A study of drug interactions between Diphenhydramine Hcl, Bevacizumab, Vicodin, Hydrochlorothiazide, Keppra, Afinitor for a Male patient aged 51
This is a personalized study of Diphenhydramine Hcl, Bevacizumab, Vicodin, Hydrochlorothiazide, Keppra, Afinitor drug interactions for a 51 year old male patient. The study is created by eHealthMe based on 3 reports from FDA.
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What are the drugs
Diphenhydramine hcl has active ingredients of diphenhydramine hydrochloride.
Bevacizumab has active ingredients of bevacizumab.
Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is used in pain, back pain - low, back pain, surgery, pain in limb, arthritis.
Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is used in high blood pressure, fluid retention, swelling, diuretic effect, foot, leg, and ankle swelling, diuretic therapy.
Keppra has active ingredients of levetiracetam. It is used in epilepsy, seizures, generalized tonic-clonic seizure, petit mal seizure, temporal lobe seizure, complex partial seizures.
Afinitor has active ingredients of everolimus. It is used in renal cancer metastatic.
On May, 10, 2013: 3 people who reported to have interactions when taking Diphenhydramine Hcl, Bevacizumab, Vicodin, Hydrochlorothiazide, Keppra, Afinitor are studied
Information of the patient in this study:
Age: 51
Gender: male
Conditions: Renal Cell Carcinoma, Glioblastoma Multiforme
Drugs taking:
- Diphenhydramine Hcl
- Bevacizumab
- Vicodin
- Hydrochlorothiazide
- Keppra
- Afinitor
- Afinitor
Drug interactions have: Tremor, Oxygen Saturation Decreased, Hypotension, Hypersensitivity, Chills
eHealthMe real world results:
For males aged 51 (±5):
Comparison with this patient's adverse outcomes:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports |
| Tremor | 3 (100.00%) |
| Oxygen Saturation Decreased | 3 (100.00%) |
| Hypotension | 3 (100.00%) |
| Hypersensitivity | 1 (33.33%) |
| Chills | 3 (100.00%) |
Most common interactions experienced by males aged 51 (±5) in the use of Diphenhydramine Hcl, Bevacizumab, Vicodin, Hydrochlorothiazide, Keppra, Afinitor:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Pyrexia | 3 |
| 2 | Tremor | 3 |
| 3 | Oxygen Saturation Decreased | 3 |
| 4 | Chills | 3 |
| 5 | Hypotension | 3 |
| 6 | Lung Infiltration | 2 |
| 7 | Pneumonia | 2 |
| 8 | Hypersensitivity | 1 |
| 9 | Drug Hypersensitivity | 1 |
Login or sign up (it's free) to view more results. Or personalize this study
Most common interactions experienced by males aged 51 (±5) in long term use of Diphenhydramine Hcl, Bevacizumab, Vicodin, Hydrochlorothiazide, Keppra, Afinitor:
(click on each outcome to view in-depth analysis, incl. how people recovered)| None. |
For people in general (regardless of gender or age):
Comparison with this patient's adverse outcomes:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports |
| Tremor | 3 (100.00%) |
| Oxygen Saturation Decreased | 3 (100.00%) |
| Hypotension | 3 (100.00%) |
| Hypersensitivity | 1 (33.33%) |
| Chills | 3 (100.00%) |
Most common interactions experienced by people in the use of Diphenhydramine Hcl, Bevacizumab, Vicodin, Hydrochlorothiazide, Keppra, Afinitor:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Pyrexia | 3 |
| 2 | Tremor | 3 |
| 3 | Oxygen Saturation Decreased | 3 |
| 4 | Chills | 3 |
| 5 | Hypotension | 3 |
| 6 | Lung Infiltration | 2 |
| 7 | Pneumonia | 2 |
| 8 | Hypersensitivity | 1 |
| 9 | Drug Hypersensitivity | 1 |
Login or sign up (it's free) to view more results. Or personalize this study
Most common interactions experienced by people in long term use of Diphenhydramine Hcl, Bevacizumab, Vicodin, Hydrochlorothiazide, Keppra, Afinitor:
(click on each outcome to view in-depth analysis, incl. how people recovered)| None. |
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Alternative drugs:
- Glioblastoma Multiforme (4 drugs) (updated 1 month ago)
- Renal Cell Carcinoma (3 drugs) (updated 3 months ago)
Comments from related studies:
From this study (6 days ago):
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peanuts on Mar, 31, 2010:
my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????
jimmy on Apr, 29, 2013:
Susan,
Finally, I'd been reading thru here and finnaly, what doctor in the U.S. still prescribes cocaine? LOL
jimmy on Apr, 29, 2013:
IF you donT see my other comments, Never take Cymbalta or anything containing same ingrediants or speeding thru the same side effects durring their enjoyable living advertizements!
