Drug interactions between Advil, Simvastatin for a Male patient aged 69
This is a personalized study of Advil, Simvastatin drug interactions for a 69 year old male patient who has Muscle Aches, Cholesterol. The study is created by eHealthMe based on 3,433 reports from FDA.
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What are the drugs
Advil has active ingredients of ibuprofen. It is used in headache, pain, arthritis, back pain - low, muscle aches, fever.
Simvastatin has active ingredients of simvastatin. It is used in high blood cholesterol, high blood pressure, hyperlipidaemia, blood cholesterol decreased, coronary heart disease, high density lipoprotein abnormal.
On Apr, 16, 2013: 3,433 people who reported to have interactions when taking Advil, Simvastatin are studied

Information of the patient in this study:
Age: 65
Gender: male
Conditions: Muscle Aches, Cholesterol
Drugs taking:
- Advil (ibuprofen): used for < 1 month
- Simvastatin (simvastatin): used for 2 - 5 years
eHealthMe real world results:
For males aged 65 (±5):
Comparison with this patient's adverse outcomes:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports among males aged 65 (±5) who take the drugs |
| Simvastatin | The drug has been added in the study. Outcomes of the drug mix are shown. |
Most common interactions experienced by males aged 65 (±5) in the use of Advil, Simvastatin:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Vomiting | 102 |
| 2 | Anxiety | 81 |
| 3 | Dyspnoea | 73 |
| 4 | Diarrhoea | 72 |
| 5 | Renal Failure | 70 |
| 6 | Nausea | 44 |
| 7 | Dizziness | 42 |
| 8 | Renal Failure Acute | 40 |
| 9 | Injury | 37 |
| 10 | Emotional Distress | 36 |
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Most common interactions experienced by males aged 65 (±5) in long term use of Advil, Simvastatin:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Renal Failure | 18 |
| 2 | Coronary Artery Disease | 10 |
| 3 | Rash | 8 |
| 4 | Myocardial Infarction | 8 |
| 5 | Lung Adenocarcinoma | 8 |
| 6 | Pleural Effusion | 7 |
| 7 | Disease Progression | 6 |
| 8 | Depression | 5 |
| 9 | Nasopharyngitis | 4 |
| 10 | Fear | 4 |
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For people in general (regardless of gender or age):
Comparison with this patient's adverse outcomes:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports among people in general who take the drugs |
| Simvastatin | The drug has been added in the study. Outcomes of the drug mix are shown. |
Most common interactions experienced by people in the use of Advil, Simvastatin:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Anxiety | 999 |
| 2 | Dyspnoea | 693 |
| 3 | Diarrhoea | 485 |
| 4 | Pain | 409 |
| 5 | Fatigue | 363 |
| 6 | Nausea | 352 |
| 7 | Chest Pain | 339 |
| 8 | Back Pain | 311 |
| 9 | Depression | 291 |
| 10 | Weight Decreased | 243 |
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Most common interactions experienced by people in long term use of Advil, Simvastatin:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Myalgia | 48 |
| 2 | Muscular Weakness | 43 |
| 3 | Myocardial Infarction | 38 |
| 4 | Renal Failure | 38 |
| 5 | Arthralgia | 34 |
| 6 | Coronary Artery Disease | 32 |
| 7 | Chest Pain | 32 |
| 8 | Pain In Extremity | 23 |
| 9 | Back Pain | 20 |
| 10 | Oedema Peripheral | 20 |
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How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
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Related studies:
- Advil and Simvastatin drug interactions (3,433 reports)
Drug effectiveness in real world:
- Advil for Muscle Aches reported by 10 people (updated 1 year ago)
- Simvastatin for Cholesterol reported by 2,079 people (updated 6 hours ago)
Side effects in real world:
Alternative drugs:
- Cholesterol (85 drugs) (updated 6 hours ago)
- Muscle Aches (44 drugs) (updated 2 weeks ago)
Comments from related studies:
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I brush my hair once a day. After this brushing, the hair brush is COVERED in hair, and I must clean the brush at that time. The crown of my head shows moderate to sever hair loss, and I don't know what to do about this problem.
