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Mirtazapine, Lyrica - 25MG for a 48-year old man





Summary: 34 male patients aged 48 (±5) who take the same drugs are studied.

This is a personalized study for a 48 year old male patient who has Depression - chronic, Insomnia. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Mirtazapine has active ingredients of mirtazapine. It is often used in depression. (latest outcomes from Mirtazapine 17,934 users)

What are the conditions

Depression - chronic (chronic depression lasting at least for two years) can be treated by Cymbalta, Prozac, Wellbutrin Xl, Zoloft, Effexor Xr, Lexapro. (latest reports from Depression - Chronic 2,585 patients)

Insomnia (sleeplessness) can be treated by Ambien, Trazodone Hydrochloride, Lunesta, Zolpidem Tartrate, Ambien Cr, Melatonin. (latest reports from Insomnia 135,811 patients)

On Dec, 17, 2014: 34 males aged 43 (±5) who take Mirtazapine, Lyrica - 25MG are studied

Mirtazapine, Lyrica - 25MG outcomes

Information of the patient in this study:

Age: 43

Gender: male

Conditions: Depression - chronic, Insomnia

Drugs taking:
- Mirtazapine - 15MG (mirtazapine): used for 1 - 2 years
- Lyrica - 25MG (pregabalin): used for 1 - 2 years

eHealthMe real world results:

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Mirtazapine is effectiven/a0.00%
(0 of 1 people)
n/an/an/an/an/an/a
Lyrica - 25MG is effectiven/a100.00%
(1 of 1 people)
n/an/an/an/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
n/aGamma-glutamyltransferase Increasedn/an/an/an/an/aNeuropathy Peripheral (surface nerve damage)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)Pneumonia
Myalgia (muscle pain)Pain
Arthralgia (joint pain)Anxiety
Rash (redness)Decreased Appetite (decreased appetite occurs when you have a reduced desire to eat)
Drug IneffectivePyrexia (fever)
Pruritus (severe itching of the skin)Gait Disturbance
Vision BlurredAbdominal Pain
DrowsinessCardiomegaly (increased size of heart than normal)
Tonic Clonic Movements (generalized seizure that affects the entire brain)Compression Fracture (fracture due to pressure caused by injury)

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

You are not alone! Join a related mobile support group:
- support group for people who have Depression - Chronic
- support group for people who have Insomnia
- support group for people who take Mirtazapine

Recent conversations of related support groups:

  • Support group for people who have Insomnia
    My insomnia was provoked by a 'medicine cocktail', prescribed medications that were contraindicated. I just had a rough experience with Serotonin Syndrome, grateful to be alive.

Can you answer these questions (Ask a question):

  • Does mirtazapine cause dehydration? (1 answer)
    Dehydrated lately. Urine is very concentrated showing dehydration. Wondering if the drug in question is the cause.
  • Propranolo & pregabalin - do they produce heart troubles? my meds mix has
    Being on zopiclone 75mg (sleep med) gave me terrible poly/firbomyalgia, which I was then prescrbed pregabalin to aleviate pains and anxiety, and the propranolo to help with the same. On day one of propranolo I had a medium heart attack like event, within 24hrs had a large attack and became hospitalised. But vital signs and chest xray, blood tests, then showed 'normal'. But since then have had several more (almost one or more a month) heart attacklike events, hospitalisation, etc, but still being told all 'normal'. But now I've met someone who has told me they had similar heart issues and were told professionally for years his vital signs were normal : he now has a tripple-heart-bypass. I keep being told the angina like symtoms I have are anxiety realted - "only". But when I look at the professional descriptions and illustrations of angina, and similar, I see I could have written and drawn those from my own experiences. Hellish! No where to turn to. So I'm stopping the meds now one by one in careful withdrawl - docs don't like it - but I'm convinced my meds are slowly degrading my overall health as they build up into a toxic soup in me. I started this withdrawly after I discovered that - officially - Pregabalin (a calcium ?minimiser) and Propranolol (a beta blocker) should not be taken together in case they cause heart malfunctions... shame my doctors didn't know that.... before they let me take them for 8 months!!!!!!
  • Can unisom sleep gels total 160 with mirtazapine total 100 45mg kill you if taken with alcohol
    my father died this year I also lost my best friend I had to watch them did in hospital I also split up with my girlfriend. I just feel lives not worth living
  • How long (if ever) does it take to get use to lyrica sleepiness and what does works best for fybromyalgia?
    Take several other meds. for high blood, high cholesterol, GERD and etc.

More questions for: Depression - chronic, Insomnia

You may be interested at these reviews (Write a review):

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    Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
  • A life of depression and fatigue
    1) Family history of depression, 2) Diagnosed depression 1964-not treated until 1973, 3) Worked in medical field 35 years, 4) Emergency on-call 24/7, 5) Hospital 15 times major depression, 6) Tried nearly all MAOI, TCA, SSRI, SNRI, and ECT. 7) 100% Disability in 1998 for depression. Now at age 70 I have dysthymia, chronic fatigue, COPD, and PTSD. My recommendation to younger people - do not over stress,
    do not smoke, avoid horrific or traumatic situations and try to find some enjoyment in life. If you have symptoms like mine seek early treatment put balance in your life. The often heard recommendations - get plenty of sleep, eat properly, learn to relax and avoid bad habits should not be ignored, they are critical to good physical and mental health.
  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
  • Doxylamine succinate and severe restless legs and insomnia
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  • Nexium improves my constipation
    Started taking Nexium 1 week ago and I noticed improvement with my chronic constipation.

More reviews for: Depression - chronic, Insomnia

Comments from related studies:

  • From this study (6 days ago):

  • Taking calcium in form of TUMS seems to lessen the burning skin sensation.

    Reply

  • From this study (2 years ago):

  • Need more information about the drugs I am taking. I have so many Dr.'s working on my case that I fear major drug interactio. Myathesia gravis Is getting worse. My double vision is becoming an issue. I can no longer watch more than an hour of t.v. a day. Nod off alot.

    Reply

    Oops3 on Dec, 8, 2012:

    First I would get off the Lyrica,and that is not easy to do. It messed up my mind so badly, that now that I'm off it, people are saying "" welcome back"! I guess I should mention my antidepressant failed, rheumatologist decided he wasn't prescribing them anymore to anyone, and long story short, ended up putting myself into mental ward from a sudden panic attack. Did the Lyrica help cause it, I don't know. But being off it is a godsend.

    Reply

    Neal on Dec, 8, 2012:

    Hi I am a 31 year old male who suffers from Bi Polar. Following a raised white blood cell count (lithium) extreme lethargy (quitiapine) and an ineffective anti-depressant (citalopram) a complete overhaul of my meds was under taken (correctly and slowly)
    I am currently taking lamotragine ( now been on 100mg for over a month) and have recently and gradually ended the citalopram and gradually put on Mertazapine to a dose of 30mg over the course of 2.5 weeks (1 week at 15mg and 1.5 weeks so far at 30mg)
    I have recently, over the last 2 -3 days, been experiencing symptoms of lhemerits sign and following an all night stay in A&E I have been told that I have this and it is most likely caused by the Mertazapine. apparently this is extremely rare but it does happen.

    Reply

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Drug effectiveness in real world:

Complete drug side effects:

Alternative drugs:

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

You may report adverse side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

   

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