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What could cause Insomnia, Depression, Muscle Swelling for a 75-year old man who takes Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride?





Summary: 44 male patients aged 75 (±5) who take the same drugs are studied.

This is a personalized study for a 75 year old male patient who has Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is often used in diabetes. (latest outcomes from Metformin hydrochloride 14,607 users)

Glyburide has active ingredients of glyburide. It is often used in diabetes. (latest outcomes from Glyburide 26,043 users)

Ramipril has active ingredients of ramipril. It is often used in high blood pressure. (latest outcomes from Ramipril 31,854 users)

Lipitor has active ingredients of atorvastatin calcium. It is often used in high blood cholesterol. (latest outcomes from Lipitor 132,752 users)

Niacin has active ingredients of niacin. It is often used in high blood cholesterol. (latest outcomes from Niacin 6,313 users)

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. (latest outcomes from Diphenhydramine hydrochloride 2,998 users)

What are the conditions

Diabetes mellitus non-insulin-dependent can be treated by Metformin Hydrochloride, Metformin, Januvia, Glipizide, Victoza, Janumet. (latest reports from Diabetes Mellitus Non-insulin-dependent 92,787 patients)

Hypertension (high blood pressure) can be treated by Lisinopril, Atenolol, Amlodipine Besylate, Hydrochlorothiazide, Diovan, Metoprolol Tartrate. (latest reports from Hypertension 351,152 patients)

Hypercholesterolemia (high levels of cholesterol in the blood) can be treated by Lipitor, Simvastatin, Crestor, Pravastatin Sodium, Zocor, Atorvastatin Calcium. (latest reports from Hypercholesterolemia 171,384 patients)

Treatment - hives can be treated by Benadryl, Zyrtec, Prednisone, Xyzal, Atarax, Doxepin Hydrochloride. (latest reports from Treatment - Hives 1,018 patients)

What are the symptoms

Insomnia (sleeplessness) has been reported by people with depression, quit smoking, pain, high blood pressure, stress and anxiety.(latest reports from Insomnia 143,612 patients)

Depression has been reported by people with quit smoking, multiple sclerosis, pain, osteoporosis, acne.(latest reports from Depression 276,625 patients)

Muscle swelling has been reported by people with high blood cholesterol, high blood pressure, acromegaly, pain, hepatitis b.(latest reports from Muscle swelling 335 patients)

On Dec, 18, 2014: 44 males aged 70 (±5) who take Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride are studied

Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride outcomes

Information of the patient in this study:

Age: 70

Gender: male

Conditions: Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives

Drugs taking:
- Metformin Hydrochloride - 500MG (metformin hydrochloride): used for 5 - 10 years
- Glyburide - 5MG (glyburide): used for 5 - 10 years
- Ramipril - 10MG (ramipril): used for 5 - 10 years
- Lipitor - EQ 40MG BASE (atorvastatin calcium): used for 5 - 10 years
- Niacin - 500MG (niacin): used for 2 - 5 years
- Diphenhydramine Hydrochloride - 50MG/ML (diphenhydramine hydrochloride): used for 1 - 2 years

Drug interactions have: severe insomnia, moderate depression, moderate muscle swelling

eHealthMe real world results:

Comparison with this patient's adverse outcomes:

InteractionNumber of reports on eHealthMe
Insomnia (sleeplessness)4 (9.09% of males aged 70 (±5) who take the drugs)
Depression2 (4.55% of males aged 70 (±5) who take the drugs)
Muscle Swelling2 (4.55% of males aged 70 (±5) who take the drugs)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