Jmsrocks on Jul, 25, 2012:
Probably death. Cocain and opiates together = speed ball.
Hebe on Jul, 31, 2012:
I have had two close relatives on prednisone, and for both of them it alone can make them feel really speedy. Combined with cocaine and wellbutrin would probably make sleeping very difficult. As the previous commenter mentioned, combining oxys into this is probably a bit dangerous.
Patty O'Neill on Aug, 10, 2012:
The comments about death in combination with cocaine and opiates or any other drug is possible
depending on how much and the situation. Frightening people is not the key here. Basically any drug in combination with another could cause a major health problem as we are all very much not the same makeup. Cheers,
ken on Aug, 17, 2012:
If she continues with this type of treatment, its kinda scary in all reality. Why not see a doctor, that's where the healing may start.
Jackie on Apr, 30, 2013:
I am wondering if you were diagnosed because you had pain and found out you had a neurological message going on.... or just a process of elimination over the pain after you were taking your anti psychotic medication? I've been taking oxycone for my pain my back and neck disc issues um for about a year now, was having joint pain and stiffness all over my body the Dr put me on cymbalta and now three weeks later he put me on wellbutrin and I'm wondering about seratonin syndrome... I'm having muscle twitching also lump on top of my head and vision problems.
iCaNtCaLlIt on Oct, 24, 2012:
Please coke for arthrit.? take your fish oils 2 each meal and take your perscribed pain meds(careful very addicting) stop the coke thats being silly for real. goodluck, lifes a bych and ya die thats why we get high .. p.s ankle 9 surgerys plates screws never walk normal again, fight thru it..i got hurt at work btw 7 ton crushed my leg instead of me....jus always think thingd can be worse, be a gpod person dont let this bring u dwn n b miserable..pul thru keep head up n watch those pain meds..goodluck...email if u wana talk but dont come with negatibity. buhbye
susan on Jan, 3, 2013:
have vit d blood levles ck, and supplenment. vit d is an amazing pain control helper.
nefariouson3 on Nov, 7, 2012:
I too am a chronic pain sufferer, I drove over a explosive in the middle-east. I don't understand what or why this thread was written up like a true medical study, to me it looks more like a recreational train wreck, some listed drugs have reverse reactions and others simply have no medical need what so ever, personally I would seek professional help and attempt to get off the unneeded drugs and concentrate on the true medical issues. At your age 51, you run the risk of many complications and possibility death from the listed drugs, though who am I to judge, life is way too short enjoy it when your still alive.
Th3
Had'em all on Nov, 14, 2012:
Prison and/or death. Comparing taking coke by inhalation and oxycontin orally is NOT the same thing as speed ball. Kindergarten speed ball maybe. Addiction threshold of oxy is 60mg/day. She should try to stay below that.
Get her the hell off Pristine/Ketoconazole unless it is absolutely positively necessary. If necessary, try to get a lower dose. Stuff fries the liver & with all the other crap--BAD idea.
Is there a reason she isn't taking an NSAID? I see prednisone. Would help more than oxy.
kobe77 on Jan, 3, 2013:
Lmao! Lmao! You sound like your high ......enjoy your trip!
knowledgable on Jan, 7, 2013:
Death bed us what they should expect. Mixing cocaine and oxy, are they brainless!!!!
Sydney on Jan, 9, 2013:
Tell your friend to GET OFF WHEAT. The wheat products in this country are GMO which are very bad for us and cause arthritis. Tell your friend to research. Never let the Dr.s try and figure out what's wrong with you. They won't. And they'll kill you trying.
nursing101 on Jan, 28, 2013:
Well, NSAID, you say? Hmmm....I see motrin, naproxen and aspirin on the list....all NSAID's
Billy on Feb, 2, 2013:
It is a wonder that your wife is at all coherent taking that cocktail of medications. I would try to find a new doctor that has a better grasp of toxicology and drug interactions. Cocaine and Oxycotin--can't belief any reputable doctor would prescribe that combination.
