralCondition Aggravated

Drug effectiveness by age :

Zyrtec is effectiven/a0.00%
(0 of 2 people)
(1 of 2 people)
(2 of 39 people)
(1 of 15 people)
(2 of 12 people)
(0 of 1 people)
Phenergan is effectiven/a0.00%
(0 of 2 people)
(2 of 2 people)
(1 of 39 people)
(1 of 15 people)
(5 of 12 people)
(1 of 1 people)

Most common drug interactions by age * :

n/aCoughNauseaCholecystitis ChronicAbdominal PainPainPainAnxiety
ConjunctivitisDeep Vein ThrombosisPulmonary EmbolismDepressionBack PainDizzinessWeight Decreased
Chronic SinusitisAbdominal PainChest PainNauseaArthralgiaDyspnoeaNausea
DepressionCholecystitisVomitingGastritisSinusitisBack PainBack Pain
Ear InfectionDepressionNauseaAnxietyNauseaNauseaDiarrhoea
Hallucination, AuditoryPainBack PainPainOsteonecrosis Of JawPalpitationsPain
Eczema EyelidsPulmonary InfarctionDyspnoeaEmotional DistressDyspnoeaArthralgiaOsteomyelitis
EczemaPyrexiaAbdominal PainMigraineDehydrationAnxietyBone Disorder
Attention Deficit/hyperactivity DisorderEpistaxisInjuryAbdominal Pain UpperOedema PeripheralHaemorrhagePain In Jaw
AnxietyCholecystitis ChronicPain In ExtremityMaternal Exposure During PregnancyIntervertebral Disc DegenerationChest PainSpinal Osteoarthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who take Zyrtec and Phenergan
- group for people who take Phenergan
- group for people who take Zyrtec

Comments from related studies:

  • From this study (4 months ago):

  • I have chiari (decompressed), Syringomyelia, Intracranial hypertension, Tethered cord (surgery), CranioCervical Instability, Ehlers Danlos with mixed connective tissue disorder, crohns, afib, superventricular tachycardia and mast cell activation disorder


  • From this study (8 months ago):

  • Trying to figure out if my symptoms are related to medications I am taking or due to chronic fatigue syndrome which I have been diagnosed with and maybe fibromyalgia or lumbar stenosis or MS.


  • From this study (3 years ago):

  • Jean on Apr, 16, 2011:

    Well, it seems vitreous detachment is age related anyway. In general, in males and females in their fifties, vitreous detachment will first begin. To my knowledge, the fluid becomes thickened and pulls away from the retina. Maybe the money spent on this research would have better been put to use in cancer or diabetes research.


    far on Jun, 24, 2011:

    i dont think age is related to eye floaters or retina detachment, i seen very young people suffering from eye floaters,


Post a new comment    OR    Read more comments

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More reviews for: Phenergan, Zyrtec

Complete drug side effects:

On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Phenergan (promethazine hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

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