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From FDA reports: side effects of Diphenhydramine for a Male patient aged 62

This is a personalized study for a 62 year old male patient. The study is created by eHealthMe based on reports of 34,946 people who take the same drug and have side effectsfrom FDA.

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On Jun, 20, 2014: 34,946 people who reported to have side effects when taking Diphenhydramine are studied

Trend of Diphenhydramine's drug interactions, side effects, and effectiveness reports (3019987)

Information of the patient in this study:

Age: 62

Gender: male

Conditions: Antiallergic Therapy

Drugs taking:
- Diphenhydramine: used for < 1 month

Side effects have: Delirium

eHealthMe real world results:

Comparison with this patient's adverse outcomes among males aged 62 (±5):

Side effectNumber of reports
Delirium (wild excitement)50 (2.05%)

Most common side effects experienced by males aged 62 (±5) in the use of Diphenhydramine:

Side effectNumber of reports
Dyspnoea (difficult or laboured respiration)680
Pyrexia (fever)543
Hypotension (abnormally low blood pressure)422
Pruritus (severe itching of the skin)337
Fatigue (feeling of tiredness)312
Nausea (feeling of having an urge to vomit)311
Chest Pain244

Most common side effects experienced by males aged 62 (±5) in long term use of Diphenhydramine:

Side effectNumber of reports
Memory Impairment3
Injury Nos2
Sexual Dysfunction Nos2
Tinnitus (a ringing in the ears)2
Renal Insufficiency (insufficient excretion of wastes by the kidneys)2
Hypertension Nos2
Disturbance In Attention2
Depression Nos2
Dizziness (excl Vertigo)2

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

Side effectNumber of reports
Delirium (wild excitement)322 (0.92%)

Most common side effects experienced by people in the use of Diphenhydramine:

Side effectNumber of reports
Dyspnoea (difficult or laboured respiration)9,138
Pyrexia (fever)6,877
Nausea (feeling of having an urge to vomit)5,956
Pruritus (severe itching of the skin)5,267
Fatigue (feeling of tiredness)4,287
Chest Pain3,788
Headache (pain in head)3,715

Most common side effects experienced by people in long term use of Diphenhydramine:

Side effectNumber of reports
Headache (pain in head)18
Hypoaesthesia (reduced sense of touch or sensation)18
Haemorrhage (bleeding)16
Gastrooesophageal Reflux Disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)16
Fatigue (feeling of tiredness)15
Insomnia (sleeplessness)14
Loss Of Consciousness14
Weight Decreased14

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Comments from related studies:

  • From this study (1 week ago):

  • I am vigorous and healthy. My fainting happens when my head moves backward rapidly such as when I lie down in bed too fast. I recover quickly with no additional effects. I am not sure this is caused by my medication.


  • From this study (2 weeks ago):

  • Ringing started after first few doses of Benadryl


  • From this study (3 weeks ago):

  • I have been taking large amounts of benadryl almost daily for the last two years. These last 6 months I have noticed weird and painful/scary symptoms after taking my dose (yellow skin,reversed vision; i am normally nearsighted but after taking a dose I become farsighted or completely blurred.lower back pain, stomach burning, even seizures) these symptoms fade after the benadryl works its way out of my system. I just dont know if i should be concerned or not


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Can you answer these questions (what is this?):

More questions for: Antiallergic Therapy, Delirium

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Alternative drugs:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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