Drug interactions between Mirtazapine, Lyrica - 25MG for a Male patient aged 47
This is a personalized study of Mirtazapine, Lyrica - 25MG drug interactions for a 47 year old male patient who has Depression - chronic, Insomnia. The study is created by eHealthMe based on 31 reports from FDA.
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What are the drugs
Mirtazapine has active ingredients of mirtazapine. It is used in depression, stress and anxiety, sleep disorder, insomnia, generalized anxiety disorder, depressed mood.
Lyrica - 25mg has active ingredients of pregabalin. It is used in pain.
On May, 1, 2013: 31 males aged 43 (±5) who reported to have interactions when taking Mirtazapine, Lyrica - 25MG are studied

Information of the patient in this study:
Age: 43
Gender: male
Conditions: Depression - chronic, Insomnia
Drugs taking:
- Mirtazapine - 15MG (mirtazapine): used for 1 - 2 years
- Lyrica - 25MG (pregabalin): used for 1 - 2 years
eHealthMe real world results:
Most common interactions experienced by males aged 43 (±5) in the use of Mirtazapine, Lyrica - 25MG:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Decreased Appetite | 14 |
| 2 | Anxiety | 14 |
| 3 | Pyrexia | 12 |
| 4 | Nephrolithiasis | 10 |
| 5 | Neuropathy Peripheral | 8 |
| 6 | Pneumonia | 8 |
| 7 | Pain | 8 |
| 8 | Gait Disturbance | 6 |
| 9 | Abdominal Pain | 6 |
| 10 | Nerve Root Injury Lumbar | 5 |
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Most common interactions experienced by males aged 43 (±5) in long term use of Mirtazapine, Lyrica - 25MG:
(click on each outcome to view in-depth analysis, incl. how people recovered)| None. |
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Drug effectiveness in real world:
- Mirtazapine for Depression - Chronic reported by 14 people (updated 1 month ago)
Side effects in real world:
Alternative drugs:
- Depression - Chronic (53 drugs) (updated 1 day ago)
- Insomnia (91 drugs) (updated 19 hours ago)
Comments from related studies:
From this study (6 months ago):
From this study (3 years ago):
From this study (3 years ago):
Need more information about the drugs I am taking. I have so many Dr.'s working on my case that I fear major drug interactio. Myathesia gravis Is getting worse. My double vision is becoming an issue. I can no longer watch more than an hour of t.v. a day. Nod off alot.
Oops3 on Dec, 8, 2012:
First I would get off the Lyrica,and that is not easy to do. It messed up my mind so badly, that now that I'm off it, people are saying "" welcome back"! I guess I should mention my antidepressant failed, rheumatologist decided he wasn't prescribing them anymore to anyone, and long story short, ended up putting myself into mental ward from a sudden panic attack. Did the Lyrica help cause it, I don't know. But being off it is a godsend.
Neal on Dec, 8, 2012:
Hi I am a 31 year old male who suffers from Bi Polar. Following a raised white blood cell count (lithium) extreme lethargy (quitiapine) and an ineffective anti-depressant (citalopram) a complete overhaul of my meds was under taken (correctly and slowly)
I am currently taking lamotragine ( now been on 100mg for over a month) and have recently and gradually ended the citalopram and gradually put on Mertazapine to a dose of 30mg over the course of 2.5 weeks (1 week at 15mg and 1.5 weeks so far at 30mg)
I have recently, over the last 2 -3 days, been experiencing symptoms of lhemerits sign and following an all night stay in A&E I have been told that I have this and it is most likely caused by the Mertazapine. apparently this is extremely rare but it does happen.
Sue Lang on Nov, 10, 2012:
Your best ally right now is your pharmacist! Have him look up all the drugs you are taking, and ask about interactions. His computer should be able to flag if there any. Then go to a neurologist. Forget everyone else. See a neurologist as this is his/her field.
Good luck, and if you need someone to "talk" to, you have my e-mail up there. You may use it.
Sue
The Lamotrigine seems to be helping with the depression but the lethary/drowsiness seems to be cancelling out the effectiveness of the medication. I don't know whether it is the lamotrigine thats causing the drowsiness or the combination of the medication I'm taking. My psychiatrist thinks it may be the other meds and has suggested reducing and then stopping the Mirtazepine. Any constructive feedback would be gratefully received.
I have both parents as Dr.'s but they are not involved in my medication or medical issues. I don't know how to quit Benzodiazepines and I wish I knew how all these med's interact.
Natalie on Jun, 7, 2010:
Be careful pulling yourself off of benzo's without your dr.'s knowledge. These drugs can have a rebound detox. It can be fatal. Best of luck!
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