coumadin, Miralax, Topamax, lyrica for a 46-year old woman
Summary: 21 female patients aged 46 (±5) who take the same drugs are studied.
This is a personalized study for a 46 year old female patient who has Deep Vein Thrombosis, Constipation, Migraine, Neuropathic Pain. The study is created by eHealthMe based on reports from FDA and social media.
What are the drugs
Coumadin has active ingredients of warfarin sodium. It is often used in blood clots. (latest outcomes from Coumadin 75,095 users)
Miralax has active ingredients of polyethylene glycol 3350. It is often used in constipation. (latest outcomes from Miralax 9,268 users)
Topamax has active ingredients of topiramate. It is often used in migraine. (latest outcomes from Topamax 24,579 users)
Lyrica has active ingredients of pregabalin. It is often used in fibromyalgia. (latest outcomes from Lyrica 66,558 users)
What are the conditions
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis) can be treated by Warfarin Sodium, Coumadin, Lovenox, Xarelto, Aspirin, Arixtra. (latest reports from Deep Vein Thrombosis 42,666 patients)
Constipation can be treated by Miralax, Colace, Amitiza, Senna, Lactulose, Milk Of Magnesia. (latest reports from Constipation 80,049 patients)
Migraine (headache) can be treated by Topamax, Imitrex, Maxalt, Topiramate, Propranolol Hydrochloride, Amitriptyline Hydrochloride. (latest reports from Migraine 47,669 patients)
Neuropathic pain (pain due to nerve inflammation and damage) can be treated by Gabapentin, Lyrica, Neurontin, Cymbalta, Amitriptyline Hydrochloride, Pregabalin. (latest reports from Neuropathic Pain 978 patients)
On Nov, 29, 2014: 21 females aged 41 (±5) who take coumadin, Miralax, Topamax, lyrica are studied
Information of the patient in this study:
Conditions: Deep Vein Thrombosis, Constipation, Migraine, Neuropathic Pain
- coumadin (warfarin sodium): used for 6 - 12 months
- Miralax (polyethylene glycol 3350): used for < 1 month
- Topamax (topiramate): used for 1 - 2 years
- lyrica (pregabalin): used for 1 - 6 months
eHealthMe real world results:
Drug effectiveness over time :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|coumadin is effective||n/a||n/a||n/a||n/a||n/a||n/a||n/a||n/a|
|Miralax is effective||n/a||n/a||n/a||0.00%|
(0 of 1 people)
|Topamax is effective||n/a||n/a||n/a||n/a||n/a||n/a||0.00%|
(0 of 1 people)
|lyrica is effective||n/a||n/a||0.00%|
(0 of 1 people)
Most common drug interactions over time * :
|< 1 month||1 - 6 months||6 - 12 months||1 - 2 years||2 - 5 years||5 - 10 years||10+ years||not specified|
|Fatigue (feeling of tiredness)||n/a||Night Sweats (sweating in night)||Shortness Of Breath||n/a||n/a||Inflammatory Pain||Impaired Healing|
|Insomnia (sleeplessness)||Insomnia Related To Another Mental Condition (sleeplessness related to another mental condition)||Confusional State||Swelling||Injury|
|Vision Blurred||Loss Of Control Of Legs||Headache (pain in head)||Headache (pain in head)||Intervertebral Disc Protrusion (spinal disc protrusion)|
|Weight Increased||Muscle Contractions Involuntary (uncontrolled muscle contraction)||Exhaustion, Fatigue, Lethargy, Tiredness, Weariness (feeling of tiredness)||Exhaustion, Fatigue, Lethargy, Tiredness, Weariness (feeling of tiredness)||Mastication Disorder (disease of chewing food)|
|Loss Of Appetite (lack of feeling to eat)||Muscle Fatigue (a condition in which muscles cannot exert their normal force)||Muscle Fatigue (a condition in which muscles cannot exert their normal force)||Malnutrition (condition that results from eating a diet in which certain nutrients are lacking)|
|Sacral Pain (pain at sacrum bone region)||Loss Of Control Of Legs||Fall||Granulocytopenia (lack of granulocyte)|
|Swelling||Night Sweats (sweating in night)||Night Sweats (sweating in night)||Gastritis (inflammation of stomach)|
|Fall||Palpitations Aggravated (feelings or sensations that your heart is pounding or racing- aggravated)||Insomnia Related To Another Mental Condition (sleeplessness related to another mental condition)||Dental Caries|
|Muscle Fatigue (a condition in which muscles cannot exert their normal force)||Insomnia Related To Another Mental Condition (sleeplessness related to another mental condition)||Shortness Of Breath||Depression|
|Inflammatory Pain||Fall||Muscle Contractions Involuntary (uncontrolled muscle contraction)||Disability|
* Some reports may have incomplete information.
