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What could cause Irritability for a 14-year old girl?

This is a study of Focalin Xr, Benadryl for a 14 year old female patient who has ADHD, Allergy To Animal. The study is created by eHealthMe based on 4 female patients aged 14 (±5) who take the drugs from FDA and social media.

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Information of the patient in this study:

Age: 9

Gender: female

Conditions: ADHD, Allergy To Animal

Drugs taking:
- Focalin Xr - 10MG (dexmethylphenidate hydrochloride): used for 6 - 12 months
- Benadryl - 10MG/ML (diphenhydramine hydrochloride): used for < 1 month

Drug interactions have: least irritability

On Jan, 26, 2014: 4 females aged 9 (±5) who reported to have interactions when taking Focalin Xr, Benadryl are studied

Trend of Focalin Xr, Benadryl's drug interactions, side effects and effectiveness reports (2839962)

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
among females aged 9 (±5) who take the drugs
Irritability1 (25.00%)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

SymptomNumber of reports
among females aged 9 (±5) who have the condition, regardless of which drug is taken
Irritability in Adhd84 (2.53%)
Irritability in Allergy To Animal2 (14.29%)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effectNumber of reports
among females aged 9 (±5) who take the drug
Irritability in Focalin Xr1 (1.22%)
Irritability in Benadryl5 (1.02%)

Most common interactions experienced by females aged 9 (±5) in the use of Focalin Xr, Benadryl:

InteractionNumber of reports
Cystitis (inflammation of the wall of the bladder)3
Bunion (a painful swelling on the first joint of the big toe)1
Abdominal Pain Upper1
Abdominal Pain1
Mania (a state of abnormally elevated or irritable mood)1
Oppositional Defiant Disorder (a childhood disorder described by the diagnostic and statistical manual of mental disorders)1
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)1
Gastroenteritis (inflammation of stomach and intestine)1
Homicidal Ideation (thoughts about human killing another human)1
Ear Pain1

Most common interactions experienced by females aged 9 (±5) in long term use of Focalin Xr, Benadryl:

InteractionNumber of reports
Kidney Enlargement1

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: ADHD, Allergy To Animal, Irritability

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In-depth study of side effects (who have it, when it happens and how):

Could it be a symptom from a condition:

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Comments from related studies:

  • From this study (4 years ago):

  • We have had to increase Nathan's focalin to 3 times a day so he can get home work done. He also takes Gaba calm with his focalin to help him with irratiblty at school. the benadryl was to help him go to sleep but it isn't working. what can we do he getting in trouble at school since we increased the focalin he's not getting enough rest. I don't think the Gaba Calm is working either.


  • From this study (4 years ago):

  • Just wondering if they are responsible for nausea


  • From this study (5 years ago):

  • My 13 yr. old son was diag. 2 yrs. ago with Adhd, OCD, ODD, & PTSD. Focalin xr changed our lives. We tried every combo of meds avail. once we found focalin xr everything changed. His grades are from "d's" to " A's" attitude is fantastic and overall a new child.


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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Related studies

- Benadryl side effects
- Focalin Xr side effects


Related conditions

- Attention deficit hyperactivity disorder
- Allergy to animal
- Irritability


Related drug side effects

- Irritability



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