High depression low motivation on Feb, 8, 2013:
I take fish oils and centrum vitamins for depression replacing latuda and Lexapro wich was messing with my school I was out of phase sleeping all day and cloudy thinking. Now I just take Adderall and Xanax for agoraphobia and I feel a lot better and Im actually doing homework!! I scored high on my test than on the antidepressants with low scores.
AdoreTu on Mar, 4, 2013:
Well, I just stopped at your post, and who ever is taking all of that stuff needs to take some Milk Thistle to help restore their liver.
Sam on Mar, 11, 2013:
Way back in the late 1960's I heard it called a combination of cocaine and opiate type drugs a speedball. My best guess is your friend is on the way out of this world, unless there is an intervention. In short, death is the end result/side effect of taking such a combination of drugs....
Deo Vindece,
Sam
BCS on Mar, 12, 2013:
Honestly. She can expect to die very young.
Everything from heart, kidney, liver, stomach, brain, lungs, immune system, etc. will began to shut down.
She will most likely become increasingly weak, finding herself in the hospital more often, and eventually die of organ failure. that is unless she dies from an overdoes first.
bcs on Mar, 12, 2013:
Yeah, hybrid wheat is causing all the problems. not the cocaine and oxy, mixed with other prescription drugs.
I agree Hybrid wheat is harmful and best left out of ones diet, but it's not the biggest problem here. (it hybrid not gmo) they haven't released that yet.
Susan on Mar, 12, 2013:
Are you guys really this dumb? She meant to say her friend was taking Codeine not cocaine. I'm not even going to bother asking a question on this website if you're that dumb! LOL
Jenn on Mar, 15, 2013:
I know that I am super sensitive to both codeine and oxy. They actually make me more nauseous and dizzy and i find regular tylenol or ibuprophen to be more effective against pain. I have heard some good things about omega fish oil and gluten free diets. My sister has RA too and when she flares up even pain meds dont help much. She is also gluten intolerant and can feel a marked difference in symptoms when she "slips" and eats gluten-y things. Steroids make your blood pressure high, she takes them when she gets flare ups but tries to ween herself off as the flare up dissipates. She gets weird skin breakouts because steroids also mess with the natural flora of your body. RA sux!!!!
doc moc on Mar, 25, 2013:
have tou tried cocaine? pretty sure its gluten free our previous inquisitor seemed to have some luck with its administration in combination with an assortment of other medications to treat her condition also as far as the flora issue goes i dont think cocaine is an antagonist
doc moc on Mar, 30, 2013:
oh yes BCS i agree hybrid wheat is a very dangerous substance especially when compared to the rather inocuous substances of cocaine and oxycontin! just what are your qualifications to dispense such well researched and supported opinions? You are truly a fool
Stephanie on Apr, 1, 2013:
Yeah I'm pretty sure she ment codeine. i dont visit these sites often anymore becasue my questions never get answered and everything gets way off topic.
really on Apr, 10, 2013:
people like you should visit your local humane society and have yourself spayed or neutered because the human race does not need less intelligent, human-jackass hybrid beings breeding with those of greater intellect. Cocaine was clearly written, not codeine. and please don't post your questions, prefer you be the guinea pig and take risks alerting the people who matter of potential risk factors. :)
Robert on Apr, 12, 2013:
I just wish the federal government would overhaul Richard Nixon's war on drugs and the whole controlled drug act. I have had my share of pain and you can consider yourself lucky to be able to cope with it. It is the sorry folk out there who have psychiatric disorders which affect the brain's ability to "deal" and cope, and is at a chemical level with them, a neurological mess-up. I know personally, I have phases of time when it is dangerous for me to try and tough it out when my brain sometimes slows down production and release of the natural chemicals like beta endorphin, dopamine, Gammaaminobuteric Acid, and I can find my body aches because Im not making enough natural opiate substances. SO I take drugs given by MD to make me feel normal, like clonazepam, prozac, and sometimes amphetamine in low doses. It is frustrating because people still don't understand and think I am a schmuck for taking drugs to feel normal happiness, calm, joy, relaxation, and to enjoy life's natural pleasures I periodically am unable to feel or appreciate.
