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What could cause Dry Mouth, Tooth Loss, Depressed Mood for a 62-year old man who takes Tizanidine Hydrochloride, Methadone Hydrochloride, Ibuprofen?





Summary: 124 male patients aged 62 (±5) who take the same drugs are studied.

This is a personalized study for a 62 year old male patient who has Back Injury, Back Disorder. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Tizanidine hydrochloride has active ingredients of tizanidine hydrochloride. It is often used in muscle spasms. (latest outcomes from Tizanidine hydrochloride 1,532 users)

Methadone Hydrochloride has active ingredients of methadone hydrochloride. It is often used in pain. (latest outcomes from Methadone Hydrochloride 2,835 users)

Ibuprofen has active ingredients of ibuprofen. It is often used in pain. (latest outcomes from Ibuprofen 61,602 users)

What are the conditions

Back injury can be treated by Hydrocodone Bitartrate And Acetaminophen, Flexeril, Oxycontin, Soma, Percocet, Vicodin. (latest reports from Back Injury 5,017 patients)

Back disorder can be treated by Percocet, Flexeril. (latest reports from Back Disorder 6,313 patients)

What are the symptoms

Dry mouth has been reported by people with high blood pressure, depression, chronic obstructive pulmonary disease, osteoporosis, high blood cholesterol.(latest reports from Dry mouth 30,429 patients)

Tooth loss has been reported by people with osteoporosis, metastases to bone, breast cancer, pain, multiple myeloma.(latest reports from Tooth loss 5,087 patients)

Depressed mood has been reported by people with depression, multiple sclerosis, quit smoking, stress and anxiety, high blood pressure.(latest reports from Depressed mood 13,238 patients)

On Nov, 28, 2014: 124 males aged 57 (±5) who take Tizanidine Hydrochloride, Methadone Hydrochloride, Ibuprofen are studied

Tizanidine Hydrochloride, Methadone Hydrochloride, Ibuprofen outcomes

Information of the patient in this study:

Age: 57

Gender: male

Conditions: Back Injury, Back Disorder

Drugs taking:
- Tizanidine Hydrochloride (tizanidine hydrochloride): used for 5 - 10 years
- Methadone Hydrochloride - 5MG (methadone hydrochloride): used for 5 - 10 years
- Ibuprofen - 800MG (ibuprofen): used for 5 - 10 years

Drug interactions have: severe dry mouth, severe tooth loss, moderate depressed mood

Comments from or about the patient: tooth enamel became very weak. prior to starting treatment had very strong teeth, then after about two years, cavities started occuring faster than the dentist could get me scheduled to fix them. Then started having to pull bad teeth and am eventually losing all of them. Going to have denture plates this month.
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eHealthMe real world results:

Comparison with this patient's adverse outcomes:

InteractionNumber of reports on eHealthMe
Dry Mouth6 (4.84% of males aged 57 (±5) who take the drugs)
Tooth Loss2 (1.61% of males aged 57 (±5) who take the drugs)
Depressed Mood2 (1.61% of males aged 57 (±5) who take the drugs)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

