A study of drug interactions between Propofol, Topiramate, Levetiracetam, Valproate Sodium, Phenytoin, Clonazepam, Thiopental Sodium, Norepinephrine Bitartrate, Midazolam Hcl, Ketamine Hcl for a Female patient aged 21
This is a personalized study of Propofol, Topiramate, Levetiracetam, Valproate Sodium, Phenytoin, Clonazepam, Thiopental Sodium, Norepinephrine Bitartrate, Midazolam Hcl, Ketamine Hcl drug interactions for a 21 year old female patient. The study is created by eHealthMe based on 3 reports from FDA.
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What are the drugs
Propofol has active ingredients of propofol. It is used in sedation, colonoscopy abnormal, anaesthesia, sedation during medical procedure.
Topiramate has active ingredients of topiramate. It is used in migraine, migraine with aura, epilepsy, headache, migraine without aura, obesity.
Levetiracetam has active ingredients of levetiracetam. It is used in epilepsy, seizures, generalized tonic-clonic seizure, temporal lobe seizure, partial seizures, multiple sclerosis.
Valproate sodium has active ingredients of valproate sodium. It is used in epilepsy, focal fits, bipolar disorder, mood swings, bipolar ii disorder, bipolar i disorder.
Phenytoin has active ingredients of phenytoin. It is used in epilepsy, seizures, generalized tonic-clonic seizure.
Clonazepam has active ingredients of clonazepam. It is used in stress and anxiety, generalized anxiety disorder, insomnia, panic disorder, restless leg syndrome, sleep disorder.
Thiopental sodium has active ingredients of thiopental sodium.
Norepinephrine bitartrate has active ingredients of norepinephrine bitartrate. It is used in hypotension, septic shock, endotracheal intubation.
Midazolam hcl has active ingredients of midazolam hydrochloride.
Ketamine hcl has active ingredients of ketamine hydrochloride. It is used in pain, recreational.
On Mar, 17, 2013: 3 people who reported to have interactions when taking Propofol, Topiramate, Levetiracetam, Valproate Sodium, Phenytoin, Clonazepam, Thiopental Sodium, Norepinephrine Bitartrate, Midazolam Hcl, Ketamine Hcl are studied
Information of the patient in this study:
Age: 21
Gender: female
Conditions: Status Epilepticus
Drugs taking:
- Propofol
- Topiramate
- Levetiracetam
- Valproate Sodium
- Phenytoin
- Clonazepam
- Thiopental Sodium
- Norepinephrine Bitartrate
- Midazolam Hcl
- Ketamine Hcl
Drug interactions have: Viral Upper Respiratory Tract Infection, Status Epilepticus, No Therapeutic Response, Myoclonus, Intestinal Ischaemia, Ileus Paralytic, Hypothermia, Gastrointestinal Necrosis, Complex Partial Seizures
eHealthMe real world results:
For females aged 21 (±5):
Comparison with this patient's adverse outcomes:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports |
| Viral Upper Respiratory Tract Infection | 1 (50.00%) |
| Status Epilepticus | 1 (50.00%) |
| No Therapeutic Response | 1 (50.00%) |
| Myoclonus | 1 (50.00%) |
| Intestinal Ischaemia | 1 (50.00%) |
| Ileus Paralytic | 1 (50.00%) |
| Hypothermia | 1 (50.00%) |
| Gastrointestinal Necrosis | 1 (50.00%) |
| Complex Partial Seizures | 1 (50.00%) |
Most common interactions experienced by females aged 21 (±5) in the use of Propofol, Topiramate, Levetiracetam, Valproate Sodium, Phenytoin, Clonazepam, Thiopental Sodium, Norepinephrine Bitartrate, Midazolam Hcl, Ketamine Hcl:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Status Epilepticus | 1 |
| 2 | No Therapeutic Response | 1 |
| 3 | Myoclonus | 1 |
| 4 | Viral Upper Respiratory Tract Infection | 1 |
| 5 | Intestinal Ischaemia | 1 |
| 6 | Ileus Paralytic | 1 |
| 7 | Gastrointestinal Necrosis | 1 |
| 8 | Complex Partial Seizures | 1 |
| 9 | Ventricular Fibrillation | 1 |
| 10 | Hypothermia | 1 |
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Most common interactions experienced by females aged 21 (±5) in long term use of Propofol, Topiramate, Levetiracetam, Valproate Sodium, Phenytoin, Clonazepam, Thiopental Sodium, Norepinephrine Bitartrate, Midazolam Hcl, Ketamine Hcl:
(click on each outcome to view in-depth analysis, incl. how people recovered)| None. |
For people in general (regardless of gender or age):
Comparison with this patient's adverse outcomes:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports |
| Viral Upper Respiratory Tract Infection | 1 (33.33%) |
| Status Epilepticus | 1 (33.33%) |
| No Therapeutic Response | 1 (33.33%) |
| Myoclonus | 1 (33.33%) |
| Intestinal Ischaemia | 1 (33.33%) |
| Ileus Paralytic | 1 (33.33%) |
| Hypothermia | 1 (33.33%) |
| Gastrointestinal Necrosis | 1 (33.33%) |
| Complex Partial Seizures | 1 (33.33%) |
Most common interactions experienced by people in the use of Propofol, Topiramate, Levetiracetam, Valproate Sodium, Phenytoin, Clonazepam, Thiopental Sodium, Norepinephrine Bitartrate, Midazolam Hcl, Ketamine Hcl:
(click on each outcome to view in-depth analysis, incl. how people recovered)Login or sign up (it's free) to view more results. Or personalize this study
Most common interactions experienced by people in long term use of Propofol, Topiramate, Levetiracetam, Valproate Sodium, Phenytoin, Clonazepam, Thiopental Sodium, Norepinephrine Bitartrate, Midazolam Hcl, Ketamine Hcl:
(click on each outcome to view in-depth analysis, incl. how people recovered)| None. |
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LOA/13 on Mar, 27, 2013:
Female, 57yrs, Bipolar, looking for any comments with reference to interation of the following daily dosage drugs and the introduction of Lamotrigine to my dialy regiment.
