A study of drug interactions between Humira, Methotrexate, Risedronate Sodium, Fexofenadine, Dicyclomine Hcl, Diclofenac Sodium, Leucovorin Calcium, Lithium Carbonate, Prednisone Tab, Quetiapine Fumarate, Vicodin, Ondansetron for a Female patient aged 68

This is a personalized study of Humira, Methotrexate, Risedronate Sodium, Fexofenadine, Dicyclomine Hcl, Diclofenac Sodium, Leucovorin Calcium, Lithium Carbonate, Prednisone Tab, Quetiapine Fumarate, Vicodin, Ondansetron drug interactions for a 68 year old female patient. The study is created by eHealthMe based on 8 reports from FDA.

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What are the drugs

Humira has active ingredients of adalimumab. It is used in rheumatoid arthritis, crohn's disease, psoriasis, psoriatic arthritis, ankylosing spondylitis, croup.

Methotrexate has active ingredients of methotrexate sodium. It is used in rheumatoid arthritis, psoriatic arthritis, arthritis, psoriasis, systemic lupus erythematosus, psoriatic arthropathy.

Risedronate sodium has active ingredients of risedronate sodium. It is used in osteoporosis.

Fexofenadine has active ingredients of fexofenadine hydrochloride.

Dicyclomine hcl has active ingredients of dicyclomine hydrochloride.

Diclofenac sodium has active ingredients of diclofenac sodium. It is used in arthritis, pain, back pain - low, inflammation, osteoarthritis, rheumatoid arthritis.

Leucovorin calcium has active ingredients of leucovorin calcium. It is used in rheumatoid arthritis.

Lithium carbonate has active ingredients of lithium carbonate. It is used in bipolar disorder, bipolar i disorder, bipolar ii disorder, depression, mood swings, bipolar mania.

Prednisone tab has active ingredients of prednisone.

Quetiapine fumarate has active ingredients of quetiapine fumarate. It is used in bipolar disorder, insomnia, sleep disorder, depression, borderline personality disorder, stress and anxiety.

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is used in pain, back pain - low, back pain, surgery, pain in limb, arthritis.

Ondansetron has active ingredients of ondansetron hydrochloride. It is used in nausea, nausea and vomiting, nausea postoperative.

On May, 1, 2013: 8 people who reported to have interactions when taking Humira, Methotrexate, Risedronate Sodium, Fexofenadine, Dicyclomine Hcl, Diclofenac Sodium, Leucovorin Calcium, Lithium Carbonate, Prednisone Tab, Quetiapine Fumarate, Vicodin, Ondansetron are studied

Information of the patient in this study:

Age: 68

Gender: female

Conditions: Rheumatoid Arthritis, Hypersensitivity, Inflammation, Supplementation Therapy, Pain

Drugs taking:
- Humira: used for 1 - 2 years
- Humira
- Methotrexate
- Risedronate Sodium
- Fexofenadine
- Dicyclomine Hcl
- Diclofenac Sodium
- Leucovorin Calcium
- Lithium Carbonate
- Prednisone Tab
- Quetiapine Fumarate
- Vicodin
- Ondansetron

Drug interactions have: Chest Discomfort, Cholelithiasis, Discomfort, Nausea

eHealthMe real world results:

For females aged 68 (±5):

Comparison with this patient's adverse outcomes:

Most common interactions experienced by females aged 68 (±5) in the use of Humira, Methotrexate, Risedronate Sodium, Fexofenadine, Dicyclomine Hcl, Diclofenac Sodium, Leucovorin Calcium, Lithium Carbonate, Prednisone Tab, Quetiapine Fumarate, Vicodin, Ondansetron:

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Most common interactions experienced by females aged 68 (±5) in long term use of Humira, Methotrexate, Risedronate Sodium, Fexofenadine, Dicyclomine Hcl, Diclofenac Sodium, Leucovorin Calcium, Lithium Carbonate, Prednisone Tab, Quetiapine Fumarate, Vicodin, Ondansetron:

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For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

