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Review: what could cause Insomnia, Depression, Muscle Swelling for a 75-year old man?

This is a personalized study of taking Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride for a 75 year old male patient who has Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives. The study is created by eHealthMe based on 40 male patients aged 75 (±5) who take the drugs from FDA and social media.

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Information of the patient in this study:

Age: 70

Gender: male

Conditions: Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives

Drugs taking:
- Metformin Hydrochloride - 500MG (metformin hydrochloride): used for 5 - 10 years
- Glyburide - 5MG (glyburide): used for 5 - 10 years
- Ramipril - 10MG (ramipril): used for 5 - 10 years
- Lipitor - EQ 40MG BASE (atorvastatin calcium): used for 5 - 10 years
- Niacin - 500MG (niacin): used for 2 - 5 years
- Diphenhydramine Hydrochloride - 50MG/ML (diphenhydramine hydrochloride): used for 1 - 2 years

Drug interactions have: severe insomnia, moderate depression, moderate muscle swelling

On Jan, 28, 2014: 40 males aged 70 (±5) who reported to have interactions when taking Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride are studied

Trend of Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride's drug interactions, side effects and effectiveness reports (2945833)

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
among males aged 70 (±5) who take the drugs
Insomnia (sleeplessness)2 (5.00%)
Depression1 (2.50%)
Muscle Swelling1 (2.50%)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

SymptomNumber of reports
among males aged 70 (±5) who have the condition, regardless of which drug is taken
Insomnia in Diabetes Mellitus Non-insulin-dependent59 (0.66%)
Insomnia in Hypertension337 (1.48%)
Insomnia in Hypercholesterolemia281 (2.27%)
Insomnia in Treatment - Hives1 (7.69%)
Depression in Diabetes Mellitus Non-insulin-dependent35 (0.39%)
Depression in Hypertension255 (1.12%)
Depression in Hypercholesterolemia188 (1.52%)
Depression in Treatment - Hives1 (7.69%)
Muscle Swelling in Diabetes Mellitus Non-insulin-dependent1 (0.01%)
Muscle Swelling in Hypertension3 (0.01%)
Muscle Swelling in Hypercholesterolemia7 (0.06%)
Muscle Swelling in Treatment - Hives1 (7.69%)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effectNumber of reports
among males aged 70 (±5) who take the drug
Insomnia in Metformin Hydrochloride16 (1.16%)
Insomnia in Glyburide57 (1.44%)
Insomnia in Ramipril44 (0.98%)
Insomnia in Lipitor254 (1.85%)
Insomnia in Niacin18 (1.76%)
Insomnia in Diphenhydramine Hydrochloride3 (2.42%)
Depression in Metformin Hydrochloride6 (0.43%)
Depression in Glyburide48 (1.21%)
Depression in Ramipril29 (0.65%)
Depression in Lipitor275 (2.00%)
Depression in Niacin12 (1.17%)
Depression in Diphenhydramine Hydrochloride3 (2.42%)
Muscle Swelling in Metformin Hydrochloride1 (0.07%)
Muscle Swelling in Glyburide1 (0.03%)
Muscle Swelling in Ramipril1 (0.02%)
Muscle Swelling in Lipitor3 (0.02%)
Muscle Swelling in Niacin2 (0.20%)
Muscle Swelling in Diphenhydramine Hydrochloride1 (0.81%)

Most common interactions experienced by males aged 70 (±5) in the use of Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride:

InteractionNumber of reports
Asthenia (weakness)11
Cerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)8
Dizziness6
Blood Glucose Increased6
Fatigue (feeling of tiredness)5
Oedema Peripheral (superficial swelling)4
Listless (lack of interest, energy, or spirit)4
Weight Increased4
Dehydration (dryness resulting from the removal of water)3
Product Quality Issue3

Most common interactions experienced by males aged 70 (±5) in long term use of Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride:

InteractionNumber of reports
Insomnia (sleeplessness)1
Depression1
Muscle Swelling1

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Related topic: Depression, Diabetes Mellitus Non-insulin-dependent, Hypercholesterolemia, Hypertension, Insomnia, Muscle Swelling, Treatment - hives

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Comments from related studies:

  • From this study (5 days ago):

  • have been abstinent for 6 weeks; one testicle and penis became grossly swollen and painful, Dr. treated with Sulfamethox 2DSx twice daily-in six days had anaphylactic reaction hives,etc. so discontinued; after swelling subsided and resumption of sex,have had three bloody ejaculations.
    Have had quadruple heart bypass,AAA,permanent thrombosis in leg from vein harvest, double (saddlebag) pulmonary emboli.

    Reply

  • From this study (5 days ago):

  • have been abstinent for 6 weeks; one testicle and penis became grossly swollen and painful, Dr. treated with Sulfamethox 2DSx twice daily-in six days had anaphylactic reaction hives,etc. so discontinued; after swelling subsided and resumption of sex,have had three bloody ejaculations.

    Reply

  • From this study (4 weeks ago):

  • Iron tablets for iron deficiency anemia

    Reply

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