Drug interactions between Klonopin, Opana Er, Oxycodone Hydrochloride, Tramadol Hydrochloride for a Female patient aged 47
This is a personalized study of Klonopin, Opana Er, Oxycodone Hydrochloride, Tramadol Hydrochloride drug interactions for a 47 year old female patient who has Anxiety Disorder, Rotator Cuff Repair, Endometrial Disorder, shoulder pain. The study is created by eHealthMe based on 844 reports from FDA.
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What are the drugs
Klonopin has active ingredients of clonazepam. It is used in stress and anxiety, generalized anxiety disorder, panic disorder, insomnia, panic attack, restless leg syndrome.
Opana er has active ingredients of oxymorphone hydrochloride. It is used in pain, back pain - low, chronic gouty arthritis, rotator cuff repair, fibromyalgia, back pain.
Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is used in pain, back pain - low, breakthrough pain, endometrial disorder, fibromyalgia, chronic pain.
Tramadol hydrochloride has active ingredients of tramadol hydrochloride. It is used in pain, back pain - low, fibromyalgia, arthritis, pain in extremity, pain in limb.
On Apr, 30, 2013: 844 females aged 44 (±5) who reported to have interactions when taking Klonopin, Opana Er, Oxycodone Hydrochloride, Tramadol Hydrochloride are studied

Information of the patient in this study:
Age: 44
Gender: female
Conditions: Anxiety Disorder, Rotator Cuff Repair, Endometrial Disorder, shoulder pain
Drugs taking:
- Klonopin (clonazepam): used for 10+ years
- Opana Er - 10MG (oxymorphone hydrochloride): used for < 1 month
- Oxycodone Hydrochloride - 30MG (oxycodone hydrochloride): used for 1 - 6 months
- Tramadol Hydrochloride (tramadol hydrochloride)
eHealthMe real world results:
Comparison with this patient's adverse outcomes:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports among females aged 44 (±5) who take the drugs |
| Sleep | 41 (4.86%) |
(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)
| Symptom | Number of reports among females aged 44 (±5) who have the condition, regardless of which drug is taken |
| Sleep in Anxiety Disorder | 9 (2.84%) |
| Sleep in Rotator Cuff Repair | 0 (0.00%) |
| Sleep in Endometrial Disorder | 0 (0.00%) |
| Sleep in Shoulder Pain | 0 (0.00%) |
(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)
| Side effect | Number of reports among females aged 44 (±5) who take the drug |
| Sleep in Klonopin | 166 (3.79%) |
| Sleep in Opana Er | 4 (3.54%) |
| Sleep in Oxycodone Hydrochloride | 0 (0.00%) |
| Sleep in Tramadol Hydrochloride | 12 (3.57%) |
Most common interactions experienced by females aged 44 (±5) in the use of Klonopin, Opana Er, Oxycodone Hydrochloride, Tramadol Hydrochloride:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Anxiety | 248 |
| 2 | Vomiting | 204 |
| 3 | Arthralgia | 198 |
| 4 | Nausea | 148 |
| 5 | Pain | 138 |
| 6 | Depression | 119 |
| 7 | Headache | 108 |
| 8 | Fatigue | 101 |
| 9 | Chest Pain | 87 |
| 10 | Drug Ineffective | 79 |
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Most common interactions experienced by females aged 44 (±5) in long term use of Klonopin, Opana Er, Oxycodone Hydrochloride, Tramadol Hydrochloride:
(click on each outcome to view in-depth analysis, incl. how people recovered)| Interaction | Number of reports | |
| 1 | Anxiety | 34 |
| 2 | Vomiting | 30 |
| 3 | Arthralgia | 28 |
| 4 | Depression | 19 |
| 5 | Nausea | 17 |
| 6 | Urinary Tract Infection | 16 |
| 7 | Constipation | 15 |
| 8 | Fall | 14 |
| 9 | Headache | 13 |
| 10 | Pain | 11 |
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Related studies:
- Klonopin and Opana Er drug interactions (153 reports)