Most common interactions experienced by people in the use of Humira, Methotrexate, Risedronate Sodium, Fexofenadine, Dicyclomine Hcl, Diclofenac Sodium, Leucovorin Calcium, Lithium Carbonate, Prednisone Tab, Quetiapine Fumarate, Vicodin, Ondansetron:

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Most common interactions experienced by people in long term use of Humira, Methotrexate, Risedronate Sodium, Fexofenadine, Dicyclomine Hcl, Diclofenac Sodium, Leucovorin Calcium, Lithium Carbonate, Prednisone Tab, Quetiapine Fumarate, Vicodin, Ondansetron:

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Drug effectiveness in real world:

• Diclofenac Sodium for Inflammation reported by 31 people (updated 2 months ago)
• Humira for Rheumatoid Arthritis reported by 179 people (updated 1 day ago)
• Vicodin for Pain reported by 537 people (updated 20 hours ago)

Alternative drugs:

• Inflammation (36 drugs) (updated 1 day ago)
• Rheumatoid Arthritis (46 drugs) (updated 48 minutes ago)
• Supplementation Therapy (8 drugs) (updated 3 weeks ago)
• Pain (209 drugs) (updated 20 hours ago)

Comments from related studies:

• From this study (7 days ago):

peanuts on Mar, 31, 2010:

my friend is suffering from rhumatory arthertis.and is currenty taking cocaine. oxy cotin,prestine, wellbutrim, predisone 10mg what side effects should she expect ?????

Reply

jimmy on Apr, 29, 2013:

Susan,
Finally, I'd been reading thru here and finnaly, what doctor in the U.S. still prescribes cocaine? LOL

Reply

jimmy on Apr, 29, 2013:

IF you donT see my other comments, Never take Cymbalta or anything containing same ingrediants or speeding thru the same side effects durring their enjoyable living advertizements!

Reply

Jmsrocks on Jul, 25, 2012:

Probably death. Cocain and opiates together = speed ball.

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Hebe on Jul, 31, 2012:

I have had two close relatives on prednisone, and for both of them it alone can make them feel really speedy. Combined with cocaine and wellbutrin would probably make sleeping very difficult. As the previous commenter mentioned, combining oxys into this is probably a bit dangerous.

Reply

Patty O'Neill on Aug, 10, 2012:

The comments about death in combination with cocaine and opiates or any other drug is possible
depending on how much and the situation. Frightening people is not the key here. Basically any drug in combination with another could cause a major health problem as we are all very much not the same makeup. Cheers,

Reply

ken on Aug, 17, 2012:

If she continues with this type of treatment, its kinda scary in all reality. Why not see a doctor, that's where the healing may start.

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Jackie on Apr, 30, 2013:

I am wondering if you were diagnosed because you had pain and found out you had a neurological message going on.... or just a process of elimination over the pain after you were taking your anti psychotic medication? I've been taking oxycone for my pain my back and neck disc issues um for about a year now, was having joint pain and stiffness all over my body the Dr put me on cymbalta and now three weeks later he put me on wellbutrin and I'm wondering about seratonin syndrome... I'm having muscle twitching also lump on top of my head and vision problems.

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iCaNtCaLlIt on Oct, 24, 2012:

Please coke for arthrit.? take your fish oils 2 each meal and take your perscribed pain meds(careful very addicting) stop the coke thats being silly for real. goodluck, lifes a bych and ya die thats why we get high .. p.s ankle 9 surgerys plates screws never walk normal again, fight thru it..i got hurt at work btw 7 ton crushed my leg instead of me....jus always think thingd can be worse, be a gpod person dont let this bring u dwn n b miserable..pul thru keep head up n watch those pain meds..goodluck...email if u wana talk but dont come with negatibity. buhbye

Reply

susan on Jan, 3, 2013:

have vit d blood levles ck, and supplenment. vit d is an amazing pain control helper.

Reply

nefariouson3 on Nov, 7, 2012:

I too am a chronic pain sufferer, I drove over a explosive in the middle-east. I don't understand what or why this thread was written up like a true medical study, to me it looks more like a recreational train wreck, some listed drugs have reverse reactions and others simply have no medical need what so ever, personally I would seek professional help and attempt to get off the unneeded drugs and concentrate on the true medical issues. At your age 51, you run the risk of many complications and possibility death from the listed drugs, though who am I to judge, life is way too short enjoy it when your still alive.

