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Review: taking Zyrtec and Phenergan together

Summary: drug interactions are reported among people who take Zyrtec and Phenergan together. This review analyzes the effectiveness and drug interactions between Zyrtec and Phenergan. It is created by eHealthMe based on reports of 536 people who take the same drugs from FDA and social media, and is updated regularly.

Personalized health information: on eHealthMe you can find out what patients like me (same gender, age) reported their drugs and conditions on FDA and social media since 1977. Our tools are free and anonymous. 66 million people have used us. 200+ peer-reviewed medical journals have referenced our original studies. Start now >>>


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What are the drugs

Zyrtec has active ingredients of cetirizine hydrochloride. It is often used in allergies. (latest outcomes from 29,990 Zyrtec users)

Phenergan has active ingredients of promethazine hydrochloride. It is often used in nausea. (latest outcomes from 13,036 Phenergan users)

On Apr, 30, 2015: 536 people who take Zyrtec, Phenergan are studied

Zyrtec, Phenergan outcomes

Drug combinations in study:
- Zyrtec (cetirizine hydrochloride)
- Phenergan (promethazine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zyrtec is effective0.00%
(0 of 1 people)
(0 of 4 people)
(0 of 1 people)
(0 of 2 people)
(1 of 3 people)
(4 of 5 people)
(1 of 1 people)
Phenergan is effective66.67%
(4 of 6 people)
(1 of 1 people)
(1 of 1 people)
(1 of 3 people)
(2 of 3 people)
(1 of 3 people)

Drug effectiveness by gender :

Zyrtec is effective31.25%
(5 of 16 people)
(1 of 1 people)
Phenergan is effective56.25%
(9 of 16 people)
(1 of 1 people)

Drug effectiveness by age :

Zyrtec is effectiven/a0.00%
(0 of 2 people)
(1 of 2 people)
(2 of 39 people)
(1 of 15 people)
(2 of 12 people)
(0 of 1 people)
Phenergan is effectiven/a0.00%
(0 of 2 people)
(2 of 2 people)
(1 of 39 people)
(1 of 15 people)
(5 of 12 people)
(1 of 1 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
GastritisChest PainChronic Fatigue SyndromeNauseaSjogren's SyndromePanic Attackn/aPain
Toxic Epidermal NecrolysisDyspnoea ExertionalHerpes SimplexDyspepsiaMigraineAnxietyNausea
VomitingPain In ExtremitySinusitisBiliary DyskinesiaChronic Fatigue SyndromeManiaBack Pain
PruritusHypoaesthesiaNephrolithiasisPainHepatic FailureVertigoDyspnoea
NauseaTendernessMigraineAbdominal PainJoint InstabilityVision BlurredVomiting
DiarrhoeaPulmonary EmbolismSjogren's SyndromeGallbladder DisorderLumbar PainDisorientationAnxiety
Blood Potassium IncreasedOedema PeripheralRestless Legs SyndromeImpaired Gastric EmptyingCervical Root PainMigraineAbdominal Pain
HypophagiaPainTinnitus AggravatedVomitingRestless Legs SyndromeHeadacheArthralgia
RashSubclavian Vein ThrombosisLumbar PainMigraineTinnitus AggravatedPsychomotor Skills ImpairedHeadache
Confusional StateGastrooesophageal Reflux DiseaseJoint InstabilityConstipationDepressionDiarrhoea

Most common drug interactions by gender * :

Back PainPyrexia
Abdominal PainConstipation
ArthralgiaChest Pain
Oedema PeripheralCondition Aggravated

Most common drug interactions by age * :

n/aCoughNauseaCholecystitis ChronicAbdominal PainPainPainAnxiety
ConjunctivitisDeep Vein ThrombosisPulmonary EmbolismDepressionBack PainDizzinessWeight Decreased
Chronic SinusitisAbdominal PainChest PainNauseaArthralgiaDyspnoeaNausea
DepressionCholecystitisVomitingGastritisSinusitisBack PainBack Pain
Ear InfectionDepressionNauseaAnxietyNauseaNauseaDiarrhoea
Hallucination, AuditoryPainBack PainPainOsteonecrosis Of JawPalpitationsPain
Eczema EyelidsPulmonary InfarctionDyspnoeaEmotional DistressDyspnoeaArthralgiaOsteomyelitis
EczemaPyrexiaAbdominal PainMigraineDehydrationAnxietyBone Disorder
Attention Deficit/hyperactivity DisorderEpistaxisInjuryAbdominal Pain UpperOedema PeripheralHaemorrhagePain In Jaw
AnxietyCholecystitis ChronicPain In ExtremityMaternal Exposure During PregnancyIntervertebral Disc DegenerationChest PainSpinal Osteoarthritis

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Get connected: join our support group of Zyrtec and Phenergan on

Do you take Zyrtec and Phenergan?


You are not alone! Join a related support group:
- support group for people who take Phenergan
- support group for people who take Zyrtec

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

More questions for: Phenergan, Zyrtec

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More reviews for: Phenergan, Zyrtec

Comments from related studies:

  • From this study (1 year ago):

  • I have chiari (decompressed), Syringomyelia, Intracranial hypertension, Tethered cord (surgery), CranioCervical Instability, Ehlers Danlos with mixed connective tissue disorder, crohns, afib, superventricular tachycardia and mast cell activation disorder


  • From this study (1 year ago):

  • Trying to figure out if my symptoms are related to medications I am taking or due to chronic fatigue syndrome which I have been diagnosed with and maybe fibromyalgia or lumbar stenosis or MS.


  • From this study (4 years ago):

  • far on Jun, 24, 2011:

    i dont think age is related to eye floaters or retina detachment, i seen very young people suffering from eye floaters,


Post a new comment    OR    Read more comments

Complete drug side effects:

On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Phenergan (promethazine hydrochloride) is often used to treat nausea. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

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