- Oxycodone Hydrochloride and Opana Er drug interactions (351 reports)
- Oxycodone Hydrochloride and Klonopin drug interactions (2,689 reports)
- Tramadol Hydrochloride and Opana Er drug interactions (35 reports)
- Tramadol Hydrochloride and Klonopin drug interactions (2,320 reports)
- Tramadol Hydrochloride and Oxycodone Hydrochloride drug interactions (1,689 reports)
Drug effectiveness in real world:
- Klonopin for Anxiety Disorder reported by 355 people (updated 6 minutes ago)
- Opana Er for Rotator Cuff Repair reported by 6 people (updated 43 years ago)
- Oxycodone Hydrochloride for Endometrial Disorder reported by 6 people (updated 43 years ago)
- Tramadol Hydrochloride for Shoulder Pain reported by 6 people (updated 8 months ago)
In-depth study of side effects (who have it, when it happens and how):
- Sleep (Drowsiness) in Klonopin reported by 1,164 people (updated 6 days ago)
- Sleep (Drowsiness) in Opana Er reported by 25 people (updated 2 weeks ago)
- Sleep (Drowsiness) in Oxycodone Hydrochloride reported by 2 people (updated 1 week ago)
- Sleep (Drowsiness) in Tramadol Hydrochloride reported by 127 people (updated 1 week ago)
Could it be a symptom from a condition:
- Sleep (Drowsiness) in Anxiety Disorder reported by 142 people (updated 3 months ago)
- Sleep (Drowsiness) in Rotator Cuff Repair reported by 2 people (updated 4 months ago)
- Sleep (Drowsiness) in Endometrial Disorder
- Sleep (Drowsiness) in Shoulder Pain reported by 2 people (updated 9 months ago)
Side effects in real world:
Browse all Klonopin side effects: 7,006 in total
Browse all Opana er side effects: 921 in total
Browse all Oxycodone hydrochloride side effects: 680 in total
Browse all Tramadol hydrochloride side effects: 3,082 in total
Browse all Klonopin side effects: 7,006 in total
Browse all Opana er side effects: 921 in total
Browse all Oxycodone hydrochloride side effects: 680 in total
Browse all Tramadol hydrochloride side effects: 3,082 in total
Alternative drugs:
- Anxiety Disorder (81 drugs) (updated 6 minutes ago)
- Endometrial Disorder
- Rotator Cuff Repair
- Shoulder Pain (14 drugs) (updated 2 weeks ago)
Drugs in real world that are associated with:
Comments from related studies:
From this study (2 weeks ago):
From this study (1 month ago):
From this study (1 month ago):
From this study (2 months ago):
I am staying very tired, sleepy alot and have weak feelings throughout my body. I also just dont want to do any of my usual activities and just overall depressed, I guess.
mrfitman on May, 8, 2013:
DITTO!! Major pain issues: shoulders to be replaced, hips already replaced.knee..and MORE!! Your statement..TRUE!! VEG!! Useless feeling
would like to know how morphine helps bipolar
shannon on Apr, 13, 2013:
Not sure exact mech. of action, however, could be to raise "Feel Good" endorphines and possibly keep you more at a "near but not fully" manic point, so to speak. I know a few with depression treated with morphine for that reason...it increases the available dopamine between the nerve cells called the synapsis, in turn, giving a feeling of "well being". This effct is opposite in some people...such as scizophrenics...it seems to make them more apt
to do stranger stuff and hallucinate. Im just a paramedic that researches stuff like this and no physician by a long shot...just picked it up after researching a patient I thought was lying to me about a depression treatment plan with narcotic medication....I had to find it out for myself and the above explanation is the guts of the study....hope it helps....I research alot of "cases" I transport to the hospital with good stories...
Pressure and clogging of ears. Don't notice I'm not hearing out of one ear or the other until hearing comes back out of the blue.
