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From FDA reports: drug interactions between Trisenox, Methotrexate for a Male patient aged 40

This is a personalized study for a 40 year old male patient. The study is created by eHealthMe based on reports of 38 people who take the same drugs and have drug interactionsfrom FDA.

On Dec, 22, 2014: 38 people who reported to have interactions when taking Trisenox, Methotrexate are studied

Trend of Trisenox, Methotrexate's drug interactions, side effects, and effectiveness reports (1565864)

Information of the patient in this study:

Age: 40

Gender: male

Conditions: Acute Lymphocytic Leukaemia

Drugs taking:
- Trisenox: used for < 1 month
- Methotrexate

Drug interactions have: Biopsy Bone Marrow Abnormal, Blood Bilirubin Increased, Mental Status Changes, Sepsis Nos

eHealthMe real world results:

Comparison with this patient's adverse outcomes among males aged 40 (±5):

InteractionNumber of reports
Biopsy Bone Marrow Abnormal2 (50.00%)
Blood Bilirubin Increased2 (50.00%)
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)2 (50.00%)
Sepsis Nos2 (50.00%)

Most common interactions experienced by males aged 40 (±5) in the use of Trisenox, Methotrexate:

InteractionNumber of reports
Sensory Disturbance (sense disturbance)4
White Blood Cell Count Decreased4
Pyramidal Tract Syndrome (disorder characterized by dysfunction of the corticospinal (pyramidal) tracts of the spinal cord)4
Dysstasia (difficulty in standing)4
Hypoaesthesia (reduced sense of touch or sensation)4
Nervous System Disorder (a general class of medical conditions affecting the nervous system)4
Monoplegia (a paralysis of a single limb)4
Irritability2
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell)2
Chest Discomfort2

Most common interactions experienced by males aged 40 (±5) in long term use of Trisenox, Methotrexate:

None.

For people in general (regardless of gender or age):

Comparison with this patient's adverse outcomes:

InteractionNumber of reports
Biopsy Bone Marrow Abnormal2 (5.26%)
Blood Bilirubin Increased2 (5.26%)
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)2 (5.26%)
Sepsis Nos4 (10.53%)

Most common interactions experienced by people in the use of Trisenox, Methotrexate:

InteractionNumber of reports
Alanine Aminotransferase Increased18
Hepatic Function Abnormal16
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)16
Cataract (clouding of the lens inside the eye)12
Depressed Level Of Consciousness10
Electrocardiogram Qt Prolonged10
White Blood Cell Count Decreased10
Electrocardiogram Qt Corrected Interval Prolonged8
Pyrexia (fever)8
Haemoglobin Decreased8

Most common interactions experienced by people in long term use of Trisenox, Methotrexate:

None.

How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood.

You can also:

Can you answer these questions (Ask a question):

  • Does humira cause excessive sweating?
    Having psoriaticarthritis,fibromyalgia,psoriais,restless leg syndrome,roseacea and high blood pressure means complex health issues and a complex list of medication to go with it. Iam suffering extreme sweating,flushing and now a tickled cough. Now it could be due to going through the change (menopause) but that started a year ago and although I was getting the flushes and sweating,it was nothing like it is now! To me,it seems the excessive sweating started roughly a month after taking Humira. Having so many health issues I'm in tune with any changes and note and monitor them. I started Humira 10 months ago now. My Psoriasis has cleared completely so I'm really pleased. Usually,there's a trade off and you end up with something else! Could the issues I have be down to a single drug on the list,or a combination?
  • Would the tinnitus abate with if i discontinue methotrexate?
    I've just begun my 4th year of Methotrexate for Rheumatoid issue, but it also alleviated my psoriasis. I am hesitant to discontinue because the benefits are great. However, the tinnitus is becoming unbearable and almost maddening. I will more likely consider talking to my doctor about changing medications if 1. The tinnitus subsides with the discontinuance of Methotrexate and if 2. Other rheumatoid medication would not have the same issues with tinnitus. Just discovered the possible connection minutes ago and am eager and hopeful. Please help. Thank you. -Celeste
  • Can i take humira while i still have pinpoint red spots on my skin? i have been told to stop the methotrextrate and they started me on prednisone to clear it up, i am scheduled to start humira.
    I have been diagnosed with R/A and started taking Methotrextate and Folic Acid. I began to break out like I had the measles. Was told it was a reaction to the methotrextate. I was taken off of it and given a large dose of prednisone. My question is I am scheduled to start taking Humira injections and I have been off of the methotrextate 24 days and it has not cleared up yet. Is is safe to start the Humira injections?

More questions for: Acute Lymphocytic Leukaemia, Biopsy Bone Marrow Abnormal, Blood Bilirubin Increased, Mental Status Changes, Methotrexate, Trisenox

You may be interested at these reviews (Write a review):

  • Humira: my experience
    I have had some form of arthritis probably since birth. My father and maternal grandfather had some form of arthritis. I began to realize pain in both ankles if I stood or walked too long.

    I began taking many NSAIDs when I was around 22. I've done gold, prednisone (twice), plaquenil, butazoidin, sulfasalazine, etc. My best results came with methotrexate after I got cellulitis in my knee (scratch it while kayaking in the summer, fiberglass boat). It dropped my sed rate from over 100 to 35 or so within a few months. I continued with MTX from 1977 to 2000 when my MD suggested Enbrel and stopping MTX. That was a VERY bad decision. Enbrel appeared to mask the disease for a few years. I had my left MCP replaced in 2004, my right heel debrided in 2010, and both my TMJs replaced in 2012. I strongly believe that if I had kept with the MTX it would have delayed those changes. Additionally, in 2011 I was in a bus crash returning from RAGBRAI. I got knocked out from three to six minutes. I had a nasty concussion that lasted 2+ years. Towards the end of the third year post accident I started exercising more aggressively. After doing several 40, 50, and 60 miles rides, I took a leisurely 50 mile ride around Boston at night. Two days later I had a spinal edema. So much for biking and other active sports! :-(

    I have continued with MTX. Late 2013 my MD increased my MTX to .8/week. I had been taking .6/week. I stopped taking Enbrel and switched to Humira in early 2014. I took it for a few months before my doc and I realized it was not doing any better than Enbrel. I tried Humira for three months but it did not seem to work any better than Enbrel. In early June I stopped Humira and waited a few weeks before I started Otezla. I stopped Oterzla on 9/15/14 because it made me depressed and allowed my morning stiffness to get much worse.

    I started prednisone again from the start of July. By mid-August I told my MD that I was screaming louder than I ever had; my dog was very startled. I stopped it gradually over the next two weeks. Meanwhile, the Otezla made me feel awful.

    My MD is going to get me onto another injectable that I take monthly. I forget its name.
  • Psoratic arthritis and trigeminal neuralgia
    hi i suffer from psorisis and psoratic athritis i was just diagnosed with trigeminal neuralgia i was looking for the connection between the two and i see that there is one from your study
    the thing is all 13 people in the study said to have psoriatic arthropathy yet only one said to have psoratic arthritis yet to the best of my knowledge it is the same condition just a diffrent name which means all those studied have psoratic arthritis like me
    also i have not been taking those medicines in the study yet i have the same condition so if you take me into account could be the oly conecction between all of us is the psorisis and psoratic arthritis and not the medicine
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More reviews for: Acute Lymphocytic Leukaemia, Biopsy Bone Marrow Abnormal, Blood Bilirubin Increased, Mental Status Changes, Methotrexate, Trisenox

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