Robert on Apr, 12, 2013:
It is true that speedballs, containing opiates and any stimulant. The "speed" in speedball likely refers to amphetamine, which was, prior to 1970, the original or at least most widely used upper in the 1960's. When the Controlled Drug Act was made official, cocaine became hugely popular, as an easier and more available alternative. SO strangely enough it became easier to get a totally outlawed drug than legal controlled drugs, because the new DEA and their most overzealous zealots were too busy finally settling old scores and getting the "dopeheads" and "speedfreeks" with the new Nixonian legislation backing them up like the word of God
Michele on Apr, 12, 2013:
I totally understand where you are coming from. Your comment at the end there helped me understand that I am not "a druggy" as my husband calls me because I need medications to feel an enjoy simple life activities. You're lucky to have found the right combination of medicines to treat your depression. I feel like I've been on a roller coaster for the last 20 years. If I find the "right" combination to treat my severe depression/bipolar2 disorders, then I find myself with one or more intolerable side effects that I must live with, like extreme teeth pain/bruxism. I look at people all the time and say to myself "That person is "normal." "That person is enjoying life." "That person sleeps normally and doesn't need help." "That person is a good mom for doing activities with her child/children." I get sorta jealous, then I start believing what my husband says about me being a druggy and that I am not a good teacher/mom/wife. That I shouldn't need medicine to just have energy to get up and get dressed. But when I read your post it made me feel good, not that you were dealing with depression, but that someone else out there understands how it feels, that my husband is dead wrong and out of line, that my depression is a real disorder and not my fault. Thank you for your post.
shannon on Apr, 13, 2013:
What shouldnt the expexation be...yes, cocaone is an antisthetic...only local, dentists "pink" mouth swab is cocaine based to numb the area and costrict blood vessels toz reduce swelling and bleeding....not for arthritis!..sounds like its a way to find a way out faster by destroying the heart muscle fro. The cocke's super stimulative effect and leave this world. There are other means to treat pain than death and mega doses of narcotics to mask the pain and increase the tolernance of the mds to the point that either there are no interior sinuses lrft by coke use or not enough pain meds to overcome the tolerance....ven IV cocaine use will burn the veins you shoot it in...its a loosing battle...and a painful one from damag thats beendone...Im praying for you guys...
Russ on May, 7, 2013:
Formally of you bashing the cocaine for pain, do some research! Brompton's Cocktail is a chronic pain medicine in liquid form that contains cocaine, opiates, and some other meds. It is an evidenced based treatment for chronic pain, so please don't assume just because it has cocaine in it means it's gonna kill you. People suffering from chronic.pain need relief. if Brompton's works, then let them get their much needed relief!!! Without judgement!!
i also take garlic,tumeric,vitamin c,b complex,milk thistle,calium,evening primrose,chronium picolinate,multiple vitamin,fiber,vitamin d,
Have started getting petechiae and blood blisters on my forearms.
My lips have blistered and are being treated with topical steroid , on 300 mg going up to 400 sjs allergy began backed down blistered mouth healed in two week but it's again in question right now I'm.concerned about aseptic meningitis. Just received dexamethasone inj six days ago caused high fever flushing red face chest neck back severe headache and worsening neck pain eyes hurt fevers coming and going brain tingles pain increased it's unbearable
Just wondering with the vast amounts of drugs my husband is prescribed by so many different doctors - if one would bother another? All doctors do have lists of what the others prescribe. And occassionally the pharmacist calls us to the side when a new drug is mixed in to give us specific warnings.
Gary Dunn on Oct, 22, 2012:
I am not a doctor and realize that being an expert on every field is imposable regardless of how many years of college (21) or exposure to individual cases. Being older has the advantage that you have made an lot of mistakes and if you can learn a small bit from each and know that, you have and advantage is you can walk on the shoulder of millions that have gone down this pathway before you. I suggest that you contact an expert on drug interaction like the Phar Dept at Wingate College in NC, as they have an "interaction awareness" curriculum at their school. You must contact them directly and I do not know if there is a charge... I have sent several people to them with great results. Most pharmacologist and doctors do not have the expertise to make a complete evaluation on the subject, the field is very specific and requires a panel of experts such as exist at Wingate College. Thank you Gary Dunn.
Jamie on Jun, 13, 2012:
Male 39, chronic neck and shoulder pain from motocross accident. Been taking cymbalta 60 mg and opana 10 mg ir for a couple months. Have been depressed and am loosing weight like crazy, no appetite. Also take Xanax as needed for anxiety. Went from 220lbs to 184lbs in 6 months. Time for a med ajustment.
