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What could cause Fatigue, Difficulty breathing for a 41-year old woman who takes Zoloft, Methylprednisolone, Topamax, Acyclovir, Klonopin, Plaquenil?





Summary: 4 female patients aged 41 (±5) who take the same drugs are studied.

This is a personalized study for a 41 year old female patient who has Chronic Depression, Sjogren's Syndrome, Herpes Simplex, Anxiety. The study is created by eHealthMe based on reports from FDA and social media.

What are the drugs

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. (latest outcomes from Zoloft 78,283 users)

Methylprednisolone has active ingredients of methylprednisolone. It is often used in inflammation. (latest outcomes from Methylprednisolone 5,875 users)

Topamax has active ingredients of topiramate. It is often used in migraine. (latest outcomes from Topamax 24,579 users)

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. (latest outcomes from Acyclovir 1,284 users)

Klonopin has active ingredients of clonazepam. It is often used in stress and anxiety. (latest outcomes from Klonopin 31,277 users)

Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. (view latest outcomes from 15,517 users)

What are the conditions

Chronic depression (long lasting stress state of low mood) can be treated by Cymbalta, Wellbutrin Xl, Prozac, Zoloft, Celexa, Effexor Xr. (latest reports from Chronic Depression 4,129 patients)

Sjogren's syndrome (a disease that causes dryness in the mouth and eyes) can be treated by Plaquenil, Evoxac, Hydroxychloroquine Sulfate, Prednisone, Restasis. (latest reports from Sjogren's Syndrome 2,452 patients)

Herpes simplex (herpes simplex is a common viral infection) can be treated by Valtrex, Acyclovir, Valacyclovir, Valacyclovir Hydrochloride, Zovirax, Famciclovir. (latest reports from Herpes Simplex 6,809 patients)

Anxiety can be treated by Xanax, Klonopin, Clonazepam, Zoloft, Lexapro, Ativan. (latest reports from Anxiety 197,075 patients)

What are the symptoms

Fatigue (feeling of tiredness) has been reported by people with multiple sclerosis, high blood pressure, depression, rheumatoid arthritis, osteoporosis.(latest reports from Fatigue 198,350 patients)

Difficulty breathing has been reported by people with high blood pressure, asthma, rheumatoid arthritis, pain, chronic obstructive pulmonary disease.(latest reports from Difficulty breathing 164,496 patients)

On Nov, 19, 2014: 4 females aged 35 (±5) who take Zoloft, Methylprednisolone, Topamax, Acyclovir, Klonopin, Plaquenil are studied

Zoloft, Methylprednisolone, Topamax, Acyclovir, Klonopin, Plaquenil outcomes

Information of the patient in this study:

Age: 35

Gender: female

Conditions: Chronic Depression, Sjogren's Syndrome, Herpes Simplex, Anxiety

Drugs taking:
- Zoloft (sertraline hydrochloride): used for 1 - 2 years
- Methylprednisolone (methylprednisolone): used for 1 - 2 years
- Topamax (topiramate): used for 2 - 5 years
- Acyclovir (acyclovir): used for 1 - 2 years
- Klonopin (clonazepam): used for 2 - 5 years
- Plaquenil (hydroxychloroquine sulfate): used for 1 - 2 years

Drug interactions have: severe fatigue, moderate difficulty breathing

eHealthMe real world results:

Comparison with this patient's adverse outcomes:

InteractionNumber of reports on eHealthMe
Fatigue (feeling of tiredness)4 (100.00% of females aged 35 (±5) who take the drugs)
Difficulty Breathing2 (50.00% of females aged 35 (±5) who take the drugs)

(as an adverse outcome could be a symptom of a condition, additional studies are listed to help identify the cause: for example, regardless of which drug is taken, how many female HBP patients aged 50 (±5) have nausea)

Symptom (click a symptom for in-depth analysis)Number of reports on eHealthMe
Fatigue in Chronic Depression20 (4.57% of females aged 35 (±5) who have Chronic depression)
Fatigue in Sjogren's Syndrome5 (7.46% of females aged 35 (±5) who have Sjogren's syndrome)
Fatigue in Herpes Simplex7 (2.71% of females aged 35 (±5) who have Herpes simplex)
Fatigue in Anxiety355 (4.36% of females aged 35 (±5) who have Anxiety)
Difficulty Breathing in Chronic Depression6 (1.37% of females aged 35 (±5) who have Chronic depression)
Difficulty Breathing in Sjogren's Syndrome3 (4.48% of females aged 35 (±5) who have Sjogren's syndrome)
Difficulty Breathing in Herpes Simplex5 (1.94% of females aged 35 (±5) who have Herpes simplex)
Difficulty Breathing in Anxiety207 (2.54% of females aged 35 (±5) who have Anxiety)

(as an adverse outcome could be a side effect of a drug, additional studies are listed to help identify the cause: for example, how many female Aspirin users aged 50 (±5) have nausea)

