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From FDA reports: drug interactions between Methotrexate, Cytoxan for a Female patient aged 38

This is a personalized study for a 38 year old female patient. The study is created by eHealthMe based on reports of 7,506 people who take the same drugs and have drug interactionsfrom FDA.

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On Jul, 23, 2014: 7,506 people who reported to have interactions when taking Methotrexate, Cytoxan are studied

Trend of Methotrexate, Cytoxan's drug interactions, side effects, and effectiveness reports (1983062)

Information of the patient in this study:

Age: 38

Gender: female

Drugs taking:
- Methotrexate
- Cytoxan

Drug interactions have: Grand Mal Convulsion

eHealthMe real world results:

Comparison with this patient's adverse outcomes among females aged 38 (±5):

InteractionNumber of reports
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain)4 (1.26%)

Most common interactions experienced by females aged 38 (±5) in the use of Methotrexate, Cytoxan:

InteractionNumber of reports
Pyrexia (fever)97
Neutropenia (an abnormally low number of neutrophils)82
Vomiting57
Platelet Count Decreased51
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)50
Nausea (feeling of having an urge to vomit)46
Stomatitis (inflammation of mucous membrane of mouth)36
Headache (pain in head)34
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant)32
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)32

Most common interactions experienced by females aged 38 (±5) in long term use of Methotrexate, Cytoxan:

InteractionNumber of reports
Facial Palsy (paralysis of face nerve)3
Hypoaesthesia (reduced sense of touch or sensation)3
Nervous System Disorder (a general class of medical conditions affecting the nervous system)3
Burkitt's Lymphoma (cancer of the lymphatic system)3
Csf Protein Increased2
Blood Lactate Dehydrogenase Increased2
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)2
Neuropathy Peripheral (surface nerve damage)2
Trigeminal Nerve Disorder (disease of facial nerve)2
Nuclear Magnetic Resonance Imaging Brain Abnormal2

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain)106 (1.41%)

Most common interactions experienced by people in the use of Methotrexate, Cytoxan:

InteractionNumber of reports
Pyrexia (fever)2,165
Neutropenia (an abnormally low number of neutrophils)1,476
Diarrhoea1,157
Vomiting1,060
Febrile Neutropenia (fever with reduced white blood cells)1,004
Sepsis (a severe blood infection that can lead to organ failure and death)792
Nausea (feeling of having an urge to vomit)760
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)736
Mucosal Inflammation (infection of mucous membrane)636
Thrombocytopenia (decrease of platelets in blood)608

Most common interactions experienced by people in long term use of Methotrexate, Cytoxan:

InteractionNumber of reports
Neutropenia (an abnormally low number of neutrophils)27
Drug Toxicity22
Haematotoxicity (toxins that destroy red blood cells)14
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)13
Anaemia (lack of blood)12
Renal Failure (kidney dysfunction)12
Pyrexia (fever)12
Burkitt's Lymphoma (cancer of the lymphatic system)10
Blood Disorder10
Thrombocytopenia (decrease of platelets in blood)8

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

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Comments from related studies:

  • From this study (2 years ago):

  • I was treated for ALL in 1989 by the VA. It was service connected, so I was given a very aggressive 4 year treatment which included intra-thecal administration, as well as, a plethora of different drugs. I'm trying to find out all of the possible long-term side effects of all of these treatments.

    Reply

  • From this study (3 years ago):

  • D on Feb, 27, 2012:

    I was switched to an inhaler (Beclomethasone)a year and half ago and had a break out of erythema Multiforme a year ago. I had no idea what it was and by the time I was able to see a Dermatologist the blisters on my hands and feet had gone away. Now I've been having break outs every 3 months. Finally made it to see a dermatologist and had a biopsy done. I was diagnoised with Erythema Multiforme. They asked if I was on any new medications and of cource my response had been no. I did not even think about my asthma medication that I had started 6 months prior to my first breakout. They gave me acivlor to try and control the break out. I have been desparate trying to figure this out. I finally looked up my inhaler medication and the disease and bingo found several sites documenting the reaction with this medication. I am so glad "I" figured this out. Unfortunatley for me, I did mention I was on Asthma medication but it didn't click with the Derm Doc's I guess and they didn't bother to ask the name of the Medication I was taking.

    Reply

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