(Report ID: 99066)

Drug interactions analysis of:
Cyclophosphamide, Fludarabine

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As of Nov, 21, 2008, eHealthMe analyzes 10,180,648 drug interactions and side effects of 21,667 FDA-approved drugs from 1977 to the present.

Results on Nov, 21, 2008: 1,651 relevant incidents

Trend of Cyclophosphamide, Fludarabine's relevant incidents of drug interactions and side effects

Note:
The incidents can not include all actual occurrences

Data of 2008 is not complete

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Basic information:

Report ID	Date of submission	Patient age	Patient gender
99066	Apr, 9, 2006	69	Male

List of drugs the patient takes:

Drug
Cyclophosphamide
Fludarabine

List of drug interactions, adverse side effects / events the patient has:

Name
Pneumocystis Jiroveci Pneumonia

Results from eHealthMe: 1,651 relevent incidents

1) Comparison with the patient's adverse outcomes:

Name	Count (% of total reports)
Pneumocystis Jiroveci Pneumonia	15 (0.91%)

2) Top drug interactions, adverse side effects reported for the past 12 months:

Death: 10 (5.26% of total reports)
Cancer: 4 (2.11% of total reports)

	Name	Count (% of total reports)
1	Febrile Neutropenia	21 (11.05%)
2	Progressive Multifocal Leukoencephalopathy	17 (8.95%)
3	Pyrexia	16 (8.42%)
4	Death	10 (5.26%)
5	Acute Myeloid Leukaemia	9 (4.74%)
6	Metabolic Acidosis	8 (4.21%)
7	Asthenia	7 (3.68%)
8	Acute Graft Versus Host Disease	7 (3.68%)
9	Myelodysplastic Syndrome	7 (3.68%)
10	Pancytopenia	7 (3.68%)

3) Top co-used drugs drugs reported for the past 12 months:

	Name	Count
1	Rituximab	49
2	Mitoxantrone	29
3	Vincristine	27
4	Prednisone Tab	25
5	Doxorubicin Hcl	23
6	Cytarabine	22
7	Rituxan	21
8	Dexamethasone Tab	19
9	Cyclosporine	16
10	Allopurinol	15

4) Top drug interactions, adverse side effects reported of all time:

Death: 32 (1.94% of total reports)
Cancer: 30 (1.82% of total reports)

	Name	Count (% of total reports)
1	Pyrexia	163 (9.87%)
2	Neutropenia	137 (8.30%)
3	Graft Versus Host Disease	119 (7.21%)
4	Febrile Neutropenia	105 (6.36%)
5	Pancytopenia	96 (5.81%)
6	Thrombocytopenia	93 (5.63%)
7	Platelet Count Decreased	74 (4.48%)
8	Haemoglobin Decreased	70 (4.24%)
9	White Blood Cell Count Decreased	67 (4.06%)
10	Pneumonia	59 (3.57%)

5) Top co-used drugs drugs reported of all time:

	Name	Count
1	Cytoxan	203
2	Allopurinol	183
3	Cyclosporine	176
4	Rituxan	166
5	Acyclovir	158
6	Methotrexate	142
7	Prednisone	124
8	Mitoxantrone	105
9	Neupogen	104
10	Vincristine	104

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Drug interactions analysis of: Cyclophosphamide, Fludarabine

Results on Nov, 21, 2008: 1,651 relevant incidents

Note: The incidents can not include all actual occurrences Data of 2008 is not complete

Content:

Basic information:

Male

List of drugs the patient takes:

Cyclophosphamide

Fludarabine

List of drug interactions, adverse side effects / events the patient has:

Pneumocystis Jiroveci Pneumonia

Results from eHealthMe: 1,651 relevent incidents

1) Comparison with the patient's adverse outcomes:

Pneumocystis Jiroveci Pneumonia

2) Top drug interactions, adverse side effects reported for the past 12 months:

Death: 10 (5.26% of total reports)Cancer: 4 (2.11% of total reports)

1

Febrile Neutropenia

2

Progressive Multifocal Leukoencephalopathy

3

Pyrexia

4

Death

5

Acute Myeloid Leukaemia

6

Metabolic Acidosis

7

Asthenia

8

Acute Graft Versus Host Disease

9

Myelodysplastic Syndrome

10

Pancytopenia

3) Top co-used drugs drugs reported for the past 12 months:

1

Rituximab

2

Mitoxantrone

3

Vincristine

4

Prednisone Tab

5

Doxorubicin Hcl

6

Cytarabine

7

Rituxan

8

Dexamethasone Tab

9

Cyclosporine

10

Allopurinol

4) Top drug interactions, adverse side effects reported of all time:

Death: 32 (1.94% of total reports)Cancer: 30 (1.82% of total reports)

1

Pyrexia

2

Neutropenia

3

Graft Versus Host Disease

4

Febrile Neutropenia

5

Pancytopenia

6

Thrombocytopenia

7

Platelet Count Decreased

8

Haemoglobin Decreased

9

White Blood Cell Count Decreased

10

Pneumonia

5) Top co-used drugs drugs reported of all time:

Drug interactions analysis of:
Cyclophosphamide, Fludarabine

Note:
The incidents can not include all actual occurrences

Data of 2008 is not complete

Death: 10 (5.26% of total reports)
Cancer: 4 (2.11% of total reports)

Death: 32 (1.94% of total reports)
Cancer: 30 (1.82% of total reports)