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What could cause Insomnia, Depression, Muscle Swelling for a 75-year old man?

This is a personalized study for a 75 year old male patient who has Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives. The study is created by eHealthMe based on reports of 44 male patients aged 75 (±5) who take the same drugs from FDA and social media.

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What are the drugs

Metformin hydrochloride (what 14,592 Metformin Hydrochloride users reported?) has active ingredients of metformin hydrochloride. It is used in diabetes.

Glyburide (what 26,034 Glyburide users reported?) has active ingredients of glyburide. It is used in diabetes.

Ramipril (what 31,815 Ramipril users reported?) has active ingredients of ramipril. It is used in high blood pressure.

Lipitor (what 132,648 Lipitor users reported?) has active ingredients of atorvastatin calcium. It is used in high blood cholesterol.

Niacin (what 6,303 Niacin users reported?) has active ingredients of niacin. It is used in high blood cholesterol.

Diphenhydramine hydrochloride (what 2,983 Diphenhydramine Hydrochloride users reported?) has active ingredients of diphenhydramine hydrochloride. It is used in insomnia.

What are the conditions

Diabetes mellitus non-insulin-dependent (what 220,595 Diabetes Mellitus Non-insulin-dependent patients reported?) can be treated by Metformin Hydrochloride, Metformin, Januvia, Glipizide, Victoza, Janumet.

Hypertension (what 1,161,788 Hypertension patients reported?) can be treated by Lisinopril, Amlodipine Besylate, Atenolol, Norvasc, Diovan, Hydrochlorothiazide.

Hypercholesterolemia (what 453,883 Hypercholesterolemia patients reported?) can be treated by Lipitor, Simvastatin, Crestor, Pravastatin Sodium, Zocor, Atorvastatin Calcium.

Treatment - hives (what 3,241 Treatment - Hives patients reported?) can be treated by Benadryl, Zyrtec, Prednisone, Xyzal, Atarax, Doxepin Hydrochloride.

What are the symptoms

Insomnia (sleeplessness) (what 767,941 Insomnia patients reported?) has been reported by people with depression, quit smoking, high blood pressure, pain, stress and anxiety.

Depression (what 1,148,081 Depression patients reported?) has been reported by people with quit smoking, multiple sclerosis, pain, osteoporosis, high blood pressure.

Muscle Swelling (what 1,623 Muscle Swelling patients reported?) has been reported by people with high blood cholesterol, high blood pressure, acromegaly, pain, rheumatoid arthritis.

On Jul, 28, 2014: 44 males aged 70 (±5) who take Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride are studied

Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride outcomes

Information of the patient in this study:

Age: 70

Gender: male

Conditions: Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives

Drugs taking:
- Metformin Hydrochloride - 500MG (metformin hydrochloride): used for 5 - 10 years
- Glyburide - 5MG (glyburide): used for 5 - 10 years
- Ramipril - 10MG (ramipril): used for 5 - 10 years
- Lipitor - EQ 40MG BASE (atorvastatin calcium): used for 5 - 10 years
- Niacin - 500MG (niacin): used for 2 - 5 years
- Diphenhydramine Hydrochloride - 50MG/ML (diphenhydramine hydrochloride): used for 1 - 2 years

Drug interactions have: severe insomnia, moderate depression, moderate muscle swelling

eHealthMe real world results:

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
among males aged 70 (±5) who take the drugs
Insomnia (sleeplessness)4 (9.09%)
Depression2 (4.55%)
Muscle Swelling2 (4.55%)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

