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Review: Zyrtec and Zoloft

This review analyzes the effectiveness and drug interactions between Zyrtec and Zoloft. It is created by eHealthMe based on 1,646 people who take the drugs. The review uses reports from FDA and social media, and is updated regularly.

On Apr, 10, 2014: 1,646 people who take Zyrtec, Zoloft are studied

Zyrtec, Zoloft outcomes

Drug combinations in study:
- Zyrtec (cetirizine hydrochloride)
- Zoloft (sertraline hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zyrtec is effective20.00%
(2 of 10 people)
26.67%
(4 of 15 people)
77.78%
(7 of 9 people)
42.86%
(9 of 21 people)
59.09%
(13 of 22 people)
52.94%
(9 of 17 people)
88.89%
(8 of 9 people)
n/a
Zoloft is effective10.00%
(1 of 10 people)
38.89%
(7 of 18 people)
57.14%
(4 of 7 people)
61.54%
(8 of 13 people)
51.72%
(15 of 29 people)
50.00%
(6 of 12 people)
81.25%
(13 of 16 people)
n/a

Drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Drug Hypersensitivity
(6 reports)

Rash
(5 reports)

Sleep Disorder
(5 reports)

Depression
(4 reports)

Oedema Peripheral
(4 reports)

Oedema Peripheral
(10 reports)

Chest Pain
(10 reports)

Pulmonary Embolism
(10 reports)

Fatigue
(7 reports)

Atrial Septal Defect
(6 reports)

Insomnia
(2 reports)

Foetal Exposure During Pregnancy
(2 reports)

Congenital Anomaly
(2 reports)

Sudden Infant Death Syndrome
(2 reports)

Raoultella Ornithinolytica Infection
(1 report)

Pulmonary Embolism
(9 reports)

Chest Pain
(5 reports)

Pain In Extremity
(5 reports)

Hypoaesthesia
(5 reports)

Tenderness
(5 reports)

Abdominal Pain
(6 reports)

Pain
(6 reports)

Biliary Dyskinesia
(6 reports)

Nausea
(5 reports)

Depression
(4 reports)

Depression
(3 reports)

Anxiety
(3 reports)

Fatigue
(2 reports)

Insomnia
(2 reports)

Exacerbation Of Anxiety
(1 report)

Fatigue
(2 reports)

Systolic Bruit
(1 report)

Nasal Ulcer
(1 report)

Cholestasis
(1 report)

Constipation
(1 report)

Anxiety
(168 reports)

Pain
(168 reports)

Nausea
(114 reports)

Dyspnoea
(111 reports)

Back Pain
(109 reports)

Drug effectiveness by gender :

FemaleMale
Zyrtec is effective51.81%
(43 of 83 people)
45.00%
(9 of 20 people)
Zoloft is effective59.04%
(49 of 83 people)
22.73%
(5 of 22 people)

Drug interactions by gender * :

FemaleMale
Common drug interactions Pain
(152 reports)

Anxiety
(137 reports)

Nausea
(133 reports)

Depression
(117 reports)

Fatigue
(109 reports)

Anxiety
(83 reports)

Pain
(69 reports)

Anaemia
(63 reports)

Chest Pain
(61 reports)

Dyspnoea
(59 reports)

Drug effectiveness by age :

0-12-910-1920-2930-3940-4950-5960+
Zyrtec is effectiven/an/a33.33%
(3 of 9 people)
36.84%
(7 of 19 people)
35.90%
(14 of 39 people)
32.08%
(17 of 53 people)
38.10%
(8 of 21 people)
30.00%
(3 of 10 people)
Zoloft is effectiven/an/a37.50%
(3 of 8 people)
50.00%
(10 of 20 people)
45.00%
(18 of 40 people)
17.46%
(11 of 63 people)
42.86%
(9 of 21 people)
27.27%
(3 of 11 people)

Drug interactions by age * :

0-12-910-1920-2930-3940-4950-5960+
Common drug interactions n/aDrug Administration Error
(3 reports)

Drug Ineffective
(3 reports)

Neck Pain
(1 report)

Dystonia
(1 report)

Suicide Attempt
(8 reports)

Dyspnoea
(7 reports)

Anxiety
(6 reports)

Vomiting
(5 reports)

Pleural Effusion
(4 reports)

Pulmonary Embolism
(16 reports)

Abdominal Pain
(10 reports)

Pain In Extremity
(9 reports)

Chest Pain
(9 reports)

Rash
(8 reports)

Pain
(12 reports)

Rash
(10 reports)

Dyspnoea
(10 reports)

Depression
(10 reports)

Gastritis
(9 reports)

Pain
(42 reports)

Headache
(38 reports)

Fatigue
(35 reports)

Anxiety
(34 reports)

Back Pain
(30 reports)

Anxiety
(46 reports)

Nausea
(43 reports)

Asthenia
(38 reports)

Diarrhoea
(37 reports)

Pain
(34 reports)

Nausea
(80 reports)

Anxiety
(72 reports)

Pain
(71 reports)

Chest Pain
(60 reports)

Dyspnoea
(60 reports)

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Zoloft, Zyrtec

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Complete drug side effects:

On eHealthMe, Zyrtec (cetirizine hydrochloride) is often used to treat allergies. Zoloft (sertraline hydrochloride) is often used to treat depression. Find out below the conditions the drugs are used for, how effective they are, and any alternative drugs that you can use to treat those same conditions.

What is the drug used for and how effective is it:

Other drugs that are used to treat the same conditions:

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Post a new comment    OR    Read more comments

Can you answer these questions (what is this?):

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    I have been on Zoloft (sertraline) for 19 years for chronic depression. When I first started taking Zoloft, it made a huge positive impact on my life. It was a miracle drug for me. I believe it saved my life. Ten or so years ago it suddenly stopped working. My doctor had me try several other S ...

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More questions for: Zoloft, Zyrtec

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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