Contestants epigastric pain, chronic pancreatits, have had gallbladder removed, also pseudocyst drainage and roux on y loop
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- A study of drug interactions between Oxycodone Hcl, Avonex, Synthroid, Aciphex, Celexa, Wellbutrin, Neurontin, Ultram, Prednisone, Glipizide, Seroquel, Remeron, Methadose, Klonopin, Ritalin for a patient with Multiple Sclerosis. The patient has Arthralgia, Chest Pain, Diabetes Mellitus, Fall, Head Injury, Hypertension, Injection Site Erythema, Loss Of Consciousness, Procedural Complication, Syncope, Treatment Noncompliance
- A study of drug interactions between Oxycontin, Clonazepam, Lotrel, Ultram, Zanaflex for a patient with Pain. The patient has Anxiety, Asthenia, Back Pain, Chest Pain, Contusion, Depression, Dizziness, Drug Dependence, Drug Withdrawal Syndrome, Dyspnoea, Headache, Loss Of Consciousness, Memory Impairment, Neck Pain, Pain, Pain In Extremity, Road Traffic Accident, Vision Blurred
- A study of drug interactions between Oxycontin, Tramadol Hcl, Oxymorphone Hydrochloride, Ultram, Celebrex, Soma for a patient with Pain. The patient has Accidental Overdose, Cardiac Arrest, Circulatory Collapse, Drug Dependence, Malaise, Nausea
- A study of drug interactions between Oxycodone Hcl, Provigil, Oxycontin, Ritalin Tab, Ultram, Prozac, Klonopin, Vistaril, Percocet, Marcaine, Hydromorphone Hcl, Tylenol, Ancef, Actiq, Valium, Dulcolax, Aspirin, Lovenox, Desyrel, Roxicodone, Dilaudid, Oruvail, Baclofen, Soma, Catapres-tts-1, Skelaxin, Nadolol, Amoxil, Fosamax, Neurontin, Hydroxyzine Pamoate, Celebrex, Wellbutrin Sr, Trazodone Hcl for a patient with Pain. The patient has Adjustment Disorder With Depressed Mood, Bone Density Decreased, Constipation, Depressed Mood, Depression, Dislocation Of Joint Prosthesis, Disturbance In Attention, Dizziness, Drug Dependence, Drug Tolerance, Drug Withdrawal Syndrome, Fall, Feeling Cold, Groin Pain, Headache, Hypersomnia, Hypoaesthesia, Incontinence, Irritability, Lethargy, Nervousness, Night Sweats, Pain, Post Procedural Cellulitis, Pruritus, Radiculopathy, Sedation, Sinusitis, Somnolence, Temperature Intolerance, Vision Blurred
- A study of drug interactions between Oxycodone Hcl, Oxycontin, Ritalin, Ultram, Prozac, Klonopin, Vistaril, Percocet, Marcaine, Hydromorphone Hcl, Tylenol, Ancef, Actiq, Valium, Dulcolax, Aspirin, Lovenox, Desyrel, Roxicodone, Dilaudid, Oruvail, Baclofen, Soma, Catapres-tts-1, Skelaxin, Nadolol, Amoxil, Fosamax, Neurontin, Hydroxyzine Pamoate, Celebrex, Provigil, Wellbutrin Sr for a patient with Pain. The patient has Anorexia, Anxiety, Arthralgia, Back Pain, Bursitis, Buttock Pain, Constipation, Depressed Mood, Depression, Dislocation Of Joint Prosthesis, Disturbance In Attention, Drug Dependence, Drug Tolerance, Drug Withdrawal Syndrome, Fall, Fatigue, Feeling Cold, Feeling Hot And Cold, Headache, Hip Arthroplasty, Hot Flush, Hypersomnia, Hypoaesthesia, Incontinence, Irritability, Lethargy, Monoplegia, Muscle Cramp, Muscle Spasms, Nervousness, Night Sweats, Pain, Post Procedural Cellulitis, Pruritus, Pyrexia, Sedation, Self-medication, Sinusitis, Somnolence, Temperature Intolerance, Vision Blurred, Vomiting