Symptom (click a symptom for in-depth analysis)Number of reports
among males aged 70 (±5) who have the condition, regardless of which drug is taken
Insomnia in Diabetes Mellitus Non-insulin-dependent62 (0.66%)
Insomnia in Hypertension356 (1.46%)
Insomnia in Hypercholesterolemia300 (2.28%)
Insomnia in Treatment - Hives1 (7.69%)
Depression in Diabetes Mellitus Non-insulin-dependent37 (0.39%)
Depression in Hypertension272 (1.11%)
Depression in Hypercholesterolemia209 (1.59%)
Depression in Treatment - Hives1 (7.69%)
Muscle Swelling in Diabetes Mellitus Non-insulin-dependent1 (0.01%)
Muscle Swelling in Hypertension5 (0.02%)
Muscle Swelling in Hypercholesterolemia7 (0.05%)
Muscle Swelling in Treatment - Hives1 (7.69%)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effect (click a side effect for in-depth analysis)Number of reports
among males aged 70 (±5) who take the same drug
Insomnia in Metformin Hydrochloride20 (1.19%)
Insomnia in Glyburide57 (1.40%)
Insomnia in Ramipril46 (0.94%)
Insomnia in Lipitor262 (1.83%)
Insomnia in Niacin18 (1.71%)
Insomnia in Diphenhydramine Hydrochloride3 (2.10%)
Depression in Metformin Hydrochloride8 (0.48%)
Depression in Glyburide51 (1.26%)
Depression in Ramipril29 (0.59%)
Depression in Lipitor292 (2.04%)
Depression in Niacin12 (1.14%)
Depression in Diphenhydramine Hydrochloride3 (2.10%)
Muscle Swelling in Metformin Hydrochloride1 (0.06%)
Muscle Swelling in Glyburide1 (0.02%)
Muscle Swelling in Ramipril1 (0.02%)
Muscle Swelling in Lipitor3 (0.02%)
Muscle Swelling in Niacin2 (0.19%)
Muscle Swelling in Diphenhydramine Hydrochloride1 (0.70%)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Metformin Hydrochloride is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Glyburide is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Ramipril is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Lipitor is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Niacin is effectiven/an/an/an/a0.00%
(0 of 1 people)
n/an/an/a
Diphenhydramine Hydrochloride is effectiven/an/an/a100.00%
(1 of 1 people)
n/an/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
n/an/an/aMuscle SwellingMuscle SwellingMuscle Swellingn/aCerebrovascular Accident
DepressionDepressionDepressionBlood Glucose Increased
InsomniaInsomniaInsomniaDizziness
Headache
Fatigue
Asthenia
Oedema Peripheral
Listless
Polyp
Haemoglobin Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who have Diabetes Mellitus Non-insulin-dependent
- group for people who have Hypercholesterolemia
- group for people who have Hypertension
- group for people who have Treatment - Hives
- group for people who have Depression
- group for people who have Insomnia
- group for people who have Muscle Swelling
- group for people who take Diphenhydramine Hydrochloride
- group for people who take Glyburide
- group for people who take Lipitor
- group for people who take Metformin Hydrochloride
- group for people who take Niacin
- group for people who take Ramipril

Comments from related studies:

  • From this study (5 days ago):

  • BP ranges 125-130 over 75-87 when getting up prior to meds to 90-50 sometimes in the evening. I am a little stressed and so diphenhydramine helps me sleep along with melatonin. THese are OTC

    Reply

  • From this study (3 weeks ago):

  • never done full panel of hormones; cortisol flatlined 5 years ago now too high; testing also showed high estrogen levels for peri-menopausal female

    Reply

  • From this study (3 weeks ago):

  • Need seroquel for panic/anxiety/depression/bipolar, but it seems to bring significant nasal congestion. Can't fight it w/Afrin for more than a couple days or risk rebound nasal congestion although Afrin does bring relief. Using Sudafed PE with mixed results and often need Afrin to breathe through my nose. Often have feeling of diffculty swallowing although a recent endoscopy did notfind anything physical. Panic/anxiety most often in the evening/night which are moretolerable when I stand-up and move around. Coping with anxiety and swallowing issues at night often result in little sleep on many nights per week.

    Reply

    tunafilet on Aug, 3, 2014:

    Female, 70 yrs old. Taking Welbutrin and Lexapro. Cannot fall or stay asleep at night even after taking many different sleep aids. Severe nasal congestion (snorting) adds to the problem. Seems to start up after trying to sleep for a few hours and does not stop. Anyone else?

    Reply

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