Th3

Reply

Had'em all on Nov, 14, 2012:

Prison and/or death. Comparing taking coke by inhalation and oxycontin orally is NOT the same thing as speed ball. Kindergarten speed ball maybe. Addiction threshold of oxy is 60mg/day. She should try to stay below that.
Get her the hell off Pristine/Ketoconazole unless it is absolutely positively necessary. If necessary, try to get a lower dose. Stuff fries the liver & with all the other crap--BAD idea.
Is there a reason she isn't taking an NSAID? I see prednisone. Would help more than oxy.

Reply

kobe77 on Jan, 3, 2013:

Lmao! Lmao! You sound like your high ......enjoy your trip!

Reply

knowledgable on Jan, 7, 2013:

Death bed us what they should expect. Mixing cocaine and oxy, are they brainless!!!!

Reply

Sydney on Jan, 9, 2013:

Tell your friend to GET OFF WHEAT. The wheat products in this country are GMO which are very bad for us and cause arthritis. Tell your friend to research. Never let the Dr.s try and figure out what's wrong with you. They won't. And they'll kill you trying.

Reply

nursing101 on Jan, 28, 2013:

Well, NSAID, you say? Hmmm....I see motrin, naproxen and aspirin on the list....all NSAID's

Reply

Billy on Feb, 2, 2013:

It is a wonder that your wife is at all coherent taking that cocktail of medications. I would try to find a new doctor that has a better grasp of toxicology and drug interactions. Cocaine and Oxycotin--can't belief any reputable doctor would prescribe that combination.

Reply

High depression low motivation on Feb, 8, 2013:

I take fish oils and centrum vitamins for depression replacing latuda and Lexapro wich was messing with my school I was out of phase sleeping all day and cloudy thinking. Now I just take Adderall and Xanax for agoraphobia and I feel a lot better and Im actually doing homework!! I scored high on my test than on the antidepressants with low scores.

Reply

AdoreTu on Mar, 4, 2013:

Well, I just stopped at your post, and who ever is taking all of that stuff needs to take some Milk Thistle to help restore their liver.

Reply

Sam on Mar, 11, 2013:

Way back in the late 1960's I heard it called a combination of cocaine and opiate type drugs a speedball. My best guess is your friend is on the way out of this world, unless there is an intervention. In short, death is the end result/side effect of taking such a combination of drugs....

Deo Vindece,

Sam

Reply

BCS on Mar, 12, 2013:

Honestly. She can expect to die very young.

Everything from heart, kidney, liver, stomach, brain, lungs, immune system, etc. will began to shut down.
She will most likely become increasingly weak, finding herself in the hospital more often, and eventually die of organ failure. that is unless she dies from an overdoes first.

Reply

bcs on Mar, 12, 2013:

Yeah, hybrid wheat is causing all the problems. not the cocaine and oxy, mixed with other prescription drugs.

I agree Hybrid wheat is harmful and best left out of ones diet, but it's not the biggest problem here. (it hybrid not gmo) they haven't released that yet.

Reply

Susan on Mar, 12, 2013:

Are you guys really this dumb? She meant to say her friend was taking Codeine not cocaine. I'm not even going to bother asking a question on this website if you're that dumb! LOL

Reply

Jenn on Mar, 15, 2013:

I know that I am super sensitive to both codeine and oxy. They actually make me more nauseous and dizzy and i find regular tylenol or ibuprophen to be more effective against pain. I have heard some good things about omega fish oil and gluten free diets. My sister has RA too and when she flares up even pain meds dont help much. She is also gluten intolerant and can feel a marked difference in symptoms when she "slips" and eats gluten-y things. Steroids make your blood pressure high, she takes them when she gets flare ups but tries to ween herself off as the flare up dissipates. She gets weird skin breakouts because steroids also mess with the natural flora of your body. RA sux!!!!