Seroquel 800mg, Metforin 2000mg, Vimovo 500/40mg, Tylenol 2000mg. My Doc now would like to introduce Lamotrigine as a counter measure to my mood swings.
Does anyone have comments of the interation of these 4 drugs with Lamotrigine?
Your current and introductional experiences of this drug is appreciated. Thanks
LOA/13 on Mar, 27, 2013:
Hi Marie L,
I am also a female 57yrs, and have been trying to manage my Bipolar since my very early years. I like you, had surgery and because it was emergency surgery, no one had my medical records. At that time I was taking Lithium, the outcome was sever infection which took over 8mos to counteract. I appreciate your candor with your disclosure, because up until now (15 years later) I was only told the infection was due to the nature of the surgery (being emergency). Which I concluded, it was my fault for the outcome. I always thought the surgeons simplistic reasoning for the infection was a means by which to not have to fully disclaim the actual Reason = Lithium in my blood stream. I required another surgery for a broken arm (six places), which was postpone for several weeks. Now it makes sence for the postponement, he wanted to make sure the Lithium was out of my blood prior. This other surgery went off without a hitch. When and were possible, I highly recommend people to wear Medic Alert Bracelets, listing the medications you are taking. Thanks for listening.
Marie L on Jun, 20, 2012:
I am a 54-year-old Caucasian woman who recently underwent removal of a benign brain tumor via general anesthetic. Although I advised the anesthesia staff that I had been taking lithium for about 30 years, at the time of my surgery, I didn't know that lithium should be discontinued at least 72 hours to two weeks before surgery to avoid dehydration and resulting diabetes insipidis (abnormal urination)which is known to cause blindness. After my surgery, I was unable to be awakened and went into a "metabolic encephalopathy" for about three weeks. When I woke up, I was blind in my right eye. According to my neurosurgeon, the reason for the coma was due to lithium being in my system. As a result, I have total, irreversible blindness in my right eye. My surgeon's position is that it was not from the surgery and, instead, the medical staff had to wait until the lithium was flushed out of my body. This NEVER should have happened. My sodium levels sky-rocketed along with my blood pressure and blood sugar. If I would have known all of this before surgery, I would not have taken my lithium for the prescribed amount of time and definitely would have advised the doctor and medical staff accordingly. If you are taking lithium and have a general anesthesia scheduled, be sure to advise your surgeon and the anesthesia staff that you want to discontinue lithium until after the surgery when your vital signs are stable. Good luck to you.
I was in a car accident and this all started after I had my accident. My doc did a some blood test and urine and advised me I had a UTI, but I disagree. I have looked online and my symptoms don't match and I have no symptoms of a UTI. So help!
A Kian on Jan, 30, 2013:
Find another Doc. You could injuries to the spinal areas that control your bladder or kidneys. If me I would head for a Neuro surgeon. If you can't stand on your heals or toes tell them. Also if you loose ability to use the restroom (either) it's a 911 call. Good luck your Doc's a quack.
I am still taking the drug. Will keep checking back.
The pain seems to be getting worse, and I am questioning everything and anything that could be causing it. My diet is somewhat limited bec. of intestinal scarring, so it could be that some limited intake of a nutrient could be to blame. I am desperate to find a cause to the pain.
i am on multiple meds after total removal of para and thyroid glands
june turner 256557 9964 on Apr, 17, 2012:
i still have seizures most everday, pain from fibromyalgia, numbness in left arm hand ,leg and shoulder, need help on diagnosis and help. i have reactions to light ,heat, cold,sound, and numerous others due to this...
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