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Review: taking Zyrtec and Zoloft together

Summary: drug interactions are reported among people who take Zyrtec and Zoloft together.

This review analyzes the effectiveness and drug interactions between Zyrtec and Zoloft. It is created by eHealthMe based on reports of 1,661 people who take the same drugs from FDA and social media, and is updated regularly.


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On Apr, 19, 2015: 1,661 people who take Zyrtec, Zoloft are studied

Zyrtec, Zoloft outcomes

Drug combinations in study:
- Zyrtec (cetirizine hydrochloride)
- Zoloft (sertraline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zyrtec is effective20.00%
(2 of 10 people)
(4 of 17 people)
(8 of 10 people)
(9 of 23 people)
(13 of 25 people)
(9 of 18 people)
(9 of 12 people)
(1 of 1 people)
Zoloft is effective18.18%
(2 of 11 people)
(8 of 22 people)
(4 of 7 people)
(10 of 15 people)
(16 of 30 people)
(8 of 16 people)
(14 of 17 people)

Drug effectiveness by gender :

Zyrtec is effective46.81%
(44 of 94 people)
(11 of 22 people)
Zoloft is effective58.51%
(55 of 94 people)
(7 of 24 people)

Drug effectiveness by age :

Zyrtec is effectiven/an/a27.27%
(3 of 11 people)
(7 of 19 people)
(15 of 63 people)
(18 of 56 people)
(8 of 24 people)
(4 of 15 people)
Zoloft is effectiven/an/a30.00%
(3 of 10 people)
(10 of 20 people)
(22 of 64 people)
(13 of 66 people)
(10 of 24 people)
(4 of 16 people)

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug HypersensitivityChest PainInsomniaPulmonary EmbolismAbdominal PainAnxietyFatiguePain
RashPulmonary EmbolismFoetal Exposure During PregnancyChest PainBiliary DyskinesiaDepressionNasal UlcerAnxiety
Sleep DisorderOedema PeripheralCongenital AnomalyPain In ExtremityPainFatigueSystolic BruitNausea
DepressionFatigueSudden Infant Death SyndromeOedema PeripheralNauseaInsomniaConstipationFatigue
Oedema PeripheralPain In ExtremityVaginitisTendernessDepressionDepression AggravatedDiverticulitis AggravatedDyspnoea
DyspnoeaAtrial Septal DefectDental CariesHypoaesthesiaDiarrhoeaExacerbation Of AnxietyCholestasisFall
Condition AggravatedMyocardial InfarctionVaginal HaemorrhageDyspnoea ExertionalAtelectasisVomiting NosRashBack Pain
Feeling JitteryDyspnoeaSinus CongestionSubclavian Vein ThrombosisPneumoniaChest PainBlurred VisionChest Pain
Pharyngolaryngeal PainDepressionRashNauseaUrinary Tract InfectionDiarrhoeaDizzinessAsthenia
OsteoporosisHypoaesthesiaRaoultella Ornithinolytica InfectionMitral Valve IncompetencePulmonary EmbolismColitisHivesDepression

Most common drug interactions by gender * :

DepressionChest Pain
DyspnoeaOsteonecrosis Of Jaw
FallBack Pain
Pain In ExtremityArteriosclerosis

Most common drug interactions by age * :

n/aDrug Administration ErrorSuicide AttemptPulmonary EmbolismPainPainAnxietyNausea
Drug IneffectiveDyspnoeaAbdominal PainDepressionHeadacheNauseaAnxiety
Neck PainAnxietyPain In ExtremityRashFatigueAstheniaPain
DystoniaVomitingChest PainDyspnoeaAnxietyDiarrhoeaChest Pain
Condition AggravatedRashGastritisBack PainPainFatigue
Abnormal BehaviourPainCholelithiasisChest PainFatigueDyspnoea
Pulmonary EmbolismNauseaAbdominal PainArthralgiaDepressionFall
Pleuritic PainBiliary DyskinesiaNauseaDyspnoeaVomitingSpinal Osteoarthritis
Non-cardiac Chest PainYawningGallbladder DisorderNauseaPyrexiaOsteonecrosis Of Jaw
Loss Of ConsciousnessPalpitationsInjuryFallArthralgiaPain In Jaw

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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- support group for people who take Zoloft
- support group for people who take Zyrtec

Recent related drug studies (Check your drugs):

Complete drug side effects:

On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.


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