Reply

doc moc on Mar, 25, 2013:

have tou tried cocaine? pretty sure its gluten free our previous inquisitor seemed to have some luck with its administration in combination with an assortment of other medications to treat her condition also as far as the flora issue goes i dont think cocaine is an antagonist

Reply

doc moc on Mar, 30, 2013:

oh yes BCS i agree hybrid wheat is a very dangerous substance especially when compared to the rather inocuous substances of cocaine and oxycontin! just what are your qualifications to dispense such well researched and supported opinions? You are truly a fool

Reply

Stephanie on Apr, 1, 2013:

Yeah I'm pretty sure she ment codeine. i dont visit these sites often anymore becasue my questions never get answered and everything gets way off topic.

Reply

really on Apr, 10, 2013:

people like you should visit your local humane society and have yourself spayed or neutered because the human race does not need less intelligent, human-jackass hybrid beings breeding with those of greater intellect. Cocaine was clearly written, not codeine. and please don't post your questions, prefer you be the guinea pig and take risks alerting the people who matter of potential risk factors. :)

Reply

Robert on Apr, 12, 2013:

I just wish the federal government would overhaul Richard Nixon's war on drugs and the whole controlled drug act. I have had my share of pain and you can consider yourself lucky to be able to cope with it. It is the sorry folk out there who have psychiatric disorders which affect the brain's ability to "deal" and cope, and is at a chemical level with them, a neurological mess-up. I know personally, I have phases of time when it is dangerous for me to try and tough it out when my brain sometimes slows down production and release of the natural chemicals like beta endorphin, dopamine, Gammaaminobuteric Acid, and I can find my body aches because Im not making enough natural opiate substances. SO I take drugs given by MD to make me feel normal, like clonazepam, prozac, and sometimes amphetamine in low doses. It is frustrating because people still don't understand and think I am a schmuck for taking drugs to feel normal happiness, calm, joy, relaxation, and to enjoy life's natural pleasures I periodically am unable to feel or appreciate.

Reply

Robert on Apr, 12, 2013:

It is true that speedballs, containing opiates and any stimulant. The "speed" in speedball likely refers to amphetamine, which was, prior to 1970, the original or at least most widely used upper in the 1960's. When the Controlled Drug Act was made official, cocaine became hugely popular, as an easier and more available alternative. SO strangely enough it became easier to get a totally outlawed drug than legal controlled drugs, because the new DEA and their most overzealous zealots were too busy finally settling old scores and getting the "dopeheads" and "speedfreeks" with the new Nixonian legislation backing them up like the word of God

Reply

Michele on Apr, 12, 2013:

I totally understand where you are coming from. Your comment at the end there helped me understand that I am not "a druggy" as my husband calls me because I need medications to feel an enjoy simple life activities. You're lucky to have found the right combination of medicines to treat your depression. I feel like I've been on a roller coaster for the last 20 years. If I find the "right" combination to treat my severe depression/bipolar2 disorders, then I find myself with one or more intolerable side effects that I must live with, like extreme teeth pain/bruxism. I look at people all the time and say to myself "That person is "normal." "That person is enjoying life." "That person sleeps normally and doesn't need help." "That person is a good mom for doing activities with her child/children." I get sorta jealous, then I start believing what my husband says about me being a druggy and that I am not a good teacher/mom/wife. That I shouldn't need medicine to just have energy to get up and get dressed. But when I read your post it made me feel good, not that you were dealing with depression, but that someone else out there understands how it feels, that my husband is dead wrong and out of line, that my depression is a real disorder and not my fault. Thank you for your post.

Reply

shannon on Apr, 13, 2013:

What shouldnt the expexation be...yes, cocaone is an antisthetic...only local, dentists "pink" mouth swab is cocaine based to numb the area and costrict blood vessels toz reduce swelling and bleeding....not for arthritis!..sounds like its a way to find a way out faster by destroying the heart muscle fro. The cocke's super stimulative effect and leave this world. There are other means to treat pain than death and mega doses of narcotics to mask the pain and increase the tolernance of the mds to the point that either there are no interior sinuses lrft by coke use or not enough pain meds to overcome the tolerance....ven IV cocaine use will burn the veins you shoot it in...its a loosing battle...and a painful one from damag thats beendone...Im praying for you guys...

