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Related topic: Dental Care, Dental Caries, Tooth Loss

From FDA reports: side effects of Listerine Whitening Pre-brush Rinse

This is a real world study of Listerine Whitening Pre-brush Rinse side effects. The study is created by eHealthMe based on 829 people who take the drug and have side effects.

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Information of the patient in this study:

Gender: female

Conditions: Dental Care

Drugs taking:
- Listerine Whitening Pre-brush Rinse

Side effects have: Tooth Loss, Dental Caries

On Jan, 29, 2014: 829 people who reported to have side effects when taking Listerine Whitening Pre-brush Rinse are studied

Trend of Listerine Whitening Pre-brush Rinse's drug interactions, side effects, and effectiveness reports (3019577)

eHealthMe real world results:

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

Side effectNumber of reports
Tooth Loss8 (0.97%)
Dental Caries5 (0.60%)

Most common side effects experienced by people in the use of Listerine Whitening Pre-brush Rinse:

Side effectNumber of reports
Application Site Burn128
Drug Abuse113
Incorrect Route Of Drug Administration102
Product Quality Issue74
Lip Swelling54
Stomatitis (inflammation of mucous membrane of mouth)54
Ageusia (loss of taste functions of the tongue)52
Oral Discomfort (pain or irritation in mouth)47
Oral Pain46
Glossodynia (a burning or painful sensation in the tongue)45

Most common side effects experienced by people in long term use of Listerine Whitening Pre-brush Rinse:

Side effectNumber of reports
Gingival Swelling (gums swelling)4
Hypoaesthesia Oral (reduced sense of touch or sensation in mouth)2
Dyspnoea (difficult or laboured respiration)2
Application Site Ulcer2
Chapped Lips (cracking, fissuring, and peeling of the skin f lip)1
Application Site Irritation1
Mouth Haemorrhage (bleeding from mouth)1
Oral Mucosal Exfoliation (removal of mucous membrane of mouth)1
Dry Mouth1

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Alternative drugs:

Comments from related studies:

  • From this study (1 year ago):

  • Listerine Zero clean mint mouthwash


  • From this study (2 years ago):

  • Lizanne on Aug, 8, 2012:

    Wondering if any Speech Pathologists are using these with their NPO patients... small research study at MarionJoy Rehab in Wheaton Illinois indicating that they are "safe" and that they increase number of swallows per minute- if you're an SLP you'll know what I'm talking about...


  • From this study (3 years ago):

  • Twice I have ended up with swollen lips from gargling Listerine. Sometimes when I start to get a sore throat I will gargle with it as it will kill germs that are involved with sore throats. I will also take a cotton swab and swab the back of my throat gently with the listerine. I will usually gargle with it twice a day when my throat is a little sore. I notice this is always around the time that my lips will be swollen. Once my lips were very swollen to the point I was concerned I was having a severe reaction. I didnt realize it was the listerine the first time but after the 2nd time I have finally put it together.


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More questions for: Dental Care, Dental Caries, Tooth Loss

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Related conditions

- Dental care


Related drug side effects

- Dental Caries
- Tooth Loss



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