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Methotrexate Sodium, Metformin Hydrochloride for a 44-year old woman

This is a study of Methotrexate Sodium, Metformin Hydrochloride for a 44 year old female patient who has Rheumatoid Arthritis, Diabetes Mellitus. The study is created by eHealthMe based on 76 female patients aged 44 (±5) who take the drugs from FDA and social media.

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On Mar, 10, 2014: 76 females aged 39 (±5) who reported to have interactions when taking Methotrexate Sodium, Metformin Hydrochloride are studied

Trend of Methotrexate Sodium, Metformin Hydrochloride's drug interactions, side effects and effectiveness reports (2614276)

Information of the patient in this study:

Age: 39

Gender: female

Conditions: Rheumatoid Arthritis, Diabetes Mellitus

Drugs taking:
- Methotrexate Sodium (methotrexate sodium): used for < 1 month
- Metformin Hydrochloride - 500MG (metformin hydrochloride): used for 5 - 10 years

eHealthMe real world results:

Most common interactions experienced by females aged 39 (±5) in the use of Methotrexate Sodium, Metformin Hydrochloride:

InteractionNumber of reports
Nausea (feeling of having an urge to vomit)8
Oedema Peripheral (superficial swelling)6
Weight Decreased6
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)6
Drug Ineffective5
Fatigue (feeling of tiredness)5
Swelling Face5
Pancreatitis Acute (sudden inflammation of pancreas)5
Tachycardia (a heart rate that exceeds the range of 100 beats/min)5

Most common interactions experienced by females aged 39 (±5) in long term use of Methotrexate Sodium, Metformin Hydrochloride:

InteractionNumber of reports
Myalgia (muscle pain)2
Malaise (a feeling of general discomfort or uneasiness)2
Hip Arthroplasty2
Staphylococcal Sepsis (blood infection by an infection with staphylococcus bacteria)2
Fatigue (feeling of tiredness)2
Nausea And Vomiting1
Implant Site Infection1
Tonic Seizures (all the muscles to suddenly become stiff)1
Arthritis Infective (purulent invasion of a joint by an infectious agent which produces arthritis)1
Arthritis Bacterial (form of joint disorder that involves inflammation of one or more joints due to bacterial infection)1

How effective are the drugs for females aged 39 (±5):

not at allsomewhatmoderatehighvery high
Methotrexate Sodium0.00%50.00%50.00%0.00%0.00%
Metformin Hydrochloride0.00%0.00%100.00%0.00%0.00%

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

Related topic: Diabetes Mellitus, Methotrexate Sodium, Rheumatoid Arthritis

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Drug effectiveness in real world:

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Comments from related studies:

  • From this study (12 months ago):

  • Have Diabetes II and keep hearing and reading that Breast Cancer can be caused by Insulin and reoccur from insulin feeding the cancer and making it harder to get rid of. I have had a lumpectomy and radiation and am starting to heal. Besides not eating carbs and sugars are the medicines mentioned also putting me at risk for a reoccurance.


  • From this study (2 years ago):

  • Second seizure in 3 months. Been on methotrexate injection for 6 months. No seizure disorder found


  • From this study (2 years ago):

  • Does this drugs interact with coq10 or folid acid?


    Marnie Spencer on May, 11, 2012:

    I am 76years of age. I have Type2 diabetes for the past 6 years.. My blood sugars are twix 6.00 and 7.00.Presently 6.5. I take 20mg of Glimepiride each day. I suffer from nausea,sickness, vomiting, bloating, acute indigestion and stomach pain daily. If I don't take the Glimepiride I do not have these stomach problems. My Doctor insists that I persevere but she is not the one feeling/being sick until noon each day. I just want to know what would happen if I did not take the medication . Will it shorten my life substantially ? Isn't it better to have a shorter, happier life free from all this illness than maybe to live a little longer in misery each day. My Doctor is not able to answer this question of course, her job is to prescribe ,Can anyone else help ?


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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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DISCLAIMER: All material available on is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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Related studies

- Metformin Hydrochloride side effects
- Methotrexate Sodium side effects


Related conditions

- Diabetes
- Rheumatoid arthritis



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