Reply

Russ on May, 7, 2013:

Formally of you bashing the cocaine for pain, do some research! Brompton's Cocktail is a chronic pain medicine in liquid form that contains cocaine, opiates, and some other meds. It is an evidenced based treatment for chronic pain, so please don't assume just because it has cocaine in it means it's gonna kill you. People suffering from chronic.pain need relief. if Brompton's works, then let them get their much needed relief!!! Without judgement!!

Reply

• From this study (2 months ago):

Diagnosed psoriatic arthritis 1981, severe arthritis remission 1982 with minor after. Used cortisone compounds for plaque psoriasis since with minimal effectiveness. Started Humira 10 mths ago. Initially experienced Very High effectiveness with improved nails. Now winter time, few minor blemishes reappeared. PCP had me on statins for high cholesterol years with minimal results or side effects. Recently endocrinologist prescribed Lipitor (now atorvastatin calcium @ 40mg/day since generic ~ 11/2012) with better results, but experienced tolerable headaches and depressed moods/lack of enthusiasm.

3 weeks ago atorvastatin switched to 80mg/day to increase effectiveness, headaches & moodiness also increased. One week after 80mg/day, morning of day Humira shot due (evening every 2 weeks), experienced never before encountered localized pustular psoriasis on hands & feet. Dermatologist directed take Humira that evening & prescribed Clobex with no outbreak explanation. Can doubling atorvastatin cause pustular psoriasis outbreak or any interactions with listed drugs or supplements?

Reply

• From this study (3 months ago):

I was in a car accident in 2000. My lower back was trashed, and had to be reconstructed basically. I have fusions and titanium, all of this as causd many other health problems to arise over the last 10 years. But, I live a pretty normal life, most people don't even know there is anything wrong with me. : )

Ultracet and Ultram, any drug from that family can be very dangerous, I had a serious reaction with Ultracet. I had 3 seizures before we figured out what was happening to me.

Solu-Medrol was used in the hospital through my IV, for a complicated migraine problem. I do not know if I had some kind of allergic reaction to it, or if that drug just does that to people, but, I was ripping the IV out of my arm! I couldn't stand it! It felt like fire ants were under every inch of my skin crawling and biting me all the way down and back up my arms and legs! It took hours to stop, and it did not help the migraine either.

Reply

Allergic... on Mar, 6, 2013:

allergic reaction to vancomycin and sulfamethoxazole....
I was given vancomycin through an iv 2 days ago. Today I decided to take some sulfamethoxazole and the allergic reaction is unbearable. It's been 4 hrs and the burning aching hasn't stopped. How did u manage to stop the allergic reaction. I'm wondering if I should wait it out or go into er.

Reply

• From this study (4 months ago):

I was wondering if all of these together could have an adverse effect on my liver?

Reply

• From this study (5 months ago):

RESOTRAN 2 MG (PRUCALOPRIDE SUCCINATE) was not recognized. It was prescribed to stimulate bowel despite the fact that it clearly says it is not to be used for Crohn's patiens.

