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From FDA reports: drug interactions between Spiriva, Flovent, Norvasc, Alphagan for a Female patient aged 87

This is a personalized study for a 87 year old female patient. The study is created by eHealthMe based on reports of 2 people who take the same drugs and have drug interactionsfrom FDA.

On Dec, 17, 2014: 2 people who reported to have interactions when taking Spiriva, Flovent, Norvasc, Alphagan are studied

Trend of Spiriva, Flovent, Norvasc, Alphagan's drug interactions, side effects, and effectiveness reports (2418357)

Information of the patient in this study:

Age: 87

Gender: female

Conditions: Asthma, Chronic Obstructive Pulmonary Disease, Hypertension

Drugs taking:
- Spiriva
- Flovent
- Norvasc
- Alphagan

Drug interactions have: Dyspnoea, Hypoxia

eHealthMe real world results:

Comparison with this patient's adverse outcomes among females aged 87 (±5):

InteractionNumber of reports
Dyspnoea (difficult or laboured respiration)2 (100.00%)
Hypoxia (low oxygen conditions)2 (100.00%)

Most common interactions experienced by females aged 87 (±5) in the use of Spiriva, Flovent, Norvasc, Alphagan:

InteractionNumber of reports
Dyspnoea (difficult or laboured respiration)2
Hypoxia (low oxygen conditions)2

Most common interactions experienced by females aged 87 (±5) in long term use of Spiriva, Flovent, Norvasc, Alphagan:

None.

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
Dyspnoea (difficult or laboured respiration)2 (100.00%)
Hypoxia (low oxygen conditions)2 (100.00%)

Most common interactions experienced by people in the use of Spiriva, Flovent, Norvasc, Alphagan:

InteractionNumber of reports
Dyspnoea (difficult or laboured respiration)2
Hypoxia (low oxygen conditions)2

Most common interactions experienced by people in long term use of Spiriva, Flovent, Norvasc, Alphagan:

None.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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  • Believe my problem is with Formoterol. Symptoms (breathlessness and being winded with minimal exertion) first noted three years ago after taking Foradil aerolizer (formoterol) and asmanex twisthaler for one to two years. Health, stamina gradually dimished to shortness of breath with minimal exertion. One - two years ago prescription changed to symbicort. health improved dramatically for approximately two months. Began walking one to two miles a day. Now back to being winded with minimal exertion. Health seems better until I take my symbicort. Spiriva seems to counter act breathlessness at morning when I take with symbicort. At evening with no Spiriva, breathlessness prevails. using Spiriva twice daily works but doctor says no.

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Can you answer these questions (Ask a question):

  • I have had the history of seizures, kidney stones, high blood pressure and migraine headaches. i am soon going back to school and need something to help with memory . what is best to help in this way
    Not sure what I am suppose to write here. My mind is never clear and it feels as if there is swelling that keeps me from wanting to learn or work. Taking IBprofen helps take some of the swelling away but not all.
  • Could my occasional a-fib be caused by amlodipine?
    My a-fib comes and goes. A year ago I was having episodes occasionally, usually related to either caffeine or alcohol. After I stopped using either my a-fibs disappeared for 9 months, then in September I started having them again, suddenly increasing this month to 3 times per week. I have been taking 5 mg of amlodipine besylate per day for 7 years. With my cardiologist's permission I just recently reduced my dosage by half since my blood pressure was occasionally very low. Could the reduction in dosage actually have triggered the increased frequency?
  • Is there a published study that shows propranolol can cause shortness of breath and chest tightness?
    I am a pharmacy student in his final year on rotation at the VA Memorial Hospital. While working up a patient I noticed she has called many times complaining of "panic attacks" stating that she can't breath and has chest tightness. Over the previous two week I also noticed she has been to the ER for these same symptoms.

    Patient is a 61 year old female, with history of hypertension, dyslipidemia, migraine without aura, and while I don't see a specific diagnosis the patient current has a script for albuterol and at one time had a script for ipratropium. Patient has been a lifelone smoker who quit this past June.

    This patient was diagnosed with migraine headaches in 1986 and has been on propranolol 80mg ever since - 28 years. Interestingly, 1986 was around the time Inderal lost its patent and propranolol became generic.

    The patient served in the army from 1972-1976 during the vietnam war. She has a history of mental health issues (not sure what) and anxiety. I feel she has been "labeled" and current episodes of "panic attacks" are answered with benzodiazapines and she is sent on her way.

    During my first look into propranolol, the very first page said, "Check with your doctor immediately if you have any of the following side effects:
    1)Coughing up Mucus
    2)Shortness of Breath
    3)Tightness in the Chest"

    This caught my attention. I then started probing deeper and found an article written by Dr. Noreen Kassem titled "The Long Term Side Effects of Propranolol." In the article she wrote, "...propranolol and other beta blockers can also worsen breathing disorders, such as emphysema and asthma, because they constrict the air passageways of the lungs and can cause fluid build-up in the lungs. This can result in shortness of breath, difficulty breathing and chest tightness in patients who are on propranolol for long periods of time, or who have respiratory disorders."

    I tried to find Dr. Kassem to no avail. I wanted to know exactly where she got this information. I would like to find some primary literature on this topic but haven't had any luck. I need proof, because as of right now I'm a student being told that "she has been on this agent for 28 years, I doubt it's bothering her now." I'm not buying it and I think something is here.

    -61 year olf lifelone smoker with almost guaranteed declining lung function
    -28 year (chronic) use of propranlol (a non-selective beta blocker)
    -Possible asthmatic
    -Experiencing "shortness of breath" and "Chest tightness" that she and everyone else is called anxiety and/or panic attacks.

    I think the propranolol, while not the cause of these problems, is certainly exacerbating them. Does anyone have proof of this happening; peer reviewed articles, anything. My rotation is done in 2 weeks and I know no one will ever look into this again after I'm gone.

    ps... forgive any typos

More questions for: Alphagan, Asthma, Chronic Obstructive Pulmonary Disease, Dyspnoea, Flovent, Hypertension, Hypoxia, Norvasc, Spiriva

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Complete side effects:

In-depth study of side effects (who have it, when it happens and how):

Could it be a symptom from a condition:

Drug effectiveness in real world:

Alternative drugs:

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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