Jemini on Feb, 11, 2013:
I'm a female, age 53. My doctor prescribed HCTZ 25/ Triamterene 37.5 MG for my High Blood Pressure. After taking it for about 3 days, on the 4th day I developed really bad muscle spasms in my mid back area. I did loose water weight really good but could not deal with the spasms. I informed my Dr and was taken off the medication. I explained to my Dr the pain & the Dr told me if it was spasms it was a rare side effect. I did read up on the medication once I started developing the pain in back and read that HCTZ could cause muscle spasms. After about 3 - 4 days after not taking HCTZ the pain went away. If it wasn't for the pain I would have continued it because I lost about 9 pds & my BP went down.
1) Re GERD: Despite taking 80 mg/day of Nexium, frequently supplemented by OTC famotidine and Tums, my GERD was so severe that surgery (Nissen fundoplication) was being considered to bring it under control. However, its intensity dropped markedly (and swiftly) after I stopped taking Prozac, with no other changes in medication or lifestyle. Today I am able to manage my GERD adequately with 40 mg/day of Nexium and 20 mg/day of Prilosec OTC, on rare occasions supplemented with famotidine or Tums.
2) ***PLEASE NOTE: Your form refused to accept an entry for hyoscyamine sulfate (brand names Levsin; Levbid, Hyosol, Anaspaz and more), an Rx antispasmodic that for nearly two decades has helped relieve pain/cramping associated with my Irritable Bowel Syndrome. This glitch on your site surprised me; amongst IBS sufferers, hyoscamine is neither a rare or obscure treatment option. It also merits full coverage within the NIH's Medline Plus website, where it has its own dedicated webpage.
Because I was unable to input this medication in your form, I decided to list in its stead Hyoscyami Folium (Henbane), an herbal supplement suggested to me by your database, whch seemingly is the only available choice containing hyoscyamine. However, Hyoscyami Folium evidently also contains another antispasmodic agent, scopolamine, which I do NOT take, so unfortunately any information I receive may be less than 100% accurate.
Although I have read reports that hyoscyamine is no longer being manufactured, I was able easily to fill a prescription for it less than a month ago (Dec. 2012). Given its continued availability, may I respectfully request that it be added to your database? I as well as many other hyoscyamine users would be grateful. Thank you.
Becca on Dec, 30, 2012:
I take Synthroid@75 mcg per day, but I don't need the other drugs. I found higher doses of Synthroid made my hair fall out. A new doctor's diagnosis of the problem with new blood work changed the dose for me.
When I was in the hospital for a hip replacement due to injury and perhaps the beginning of Osteoporosis, I was diagnosed by the hospital physician as having a heart murmur, extremely high cholesterol levels, not to mention being very over weight. He put me on a whole lot of drugs which all caused side effects. Instead of finding a better drug, I was put on another drug to reduce the side effects of the previous drug. In all, I was on 10 medications that I had never taken before and chose not to take again.
I changed the way I ate, avoiding meat which helped me lose weight and lower my cholesterol level. But, this year after fracturing my spine, I became much more serious and bought Dr. Neal Barnard's book, Foods that Fight Pain. He speaks of pain from heart disease, cancers, back pain, all sorts of pains and inflammation that the right diet can reduce. I do not have migraines, and in fact, I rarely have headaches. But, I'm not on layers and layers of drugs!
I'm 70 years old and fighting to get stronger. Having a private lesson with a Pilates instructor twice a week helps me get stronger, and I do not get down to the floor (mat) because of my back injury. Pilates is meant to help people heal and if you find someone who really knows what they are doing, it is very beneficial at building bone. I'm starting to add some weight bearing exercise, just a little at a time. I am getting stronger, but can only walk around the block with my rolling walker. Cannot walk far yet!
Becca on Dec, 30, 2012:
Wanda,
What do you eat? Can you eat vegetables such as collard greens? Cooked collard greens contain 375 mg calcium per cup, I generally eat three cups per day stir fried cooked in one teaspoon Eden Organic Miso with one cup water, for 5 minutes. Drained and sauteed in one tablespoon olive oil with 5 mashed garlic cloves, one tablespoon ginger root and perhaps a tablespoon of tumeric. The roots of ginger, tumeric and garlic cloves have anti-inflammatory properties and reduce pain immensly, as well as add flavor. The collard greens are full of calcium, more that milk per 8 oz class, and vitamin D3 at a rate of 1,000 IU should be taken to make the calcium work better and go to the bones. If you can bare much of your skin to the sun for 15 minutes a day, you can get all the vitamin D you need without taking supplements. But do not use sun screen. Instead be out side before 10 a.m. or after 3:00 p.m. This time of the year it is tough unless you live in South Florida.