Reply

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• Humira, Methotrexate, Hydroxychloroquine Phosphate, Risedronate Sodium, Calcium Citrate, Prednisone, Vicodin, Folic Acid drug interactions for Rheumatoid Arthritis. The patient has Insomnia, Restless Legs Syndrome
• Humira, Fexofenadine Hydrochloride, Palenol, Alprazolam, Prednisone, Lexapro, Lithium Carbonate, Potassium, Temazepam, Gabapentin, Vicodin, Oxycodone Hcl drug interactions for Rheumatoid Arthritis. The patient has Dizziness, Dysphagia, Dyspnoea, Hoarseness, Rigors, Sensation Of Blood Flow, Swelling, Unevaluable Event
• Humira, Lamotrigine, Leucovorin Calcium, Methotrexate, Prednisone, Hydrochlorothiazide, Folic Acid, Risedronate Sodium drug interactions for Rheumatoid Arthritis. The patient has Injection Site Haemorrhage, Injection Site Irritation
• Humira, Risedronate Sodium, Methotrexate, Voltaren, Folic Acid, Calcium Gluconate, Estrace, Medroxyprogesterone Acetate, Acetaminophen, Prednisone drug interactions for Rheumatoid Arthritis. The patient has Alopecia, Balance Disorder, Condition Aggravated, Difficulty In Walking, Gait Disturbance, Skin Discolouration
• Humira, Furosemide, Prednisone, Methotrexate, Leucovorin Calcium, Mirtazapine, Zolpidem Tartrate, Risedronate Sodium drug interactions for Rheumatoid Arthritis. The patient has Rash
• Humira, Sulfadiazine, Methotrexate Sodium, Folic Acid, Prednisone Tab, Hydrochlorothiazide, Tramadol Hcl, Acetaminophen, Diclofenac Sodium, Lithium Carbonate, Lansoprazole drug interactions for Rheumatoid Arthritis. The patient has Fall, Hypertension, Skin Laceration
• Humira, Methotrexate Sodium, Prednisone Tab, Risedronate Sodium, Sulfasalazine, Arthrotec, Vicodin drug interactions for Rheumatoid Arthritis. The patient has Abdominal Pain, Diarrhoea, Pneumonia, Vomiting
• Humira, Prednisone Tab, Nabumetone, Pantoprazole Sodium, Metaxalone, Vicodin, Cetirizine Hcl, Risedronate Sodium, Lomotil, Methotrexate, Orphenadrine Citrate drug interactions for Rheumatoid Arthritis. The patient has Fatigue, Hepatic Enzyme Increased, Injection Site Irritation, Palpitations, Rash
• Humira, Methotrexate, Duragesic, Prednisone, Metformin Hcl, Voltaren, Zocor, Acetaminophen, Vicodin drug interactions for Rheumatoid Arthritis. The patient has Myocardial Infarction
• Humira, Methotrexate, Prednisone, Leucovorin Calcium, Phenytoin Sodium, Vicodin, Levothyroxine Sodium drug interactions for Rheumatoid Arthritis. The patient has Pruritus, Rash
• Humira, Risedronate Sodium, Sertraline Hydrochloride, Methotrexate, Folic Acid, Trexall, Omeprazole, Meloxicam, Prednisone, Citalopram Hydrobromide, Leflunomide, Furosemide, Metaxalone, Ultracet, Propacet 100, Cyclobenzaprine Hydrochloride, Gabapentin, Zolpidem Tartrate, Vicodin, Rabeprazole Sodium drug interactions for Rheumatoid Arthritis. The patient has Body Height Decreased, Breast Cancer In Situ, Rash Generalised, Weight Decreased
• Humira, Methotrexate, Risedronate Sodium, Folic Acid, Prednisone, Verapamil Hydrochloride, Alprazolam, Ascorbic Acid, Tocopherol Concentrate Cap, Vicodin, Aspirin, Cyanocobalamin drug interactions for Rheumatoid Arthritis. The patient has Cystitis, Haematuria, Rash
• Humira, Risedronate Sodium, Methotrexate, Voltaren, Folic Acid, Estrace, Medroxyprogesterone Acetate, Prednisone drug interactions for Rheumatoid Arthritis. The patient has Alopecia, Balance Disorder, Condition Aggravated, Skin Discolouration
• Vitamin E, Folic Acid, Remicade, Prednisone Tab, Mestinon, Prilosec, Multi-vitamin, Paxil, Methotrexate Sodium, Vicodin, Evista, Humira, Tylenol, Omeprazole, Ditropan Xl, Nystatin, Darvocet-n 100, Actonel drug interactions for Rheumatoid Arthritis. The patient has Asthenia, Drug Ineffective
• Lyrica, Remicade, Procrit, Levoxyl, Leucovorin Calcium, Methotrexate, Progesterone, Promethazine, Prednisone Tab, Zometa, Vicodin, Humira, Effexor Xr drug interactions for Neuralgia, Ill-defined Disorder. The patient has Cardiac Output Decreased, Myalgia

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