How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.
You can also:
- Check your drugs or symptoms
- Subscribe the study: get notified of updates
- Post a comment: or see what other people said about the study
- Join a related mobile support group
You are not alone! Join a related mobile support group:
- support group for people who have Constipation
- support group for people who have Deep Vein Thrombosis
- support group for people who have Migraine
- support group for people who have Neuropathic Pain
- support group for people who take Miralax
- support group for people who take Topamax
- support group for people who take Coumadin
- support group for people who take Lyrica
Recent conversations of related support groups:
- Support group for people who take Lyrica
I have gained about 35 pounds, and I have the cognitive effects listed in the prescribing information--problems with thinking and concentration." I've been off Lyrica once, and the side effects went away, but I couldn't get out of bed in the morning
Can you answer these questions (Ask a question):
- Does topamax effect sexual desire and cause weight gain (1 answer)
I have taken topamax for 10 years and have been gaining weight steadily every year. My doctor says the medication is not the reason because Topamax causes people to loose weight. I have also voiced my concerns to him that since I started taking this medication I have no desire for sex. He says this medication would not affect this. Please help so I can get him to change my medication.
- Can sulfalazine cause bed wetting
I had been taking the Sulfalazine for around 6 months with no real side effects, Then twice in one week I lost control of my bladder while sleeping. This has never happened to me before. My GP took me off the sulfalazine and I was fine, He had thought they where causing some sort of convulsion while Sleeping. About 6 weeks later my GP rand and told me to go back on them as he no longer thought that they where causing the problem, 5 days in and it has just happened again, My bed and myself soaked, It's completley frustrating, Can any one please help with any suggestions?
- Have you noticed extreme edema after taking both of these drugs?
I have been taking Topamax for years for treatment of migraine headaches. Two months ago I was placed on Lithium and Latuda for Mood Disorder NOS. I had a host of bad reactions to both drugs and have since been removed. A week ago I started taking Tegretol. Since coming down off the Lithium and starting the Tegretol with the Topamax I have started retaining another water to fill up Death Valley. Just wondering if this was a aide effect of the medication or something else.
- How are people being treated with may-thurner syndrome?
I was diagnosed with May-Thurner Syndrome after two DVT's five years apart. Have been treated with Coumadin for the last 10 years but now a Doctor has changed me to Plavix and aspirin therapy.
- How often does thromboyctopenia occur?
73 year old patient with thrombocytopenia of unknown origin. He has failed Rituxin treatments and initial therapy with steroids has actually caused his platelets to lower. Requesting to see if his current medications may be the culprit.
You may be interested at these reviews (Write a review):
- Hot flashes while taking miralax
After being on daily dose of Miralax for a year and then going off for a few months, after starting back in 2 weeks, experiencing hot flushes periodically all day long last around 30 seconds. I didn't realize when I first started the Miralax for the 1st year that my Hot Flushes may have been a side affect. I even had requested labs to test for menopause which show negative. Again, after I stopped the miralax the hot flushes ceased. As stated above they are back. These did not wait for me to be on the drug 2 or more years either it was within weeks of starting.
- Leg pain especially near knees after taking lyrica
Had to stop taking Lyrica due to joint pain in both legs. Difficult to get up from sitting position to stand. Ache in knee's can't relax to sleep. Motrin and vicodin not helping with pain. Also have applied muscle cream not working for pain. Have been off the lyrica for 3 months with no let up in pain. Did not have this pain before taking lyrica.
