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Drug interactions between Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride for a Male patient aged 74

This is a personalized study of Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride drug interactions for a 74 year old male patient who has Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives. The study is created by eHealthMe based on 876 reports from FDA.

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What are the drugs

Metformin hydrochloride has active ingredients of metformin hydrochloride. It is used in diabetes, type 2 diabetes, polycystic ovary disease, insulin resistance, type 1 diabetes mellitus , type 1 diabetes.

Glyburide has active ingredients of glyburide. It is used in diabetes, type 2 diabetes, gestational diabetes, diabetes mellitus inadequate control, hyperglycemia.

Ramipril has active ingredients of ramipril. It is used in high blood pressure, essential hypertension, heart attack, hypotension, high blood cholesterol, heart failure.

Lipitor has active ingredients of atorvastatin calcium. It is used in high blood cholesterol, high blood pressure, hyperlipidaemia, blood cholesterol decreased, high density lipoprotein abnormal, heart attack.

Niacin has active ingredients of niacin. It is used in high blood cholesterol, weight abnormal, high blood pressure, general physical condition abnormal, healthy living, lipids abnormal.

Diphenhydramine hydrochloride has active ingredients of diphenhydramine hydrochloride. It is used in insomnia, sleep disorder, allergic reactions, allergies, allergen, natural short sleeper.

On Apr, 29, 2013: 876 males aged 70 (±5) who reported to have interactions when taking Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride are studied

Trend of Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride's drug interactions, side effects and effectiveness reports (2945833)

Information of the patient in this study:

Age: 70

Gender: male

Conditions: Diabetes Mellitus Non-insulin-dependent, Hypertension, Hypercholesterolemia, Treatment - hives

Drugs taking:
- Metformin Hydrochloride - 500MG (metformin hydrochloride): used for 5 - 10 years
- Glyburide - 5MG (glyburide): used for 5 - 10 years
- Ramipril - 10MG (ramipril): used for 5 - 10 years
- Lipitor - EQ 40MG BASE (atorvastatin calcium): used for 5 - 10 years
- Niacin - 500MG (niacin): used for 2 - 5 years
- Diphenhydramine Hydrochloride - 50MG/ML (diphenhydramine hydrochloride): used for 1 - 2 years

Drug interactions have: severe insomnia, moderate depression, moderate muscle swelling

eHealthMe real world results:

Comparison with this patient's adverse outcomes:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
among males aged 70 (±5) who take the drugs
Insomnia14 (1.60%)
Depression9 (1.03%)
Muscle Swelling0 (0.00%)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

SymptomNumber of reports
among males aged 70 (±5) who have the condition, regardless of which drug is taken
Insomnia in Diabetes Mellitus Non-insulin-dependent57 (0.65%)
Insomnia in Hypertension321 (1.62%)
Insomnia in Hypercholesterolemia265 (2.59%)
Insomnia in Treatment - Hives0 (0.00%)
Depression in Diabetes Mellitus Non-insulin-dependent34 (0.39%)
Depression in Hypertension246 (1.24%)
Depression in Hypercholesterolemia177 (1.73%)
Depression in Treatment - Hives0 (0.00%)
Muscle Swelling in Diabetes Mellitus Non-insulin-dependent0 (0.00%)
Muscle Swelling in Hypertension2 (0.01%)
Muscle Swelling in Hypercholesterolemia5 (0.05%)
Muscle Swelling in Treatment - Hives0 (0.00%)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effectNumber of reports
among males aged 70 (±5) who take the drug
Insomnia in Metformin Hydrochloride14 (1.36%)
Insomnia in Glyburide56 (1.43%)
Insomnia in Ramipril42 (0.98%)
Insomnia in Lipitor248 (1.90%)
Insomnia in Niacin17 (1.76%)
Insomnia in Diphenhydramine Hydrochloride2 (2.22%)
Depression in Metformin Hydrochloride5 (0.49%)
Depression in Glyburide47 (1.20%)
Depression in Ramipril27 (0.63%)
Depression in Lipitor271 (2.07%)
Depression in Niacin11 (1.14%)
Depression in Diphenhydramine Hydrochloride2 (2.22%)
Muscle Swelling in Metformin Hydrochloride0 (0.00%)
Muscle Swelling in Glyburide0 (0.00%)
Muscle Swelling in Ramipril0 (0.00%)
Muscle Swelling in Lipitor2 (0.02%)
Muscle Swelling in Niacin0 (0.00%)
Muscle Swelling in Diphenhydramine Hydrochloride0 (0.00%)

Most common interactions experienced by males aged 70 (±5) in the use of Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
1Hallucination161
2Flushing136
3Myocardial Infarction134
4Hypertension106
5Diarrhoea103
6Dyspnoea98
7Blood Glucose Increased72
8Renal Failure Acute71
9Fatigue55
10Pain51

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Most common interactions experienced by males aged 70 (±5) in long term use of Metformin Hydrochloride, Glyburide, Ramipril, Lipitor, Niacin, Diphenhydramine Hydrochloride:

(click on each outcome to view in-depth analysis, incl. how people recovered)
InteractionNumber of reports
1Cerebrovascular Accident10
2Flushing6
3Bladder Cancer5
4Weight Decreased4
5Deep Vein Thrombosis4
6Ventricular Fibrillation3
7Cerebral Ischaemia2
8Food Poisoning2
9Multiple Myeloma2
10Renal Failure Acute2

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Comments from related studies:

  • From this study (3 weeks ago):

  • i have not changed any doctor ordered medications , however, due to allergies, I recently bought over the counter Claritin and then zyrtec. Since then, I am getting the tingling in my right hand? Can you advise?

    Reply

  • From this study (1 month ago):

  • feeling malaise and sick strange in the upper abdomen

    Reply

  • From this study (1 month ago):

  • Lipitor immediately causes my blood sugar and blood pressure to elevate. When I stop taking it they drop back down to previous levels.

    Reply

  • From this study (1 month ago):

  • my face and chest are really red like a bab sun burn

    Reply

  • From this study (2 months ago):

  • have some elevated / high potassium in recent lab test

    Reply

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