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- Lexapro, Diovan, Norvasc, Dexamethasone Tab, Keppra, Avastin, Temozolomide, Afinitor drug interactions for Glioblastoma Multiforme. The patient has Confusional State, Decreased Appetite, Dyspnoea, Fatigue, Interstitial Lung Disease, Lung Infiltration, Pneumonitis
- Keppra, Lorazepam, Pepcid, Decadron, Depakote, Metoprolol Tartrate, Citalopram Hydrobromide, Calan, Dilantin, Zolpidem, Prochlorperazine, Divalproex Sodium, Everolimus, Bevacizumab drug interactions for Glioblastoma Multiforme. The patient has Asthenia, Atelectasis, Blood Sodium Decreased, Blood Urine Present, Brain Oedema, Convulsion, Dehydration, Disease Progression, Dizziness, Dysstasia, Glioblastoma Multiforme, Hypertension, Hypotension, Leukocyturia, Malignant Neoplasm Progression, Nitrite Urine Present, Nuclear Magnetic Resonance Imaging Brain Abnormal, Pneumonia, Protein Urine Present, Pyuria, Tachycardia, Urine Ketone Body Present
- Colace, Temozolomide, Avastin, Afinitor, Keppra, Tricor, Contrast Media drug interactions for Glioblastoma Multiforme. The patient has Vena Cava Filter Insertion, Spinal Osteoarthritis, Pulmonary Embolism, Pneumonitis, Pneumonia, Pleural Effusion, Pain In Extremity, Musculoskeletal Pain, Lung Neoplasm, Lung Infiltration Malignant, Lung Infiltration, Lung Consolidation, Inflammation, Hilar Lymphadenopathy, Deep Vein Thrombosis, Chest Pain, Atelectasis, Arteriosclerosis
- Keppra, Lorazepam, Pepcid, Decadron, Citalopram Hydrobromide, Calan - Slow Release, Depakote, Metoprolol, Arixtra, Afinitor, Avastin, Temozolomide drug interactions for Glioblastoma Multiforme. The patient has Atelectasis, Confusional State, Dizziness, Dyspnoea, Dysstasia, General Physical Health Deterioration, Hypotension, Lung Infiltration, Mental Status Changes, Pneumonia, Rhabdomyolysis, Tachycardia
- Keppra, Lorazepam, Pepcid, Decadron, Citalopram Hydrobromide, Calan - Slow Release, Depakote, Metoprolol Tartrate, Afinitor, Avastin, Temozolomide drug interactions for Glioblastoma Multiforme. The patient has Atelectasis, Dizziness, Dysstasia, Hypotension, Lung Infiltration, Tachycardia
- Colace, Contrast Media, Afinitor, Tricor, Keppra, Avastin, Temozolomide drug interactions for Glioblastoma Multiforme. The patient has Arteriosclerosis, Atelectasis, Chest Pain, Deep Vein Thrombosis, Hilar Lymphadenopathy, Inflammation, Lung Consolidation, Lung Infiltration, Lung Infiltration Malignant, Lung Neoplasm, Musculoskeletal Pain, Pain In Extremity, Pleural Effusion, Pneumonia, Pneumonitis, Pulmonary Embolism, Spinal Osteoarthritis, Vena Cava Filter Insertion
- Famotidine, Acetaminophen, Atenolol, Acetaminophen And Hydrocodone Bitartrate, Bactrim, Zolpidem, Midazolam Hcl, Avastin, Afinitor drug interactions for Glioblastoma Multiforme. The patient has Anaemia, Cheilitis, Chest Pain, Deep Vein Thrombosis, Device Related Infection, Dyspnoea, Pulmonary Embolism, Urinary Tract Infection, Vena Cava Filter Insertion
- Keppra, Lorazepam, Pepcid, Decadron, Citalopram, Calan - Slow Release, Depakote, Metoprolol Tartrate, Arixtra, Temozolomide, Afinitor, Avastin drug interactions for Glioblastoma Multiforme. The patient has Atelectasis, Brain Oedema, Confusional State, Convulsion, Dizziness, Dyspnoea, Dysstasia, General Physical Health Deterioration, Hypotension, Lung Infiltration, Malignant Neoplasm Progression, Mental Status Changes, Pneumonia, Rhabdomyolysis, Tachycardia
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