- Urea urine increased while taking topamax
I was on Topamax to lose weight. It worked for me, I lost weight but my blood urea increased. I have to stop taking it.
- 3 strong drugs together against neuropathic pain
Neuropathic pain debuted when I was 24, now I'm 50. Received diagnosed with Ehler-Danlos syndrome (EDS), joint hypermobility type, when I was 35 years old. So it can take some time to get a diagnose. And as EDS-patient I do not belong to any clinic. Orthopedics says that EDS is not orthopedic, rheumatology says that EDS is not an autoimmune disease, GPs say that EDS is too difficult, and so on. Sooner or later we all end up at Psychiatry, even if we are not depressed.
The first kind of pain I got when I was 24 came from low back, but I experienced as pelvic pain and leg pain. It was clearly a neuropathic pain, but it took years to find out. Later it was treated by a pain clinic with cortisone around the genitofemoral nerves (both sides). Since this treatment didn't result in lasting freedom from pain, the pain clinic started to give me RF (radio frequency) treatment. This made the pain disappeared after one year, and I was 80% free from it between 2002 and 2014, 12 years. The pain doctors said pain could return after 10 years.
The other kind of neuropathic pain started 2003 with intense stomach pain. During 6 months I could hardly eat nothing due to nausea and vomiting. After this 6 months, stomach pain changed to almost unbearable pain in upper back.
What happened 2003, and what all the doctors missed, was that the right lowest ribs slid up over the sternum. This rib dislocation is till there today, but now with a lot of cartilage formed around the rib where it is stuck in the lower end of the sternum. The dislocation is clearly visible on X-ray. This has greatly affected the thoracic spine. I have a scoliosis which I had not before 2003. And I still have severe pain in the thoracic spine.
It was initially treated with morphine daily, and later with Durogesic (fentanyl), but this didn't help much. 2005 I was hospitalized because I had too much pain to take care of myself and my hygiene. After some months the doctors started to give me clonazepam because the muscles along the spine was in a chronic seizures. Clonazepam helped, but I could still have a lot of pain in two vertebrae in the thoracic spine. It felt as if someone drilled into the vertebrae without anesthesia. After a few months, doctors also prescribed me methadone. Then the pain disappeared almost completely. Since 2006, I have eaten clonazepam and methadone every day, and I need to sleep in an armchair to not get more pain because of moving during sleep.
There are side effects. After 1,5 years with clonazepam and methadone I started to have panic attacks. Or rather one long panic attack which didn't stop before I got treatment with amitryptilin and pregabalin (Lyrica). These 2 medicines stopped the panic disorder completely after some hours, and the panic was then gone. Then I got side effects of these 2 medicines, amitryptilin & Lyrica, too. I gained a lot of weight (from 83 to 148 kg) and got much water (edema) in both my legs under the knees and in both feet. The feet could swallow to the double size. 2012 I stopped with amitryptilin and started to loose weight again (in Aug 2014 below 80 kg) and get less water in my legs. Today I eat as little medicines I can, but I have to take methadone, clonazepam and Lyrica every day, twice. If I try to take away one of these 3 medicines, I got pain problems at once. Lyrica is the most painful one to take away. In Sept-Dec 2013 I lowered Lyrica from 300 mg daily, to 150, then to 75 and finally 0 mg. The pain I had was extremely difficult to handle. It didn't help to take more methadone or anything else. I have checked on Internet and found that many people got pain from quitting with Lyrica. Most people start eating it again. So did I. But 2006 and 2007 it was enough to treat the pain with methadone and clonazepam, I got the Lyrica against anxiety not pain. But today I take Lyrica against pain.
Beside weight gain and leg edema, clonazepam and Lyrica significantly affect the sexual desire. And Lyrica alone makes it almost impossible to ejaculate. All four drugs together (clonazepam, methadone, amitryptiline and Lyrica), make one forget all about sex life. You don't even miss it. When I stopped with amitryptiline and lowered Lyrica (still taking clonazepam and methadone), I could suddenly easily get erections again, feel desire, but not getting orgasms. This is quite difficult to deal with.