I am eating vegan. That is a plant based diet --no meat, fish, or dairy. Plant foods like lentils and rice or quinoa make complimentary proteins and drive away pain. Animal foods create pain, as does nuts, corn, wheat.
Get the book Foods That Fight Pain by physician and nutritionist, Neal Barnard, M.D. If you can follow his diet for 3 weeks, you may be able to eliminate some of the drugs giving you the most problem.
I am NOT a physician. I am eating to fight pain caused by a spinal fracture. Also have a total hip and total knee replacement, the former of which is causing pain if I don't follow the diet.
wanda on May, 19, 2010:
citalopram genric is celexa 20 mg--i have to take 3000calcium tablets aday as i have no throid nor parathroid==also i have high bp so the only allergie med they say i should take is claatin D ==I ALSO TAKE HYDROCHLORT FOR EDEMA,, ALSO AMLODIPINE 5MG FOR BP,LISNOPRIL FOR BP PLEASE GIVE ME INTERACTIONS AND SIDE AFFECTS -WHILE I GOT YOU WHAT ABOUT SINTHYROID 112MG, LOVASTIN40MG AND FINALY MOTRUME FOR ADULT 2 DIABETICE==WHEW!!
halsbury tosih????
Been tested for various urinary conditions without meaningful results. Have had cystoscope procedure which revealed bladder diverticula and non-cancerous polyps. Continue to have urethritis and mild incontinence, discomfort and frequent urination. I'm disappointed that my uroligist will not see me for 9 months without a diagnosis or remedy.
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- Gammagard Liquid, Diphenhydramine Hydrochloride, Felodipine, Simvastatin, Prilosec, Vitamin D, Advil Liqui-gels, Apap Tab drug interactions for Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Off Label Use, Primary Immunodeficiency Syndrome, Premedication, Hypertension, Hyperlipidaemia, Gastrooesophageal Reflux Disease, Vitamin Supplementation, Pain. The patient has Hepatitis B
- Zocor, Nyquil, Aldactazide, Advil Liqui-gels drug interactions for Hyperlipidaemia, Product Used For Unknown Indication. The patient has Blood Glucose Increased, Blood Urea Increased, Gastric Ulcer Haemorrhage, White Blood Cell Count Increased
- Adderall 30, Wellbutrin Xl (Smithkline Beecham) - 300MG, Zoloft (Pfizer) - EQ 100MG BASE, Levothyroxine Sodium (Mylan) - 0.075MG, Simvastatin (Synthon Pharms) - 40MG, Ibuprofen (Leiner) - 600MG, Vitamin A (Banner Pharmacaps) - EQ 50,000 UNITS BASE, Multivitamin, Vitamin C drug interactions for ADHD, Depression, Obsessive-compulsive Personality Disorder, Primary Hypothyroidism, High Density Lipoprotein, Pain, Hypothyroidism, General Physical Condition. The patient has Urine Odour Foul
- Seroquel, Hctz, Enalapril Maleate, Simvastatin, Propranolol, Ibuprofen, Ambien, Lithium Citrate drug interactions for Bipolar Disorder. The patient has Antipsychotic Drug Level Above Therapeutic, Diarrhoea, Nausea, Renal Failure Acute, Tremor, Vomiting
- Simvastatin, Amlodipine, General Nutrients, Ibuprofen, Caduet drug interactions for Hypertension, Blood Cholesterol Increased. The patient has Asthenia, Blood Uric Acid Increased, Feeling Cold, Heart Rate Increased, Myalgia, Pruritus, Speech Disorder, Unevaluable Event
- Other Unspecified Medications From Russia, Amias, Paracetamol, Erlotinib, Potassium, Simvastatin, Dalteparin Sodium, Ibuprofen, Adalat drug interactions for Lung Neoplasm Malignant. The patient has Disease Progression, Lung Adenocarcinoma, Pleural Effusion, Renal Failure
- Vitamine D, Fish Oil, Ibuprofen, Glucosamine, Melatonin, Zocor, Toprol-xl, Gemcitabine Hydrochloride, Pemetrexed Disodium, Vinorelbine Tartrate, Aspirin, Levofloxacin, Bevacizumab, Cisplatin, Docetaxel drug interactions for Non-small Cell Lung Cancer. The patient has Cardiac Arrest, Cerebral Ischaemia, Pulmonary Haemorrhage
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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