- A study of drug interactions between Oxycodone Hcl, Oxycontin, Ritalin Tab, Ultram, Prozac, Klonopin, Vistaril, Percocet, Marcaine, Hydromorphone Hcl, Tylenol, Ancef, Fentanyl, Valium, Dulcolax, Aspirin, Lovenox, Desyrel, Dilaudid, Roxicodone, Oruvail, Baclofen, Soma, Catapres-tts-1, Skelaxin, Nadolol, Amoxil, Fosamax, Neurontin, Hydroxyzine Pamoate, Celebrex, Provigil, Wellbutrin Sr for a patient with Pain. The patient has Affective Disorder, Anorexia, Anxiety, Arthralgia, Back Pain, Bursitis, Buttock Pain, Cellulitis, Constipation, Depression, Dislocation Of Joint Prosthesis, Disturbance In Attention, Drug Dependence, Drug Tolerance, Drug Withdrawal Syndrome, Exostosis, Fall, Feeling Cold, Headache, Hot Flush, Hypoaesthesia, Incontinence, Insomnia, Irritability, Lethargy, Markedly Reduced Dietary Intake, Muscle Cramp, Muscle Spasms, Nausea, Nervousness, Night Sweats, Pain, Post Procedural Complication, Pruritus, Pyrexia, Sedation, Sinusitis, Somnolence, Temperature Intolerance, Tremor, Vision Blurred, Vomiting
- A study of drug interactions between Lamictal, Oxycontin, Soma, Duragesic, Morphine, Ultram, Klonopin, Seroquel, Methadone Hcl for a patient with Epilepsy. The patient has Arthralgia, Decreased Appetite, Headache, Insomnia, Nausea, Vertigo, Vomiting
- A study of drug interactions between Opana Er, Remeron, Ultram, Skelaxin, Cymbalta, Klonopin for a patient with Pain. The patient has Back Pain, Blood Creatine Increased, Blood Potassium Increased, Diarrhoea, Hepatic Failure
- A study of drug interactions between Opana Er, Remeron, Ultram, Skelaxin, Cymbalta, Klonopin for a patient with Pain. The patient has Diarrhoea, Liver Function Test Abnormal, Malaise, Nausea, Vomiting
- A study of drug interactions between Oxycodone Hcl, Avonex, Catapres-tts-1, Tramadol Hcl, Depakote, Zonegran, Klonopin, Zanaflex, Baclofen, Cymbalta for a patient with Multiple Sclerosis. The patient has Condition Aggravated, Multiple Sclerosis, Optic Neuritis
- A study of drug interactions between Avonex, Catapres-tts-1, Tramadol Hcl, Depakote, Zonegran, Klonopin, Zanaflex, Baclofen, Cymbalta, Oxycodone Hcl for a patient with Multiple Sclerosis. The patient has Condition Aggravated, Headache, Multiple Sclerosis, Optic Neuritis
- A study of drug interactions between Fentanyl Transdermal System, Carisoprodol, Gemfibrozil, Fluoxetine, Clonazepam, Trazodone Hcl, Furosemide, Tramadol Hcl, Temazepam, Lisinopril, Fenofibrate, Atorvastatin Calcium, Hydrochlorothiazide, Oxycodone Hcl for a patient with Venous Stasis, Fibromyalgia. The patient has Cardiomegaly, Coronary Artery Stenosis, Drug Abuser, Drug Ineffective, Drug Toxicity, Dyspnoea, Fibrosis, Hepatic Steatosis, Hypersomnia, Hypertrophic Cardiomyopathy, Hypoventilation, Oedema Peripheral, Portal Triaditis, Pulmonary Congestion, Pulmonary Oedema, Pulse Absent, Respiratory Distress, Sudden Death, Urinary Retention
- A study of drug interactions between Fentanyl Transdermal System, Gemfibrozil, Fluoxetine, Clonazepam, Trazodone Hcl, Furosemide, Tramadol Hcl, Carisoprodol, Temazepam, Lisinopril, Fenofibrate, Atorvastatin Calcium, Hydrochlorothiazide, Oxycodone Hcl for a patient with Pain. The patient has Cardiac Hypertrophy, Coronary Artery Stenosis, Drug Effect Decreased, Drug Toxicity, Dyspnoea, Fibrosis, Hepatic Steatosis, Hypersomnia, Hypertrophic Cardiomyopathy, Hypoventilation, Oedema, Portal Triaditis, Pulmonary Congestion, Pulmonary Oedema, Pulse Absent, Respiratory Distress, Sudden Death, Urinary Retention, Wrong Technique In Drug Usage Process
- A study of drug interactions between Oxycontin, Venlafaxine Hcl, Acetaminophen, Mirtazapine, Carisoprodol, Oxymorphone Hydrochloride, Ultram, Vicodin Es for a patient with Pain. The patient has Blood Alcohol Increased, Cholelithiasis, Completed Suicide, Multiple Drug Overdose, Muscle Spasms, Pleural Effusion
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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