The pain pattern is greatly affected, by pain and by the medicines. So is the mood. I get something which feels like heavy depression, especially if I take the medicines late that day. I should take a medicine like methadone 3 times a day, because the effects of the tablet lasts around 8 hours. But I take them every 12 hours, to have a low consumption in case doctors prescribe them too late (which happens, and then it's good to have a spouse going to the pharmacy buying them for you, because you have too much pain to go yourself).
Since methadone is also used for treating heroine addicts, medical staff treat you with disrespect when they see that it says "methadone" in your health record. I need to show a certificate that says that I deal with chronic neuropathic pain, that I never have had problems with drug addiction, to get normal respect.
I wanted to share this because I think I am alone in the world with these medicines in combination against neuropathic pain caused by hypermobile joints, joint dislocation and muscle spasms. After trying almost everything else, including surgery cutting nerves, methadone, clonazepam and Lyrica seems to be the only way to kill my pain. But it's a life where you always is questioned, because of the use of methadone. I can guarantee that everybody in the world should accept these medicines if they had experienced the unbearable pain I had in upper back before they started to give me clonazepam and methadone.
- Massive aggression within first 4 days at 50mg (1 response)
am only taking 50mg and have only been taking it for 4 days(this is the evening of the 4th day)as a preventative for migraine headaches that I have suffered from from 16 years. I have had pins and needles in my hands and feet as well as spontaneous crying fits since day 2 and Major aggression since yesterday. With normally an insurmountable amount of patience with my 1 year old son, I outright yelled at him last night. This is unacceptable. I have never felt such quick and sudden rage over nothing before, well, over anything before.
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All this occurred when I started taking the Lipitor. I'm waiting on a phone call from my doctor.
I have an non-typical pulmonary stenosis, MPA aneurysm directly above that valve. The left ventricle was also enlarged due to the stress of my third & final pregnancy put on my heart.
On March 1st (this year) I went to the ER as none of my asthma treatment weren't working. After several tests a pulmonary embolism was found in my bronchial trunk. It was successfully dissolved with heparin in 48 hours. The PE put more stress on the left ventricle. As a result I was sent home to be on bed rest as I only had trouble breathing while mobile, under stress or attempting to carry on a conversation. At rest, my heart rate & oxygen meter would go back to normal.
That is no longer the case. When I went in to my Asthma & allergy doctor's office to do my PFT, it was worse than it has ever been, including before I quit smoking 5yrs. ago. This started at the same time I began taking Coumadin & became worse as I reached therapeutic INR levels.
I suffer from severe to moderate memory loss a friend told me it was due to klonopin It has been 7 years though since I suffered a concussion in a car accident. Been trying to get disability forever. I can't even handle a minimum wage job bc the steps I have to take r instantly out of my brain. I have a masters degree. So I don't think it's the concussion I think it's the meds. The muscle relaxant r brand new so we can't blame them. So could it be the klonopin
Related drug interaction studies:
- Topamax and Miralax drug interactions (259 reports)
- Coumadin and Topamax drug interactions (602 reports)
- Lyrica and Miralax drug interactions (649 reports)
- Lyrica and Topamax drug interactions (1,149 reports)
- Lyrica and Coumadin drug interactions (2,044 reports)
- Miralax and Coumadin drug interactions (1,089 reports)
Drug effectiveness in real world:
- Coumadin for Deep Vein Thrombosis reported by 224 people (updated 22 hours ago)
- Miralax for Constipation reported by 247 people (updated 5 hours ago)
- Topamax for Migraine reported by 764 people (updated 12 hours ago)
- Lyrica for Neuropathic Pain reported by 73 people (updated 10 hours ago)
Complete drug side effects:
- Constipation (26 drugs in 799 reports) (updated 1 day ago)
- Deep Vein Thrombosis (12 drugs in 625 reports) (updated 22 hours ago)
- Migraine (130 drugs in 3,843 reports) (updated 5 days ago)
- Neuropathic Pain (15 drugs in 310 reports) (updated 4 weeks ago)
NOTE: The study is based on active ingredients. Other drugs that have the same active ingredients are also considered.
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