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From FDA reports: side effects of Diphenhydramine for a Male patient aged 62

This is a personalized study of Diphenhydramine side effects for a 62 year old male patient. The study is created by eHealthMe based on 34,946 people who take the drug and have side effects.

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On Mar, 8, 2014: 34,946 people who reported to have side effects when taking Diphenhydramine are studied

Trend of Diphenhydramine's drug interactions, side effects, and effectiveness reports (3019987)

Information of the patient in this study:

Age: 62

Gender: male

Conditions: Antiallergic Therapy

Drugs taking:
- Diphenhydramine: used for < 1 month

Side effects have: Delirium

eHealthMe real world results:

Comparison with this patient's adverse outcomes among males aged 62 (±5):

Side effectNumber of reports
Delirium (wild excitement)25 (1.02%)

Most common side effects experienced by males aged 62 (±5) in the use of Diphenhydramine:

Side effectNumber of reports
Dyspnoea (difficult or laboured respiration)474
Pyrexia (fever)362
Hypotension (abnormally low blood pressure)245
Pruritus (severe itching of the skin)226
Fatigue (feeling of tiredness)172
Nausea (feeling of having an urge to vomit)156
Chest Pain134

Most common side effects experienced by males aged 62 (±5) in long term use of Diphenhydramine:

Side effectNumber of reports
Memory Impairment2
Injury Nos1
Sexual Dysfunction Nos1
Tinnitus (a ringing in the ears)1
Renal Insufficiency (insufficient excretion of wastes by the kidneys)1
Hypertension Nos1
Disturbance In Attention1
Depression Nos1
Dizziness (excl Vertigo)1

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

Side effectNumber of reports
Delirium (wild excitement)161 (0.46%)

Most common side effects experienced by people in the use of Diphenhydramine:

Side effectNumber of reports
Dyspnoea (difficult or laboured respiration)6,334
Pyrexia (fever)4,592
Pruritus (severe itching of the skin)3,527
Nausea (feeling of having an urge to vomit)2,979
Fatigue (feeling of tiredness)2,341
Chest Pain2,218
Headache (pain in head)1,990

Most common side effects experienced by people in long term use of Diphenhydramine:

Side effectNumber of reports
Headache (pain in head)10
Haemorrhage (bleeding)9
Hypoaesthesia (reduced sense of touch or sensation)9
Gastrooesophageal Reflux Disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)8
Fatigue (feeling of tiredness)8
Insomnia (sleeplessness)7
Loss Of Consciousness7
Weight Decreased7

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Antiallergic Therapy, Delirium

You can also:

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  • From this study (7 days ago):

  • Been I'll for 9 months. Just recently found pneumonia. Can't afford dermatologist and do for doesn't know what the hives are. You can write with your finger on my skin and it will show up.


  • From this study (2 weeks ago):

  • 5/325 every 4 hours as needed. 0-4 per day. Would like to stop taking this drug as my eye pressure has increased. Only take it if the pain is 10+++. Looking for Orthopedic Surgeon to fix the bulging disks.


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More questions for: Antiallergic Therapy, Delirium

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related conditions

- Antiallergic therapy
- Delirium


Related drug side effects

- Delirium



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