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From FDA reports: side effects of Depakine Chrono Tablets 500 Mg

This is a real world study of Depakine Chrono Tablets 500 Mg side effects. The study is created by eHealthMe based on 20,202 people who take the drug and have side effects.

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Information of the patient in this study:

Gender: male

Conditions: Drug Exposure During Pregnancy

Drugs taking:
- Depakine Chrono Tablets 500 Mg

Side effects have: Drug Exposure During Pregnancy, Dysmorphism, Gastrooesophageal Reflux Disease, Hypermobility Syndrome

On Jan, 22, 2014: 20,202 people who reported to have side effects when taking Depakine Chrono Tablets 500 Mg are studied

Trend of Depakine Chrono Tablets 500 Mg's drug interactions, side effects, and effectiveness reports (2736779)

eHealthMe real world results:

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

Side effectNumber of reports
Drug Exposure During Pregnancy384 (1.90%)
Dysmorphism (difference of body structure that is suggestive of a congenital disorder)5 (0.02%)
Gastrooesophageal Reflux Disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)43 (0.21%)
Hypermobility Syndrome (abnormalities cause abnormal stress on a joint or many joint)2 (0.01%)

Most common side effects experienced by people in the use of Depakine Chrono Tablets 500 Mg:

Side effectNumber of reports
Pyrexia (fever)3,211
Asthenia (weakness)1,677
Vomiting Nos1,171
Nausea (feeling of having an urge to vomit)1,144
Fatigue (feeling of tiredness)852
Liver Function Tests Nos Abnormal714
Condition Aggravated (worse condition)699
Malaise (a feeling of general discomfort or uneasiness)653
Dizziness (exc Vertigo)591
Dermatitis Nos553

Most common side effects experienced by people in long term use of Depakine Chrono Tablets 500 Mg:

Side effectNumber of reports
Economic Problem79
Tardive Dyskinesia (a disorder that involves involuntary movements)78
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck)74
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)57
Nervous System Disorder (a general class of medical conditions affecting the nervous system)56
Activities Of Daily Living Impaired54
Deformity (disfigurement)43
Movement Disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)36
Nausea (feeling of having an urge to vomit)36

Comments for this study:

Roshini (4 years ago):

will i get PCOS if i take Depakine for 3 months?i had been suffering from Bipolar disorder hence my Doctor had prescribed Depakine for my moood swings and Depression.but ultimately it led to Pcos for i had stopped Depakine in between.but now my Doctor has suggested me to take Depakine,i'm afraid if i'll end up with this ovarian cyst syndrome?is it treatable or not?please kindly waiting for your response,
thank you.
Reply the comment

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Drug Exposure During Pregnancy, Dysmorphism, Gastrooesophageal Reflux Disease, Hypermobility Syndrome

You can also:

Comments from related studies:

  • From this study (6 months ago):

  • Muscle pain started in the right hip and is the most frequent. Right shin, Right elbow. right leg pain moving from sitting to standing. Most pain is on the right side with the exception of pain in the left triceps. The pain moves (over 4 to 8 weeks). Naproxen reduces the pain by half. Heat, a hot shower increases the pain. Massage is helpful. Physical therapy has tried stretches, they seem to help for short periods of time. Sitting and inactivity increases the problem. For my leg knee and hip walking relives the pain until I stop and sit or lay to sleep. Tried hydrocodone/acetaminophen 5/25 with no noticeable effect and discontinued use after a few days.


  • From this study (1 year ago):

  • Jelena Bakarema on Mar, 26, 2013:

    My son is 13 months and drinks Depakine syrup, but got an allergy and he attributed Loratadine.Is it safe to combine these two drugs simultaneously.
    Thank you.


  • From this study (2 years ago):

  • Anxios Son on May, 6, 2012:

    My mother had a lumber lacminectomy surgery decompression in hospital on 2012-2-24 and developed buttock clip pressure sore after disacahged from Hong Kong St. Teresa Hospital on 2012-3-3. She was admitted in another Hospital Authorty's Kwong Wah Hospital on 2012-3-27 with antibiotic treatment and wound cleansing daily. She was discharged on 2012-4-14 with nursing care at home by wound cleansing bi-daily.
    However her wound doesn't heal and subcutaneous tissue still be seen at present even though she has no infection.
    I am anxious for her old age of 71 and diabete. I takes a long time not seeing her healing. Please give special medical advice for better prognosis. She is using frame for mobility and in urinary catherisation now.
    Thanks to all,


    a Christian friend on Jun, 25, 2012:

    I forgot to say that I used Lose It!, a free online program, to help me lose weight for my diabetes problems. I also heard of a method of treating wounds with a sugar/iodine product. You could search for those things online. There is a good website with information from Dr. David Williams, also. I think it is his name plus dot com. Hope this helps a little. I will pray for your mom and you. I love Hong Kong, by the way. I used to go to church on Nathan Road at the Anglican church in TST.


    a Christian friend on Jun, 25, 2012:

    I found that allopurinol gave me candida problems which include dizziness and mental and physical fatigue and immune problems. There is an anti-candida diet and there is a product I have not tried called Threelac (from Japan). Probiotics help, like active yogurt cultures. I stopped taking the allopurinol. I found a gout diet instead. It emphasizes fruits and vegetables, and low consumption of seafood products and meats. God bless you as you care for your mother. Ask for healing in Jesus' name!


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More questions for: Drug Exposure During Pregnancy, Dysmorphism, Gastrooesophageal Reflux Disease, Hypermobility Syndrome

More reviews for: Drug Exposure During Pregnancy, Dysmorphism, Gastrooesophageal Reflux Disease, Hypermobility Syndrome

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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Related conditions

- Gastrooesophageal reflux disease


Related drug side effects

- Drug Exposure During Pregnancy
- Dysmorphism
- Gastrooesophageal Reflux Disease
- Hypermobility Syndrome



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