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What could cause Insomnia, Depression, Muscle Swelling for a 75-year old man?

This is a personalized study for a 75 year old male patient who has Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives. The study is created by eHealthMe based on reports of 44 male patients aged 75 (±5) who take the same drugs from FDA and social media.

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What are the drugs

Metformin hydrochloride (latest outcomes from 14,587 users) has active ingredients of metformin hydrochloride. It is often used in diabetes.

Glyburide (latest outcomes from 26,031 users) has active ingredients of glyburide. It is often used in diabetes.

Ramipril (latest outcomes from 31,799 users) has active ingredients of ramipril. It is often used in high blood pressure.

Lipitor (latest outcomes from 132,616 users) has active ingredients of atorvastatin calcium. It is often used in high blood cholesterol.

Niacin (latest outcomes from 6,295 users) has active ingredients of niacin. It is often used in high blood pressure.

Diphenhydramine hydrochloride (latest outcomes from 2,975 users) has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia.

What are the symptoms

Insomnia (sleeplessness) (latest reports from 776,693 patients) has been reported by people with depression, quit smoking, high blood pressure, pain, stress and anxiety.

Depression (latest reports from 1,152,889 patients) has been reported by people with quit smoking, multiple sclerosis, pain, osteoporosis, high blood pressure.

Muscle Swelling (latest reports from 1,616 patients) has been reported by people with high blood cholesterol, high blood pressure, acromegaly, pain, rheumatoid arthritis.

On Apr, 28, 2014: 44 males aged 70 (±5) who take Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride are studied

Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride outcomes

Information of the patient in this study:

Age: 70

Gender: male

Conditions: Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives

Drugs taking:
- Metformin Hydrochloride - 500MG (metformin hydrochloride): used for 5 - 10 years
- Glyburide - 5MG (glyburide): used for 5 - 10 years
- Ramipril - 10MG (ramipril): used for 5 - 10 years
- Lipitor - EQ 40MG BASE (atorvastatin calcium): used for 5 - 10 years
- Niacin - 500MG (niacin): used for 2 - 5 years
- Diphenhydramine Hydrochloride - 50MG/ML (diphenhydramine hydrochloride): used for 1 - 2 years

Drug interactions have: severe insomnia, moderate depression, moderate muscle swelling

eHealthMe real world results:

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
among males aged 70 (±5) who take the drugs
Insomnia (sleeplessness)4 (9.09%)
Depression2 (4.55%)
Muscle Swelling2 (4.55%)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

SymptomNumber of reports
among males aged 70 (±5) who have the condition, regardless of which drug is taken
Insomnia in Diabetes Mellitus Non-insulin-dependent62 (0.66%)
Insomnia in Hypertension353 (1.45%)
Insomnia in Hypercholesterolemia300 (2.29%)
Insomnia in Treatment - Hives1 (7.69%)
Depression in Diabetes Mellitus Non-insulin-dependent37 (0.39%)
Depression in Hypertension272 (1.12%)
Depression in Hypercholesterolemia209 (1.59%)
Depression in Treatment - Hives1 (7.69%)
Muscle Swelling in Diabetes Mellitus Non-insulin-dependent1 (0.01%)
Muscle Swelling in Hypertension5 (0.02%)
Muscle Swelling in Hypercholesterolemia7 (0.05%)
Muscle Swelling in Treatment - Hives1 (7.69%)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effectNumber of reports
among males aged 70 (±5) who take the drug
Insomnia in Metformin Hydrochloride20 (1.19%)
Insomnia in Glyburide57 (1.40%)
Insomnia in Ramipril46 (0.94%)
Insomnia in Lipitor262 (1.83%)
Insomnia in Niacin18 (1.71%)
Insomnia in Diphenhydramine Hydrochloride3 (2.10%)
Depression in Metformin Hydrochloride8 (0.48%)
Depression in Glyburide51 (1.26%)
Depression in Ramipril29 (0.59%)
Depression in Lipitor292 (2.04%)
Depression in Niacin12 (1.14%)
Depression in Diphenhydramine Hydrochloride3 (2.10%)
Muscle Swelling in Metformin Hydrochloride1 (0.06%)
Muscle Swelling in Glyburide1 (0.02%)
Muscle Swelling in Ramipril1 (0.02%)
Muscle Swelling in Lipitor3 (0.02%)
Muscle Swelling in Niacin2 (0.19%)
Muscle Swelling in Diphenhydramine Hydrochloride1 (0.70%)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Metformin Hydrochloride is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Glyburide is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Ramipril is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Lipitor is effectiven/an/an/an/an/a100.00%
(1 of 1 people)
n/an/a
Niacin is effectiven/an/an/an/a0.00%
(0 of 1 people)
n/an/an/a
Diphenhydramine Hydrochloride is effectiven/an/an/a100.00%
(1 of 1 people)
n/an/an/an/a

Drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
n/an/an/aMuscle Swelling
(1 report)

Depression
(1 report)

Insomnia
(1 report)

Muscle Swelling
(1 report)

Depression
(1 report)

Insomnia
(1 report)

Muscle Swelling
(1 report)

Depression
(1 report)

Insomnia
(1 report)

n/aCerebrovascular Accident
(8 reports)

Blood Glucose Increased
(6 reports)

Dizziness
(6 reports)

Headache
(5 reports)

Fatigue
(5 reports)

Asthenia
(5 reports)

Oedema Peripheral
(4 reports)

Listless
(4 reports)

Polyp
(4 reports)

Haemoglobin Decreased
(4 reports)

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Get connected! Join a mobile support group:
- group for people who have Diabetes Mellitus Non-insulin-dependent
- group for people who have Hypercholesterolemia
- group for people who have Hypertension
- group for people who have Treatment - Hives
- group for people who have Depression
- group for people who have Insomnia
- group for people who have Muscle Swelling
- group for people who take Diphenhydramine Hydrochloride
- group for people who take Glyburide
- group for people who take Lipitor
- group for people who take Metformin Hydrochloride
- group for people who take Niacin
- group for people who take Ramipril

Comments from related studies:

  • From this study (2 weeks ago):

  • Was on Metformin (1000 mg per day), which was recently increased with a goal of 2000 mg per day (gradual increase). In the AM, I usually start with a cup of coffee, then breakfast, followed by more coffee (two cups per day). I take metformin immediately following meals. I fix up my coffee with organic half & half, and pure stevia. When drinking coffee, or dairy products, I experience severe upset stomach, without bowl and abdominal sounds. Is it possible I developed a form of lactose intolerance? This is the "only" dairy I use and prefer to use unsweetened almond milk in place of dairy, except for coffee. This morning, as an experiment, I decided not to fix any coffee and the symptoms have subsided so far today.

    Reply

  • From this study (2 months ago):

  • Muscle ache makes it difficult to sleep or do anything

    Reply

  • From this study (2 months ago):

  • Recurring extreme pain in joint of big toe. Lasts for 2 to three days, then subsides. Had lab work done and was told that my uric acid level was below level that would cause any gout symptoms. I have had two painful flare ups over the past two months, about 3 weeks apart.

    Reply

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Related drug interaction studies:

Drug effectiveness in real world:

Complete drug side effects:

Alternative drugs:

Drugs associated with:

Conditions associated with:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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