Symptom (click a symptom for in-depth analysis)Number of reports on eHealthMe
Insomnia in Diabetes Mellitus Non-insulin-dependent62 (0.65% of males aged 70 (±5) who have Diabetes mellitus non-insulin-dependent)
Insomnia in Hypertension319 (1.36% of males aged 70 (±5) who have Hypertension)
Insomnia in Hypercholesterolemia301 (2.27% of males aged 70 (±5) who have Hypercholesterolemia)
Insomnia in Treatment - Hives1 (7.69% of males aged 70 (±5) who have Treatment - hives)
Depression in Diabetes Mellitus Non-insulin-dependent37 (0.39% of males aged 70 (±5) who have Diabetes mellitus non-insulin-dependent)
Depression in Hypertension265 (1.13% of males aged 70 (±5) who have Hypertension)
Depression in Hypercholesterolemia209 (1.58% of males aged 70 (±5) who have Hypercholesterolemia)
Depression in Treatment - Hives1 (7.69% of males aged 70 (±5) who have Treatment - hives)
Muscle Swelling in Diabetes Mellitus Non-insulin-dependent1 (0.01% of males aged 70 (±5) who have Diabetes mellitus non-insulin-dependent)
Muscle Swelling in Hypertension5 (0.02% of males aged 70 (±5) who have Hypertension)
Muscle Swelling in Hypercholesterolemia7 (0.05% of males aged 70 (±5) who have Hypercholesterolemia)
Muscle Swelling in Treatment - Hives1 (7.69% of males aged 70 (±5) who have Treatment - hives)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effect (click a side effect for in-depth analysis)Number of reports on eHealthMe
Insomnia in Metformin Hydrochloride20 (1.19% of males aged 70 (±5) who take Metformin hydrochloride)
Insomnia in Glyburide57 (1.40% of males aged 70 (±5) who take Glyburide)
Insomnia in Ramipril46 (0.94% of males aged 70 (±5) who take Ramipril)
Insomnia in Lipitor263 (1.84% of males aged 70 (±5) who take Lipitor)
Insomnia in Niacin18 (1.71% of males aged 70 (±5) who take Niacin)
Insomnia in Diphenhydramine Hydrochloride3 (2.10% of males aged 70 (±5) who take Diphenhydramine hydrochloride)
Depression in Metformin Hydrochloride8 (0.48% of males aged 70 (±5) who take Metformin hydrochloride)
Depression in Glyburide51 (1.26% of males aged 70 (±5) who take Glyburide)
Depression in Ramipril29 (0.59% of males aged 70 (±5) who take Ramipril)
Depression in Lipitor292 (2.04% of males aged 70 (±5) who take Lipitor)
Depression in Niacin12 (1.14% of males aged 70 (±5) who take Niacin)
Depression in Diphenhydramine Hydrochloride3 (2.10% of males aged 70 (±5) who take Diphenhydramine hydrochloride)
Muscle Swelling in Metformin Hydrochloride1 (0.06% of males aged 70 (±5) who take Metformin hydrochloride)
Muscle Swelling in Glyburide1 (0.02% of males aged 70 (±5) who take Glyburide)
Muscle Swelling in Ramipril1 (0.02% of males aged 70 (±5) who take Ramipril)
Muscle Swelling in Lipitor3 (0.02% of males aged 70 (±5) who take Lipitor)
Muscle Swelling in Niacin2 (0.19% of males aged 70 (±5) who take Niacin)
Muscle Swelling in Diphenhydramine Hydrochloride1 (0.70% of males aged 70 (±5) who take Diphenhydramine hydrochloride)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Metformin Hydrochloride is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Glyburide is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Ramipril is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Lipitor is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Niacin is effectiven/an/an/an/a0.00%
(0 of 1 people)
n/an/an/a
Diphenhydramine Hydrochloride is effectiven/an/an/a100.00%
(1 of 1 people)
n/an/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
n/an/an/aMuscle SwellingInsomnia (sleeplessness)Insomnia (sleeplessness)n/aCerebrovascular Accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Insomnia (sleeplessness)DepressionDepressionBlood Glucose Increased
DepressionMuscle SwellingMuscle SwellingDizziness
Headache (pain in head)
Fatigue (feeling of tiredness)
Asthenia (weakness)
Oedema Peripheral (superficial swelling)
Listless (lack of interest, energy, or spirit)
Polyp
Haemoglobin Decreased

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

You are not alone! Join a related mobile support group:
- support group for people who have Diabetes Mellitus Non-insulin-dependent
- support group for people who have Hypercholesterolemia
- support group for people who have Hypertension
- support group for people who have Treatment - Hives
- support group for people who have Depression
- support group for people who have Insomnia
- support group for people who have Muscle Swelling
- support group for people who take Diphenhydramine Hydrochloride
- support group for people who take Glyburide
- support group for people who take Lipitor
- support group for people who take Metformin Hydrochloride
- support group for people who take Niacin
- support group for people who take Ramipril

Recent conversations of related support groups:

Can you answer these questions (Ask a question):

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    I reduced Accupril until I am completely off Accupril. Still the BP was too low and I then reduced Metformin to one tab a day. The BP came back and gradually became too high , i.e., 150/92. I have to put Accupril back on at 5/2 mg then 5/4 mg then finally at 5/8 mg. This seems to be optimal but the Blood Sugar is at just above 100, sometimes 106. I wish to increase Metformin back to 2 a day but afraid Bp will become too low.

    Any input would be appreciated.
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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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