Side effect (click a side effect for in-depth analysis)Number of reports on eHealthMe
Fatigue in Zoloft324 (4.59% of females aged 35 (±5) who take Zoloft)
Fatigue in Methylprednisolone21 (6.02% of females aged 35 (±5) who take Methylprednisolone)
Fatigue in Topamax208 (5.48% of females aged 35 (±5) who take Topamax)
Fatigue in Acyclovir6 (4.23% of females aged 35 (±5) who take Acyclovir)
Fatigue in Klonopin285 (7.83% of females aged 35 (±5) who take Klonopin)
Fatigue in Plaquenil74 (6.08% of females aged 35 (±5) who take Plaquenil)
Difficulty Breathing in Zoloft177 (2.51% of females aged 35 (±5) who take Zoloft)
Difficulty Breathing in Methylprednisolone14 (4.01% of females aged 35 (±5) who take Methylprednisolone)
Difficulty Breathing in Topamax132 (3.48% of females aged 35 (±5) who take Topamax)
Difficulty Breathing in Acyclovir1 (0.70% of females aged 35 (±5) who take Acyclovir)
Difficulty Breathing in Klonopin138 (3.79% of females aged 35 (±5) who take Klonopin)
Difficulty Breathing in Plaquenil38 (3.12% of females aged 35 (±5) who take Plaquenil)

Drug effectiveness over time :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
Zoloft is effectiven/an/an/a100.00%
(1 of 1 people)
n/an/an/an/a
Methylprednisolone is effectiven/an/an/a0.00%
(0 of 1 people)
n/an/an/an/a
Topamax is effectiven/an/an/an/a0.00%
(0 of 1 people)
n/an/an/a
Acyclovir is effectiven/an/an/a100.00%
(1 of 1 people)
n/an/an/an/a
Klonopin is effectiven/an/an/an/a100.00%
(1 of 1 people)
n/an/an/a
Plaquenil is effectiven/an/an/a0.00%
(0 of 1 people)
n/an/an/an/a

Most common drug interactions over time * :

< 1 month1 - 6 months6 - 12 months1 - 2 years2 - 5 years5 - 10 years10+ yearsnot specified
n/an/an/aDifficulty BreathingDifficulty Breathingn/an/aDrug Hypersensitivity
Fatigue (feeling of tiredness)Fatigue (feeling of tiredness)Insulin Resistance
Oedema (fluid collection in tissue)
Diplopia (double vision)
Vision Blurred
Diabetes Mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Glucose Tolerance Impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Herpes Virus Infection

* Some reports may have incomplete information.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

You are not alone! Join a related mobile support group:
- support group for people who have Anxiety
- support group for people who have Chronic Depression
- support group for people who have Herpes Simplex
- support group for people who have Sjogren's Syndrome
- support group for people who have Difficulty Breathing
- support group for people who have Fatigue
- support group for people who take Acyclovir
- support group for people who take Klonopin
- support group for people who take Methylprednisolone
- support group for people who take Plaquenil
- support group for people who take Topamax
- support group for people who take Zoloft

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    Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.

    The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.

    The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
    What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.

    It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.

    There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.

    Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.

    The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).

    Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.

    I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
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    From what I have read on all the sites...the only way "WE" are going to get help with issues like these...is by sharing with one another. Not one of the individuals that I speak of has had any positive help with their side effects from their doctors. Am I pissed off??? You bet I am. As for depression...that only comes in small doses for me.....like yesterday...when my body hurt me so badly...my cough was out of control...I had difficulty breathing...and I could not stand on my own two feet without holding on. That moment in time has passed...but for how long??? What will I be hit with next??? When???
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More related studies for: Acyclovir, Anxiety, Chronic Depression, Difficulty Breathing, Fatigue, Herpes Simplex, Klonopin, Methylprednisolone, Plaquenil, Sjogren's Syndrome, Topamax, Zoloft

Common symptoms:

Women of age 40-49 with Chronic Depression:
  1. Fatigue (22 reports)
  2. Memory loss (17 reports)
  3. Stress and anxiety (12 reports)
  4. Depression (10 reports)
  5. Dizziness (10 reports)
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Women of age 40-49 with Sjogren's Syndrome:
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  2. Joint swelling (15 reports)
  3. Rashes (13 reports)
  4. Pain (13 reports)
  5. Stress and anxiety (12 reports)
  6. Insomnia (10 reports)
  7. Dizziness (10 reports)
  8. Oedema peripheral (10 reports)
  9. Irritability (9 reports)
  10. Confusion (9 reports)
Women of age 40-49 with Herpes Simplex:
  1. Joint swelling (15 reports)
  2. Pain (13 reports)
  3. Insomnia (10 reports)
  4. Confusion (9 reports)
  5. Irritability (9 reports)
  6. Depression (9 reports)
  7. Headache (8 reports)
  8. Injection site pain (8 reports)
  9. Nausea (8 reports)
  10. Breathing difficulty (7 reports)
Women of age 40-49 with Anxiety:
  1. Stress and anxiety (1,246 reports)
  2. Depression (783 reports)
  3. Nausea (689 reports)
  4. Fatigue (617 reports)
  5. Headache (597 reports)
  6. Insomnia (591 reports)
  7. Pain (587 reports)
  8. Dizziness (554 reports)
  9. Weight increased (421 reports)
  10. Diabetes (415 reports)

NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.

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