Symptom (click a symptom for in-depth analysis)Number of reports on eHealthMe
Dry Mouth in Back Injury1 (0.72% of males aged 57 (±5) who have Back injury)
Dry Mouth in Back Disorder3 (2.50% of males aged 57 (±5) who have Back disorder)
Tooth Loss in Back Injury1 (0.72% of males aged 57 (±5) who have Back injury)
Tooth Loss in Back Disorder1 (0.83% of males aged 57 (±5) who have Back disorder)
Depressed Mood in Back Injury1 (0.72% of males aged 57 (±5) who have Back injury)
Depressed Mood in Back Disorder2 (1.67% of males aged 57 (±5) who have Back disorder)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effect (click a side effect for in-depth analysis)Number of reports on eHealthMe
Dry Mouth in Tizanidine Hydrochloride1 (1.00% of males aged 57 (±5) who take Tizanidine hydrochloride)
Dry Mouth in Methadone Hydrochloride4 (1.82% of males aged 57 (±5) who take Methadone hydrochloride)
Dry Mouth in Ibuprofen19 (0.48% of males aged 57 (±5) who take Ibuprofen)
Tooth Loss in Tizanidine Hydrochloride2 (2.00% of males aged 57 (±5) who take Tizanidine hydrochloride)
Tooth Loss in Methadone Hydrochloride1 (0.45% of males aged 57 (±5) who take Methadone hydrochloride)
Tooth Loss in Ibuprofen30 (0.76% of males aged 57 (±5) who take Ibuprofen)
Depressed Mood in Tizanidine Hydrochloride1 (1.00% of males aged 57 (±5) who take Tizanidine hydrochloride)
Depressed Mood in Methadone Hydrochloride1 (0.45% of males aged 57 (±5) who take Methadone hydrochloride)
Depressed Mood in Ibuprofen14 (0.35% of males aged 57 (±5) who take Ibuprofen)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Tizanidine Hydrochloride is effectiven/a0.00%
(0 of 1 people)
n/an/a0.00%
(0 of 1 people)
0.00%
(0 of 1 people)
n/an/a
Methadone Hydrochloride is effectiven/an/an/a0.00%
(0 of 1 people)
n/a100.00%
(1 of 1 people)
n/an/a
Ibuprofen is effectiven/a0.00%
(0 of 1 people)
n/an/an/a100.00%
(1 of 1 people)
n/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
n/aSuicide AttemptIntentional OverdosePeroneal Nerve Palsy (dysfunction of nerve controlling movement and sensation to the lower leg, foot and toes)Stomach PainDepressed Moodn/aFatigue (feeling of tiredness)
Intentional OverdoseSuicide AttemptPleuritic PainTooth LossAnxiety
AnxietyAnxietyPalpitations (feelings or sensations that your heart is pounding or racing)Dry MouthFall
Feeling GuiltyFeeling GuiltyMusculoskeletal Chest Pain (pain in chest muscle or nerve or bones)Depression
DepressionDepressionMitral Valve Incompetence (inefficient heart valve)Osteonecrosis Of Jaw (death of bone of jaw)
Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Shoulder PainPain
Stomach PainArthralgia (joint pain)
Tricuspid Valve Incompetence (inefficient heart valve)Emotional Distress
Skin InjuryProgressive Multifocal Leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

You are not alone! Join a related mobile support group:
- support group for people who take Tizanidine Hydrochloride and have Dry Mouth
- support group for people who take Methadone Hydrochloride and have Dry Mouth
- support group for people who take Ibuprofen and have Dry Mouth
- support group for people who take Tizanidine Hydrochloride and have Tooth Loss
- support group for people who take Methadone Hydrochloride and have Tooth Loss
- support group for people who take Ibuprofen and have Tooth Loss
- support group for people who take Tizanidine Hydrochloride and have Depressed Mood
- support group for people who take Methadone Hydrochloride and have Depressed Mood
- support group for people who take Ibuprofen and have Depressed Mood
- support group for people who have Dry Mouth and Back Injury
- support group for people who have Dry Mouth and Back Disorder
- support group for people who have Tooth Loss and Back Injury
- support group for people who have Tooth Loss and Back Disorder
- support group for people who have Depressed Mood and Back Injury
- support group for people who have Depressed Mood and Back Disorder
- support group for people who have Back Disorder
- support group for people who have Back Injury
- support group for people who have Depressed Mood
- support group for people who have Dry Mouth
- support group for people who have Tooth Loss
- support group for people who take Ibuprofen
- support group for people who take Methadone Hydrochloride
- support group for people who take Tizanidine Hydrochloride

Can you answer these questions (Ask a question):

More questions for: Back Disorder, Back Injury, Depressed Mood, Dry Mouth, Tizanidine Hydrochloride, Tooth Loss

You may be interested at these reviews (Write a review):

  • 3 strong drugs together against neuropathic pain
    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
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    I am on the very edge of crazy. So starting this is pushing ne way over. I'm 49 for crap sakes. I am so tired of the pain in my body and I am just tired, this is the last slap I can't anymore. Naturally alcohol I am sure is just about the end game along with cuts.
    Just want to bleed out and not hurt anymore and be so scared to leave my house or sleep. I just want to sleep forever.
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More reviews for: Back Disorder, Back Injury, Depressed Mood, Dry Mouth, Tizanidine Hydrochloride, Tooth Loss

Comments from related studies:

  • From this study (1 month ago):

  • doc moc on Apr, 25, 2013:

    BREAK down FOOL!

    Reply

    Rhs on Oct, 13, 2012:

    Get your medical records
    and consult w/your doctor

    Reply

    trust1983 on Dec, 3, 2012:

    Is it true in the states that a psych doc can up and just leave and refuse to treat you because you tried to kill yourself, especially if you didn't have a contact for life with you r doc?

    Reply

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Drug effectiveness in real world:

In-depth study of side effects (who have it, when it happens and how):

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NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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